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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2013, Volume 110, Issue 24, pp. 9920 - 9925
The ten-eleven translocation (TET) family of methylcytosine dioxygenases initiates demethylation of DNA and is associated with tumorigenesis in many cancers;... 
Genes | DNA | Cell lines | Breast cancer | Breast neoplasms | Gene expression regulation | Promoter regions | Metastasis | Embryonic stem cells | Tumors | MAMMALIAN DNA | 5-METHYLCYTOSINE | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | MOUSE | TISSUE | GENE-EXPRESSION | 5-HYDROXYMETHYLCYTOSINE | ACTIVE DNA DEMETHYLATION | TET PROTEINS | MLL | Wnt1 Protein - genetics | Prognosis | Oligonucleotide Array Sequence Analysis | Homeodomain Proteins - metabolism | Humans | Immunoblotting | Male | Transplantation, Heterologous | Gene Expression Profiling | Wnt1 Protein - metabolism | Mammary Neoplasms, Experimental - metabolism | Mammary Neoplasms, Experimental - genetics | Breast Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Neoplasm Metastasis | HMGA2 Protein - metabolism | RNA Interference | HMGA2 Protein - genetics | Mammary Neoplasms, Experimental - pathology | Female | Proto-Oncogene Proteins - metabolism | Mice, Inbred C57BL | Kaplan-Meier Estimate | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Homeodomain Proteins - genetics | Mice, Knockout | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Mice | Genetic aspects | Research | Translocation (Genetics) | Genetic regulation | Genetic engineering | Rodents | Binding sites | Index Medicus | Biological Sciences
Journal Article
Nature Neuroscience, ISSN 1097-6256, 05/2012, Volume 15, Issue 5, pp. 713 - 721
The Huntington's disease gene product, huntingtin, is indispensable for neural tube formation, but its role is obscure. We studied neurulation in htt-null... 
TARGETED DISRUPTION | ZEBRAFISH | LACKING HUNTINGTIN | EMBRYONIC STEM-CELLS | MUTANT HUNTINGTIN | ADAM10 | MICE | DISEASE GENE HOMOLOG | WILD-TYPE HUNTINGTIN | NEUROSCIENCES | N-CADHERIN CLEAVAGE | Body Patterning - drug effects | Guanylate Kinases - genetics | Amyloid Precursor Protein Secretases - genetics | RNA, Small Interfering - genetics | Wnt1 Protein - genetics | Brain - embryology | PAX2 Transcription Factor - metabolism | Cadherins - metabolism | Apoptosis - drug effects | Embryo, Mammalian | Hedgehog Proteins - metabolism | Apoptosis - genetics | Green Fluorescent Proteins - genetics | Brain - metabolism | NFI Transcription Factors - metabolism | Cadherins - genetics | Tissue Inhibitor of Metalloproteinase-1 - pharmacology | Discs Large Homolog 1 Protein | Membrane Proteins - genetics | Gene Expression Regulation, Developmental - drug effects | PAX2 Transcription Factor - genetics | Cell Adhesion - drug effects | Mutation - genetics | Biological Evolution | Brain - drug effects | Huntingtin Protein | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Analysis of Variance | Membrane Proteins - antagonists & inhibitors | Cell Adhesion - physiology | Embryo, Nonmammalian | Guanylate Kinases - metabolism | Neuroepithelial Cells - physiology | Mice | Zebrafish Proteins - genetics | ADAM Proteins - genetics | Cerebral Ventricles - cytology | Drosophila melanogaster | Neuroepithelial Cells - drug effects | Embryonic Stem Cells - metabolism | Nestin | Immunoprecipitation | Gene Expression Regulation, Developmental - genetics | Wnt1 Protein - metabolism | Zebrafish - embryology | Cell Differentiation - genetics | Transfection | Hedgehog Proteins - genetics | Intermediate Filament Proteins - genetics | Neurons - physiology | Membrane Proteins - metabolism | Cerebral Ventricles - embryology | Neurons - drug effects | Nuclear Proteins - genetics | Hydroxamic Acids - pharmacology | Green Fluorescent Proteins - metabolism | Brain - cytology | ADAM Proteins - antagonists & inhibitors | Animals, Genetically Modified | Zebrafish Proteins - metabolism | Dipeptides - pharmacology | Cells, Cultured | ADAM10 Protein | Morpholines - pharmacology | Nuclear Proteins - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Dictyostelium | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Body Patterning - genetics | Huntington's chorea | Physiological aspects | Cadherins | Genetic aspects | Research | Embryonic stem cells | Risk factors | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 11/2012, Volume 76, Issue 4, pp. 735 - 749
Axons must switch responsiveness to guidance cues during development for correct pathfinding. Sonic Hedgehog (Shh) attracts spinal cord commissural axons... 
SLIT | RESPONSIVENESS | KINASE-A | CHEMOATTRACTANT | GROWTH-CONE ATTRACTION | NETRIN-1 | SPINAL-CORD | GUIDANCE | SPECIFICATION | NEUROSCIENCES | INTERNEURONS | RNA, Small Interfering - genetics | Wnt1 Protein - genetics | Hedgehog Proteins - pharmacology | Embryo, Mammalian | Zinc Finger Protein Gli2 | Hedgehog Proteins - metabolism | Axons - physiology | Green Fluorescent Proteins - genetics | Spinal Cord Injuries - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Time Factors | Neurons - metabolism | Cyclic AMP - metabolism | 14-3-3 Proteins - genetics | Gene Expression Regulation, Developmental - physiology | Basic Helix-Loop-Helix Transcription Factors - genetics | Simplexvirus - genetics | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Developmental - drug effects | Rats | Mice, Transgenic | Piperazines - pharmacology | Rats, Sprague-Dawley | 14-3-3 Proteins - metabolism | Analysis of Variance | Signal Transduction - drug effects | Chickens | Luminescent Proteins - genetics | Mice | beta-Galactosidase - genetics | Carbazoles - pharmacology | Kruppel-Like Transcription Factors - genetics | RNA, Small Interfering - metabolism | Gene Expression Regulation, Developmental - genetics | Neurons - cytology | Wnt1 Protein - metabolism | DNA-Binding Proteins - metabolism | Neurons - classification | Protein Isoforms - metabolism | Hedgehog Proteins - genetics | Kruppel-Like Transcription Factors - metabolism | beta-Galactosidase - metabolism | Female | Pyrazoles - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | Bacterial Proteins - genetics | Cells, Cultured | Axons - drug effects | Electroporation | DNA-Binding Proteins - genetics | Chemotaxis | Amino Acids | Pregnancy | Pyrroles - pharmacology | Animals | Protein Isoforms - genetics | Proteins | Neurons | Medical research | Spinal cord | Rodents | Migration | Mammals | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 2004, Volume 119, Issue 1, pp. 97 - 108
The Ryk receptor belongs to the atypical receptor tyrosine kinase family. It is a new member of the family of Wnt receptor proteins. However, the molecular... 
GENE LINOTTE | DROSOPHILA DERAILED RECEPTOR | NEURAL CREST DEVELOPMENT | PROTEIN | WNT/BETA-CATENIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEURONAL PATHWAY SELECTION | XENOPUS EMBRYOS | TRANSCRIPTION FACTOR LEF-1 | BETA-CATENIN | INT-1 PROTOONCOGENE | CELL BIOLOGY | Wnt1 Protein | Protein Binding - genetics | Central Nervous System - metabolism | Humans | Wnt Proteins | Receptors, Neurotransmitter - genetics | Central Nervous System - embryology | Embryo, Mammalian - metabolism | DNA-Binding Proteins - metabolism | Lymphoid Enhancer-Binding Factor 1 | Cell Differentiation - genetics | Genes, Regulator - genetics | Phosphoproteins | Dishevelled Proteins | Frizzled Receptors | Proto-Oncogene Proteins - metabolism | Cell Line | Drosophila Proteins | Receptors, G-Protein-Coupled | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Protein Structure, Tertiary - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Macromolecular Substances | Proteins - genetics | Transcription Factors - metabolism | Adaptor Proteins, Signal Transducing | Animals | Growth Cones - metabolism | Proteins - metabolism | Central Nervous System - cytology | Embryo, Mammalian - embryology | Growth Cones - ultrastructure | Receptor Protein-Tyrosine Kinases - genetics | Embryo, Mammalian - cytology | Wnt3 Protein | Mice | RNA, Small Interfering | Receptors, Neurotransmitter - metabolism | Wnt3A Protein | Homology (Biology) | Genetic aspects | Research | Drosophila | Tyrosine metabolism | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 11, pp. 8598 - 8612
Perturbations in the adipocytokine profile, especially higher levels of leptin, are a major cause of breast tumor progression and metastasis; the underlying... 
HISTONE ACETYLTRANSFERASES | STEM-CELLS | MAMMARY-TUMOR GROWTH | CARCINOMA CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | FEMALE MICE | RECEPTOR | SIGNALING PROMOTES | E-CADHERIN | METASTASIS-ASSOCIATED PROTEIN-1 | Wnt1 Protein - genetics | Cadherins - metabolism | Vimentin - metabolism | Humans | Leptin - metabolism | Glycogen Synthase Kinase 3 beta | Wnt1 Protein - metabolism | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Phosphorylation - genetics | Cell Nucleus - metabolism | Cell Nucleus - pathology | Vimentin - genetics | Epithelial-Mesenchymal Transition | Female | Pyrimidinones - pharmacology | Leptin - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Cadherins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Gene Expression Regulation, Neoplastic - genetics | Repressor Proteins - metabolism | Wnt Signaling Pathway | Histone Deacetylases - genetics | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Leptin - genetics | Glycogen Synthase Kinase 3 - metabolism | beta Catenin - metabolism | beta Catenin - genetics | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Breast Neoplasms - genetics | Cell Nucleus - genetics | Glycogen Synthase Kinase 3 - genetics | Breast Neoplasms - pathology | beta Catenin - antagonists & inhibitors | Cell Line, Tumor | Index Medicus | MTA1 | Signal Transduction | Adipokines | Breast Cancer | Leptin
Journal Article
Science, ISSN 0036-8075, 3/2003, Volume 299, Issue 5615, pp. 2039 - 2045
Classical genetic screens can be limited by the selectivity of mutational targeting, the complexities of anatomically based phenotypic analysis, or... 
Double stranded RNA | Phosphatases | Transfection | Ribosomal proteins | Drosophila | Genes | Cultured cells | Gene expression regulation | Libraries | Research Articles | Genetic screening | CUBITUS INTERRUPTUS | SUPPRESSOR | DOUBLE-STRANDED-RNA | PROTEIN | GENE | MULTIDISCIPLINARY SCIENCES | TOUT-VELU | WINGLESS | HEPARAN-SULFATE PROTEOGLYCAN | INTERFERENCE | TRANSCRIPTIONAL REGULATION | Protein Kinases - metabolism | Wnt1 Protein | Protein Kinases - genetics | Genomics | Embryo, Nonmammalian - metabolism | Drosophila Proteins - metabolism | Proteoglycans - chemistry | Hedgehog Proteins | Congenital Abnormalities - genetics | Cyclic AMP-Dependent Protein Kinases - genetics | Neoplasms - genetics | RNA Interference | Drosophila - embryology | Protein-Serine-Threonine Kinases - metabolism | Drosophila - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Genes, Insect | Proto-Oncogene Proteins - metabolism | Casein Kinases | Signal Transduction | Cells, Cultured | Computational Biology | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Proteoglycans - metabolism | Proto-Oncogene Proteins - genetics | Animals | RNA, Double-Stranded - genetics | Drosophila - metabolism | Drosophila Proteins - genetics | Genome | Proteoglycans - genetics | Proteins | Genetic research | Research | RNA | Genetics | Cellular biology | Ribonucleic acid--RNA | Ribonucleic acid | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 22, pp. 19489 - 19500
Journal Article
Journal Article
PLoS Genetics, ISSN 1553-7390, 04/2018, Volume 14, Issue 4, pp. e1007339 - e1007339
Wnt signaling provides a paradigm for cell-cell signals that regulate embryonic development and stem cell homeostasis and are inappropriately activated in... 
DISHEVELLED PROTEIN | PATHWAY ACTIVATION | AXIN | ADENOMATOUS POLYPOSIS-COLI | TUMOR-SUPPRESSOR APC | OVERLAPPING ROLES | DEP DOMAIN | NEGATIVE REGULATION | GENETICS & HEREDITY | DROSOPHILA APC2 | DIX DOMAIN | Wnt1 Protein - genetics | Drosophila melanogaster - embryology | Transcription Factors - chemistry | Axin Protein - genetics | Axin Protein - chemistry | Multiprotein Complexes - genetics | Wnt1 Protein - metabolism | Armadillo Domain Proteins - genetics | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Drosophila melanogaster - genetics | Recombinant Fusion Proteins - metabolism | Axin Protein - metabolism | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Drosophila melanogaster - metabolism | Multiprotein Complexes - metabolism | Proteolysis | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Transcription, Genetic | Wnt Signaling Pathway | Axin Signaling Complex - chemistry | Cell Line | Tumor Suppressor Proteins - metabolism | Animals, Genetically Modified | RNA, Messenger - genetics | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - genetics | Armadillo Domain Proteins - chemistry | Drosophila Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Glycogen Synthase Kinase 3 - metabolism | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Transcription Factors - metabolism | Multiprotein Complexes - chemistry | Animals | Axin Signaling Complex - metabolism | Glycogen Synthase Kinase 3 - genetics | Axin Signaling Complex - genetics | Armadillo Domain Proteins - metabolism | Recombinant Fusion Proteins - genetics | Drosophila Proteins - genetics | Binding proteins | Wnt proteins | Health aspects | Stoichiometry | Phosphorylation | Wnt protein | Funding | Glycogen synthase | Genes | Homeostasis | Kinases | Proteins | β-catenin | Embryogenesis | Ubiquitination | Localization | Dishevelled protein | Glycogen | Polymerization | Curricula | Embryos | Adenomatous polyposis coli | Microscopy | Insects | Stem cells | Regulation | Genetic engineering | Molecular biology | Cancer | Index Medicus
Journal Article
CELL, ISSN 0092-8674, 04/2002, Volume 109, Issue 1, pp. 47 - 60
Wnt/Wingless signaling controls many fundamental processes during animal development. Wnt transduction is mediated by the association of beta-catenin with... 
POLARITY | DROSOPHILA-MELANOGASTER | INTERACTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | E-CADHERIN | BINDING PROTEIN | CANCER | ARMADILLO | CELL BIOLOGY | Wnt1 Protein | Genetic Testing | Cytoskeletal Proteins - genetics | Molecular Sequence Data | Male | Wnt Proteins | Drosophila melanogaster - metabolism | Cell Nucleus - metabolism | Armadillo Domain Proteins | Cloning, Molecular | Female | Neoplasm Proteins - genetics | beta Catenin | Trans-Activators | Drosophila melanogaster - cytology | Zebrafish Proteins | Insect Proteins - genetics | Intracellular Signaling Peptides and Proteins | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Chromosome Mapping | Protein Structure, Tertiary - genetics | Signal Transduction - genetics | Sequence Homology, Nucleic Acid | Drosophila Proteins - isolation & purification | Macromolecular Substances | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Adaptor Proteins, Signal Transducing | Animals | Cell Nucleus - genetics | Carrier Proteins - isolation & purification | Drosophila melanogaster - growth & development | Transcription Factors | Drosophila Proteins - genetics | Body Patterning - genetics | High Mobility Group Proteins - genetics | Proteins | Molecules | Cell research | Analysis | Drosophila | Physiological aspects | Genetic aspects | Models | Gene expression | Wingless protein | b-catenin | Wnt protein | legless (lgs) gene | pygopus (pygo) gene | Index Medicus
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 04/2013, Volume 92, Issue 4, pp. 565 - 574
Journal Article