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Journal of Clinical Investigation, ISSN 0021-9738, 04/2018, Volume 128, Issue 4, pp. 1283 - 1299
The unfolded protein response (UPR) is a cellular homeostatic mechanism that is activated in many human cancers and plays pivotal roles in tumor progression... 
MEDICINE, RESEARCH & EXPERIMENTAL | SIGNALING PATHWAYS | XBP1 | UNFOLDED PROTEIN RESPONSE | MESSENGER-RNA | ER STRESS | KINASE | C-MYC | ENDOPLASMIC-RETICULUM STRESS | TRANSCRIPTION FACTOR | TRANSMEMBRANE PROTEIN | Endoribonucleases - genetics | Humans | Breast Neoplasms - metabolism | Drug Delivery Systems | Female | Protein-Serine-Threonine Kinases - metabolism | Unfolded Protein Response - drug effects | Endoribonucleases - metabolism | Response Elements | Unfolded Protein Response - genetics | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | Breast Neoplasms - drug therapy | Proto-Oncogene Proteins c-myc - metabolism | Docetaxel - pharmacology | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | X-Box Binding Protein 1 - metabolism | Cell Line, Tumor | Mice | Proto-Oncogene Proteins c-myc - genetics | Saccharomyces cerevisiae | X-Box Binding Protein 1 - genetics | Care and treatment | Transcription factors | Pharmacology, Experimental | Protein folding | Physiological aspects | Development and progression | Breast cancer | Genetic aspects | Research | Health aspects | Nucleotidases | Cancer | Enzymes | Animal models | Inositol | Phosphorylation | Transcription | Genes | Myc protein | Ribonuclease | Kinases | Cancer therapies | Proteins | Chemotherapy | Molecular modelling | Stem cells | Xenografts | Activating transcription factor 1 | Genetic engineering | Endoplasmic reticulum | Tumors
Journal Article
Blood, ISSN 0006-4971, 04/2017, Volume 129, Issue 17, pp. 2420 - 2428
The endoplasmic reticulum kinase inositol-requiring enzyme 1 (IRE1) and its downstream target X-box-binding protein 1 (XBP1) drive B-cell differentiation... 
GERMINAL CENTER FORMATION | MULTIPLE-MYELOMA | B-CELL LYMPHOMA | UNFOLDED-PROTEIN RESPONSE | TRANSCRIPTION FACTOR XBP-1 | CERVICAL-CANCER | ENDOPLASMIC-RETICULUM STRESS | BIVALENT PROMOTERS | DIFFERENTIATION | HEMATOLOGY | METHYLTRANSFERASE EZH2 | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | RNA, Messenger - immunology | Endoribonucleases - genetics | Cell Proliferation | Epigenesis, Genetic | Germinal Center - immunology | Humans | Gene Expression Regulation, Neoplastic | X-Box Binding Protein 1 - antagonists & inhibitors | Endoribonucleases - antagonists & inhibitors | Mice, 129 Strain | Plasma Cells - pathology | Lymphoma, Large B-Cell, Diffuse - therapy | RNA, Messenger - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lymphoma, Large B-Cell, Diffuse - immunology | Cell Differentiation | B-Lymphocytes - pathology | Promoter Regions, Genetic | Enhancer of Zeste Homolog 2 Protein - genetics | X-Box Binding Protein 1 - immunology | Histones - immunology | Lymphoma, Large B-Cell, Diffuse - pathology | Signal Transduction | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Germinal Center - pathology | Indazoles - pharmacology | Xenograft Model Antitumor Assays | Leupeptins - pharmacology | Animals | B-Lymphocytes - immunology | Histones - genetics | Enhancer of Zeste Homolog 2 Protein - immunology | Cell Line, Tumor | Protein-Serine-Threonine Kinases - immunology | Mice | Lymphoma, Large B-Cell, Diffuse - genetics | X-Box Binding Protein 1 - genetics | Pyridones - pharmacology | Endoribonucleases - immunology | Plasma Cells - immunology
Journal Article
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 04/2018, Volume 217, Issue 4, pp. 1287 - 1301
In mammalian pancreatic beta cells, the IRE1 alpha-XBP1 pathway is constitutively and highly activated under physiological conditions. To elucidate the precise... 
DIABETES-MELLITUS | DISULFIDE-ISOMERASE | XBP1 | UNFOLDED PROTEIN RESPONSE | MESSENGER-RNA | ER-STRESS | INSULIN-SECRETION | IRE1 | ENDOPLASMIC-RETICULUM STRESS | TRANSCRIPTION FACTOR | CELL BIOLOGY | Diabetes Mellitus - blood | Diabetes Mellitus - enzymology | Protein-Serine-Threonine Kinases - deficiency | Endoribonucleases - genetics | Phosphorylation | Molecular Chaperones - metabolism | Proinsulin - chemistry | Proinsulin - metabolism | Diabetes Mellitus - genetics | Protein Disulfide-Isomerases - metabolism | eIF-2 Kinase - metabolism | Insulinoma - genetics | Male | Thioredoxins - genetics | Thioredoxins - metabolism | Membrane Proteins - metabolism | Endoribonucleases - deficiency | Insulin - genetics | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | Promoter Regions, Genetic | Endoribonucleases - metabolism | Oxidation-Reduction | Signal Transduction | Membrane Proteins - genetics | Molecular Chaperones - genetics | Pancreatic Neoplasms - enzymology | Protein-Serine-Threonine Kinases - genetics | Pancreatic Neoplasms - genetics | Proinsulin - genetics | Insulinoma - enzymology | Protein Folding | Mice, Knockout | Activating Transcription Factor 6 - metabolism | Insulin - metabolism | Protein Disulfide-Isomerases - genetics | Animals | X-Box Binding Protein 1 - metabolism | Cell Line, Tumor | Blood Glucose - metabolism | X-Box Binding Protein 1 - genetics | Insulin-Secreting Cells - enzymology
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2018, Volume 71, Issue 4, pp. 629 - 636.e5
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2016, Volume 311, Issue 4, pp. H871 - H880
We previously reported that endoplasmic reticulum (ER) stress is induced in the subfornical organ (SFO) and the hypothalamic paraventricular nucleus (PVN) of... 
Heart failure | Brain | Sympathetic activity | Hypothalamic paraventricular nucleus | Mitogen-activated protein kinase | Subfornical organ | Endoplasmic reticulum stress | heart failure | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | INDUCED PHOSPHORYLATION | MYOCARDIAL-INFARCTION | ER STRESS | subfornical organ | KINASE | RATS | sympathetic activity | KAPPA-B | brain | endoplasmic reticulum stress | hypothalamic paraventricular nucleus | mitogen-activated protein kinase | UNFOLDED PROTEIN RESPONSE | PERIPHERAL VASCULAR DISEASE | UP-REGULATION | Cholagogues and Choleretics - pharmacology | Tumor Necrosis Factor-alpha - genetics | Heart Failure - physiopathology | Male | NF-KappaB Inhibitor alpha - genetics | Peptidyl-Dipeptidase A - drug effects | Interleukin-1beta - genetics | Sympathetic Nervous System - physiopathology | RNA, Messenger - metabolism | Activating Transcription Factor 6 - genetics | Subfornical Organ - drug effects | Brain - metabolism | Heat-Shock Proteins - genetics | Inflammation - metabolism | Receptor, Angiotensin, Type 1 - genetics | Cyclooxygenase 2 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Real-Time Polymerase Chain Reaction | Echocardiography | Signal Transduction | Rats | Cyclooxygenase 2 - drug effects | Heart Failure - metabolism | Rats, Sprague-Dawley | Blotting, Western | Brain - drug effects | Tumor Necrosis Factor-alpha - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Endoplasmic Reticulum Stress | Paraventricular Hypothalamic Nucleus - metabolism | Infusions, Intraventricular | Mitogen-Activated Protein Kinases - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Interleukin-1beta - drug effects | Sympathetic Nervous System - drug effects | Mitogen-Activated Protein Kinase 1 - drug effects | X-Box Binding Protein 1 - drug effects | Sympathetic Nervous System - metabolism | Transcription Factor RelA - genetics | Activating Transcription Factor 6 - drug effects | Mitogen-Activated Protein Kinase 3 - drug effects | Taurochenodeoxycholic Acid - pharmacology | Peptidyl-Dipeptidase A - genetics | Renin-Angiotensin System | Receptor, Angiotensin, Type 1 - drug effects | RNA, Messenger - drug effects | Subfornical Organ - metabolism | Heat-Shock Proteins - drug effects | Activating Transcription Factor 4 - genetics | Activating Transcription Factor 4 - drug effects | NF-KappaB Inhibitor alpha - drug effects | Paraventricular Hypothalamic Nucleus - drug effects | p38 Mitogen-Activated Protein Kinases - drug effects | Animals | Transcription Factor RelA - drug effects | X-Box Binding Protein 1 - genetics | Mitogen-Activated Protein Kinases - metabolism | Physiological aspects | Cellular signal transduction | Endoplasmic reticulum | Health aspects | Mitogen-activated protein kinases | Cardiovascular Neurohormonal Regulation
Journal Article
Nature Cell Biology, ISSN 1465-7392, 05/2017, Volume 19, Issue 6, pp. 698 - 710
The IRE1-XBP1 signalling pathway is part of a cellular programme that protects against endoplasmic reticulum (ER) stress, but also controls development and... 
HOMEOSTASIS | ER-STRESS | IN-VIVO | IRE1 | TRANSCRIPTION FACTOR XBP-1 | ENDOPLASMIC-RETICULUM STRESS | DIFFERENTIATION | MAMMALIAN-CELLS | UNFOLDED-PROTEIN-RESPONSE | TRANSLATIONAL CONTROL | CELL BIOLOGY | Transcription Factor CHOP - genetics | Protein Biosynthesis | Dendritic Cells - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | RNA, Messenger - metabolism | Respiratory Mucosa - pathology | Time Factors | Intestinal Mucosa - enzymology | Membrane Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Cell Survival | Membrane Proteins - genetics | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Respiratory Mucosa - enzymology | Activating Transcription Factor 4 - genetics | Genotype | Mice, Transgenic | RNA Stability | Unfolded Protein Response | Phenotype | Animals | Activating Transcription Factor 4 - metabolism | Dendritic Cells - enzymology | X-Box Binding Protein 1 - metabolism | Endoplasmic Reticulum Stress | Transcription Factor CHOP - metabolism | X-Box Binding Protein 1 - genetics | Apoptosis | Intestinal Mucosa - pathology | Regulators | Mucosa | Signal transduction | Alterations | Cell activation | Intestine | Immune system | Stresses | Spleen | Cell survival | Dendritic cells | mRNA turnover | Protein biosynthesis | JNK protein | Ribonucleic acid--RNA | Survival | Stress | Signaling | Lungs | Protein synthesis | Cell death | Decay | Shutdowns | Endonuclease | Endoplasmic reticulum
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 2017, Volume 58, Issue 3, pp. 504 - 511
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2016, Volume 99, pp. 308 - 322
Protein homeostasis in cells, proteostasis, is maintained through several integrated processes and pathways and its dysregulation may mediate pathology in many... 
mdx | ER stress | Myostatin | UPR | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | MDX MICE | SKELETAL-MUSCLE | DISULFIDE-ISOMERASE | GENE | MOUSE MODEL | IN-VIVO | ENDOCRINOLOGY & METABOLISM | EXPRESSION | PRESERVES MUSCLE FUNCTION | Sirtuin 1 - metabolism | Activin Receptors, Type II - metabolism | Endoribonucleases - genetics | eIF-2 Kinase - metabolism | Humans | Activin Receptors, Type II - antagonists & inhibitors | Muscle, Skeletal - metabolism | RNA, Messenger - metabolism | Activating Transcription Factor 6 - genetics | Sirtuin 1 - genetics | Heat-Shock Proteins - genetics | Thioredoxins - genetics | Muscle, Skeletal - drug effects | Mice, Inbred mdx | Eukaryotic Initiation Factor-2 - metabolism | Thioredoxins - metabolism | Phosphorylation - drug effects | Muscular Dystrophy, Duchenne - therapy | Proteostasis - drug effects | Physical Conditioning, Animal | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | eIF-2 Kinase - genetics | Unfolded Protein Response - drug effects | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Proteostasis - genetics | Signal Transduction | Heat-Shock Proteins - metabolism | RNA, Messenger - genetics | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Muscular Dystrophy, Duchenne - pathology | Carrier Proteins - genetics | Activating Transcription Factor 6 - metabolism | Animals | Carrier Proteins - metabolism | X-Box Binding Protein 1 - metabolism | Eukaryotic Initiation Factor-2 - genetics | Activin Receptors, Type II - genetics | Immunoglobulin Fc Fragments - pharmacology | Mice | Muscular Dystrophy, Duchenne - metabolism | Muscle, Skeletal - pathology | Muscular Dystrophy, Duchenne - genetics | X-Box Binding Protein 1 - genetics | Proteins | Oxidative stress | Exercise | RNA | Lysine | Analysis | Physiological aspects | Heat shock proteins | Muscular dystrophy | Glutathione transferase | Medical Biotechnology | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinsk bioteknologi | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 06/2016, Volume 109, pp. 27 - 47
The endoplasmic reticulum (ER) plays a major role in the synthesis, maturation and folding of proteins and is a critical calcium (Ca ) reservoir. Cellular... 
Anti-cancer drug | Endoplasmic reticulum | Dp44mT | Endoplasmic reticulum stress | Unfolded protein response | Transcription Factor CHOP - genetics | Endoribonucleases - genetics | Activating Transcription Factor 6 - agonists | Apoptosis - drug effects | eIF-2 Kinase - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Gene Expression Regulation, Neoplastic | Endoplasmic Reticulum - metabolism | Endoplasmic Reticulum Stress - genetics | Activating Transcription Factor 6 - genetics | Iron Chelating Agents - chemical synthesis | Heat-Shock Proteins - genetics | Endoplasmic Reticulum - drug effects | Antineoplastic Agents - pharmacology | Thiosemicarbazones - pharmacology | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | eIF-2 Kinase - genetics | Deferoxamine - pharmacology | HSP40 Heat-Shock Proteins - metabolism | Calcium-Calmodulin-Dependent Protein Kinases - genetics | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | HSP40 Heat-Shock Proteins - genetics | Oxidation-Reduction | Signal Transduction | Heat-Shock Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Thiosemicarbazones - chemical synthesis | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Activating Transcription Factor 6 - metabolism | Animals | Iron Chelating Agents - pharmacology | X-Box Binding Protein 1 - metabolism | Cell Line, Tumor | Transcription Factor CHOP - metabolism | X-Box Binding Protein 1 - genetics | Calcium-Calmodulin-Dependent Protein Kinases - metabolism
Journal Article
Cell Reports, ISSN 2211-1247, 02/2016, Volume 14, Issue 6, pp. 1382 - 1394
Journal Article