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The New England Journal of Medicine, ISSN 0028-4793, 10/2014, Volume 371, Issue 15, pp. 1407 - 1417
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 01/2013, Volume 38, Issue 1, pp. 13 - 25
Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays pivotal roles in the immune response. Discovered as a T cell growth... 
BETA-CHAIN | SEVERE COMBINED IMMUNODEFICIENCY | CYTOKINE RECEPTOR | IN-VIVO | REGULATORY T-CELLS | GENE-EXPRESSION | RECEPTOR-ALPHA-CHAIN | MONOCLONAL-ANTIBODY | IMMUNOLOGY | IL-2 RECEPTOR | GAMMA-CHAIN | T-Lymphocyte Subsets - immunology | Humans | X-Linked Combined Immunodeficiency Diseases - genetics | Interleukin Receptor Common gamma Subunit - metabolism | X-Linked Combined Immunodeficiency Diseases - immunology | Interleukin Receptor Common gamma Subunit - immunology | Leukemia-Lymphoma, Adult T-Cell - immunology | T-Lymphocytes, Regulatory - immunology | Receptors, Interleukin-2 - genetics | Interleukin-2 - physiology | T-Lymphocytes, Helper-Inducer - immunology | Immunotherapy | T-Lymphocytes, Helper-Inducer - cytology | CD8-Positive T-Lymphocytes - metabolism | Leukemia-Lymphoma, Adult T-Cell - therapy | Interleukin-2 - metabolism | Leukemia-Lymphoma, Adult T-Cell - genetics | Immune Tolerance | Receptors, Interleukin-2 - metabolism | X-Linked Combined Immunodeficiency Diseases - therapy | Interleukin Receptor Common gamma Subunit - genetics | Cell Differentiation - immunology | Animals | T-Lymphocyte Subsets - metabolism | Interleukin-15 - metabolism | Immunologic Memory | CD8-Positive T-Lymphocytes - immunology | Interleukins | T cells | Cell growth | T cell receptors | Cytokines | Kinases | Immune system
Journal Article
Nature: international weekly journal of science, ISSN 0028-0836, 01/2014, Volume 510, Issue 7504, pp. 235 - 240
Journal Article
Human Gene Therapy, ISSN 1043-0342, 02/2016, Volume 27, Issue 2, pp. 18 - 116
More than 20 years ago, X-linked severe combined immunodeficiency (SCID-X1) appeared to be the best condition to test the feasibility of hematopoietic stem... 
Reviews | MEDICINE, RESEARCH & EXPERIMENTAL | INTEGRATION SITE SELECTION | VECTOR INTEGRATION | INTERLEUKIN-2-RECEPTOR GAMMA-CHAIN | CHRONIC GRANULOMATOUS-DISEASE | CLONAL-TRACKING | DEFICIENT MICE | HEMATOPOIETIC PROGENITOR CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | LENTIVIRAL VECTOR | GENETICS & HEREDITY | GAMMARETROVIRAL VECTORS | INSERTIONAL MUTAGENESIS | X-Linked Combined Immunodeficiency Diseases - pathology | Lentivirus - immunology | Humans | X-Linked Combined Immunodeficiency Diseases - genetics | Killer Cells, Natural - pathology | X-Linked Combined Immunodeficiency Diseases - immunology | Hematopoietic Stem Cells - immunology | Retroviridae - genetics | Patient Safety | Killer Cells, Natural - immunology | Lentivirus - genetics | B-Lymphocytes - pathology | Gammaretrovirus - immunology | T-Lymphocytes - pathology | Virus Integration - genetics | Genetic Vectors - chemistry | Genetic Vectors - immunology | Hematopoietic Stem Cell Transplantation | X-Linked Combined Immunodeficiency Diseases - therapy | Retroviridae - immunology | Clinical Trials as Topic | B-Lymphocytes - immunology | Gammaretrovirus - genetics | Hematopoietic Stem Cells - cytology | T-Lymphocytes - immunology | Genetic Therapy - methods | Severe combined immunodeficiency | Leukemia | Medical treatment | Feasibility studies | Clinical trials | Immune reconstitution | Lymphocytes T | Vectors (Biology) | Hematopoietic stem cells | Hemopoiesis | Lymphocytes B | Lymphocytes | Stem cells | Hematopoietic system | Natural killer cells | Gene therapy | Expression vectors
Journal Article
Expert Opinion on Biological Therapy, ISSN 1471-2598, 06/2014, Volume 14, Issue 6, pp. 789 - 798
Introduction: During the last decade, gene therapy has emerged as a convincing therapy for primary immunodeficiencies (PIDs). Ex vivo gene transfer into... 
Wiskott-Aldrich syndrome | lentiviral vectors | adenosine deaminase | chronic granulomatous disease | primary immunodeficiency | gene therapy | severe combined immunodeficiency | Chronic granulomatous disease | Severe combined immunodeficiency | Lentiviral vectors | Adenosine deaminase | Gene therapy | Primary immunodeficiency | PROGENITOR CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | LENTIVIRUS VECTOR | CHRONIC GRANULOMATOUS-DISEASE | WISKOTT-ALDRICH-SYNDROME | FUNCTIONAL LYMPHOID RECONSTITUTION | RETROVIRAL VECTORS | TRANSGENE EXPRESSION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | TERM-FOLLOW-UP | STEM-CELL TRANSPLANTATION | Agammaglobulinemia - immunology | Agammaglobulinemia - genetics | Humans | Granulomatous Disease, Chronic - genetics | X-Linked Combined Immunodeficiency Diseases - genetics | X-Linked Combined Immunodeficiency Diseases - immunology | Granulomatous Disease, Chronic - immunology | Wiskott-Aldrich Syndrome - genetics | Wiskott-Aldrich Syndrome - therapy | Adenosine Deaminase - deficiency | Wiskott-Aldrich Syndrome - immunology | Adenosine Deaminase - genetics | Agammaglobulinemia - therapy | Severe Combined Immunodeficiency - therapy | X-Linked Combined Immunodeficiency Diseases - therapy | Treatment Outcome | Granulomatous Disease, Chronic - therapy | Severe Combined Immunodeficiency - immunology | Genetic Therapy - trends | Forecasting | Severe Combined Immunodeficiency - genetics | Animals | Adenosine Deaminase - immunology | Genetic Therapy - adverse effects | Genetic Therapy - methods
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 127, Issue 6, pp. 1356 - 1359
Gene therapy has become an option for the treatment of 2 forms of severe combined immunodeficiency (SCID): X-linked SCID and adenosine deaminase deficiency.... 
Allergy and Immunology | Wiskott-Aldrich syndrome | retrovirus | severe combined immune deficiency | Gene therapy | lentivirus | SEVERE COMBINED IMMUNODEFICIENCY | ALLERGY | LENTIVIRAL VECTOR | DISEASE | IMMUNOLOGY | RECONSTITUTION | Agammaglobulinemia - immunology | Agammaglobulinemia - genetics | Humans | X-Linked Combined Immunodeficiency Diseases - genetics | X-Linked Combined Immunodeficiency Diseases - immunology | Wiskott-Aldrich Syndrome - genetics | Wiskott-Aldrich Syndrome - therapy | Adenosine Deaminase - deficiency | Immunologic Deficiency Syndromes - immunology | Adaptive Immunity | Immunologic Deficiency Syndromes - therapy | Wiskott-Aldrich Syndrome - immunology | Adenosine Deaminase - genetics | Agammaglobulinemia - therapy | Hematopoietic Stem Cell Transplantation | Severe Combined Immunodeficiency - therapy | X-Linked Combined Immunodeficiency Diseases - therapy | Treatment Outcome | Clinical Trials as Topic | Severe Combined Immunodeficiency - immunology | Genetic Therapy - trends | Severe Combined Immunodeficiency - genetics | Immunologic Deficiency Syndromes - genetics | Genetic Vectors | Adenosine Deaminase - immunology | Genetic Therapy - adverse effects | Genetic Therapy - methods | Care and treatment | Adenosine | Viral genetics | Leukemia | Immunodeficiency | Transplantation | T cells | Health aspects | Hematopoietic stem cells | Disease | Lymphocytes | Cloning | Stem cells | Clinical trials | Ligands | Genomes | Kinases | Patients
Journal Article
Blood, ISSN 0006-4971, 12/2011, Volume 118, Issue 26, pp. 6824 - 6835
Journal Article
Blood, ISSN 0006-4971, 06/2015, Volume 125, Issue 23, pp. 3563 - 3569
Journal Article