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wnt3 protein (584) 584
animals (564) 564
mice (437) 437
wnt3a protein (359) 359
humans (327) 327
wnt proteins - metabolism (292) 292
beta-catenin (265) 265
cell biology (242) 242
signal transduction (237) 237
wnt proteins (188) 188
expression (185) 185
beta catenin - metabolism (167) 167
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wnt (158) 158
biochemistry & molecular biology (157) 157
developmental biology (148) 148
cells, cultured (123) 123
signal transduction - physiology (121) 121
differentiation (114) 114
female (104) 104
proteins - genetics (104) 104
proteins (102) 102
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proteins - metabolism (85) 85
β-catenin (85) 85
cell differentiation (81) 81
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cell proliferation (76) 76
beta catenin - genetics (75) 75
transfection (75) 75
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phosphorylation (73) 73
research (72) 72
embryonic structures (69) 69
oncology (69) 69
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apoptosis (64) 64
protein (64) 64
cells (63) 63
mice, transgenic (62) 62
multidisciplinary sciences (62) 62
proto-oncogene proteins - genetics (61) 61
beta catenin (60) 60
growth (59) 59
cell line, tumor (58) 58
genes (58) 58
wnt3 protein - genetics (56) 56
gene-expression (54) 54
genetic aspects (54) 54
molecular sequence data (54) 54
cell differentiation - physiology (53) 53
transcription factors - metabolism (53) 53
wnt3a (53) 53
zebrafish proteins (53) 53
cancer (52) 52
intercellular signaling peptides and proteins - metabolism (52) 52
proto-oncogene proteins - metabolism (52) 52
mice, inbred c57bl (51) 51
mouse (51) 51
animal structures (50) 50
cell differentiation - drug effects (50) 50
cytoskeletal proteins - metabolism (50) 50
mice, knockout (50) 50
reverse transcriptase polymerase chain reaction (50) 50
signal transduction - genetics (50) 50
wnt3 (50) 50
dishevelled proteins (49) 49
in-vitro (49) 49
neurosciences (49) 49
physiological aspects (49) 49
transcription factors - genetics (49) 49
wnt signaling (48) 48
wnt-5a protein (48) 48
genetics & heredity (45) 45
in situ hybridization (45) 45
rna, messenger - metabolism (45) 45
base sequence (43) 43
molecular biology (42) 42
analysis (41) 41
stem-cells (41) 41
models, biological (40) 40
stem cells - cytology (40) 40
wnt protein (40) 40
trans-activators - metabolism (39) 39
neurons - metabolism (38) 38
phosphoproteins - metabolism (38) 38
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The EMBO Journal, ISSN 1460-2075, 2009, Volume 29, Issue 1, pp. 41 - 54
Journal Article
Nature cell biology, ISSN 1476-4679, 2010, Volume 12, Issue 8, pp. 781 - 790
.... Von Hippel-Lindau protein-mediated ubiquitylation is critical for the binding of Dvl2 to p62, which in turn facilitates the aggregation and the LC3-mediated autophagosome recruitment of Dvl2 under starvation... 
UBIQUITINATION | ACTIVATION | INHIBITION | GENE | CATENIN PATHWAY | TUMOR-SUPPRESSOR PROTEIN | BETA-CATENIN | TUMORIGENESIS | REQUIRES DIRECT BINDING | LIGASE | CELL BIOLOGY | Immunohistochemistry | Colonic Neoplasms - genetics | Protein Binding - genetics | Immunoprecipitation | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Immunoblotting | Autophagy - physiology | Phosphoproteins - metabolism | Wnt Proteins - metabolism | Colonic Neoplasms - metabolism | Microscopy, Immunoelectron | Ubiquitination | Membrane Proteins - physiology | Apoptosis Regulatory Proteins - genetics | Autophagy - genetics | Dishevelled Proteins | Beclin-1 | Cell Line | Membrane Proteins - genetics | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Microtubule-Associated Proteins - physiology | Adaptor Proteins, Signal Transducing - physiology | Models, Biological | Adaptor Proteins, Signal Transducing - genetics | Fluorescent Antibody Technique | Cell Line, Tumor | Apoptosis Regulatory Proteins - physiology | Signal Transduction - physiology | Wnt3 Protein | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Protein Binding - physiology | Autophagy (Cytology) | Cellular signal transduction | Research | Ubiquitin-proteasome system
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2006, Volume 125, Issue 3, pp. 509 - 522
.... elegans, and for Wnt3a-mediated communication between cultured human cells. In each of these cases, Wls is acting in the Wnt-sending cells to promote the secretion of Wnt proteins... 
ENCODES | MORPHOGENESIS | CAENORHABDITIS-ELEGANS | POLARITY | PATHWAY | WINGLESS SIGNAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | ENDOPLASMIC-RETICULUM | DROSOPHILA | LONG-RANGE ACTION | CELL BIOLOGY | Drosophila melanogaster - embryology | Humans | DNA, Complementary - genetics | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Cell Communication - physiology | Male | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Wnt Proteins - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Blastomeres - metabolism | Wnt Proteins - genetics | Base Sequence | Conserved Sequence | Female | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | DNA, Complementary - analysis | Amino Acid Sequence | Membrane Proteins - isolation & purification | Caenorhabditis elegans - metabolism | Membrane Proteins - genetics | Blastomeres - cytology | Caenorhabditis elegans - embryology | Drosophila Proteins - isolation & purification | Body Patterning - physiology | Animals | Caenorhabditis elegans - cytology | Intracellular Signaling Peptides and Proteins - isolation & purification | Cell Polarity - physiology | Signal Transduction - physiology | Wnt3 Protein | Drosophila Proteins - genetics | Wnt3A Protein | Evolution, Molecular | Genetic research | Genetic aspects | Research | Drosophila | Membrane proteins | Proteins
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 12/2012, Volume 10, Issue 12, pp. 1597 - 1606
To understand the mechanisms leading to trastuzumab resistance in HER2-overexpressing breast tumors, we created trastuzumab-insensitive cell lines (SKBR3/100-8... 
MIGRATION | STEM-CELLS | INVASION | GROWTH-FACTOR-RECEPTOR | MECHANISM | LIGANDS | ONCOLOGY | HERCEPTIN | MESENCHYMAL TRANSITION | BETA-CATENIN | CONTRIBUTES | CELL BIOLOGY | Receptor, Epidermal Growth Factor - genetics | Cadherins - metabolism | Receptor, ErbB-2 - genetics | Humans | Transcriptional Activation | Receptor, ErbB-2 - metabolism | Drug Resistance, Neoplasm | Cadherins - biosynthesis | Wnt3 Protein - genetics | Breast Neoplasms - metabolism | Wnt3 Protein - biosynthesis | beta Catenin - biosynthesis | Breast Neoplasms - enzymology | Receptor, Epidermal Growth Factor - metabolism | Nuclear Proteins - biosynthesis | Antibodies, Monoclonal, Humanized - pharmacology | Female | Wnt3 Protein - metabolism | Twist-Related Protein 1 - biosynthesis | Cadherins - genetics | Nuclear Proteins - genetics | Snail Family Transcription Factors | Wnt Signaling Pathway | Receptor, Epidermal Growth Factor - biosynthesis | Receptor, ErbB-2 - biosynthesis | Organic Cation Transport Proteins - metabolism | Nuclear Proteins - metabolism | Transcription Factors - biosynthesis | Transcription Factors - genetics | Organic Cation Transport Proteins - biosynthesis | beta Catenin - metabolism | beta Catenin - genetics | Transcription Factors - metabolism | Phenotype | Breast Neoplasms - genetics | Twist-Related Protein 1 - genetics | Cell Line, Tumor | Organic Cation Transport Proteins - genetics | Twist-Related Protein 1 - metabolism | Trastuzumab | trastuzumab | β-catenin | EMT | Breast Cancer | Wnt3
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2001, Volume 107, Issue 4, pp. 513 - 523
In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass accrual during growth... 
MINERAL DENSITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | OSTEOBLAST LINEAGE | MOLECULAR-CLONING | MICE | DIFFERENTIATION | BETA-CATENIN | OSTEOPOROSIS | CELL-DEATH | FAMILY | CELL BIOLOGY | Wnt2 Protein | Humans | Child, Preschool | Male | Bone Density - genetics | Wnt Proteins | Mesoderm - cytology | Wnt-5a Protein | Eye - embryology | Osteoporosis - genetics | Animals, Outbred Strains | Dishevelled Proteins | Bone Morphogenetic Proteins - pharmacology | Child | Organ Culture Techniques | Transforming Growth Factor beta | Signal Transduction | Chromosomes, Human, Pair 11 - genetics | Adaptor Proteins, Signal Transducing | Skull - cytology | Wnt3 Protein | Mice | Receptors, LDL - physiology | COS Cells | Species Specificity | LDL-Receptor Related Proteins | DNA, Complementary - genetics | Recombinant Fusion Proteins - physiology | Cercopithecus aethiops | Culture Media, Conditioned - pharmacology | Recombinant Proteins | Transfection | Receptors, LDL - deficiency | Stromal Cells - drug effects | Adult | Female | Phosphoproteins - physiology | Proteins - physiology | Receptors, LDL - genetics | Bone Morphogenetic Protein 2 | Low Density Lipoprotein Receptor-Related Protein-5 | Mice, Inbred C57BL | Zebrafish Proteins | Proto-Oncogene Proteins - genetics | Phosphoproteins - genetics | Eye Abnormalities - genetics | Genes, Recessive | Syndrome | Proteins - genetics | Animals | Proto-Oncogene Proteins - physiology | Heterozygote | Osteoblasts - metabolism | Stromal Cells - cytology | Wnt4 Protein | Osteoporosis | Bones | Density | Low density lipoproteins | Proteins | Cell research | Lipoproteins | Growth | Analysis | Physiological aspects | Receptors, LDL | Mesoderm | Osteoblasts | Recombinant Fusion Proteins | Eye | Life Sciences | Stromal Cells | Eye Abnormalities | Phosphoproteins | Proto-Oncogene Proteins | Bone Density | Biochemistry, Molecular Biology | Culture Media, Conditioned | Skull | Chromosomes, Human, Pair 11 | Bone Morphogenetic Proteins | DNA, Complementary
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 04/2008, Volume 28, Issue 7, pp. 2368 - 2379
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e57428
... has revealed the critical role of bone morphogenetic protein (BMP) signalling in the induction of primordial germ cell (PGC) precursors. The PGC population is lost... 
PROTEIN | PATHWAY | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | MICE | GENERATION | AXIS FORMATION | SPECIFICATION | LINEAGE | TRANSCRIPTIONAL REPRESSOR | NEGATIVE REGULATOR | Embryo, Mammalian | Bone Morphogenetic Protein 4 - genetics | Phosphoproteins - metabolism | Bone Morphogenetic Protein 4 - metabolism | Wnt3 Protein - genetics | Gene Expression Regulation, Developmental | Wnt3 Protein - metabolism | Germ Cells - cytology | Germ Cells - metabolism | Dishevelled Proteins | Cell Lineage - genetics | Morphogenesis - genetics | Smad Proteins - genetics | Signal Transduction - genetics | Phosphoproteins - genetics | beta Catenin - metabolism | beta Catenin - genetics | Homozygote | Animals | Phosphoprotein Phosphatases - genetics | Adaptor Proteins, Signal Transducing - genetics | Phosphoprotein Phosphatases - deficiency | Heterozygote | Mice | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Smad Proteins - metabolism | Physiological aspects | Embryonic development | Bone morphogenetic proteins | Research | Wnt proteins | Smad protein | Phosphorylation | Transcription factors | Germ cells | Wnt protein | Serine | Phosphatase | DNA-directed RNA polymerase | Proteins | Signal transduction | Reduction | Embryology | Down-regulation | Localization | Dishevelled protein | Medical research | Bone morphogenetic protein 4 | Threonine | Developmental biology | Protein-serine/threonine phosphatase | Cell lineage | RNA polymerase | Gene expression | Ribonucleic acid--RNA | Embryos | Polymerase | Signaling | β-Catenin | Genetic engineering | Synergistic effect | Laboratory animals | RNA polymerase II | Threonine phosphatase | RNA | Ribonucleic acid
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 8/2010, Volume 107, Issue 35, pp. 15473 - 15478
.... Inhibitors of oncogenic Wnt signaling are likely to have a therapeutic effect in cancers. LRP5 and LRP6 are closely related membrane coreceptors for Wnt proteins... 
Phosphorylation | Propellers | HEK293 cells | Stem cells | Antibodies | Wnt proteins | Modulated signal processing | Heterologous transplantation | Tumors | Cancer | Antibody therapeutics | antibody therapeutics | STEM-CELLS | ACTIVATION | PATHWAY | EPIGENETIC INACTIVATION | MULTIDISCIPLINARY SCIENCES | MUTATION | DISEASE | RECEPTOR-RELATED PROTEIN-5 | BONE-MASS | cancer | SOST | LDL-Receptor Related Proteins - metabolism | Wnt1 Protein - genetics | Humans | Immunoblotting | Green Fluorescent Proteins - genetics | Wnt1 Protein - metabolism | Wnt Proteins - metabolism | LDL-Receptor Related Proteins - genetics | Neoplasms, Experimental - pathology | Wnt Proteins - genetics | Protein Binding - drug effects | Antibodies - immunology | Female | Cell Line | Green Fluorescent Proteins - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 | Neoplasms, Experimental - prevention & control | beta Catenin - metabolism | beta Catenin - genetics | Antibodies - pharmacology | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Ligands | Wnt3 Protein | Mice | Mammary Tumor Virus, Mouse - genetics | Wnt3A Protein | LDL-Receptor Related Proteins - immunology | Cell Transformation, Viral | Viral antibodies | Proteins | Control | Ligands (Biochemistry) | Health aspects | Carcinogenesis | Biological Sciences
Journal Article
The FEBS Journal, ISSN 1742-464X, 08/2017, Volume 284, Issue 15, pp. 2513 - 2526
While the cytosolic events of Wnt/β‐catenin signaling (canonical Wnt signaling) pathway have been widely studied, only little is known about the molecular... 
plasma membrane lipid | canonical Wnt | lipid raft | membrane trafficking | Wnt/β‐catenin pathway | Wnt/β-catenin pathway | FC-EPSILON-RI | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | Wnt/beta-catenin pathway | FLUORESCENCE CORRELATION SPECTROSCOPY | DETERGENT-RESISTANT MEMBRANES | SIGNAL-TRANSDUCTION | B-VIRUS INFECTION | SPIM-FCS | PATHWAY | LIPID RAFTS | IN-VIVO | Wnt3A Protein - metabolism | Cricetulus | Cytoskeletal Proteins - genetics | Membrane Microdomains - metabolism | Humans | Embryo, Nonmammalian - metabolism | Receptors, Wnt - metabolism | Wnt Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Wnt3 Protein - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | Wnt Proteins - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Wnt3 Protein - metabolism | Cell Membrane - metabolism | Genes, Reporter | Wnt Signaling Pathway | CHO Cells | Wnt3A Protein - genetics | Animals, Genetically Modified | Zebrafish Proteins - metabolism | Cells, Cultured | Niemann-Pick Diseases - metabolism | Niemann-Pick Diseases - pathology | Receptors, Wnt - agonists | Zebrafish - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - agonists | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Zebrafish - metabolism | Cell Line, Tumor | Luminescent Proteins - genetics | Zebrafish Proteins - genetics | Luminescent Proteins - metabolism | Lipids | Cell membranes | Binding | Niemann-Pick disease | Plasma | Wnt protein | β-catenin | Receptors | Molecular modelling | Ligands | Membrane trafficking | Coordination compounds | Molecular biology | Plasmas (physics) | Wnt | Original | β‐catenin pathway
Journal Article
Nature communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, p. 2610
Journal Article