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Journal of Biological Chemistry, ISSN 0021-9258, 05/2000, Volume 275, Issue 21, pp. 16242 - 16250
This study presents evidence that phosphoinositide (PI) 3-kinase is involved in T cell Ca super(2+) signaling via a phosphatidylinositol 3,4,5-trisphosphate... 
wortmannin
Journal Article
Current Biology, ISSN 0960-9822, 08/2000, Volume 10, Issue 15, pp. 886 - 895
Background: The response of eukaryotic cells to double-strand breaks in genomic DNA includes the sequestration of many factors into nuclear foci. Recently it... 
wortmannin | Rad51 protein | Rad50 protein | histone H2AX | BRCA1 protein
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 09/2018, Volume 59, Issue 39, pp. 3586 - 3588
The first total syntheses of the furanosesquiterpenoids hibiscone B and acyl hibiscone B are reported. The chemistry used to prepare hibiscone B solves an... 
Acyl hibiscone B | Hibiscone C | Hibiscone B | Furanosesquiterpenoid | Phosphatidylinositol-3-kinase inhibitor | QUINONES | WORTMANNIN | C GMELOFURAN | VIRIDIN | (+)-WORTMANNIN | PHOSPHOINOSITIDE 3-KINASES | MEDICAL LABORATORY TECHNOLOGY | INHIBITOR | Phospholipids | Synthesis | Organic compounds
Journal Article
TETRAHEDRON LETTERS, ISSN 0040-4039, 09/2018, Volume 59, Issue 39, pp. 3586 - 3588
The first total syntheses of the furanosesquiterpenoids hibiscone B and acyl hibiscone B are reported. The chemistry used to prepare hibiscone B solves an... 
QUINONES | Furanosesquiterpenoid | Phosphatidylinositol-3-kinase inhibitor | CHEMISTRY, ORGANIC | WORTMANNIN | C GMELOFURAN | Acyl hibiscone B | VIRIDIN | (+)-WORTMANNIN | Hibiscone C | PHOSPHOINOSITIDE 3-KINASES | Hibiscone B | INHIBITOR
Journal Article
Journal Article
Behavioural Brain Research, ISSN 0166-4328, 10/2018, Volume 351, pp. 4 - 16
Restoration of PI3-kinase signaling portrays therapeutic potential in Alzheimer’s disease (AD). Hyperactive Rho-kinase in AD negatively modulates PI3-kinase... 
NFκB | Wortmannin | Endothelial NOS | Memory | PI3-kinase | Acetylcholinesterase | Fasudil
Journal Article
Addiction Biology, ISSN 1355-6215, 2018
Phosphatidylinositide 3-kinases (PI3Ks) are intracellular signal transducer enzymes that recruit protein kinase B (aka Akt) to the cell membrane, the... 
wortmannin | PI3K | conditioned place preference | incubation | prefrontal cortex
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2007, Volume 404, Issue 1, pp. 15 - 21
The PI3Ks (phosphatidylinositol 3-kinases) regulate cellular signalling networks that are involved in processes linked to the survival, growth, proliferation,... 
Phosphatidylinositol 3-kinase (PI3k) | Valosin-containing protein (VCP) | Chemical proteomic strategy | LY294002 | Brd4 | 3-kinase (PI3K) | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL ANTIGEN | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR | WORTMANNIN | chemical proteomic strategy | valosin-containing protein (VCP) | phosphatidylinositol | B-CELL | PATHWAY | BRD4 BINDS | TARGETS | PHOSPHOINOSITIDE 3-KINASES | PROTEIN-KINASE INHIBITORS | Cell Line | Cell Survival - drug effects | Humans | Cells, Cultured | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Proteins - genetics | Animals | Signal Transduction - drug effects | Culture Media | Models, Animal | Kinetics | Chromones - pharmacology | Proteins - chemical synthesis | Proteins - antagonists & inhibitors | VCP | WT, wild-type | MS, liquid chromatography–electrospray–ionization tandem MS | VCP, valosin-containing protein | AA ATP, hydrolysis mutant form of p97 | EAS, epoxy-activated Sepharose | GSK3, glycogen synthase kinase 3 | Wm, Wortmannin | ALDH, aldehyde dehydrogenase | PXDK, pyridoxal kinase | PIP3, phosphatidylinositol (3,4,5) triphosphate | PI3K, phosphatidylinositol 3-kinase | DMF, dimethylformamide | mTOR, mammalian target of rapamycin | Brd, bromodomain | PI3KC3, PI3K, class 3 | CK2, casein kinase 2 | LC–ESI–MS | phosphatidylinositol 3-kinase (PI3K) | FCS, fetal calf serum
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 05/2017, Volume 139, Issue 20, pp. 6819 - 6822
Herein we describe concise enantioselective chemical syntheses of (-)-viridin and (-)-viridiol.,Our convergent approach couples two achiral fragments of... 
VIRIDIN | POTENT | BORANE-DIMETHYL SULFIDE | REDUCTION | ANALOGS | PHOSPHATIDYLINOSITOL 3-KINASE | PRODUCT | ESTERS | INHIBITOR | CHEMISTRY, MULTIDISCIPLINARY | WORTMANNIN
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2019, Volume 62, Issue 13, pp. 6241 - 6261
The phosphoinositide 3-kinase (PI3K)/mechanistic target of rapamycin (mTOR) pathway is frequently overactivated in cancer, and drives cell growth,... 
NVP-BYL719 | CHEMISTRY, MEDICINAL | PQR309 | METABOLISM | 3-KINASE/MAMMALIAN TARGET | GROWTH | NVP-BEZ235 | IDENTIFICATION | PI3K/MTOR INHIBITOR | PHOSPHOINOSITIDE 3-KINASE | WORTMANNIN
Journal Article
by Yu, SL and Wang, D and Huang, LM and Zhang, YN and Luo, RH and Adah, D and Tang, YT and Zhao, K and Lu, B
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 05/2019, Volume 294, Issue 21, pp. 8384 - 8394
The NLR family pyrin domain-containing 3 (NLRP3) inflammasome is a multimeric protein complex that mediates maturation of the cytokines IL-1 and IL-18 as well... 
IL-1 | complement system | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | WORTMANNIN | SHOCK | inflammation | ROLES | NALP3 | inflammasome | PKR | INHIBITOR | immunology | U0126
Journal Article
JOURNAL OF THE NATIONAL CANCER INSTITUTE, ISSN 0027-8874, 04/2006, Volume 98, Issue 8, pp. 545 - 556
We previously synthesized a novel s-triazine derivative, ZSTK474 [2-(2-difluoromethylbenzimidazol-1-yl)4,6-dimorpholino-1,3,5-triazine], that strongly... 
SCORING FUNCTION | IN-VITRO | LIGAND INTERACTIONS | PIK3CA GENE | ONCOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE | TUMOR-CELL-LINES | PHOSPHOINOSITIDE 3-KINASE | HUMAN CANCER | WORTMANNIN | FLEXIBLE DOCKING
Journal Article
Biomedicine & Preventive Nutrition, ISSN 2210-5239, 01/2014, Volume 4, Issue 1, pp. 85 - 85
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 06/2006, Volume 103, Issue 26, pp. 9891 - 9896
The variant histone H2AX is phosphorylated in response to UV irradiation of primary human fibroblasts in a complex fashion that is radically different from... 
RECOMBINATION | APOPTOSIS | MRE11 | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | xeroderma pigmentosum | SERINE 139 | HISTONE H2AX | REPLICATION ARREST | human fibroblasts | ULTRAVIOLET-LIGHT | ultraviolet light | DAMAGE | XERODERMA-PIGMENTOSUM | Wortmannin | chromatin structure
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2009, Volume 106, Issue 40, pp. 16996 - 17001
Mutations in oncogenes often promote tumorigenesis by changing the conformation of the encoded proteins, thereby altering enzymatic activity. The PIK3CA... 
Proteins | Enzymes | Sodium | Crystals | Lipids | Cell membranes | Biochemistry | Genetic mutation | Oncogenes | Phosphatidylinositols | p110 | p85 | Oncogene | Mutant | CATALYTIC SUBUNIT | P110-ALPHA | PIK3CA MUTATIONS | ISOFORMS | MECHANISM | MULTIDISCIPLINARY SCIENCES | oncogene | PHOSPHOINOSITIDE 3-KINASE | WORTMANNIN | CELL LUNG-CANCER | PATHWAY | mutant | INHIBITOR | Biological Sciences
Journal Article
Molecules, ISSN 1420-3049, 10/2017, Volume 22, Issue 10, p. 1669
Journal Article
Journal Article
SCIENCE, ISSN 0036-8075, 09/1998, Volume 281, Issue 5383, pp. 1674 - 1677
The ATM protein, encoded by the gene responsible for the human genetic disorder ataxia telangiectasia (A-T), regulates several cellular responses to DNA... 
MAMMALIAN TARGET | RAPAMYCIN | PROTEIN | INHIBITION | PRODUCT | MULTIDISCIPLINARY SCIENCES | KINASE | ATAXIA-TELANGIECTASIA GENE | CELL-CYCLE | PHOSPHOINOSITIDE 3-KINASE | WORTMANNIN
Journal Article
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