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Nature, ISSN 0028-0836, 08/2009, Volume 460, Issue 7258, pp. 1035 - 1039
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 28, pp. 11662 - 11667
It is increasingly recognized that the mechanisms underlying ischemic cell death are sexually dimorphic. Stroke-induced cell death in males is initiated by the... 
Messenger RNA | MicroRNA | Ischemia | Cell death | Sex linked differences | Brain ischemia | Strokes | Gene expression regulation | Female animals | Apoptosis | Second mitochondria-derived activator of caspases/direct inhibitor of apoptosis binding protein with low Pi | Spectrin cleavage | Ovariectomy | Middle cerebral artery occlusion | Estrogen | estrogen | OXIDATIVE STRESS | BRAIN-INJURY | spectrin cleavage | MULTIDISCIPLINARY SCIENCES | EXPERIMENTAL STROKE | NEUROPROTECTION | CELL-DEATH | HYPOXIA-ISCHEMIA | IN-VIVO | GENDER | MICE | MICRORNA EXPRESSION | middle cerebral artery occlusion | ovariectomy | second mitochondria-derived activator of caspases/direct inhibitor of apoptosis binding protein with low Pi | Brain Ischemia - genetics | Caspase 3 - metabolism | Brain Ischemia - metabolism | Male | MicroRNAs - metabolism | Mitochondrial Proteins - genetics | RNA, Messenger - metabolism | Brain - metabolism | X-Linked Inhibitor of Apoptosis Protein - antagonists & inhibitors | Mitochondrial Proteins - metabolism | Base Sequence | Female | 3' Untranslated Regions | Mice, Inbred C57BL | RNA, Messenger - genetics | Estradiol - administration & dosage | Binding Sites - genetics | Sex Characteristics | X-Linked Inhibitor of Apoptosis Protein - genetics | Benzoquinones - pharmacology | Brain - drug effects | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Brain Ischemia - pathology | X-Linked Inhibitor of Apoptosis Protein - metabolism | Brain - pathology | Mice | MicroRNAs - genetics | Models, Neurological | Physiological aspects | Cerebral ischemia | Genetic aspects | Health aspects | Proteins | Ribonucleic acid--RNA | Cells | Index Medicus | Brain | Stroke | Translation | Apoptosis-inducing factor | Sex | X chromosome | Sex differences | XIAP protein | mRNA | Caspase-3 | Cytochrome c | Mitochondria | miRNA | Sexual dimorphism | Injuries | Biological Sciences | direct inhibitor of apoptosis binding protein with low Pi | second mitochondria-derived activator of caspases
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2008, Volume 30, Issue 1, pp. 11 - 25
Apoptosis in response to TRAIL or TNF requires the activation of initiator caspases, which then activate the effector caspases that dismantle cells and cause... 
SYSBIO | CELLCYCLE | DEATH RECEPTORS | EFFECTOR-CASPASE ACTIVATION | PROTEIN | X-LINKED INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | SURVIVING APOPTOSIS | SMAC/DIABLO RELEASE | RESONANCE ENERGY-TRANSFER | MITOCHONDRIAL-MEMBRANE | CYTOCHROME-C RELEASE | OLIGOMERIZATION | CELL BIOLOGY | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Mathematics | Mitochondrial Proteins - genetics | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | RNA Interference | Mitochondrial Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Models, Theoretical | Mitochondria - metabolism | Membrane Potentials - physiology | TNF-Related Apoptosis-Inducing Ligand - metabolism | X-Linked Inhibitor of Apoptosis Protein - genetics | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Recombinant Fusion Proteins - genetics | Luminescent Proteins - genetics | Signal Transduction - physiology | Apoptosis - physiology | Enzyme Activation | HeLa Cells | Proto-Oncogene Proteins c-bcl-2 - genetics | TNF-Related Apoptosis-Inducing Ligand - genetics | Luminescent Proteins - metabolism | Analysis | Apoptosis | Index Medicus | Bcl-2 | proteasome | TRAIL | biological modeling | FRET reporter | apoptosis | XIAP | TNF | caspase | computational
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 5, pp. 1131 - 1141.e9
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 06/2012, Volume 46, Issue 6, pp. 746 - 758
Journal Article
Blood, ISSN 0006-4971, 01/2008, Volume 111, Issue 2, pp. 846 - 855
Sustained engagement of the B-cell receptor (BCR) increases apoptosis resistance in chronic lymphocytic leukemia (CLL) B cells, whereas transient stimulation... 
ACTIVATION | AKT PHOSPHORYLATION | BCL-2/BAX RATIO | X-LINKED INHIBITOR | MCL-1 | ANTI-IGM | SURVIVAL SIGNALS | CD38 EXPRESSION | HEMATOLOGY | APOPTOSIS PROTEIN | GENE MUTATION STATUS | RNA, Small Interfering - genetics | Humans | bcl-X Protein - genetics | Cell Survival - genetics | Male | Neoplasm Proteins - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Receptors, Antigen, B-Cell - metabolism | Neoplasm Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | MAP Kinase Signaling System - genetics | Female | B-Lymphocytes - pathology | Neoplasm Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | MAP Kinase Kinase 2 - genetics | B-Lymphocytes - metabolism | Cell Survival - drug effects | RNA, Small Interfering - pharmacology | MAP Kinase Kinase 2 - metabolism | Down-Regulation - drug effects | Down-Regulation - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | X-Linked Inhibitor of Apoptosis Protein - genetics | Phosphatidylinositol 3-Kinases - genetics | MAP Kinase Signaling System - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Myeloid Cell Leukemia Sequence 1 Protein | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Receptors, Antigen, B-Cell - genetics | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14524 - 14529
NOD1 and NOD2 are members of the NOD-like receptor (NLR) protein family that are involved in sensing the presence of pathogens and are a component of the... 
Proteins | HEK293 cells | HCT116 cells | Plasmids | Cell lines | Antibodies | Reporter genes | Ligands | Immunoblotting | Apoptosis | CYTOCHROME-C | NEGATIVE BACTERIAL-INFECTION | ACTIVATION | HOST RECOGNITION | MULTIDISCIPLINARY SCIENCES | ALPHA-DEPENDENT APOPTOSIS | IAP | CELL-SURVIVAL | PROTEIN XIAP | NF-KAPPA-B | DROSOPHILA INHIBITOR | RNA, Small Interfering - genetics | Immunoprecipitation | Luciferases - metabolism | Humans | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Green Fluorescent Proteins - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Nod1 Signaling Adaptor Protein - metabolism | Recombinant Fusion Proteins - metabolism | Luciferases - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Transfection | Interleukin-8 - metabolism | Cell Line | Green Fluorescent Proteins - metabolism | Gene Expression | Enzyme-Linked Immunosorbent Assay | Signal Transduction | HCT116 Cells | Reverse Transcriptase Polymerase Chain Reaction | X-Linked Inhibitor of Apoptosis Protein - genetics | NF-kappa B - genetics | Nod2 Signaling Adaptor Protein - metabolism | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Protein Binding | Recombinant Fusion Proteins - genetics | Mutation | Nod1 Signaling Adaptor Protein - genetics | Research | Immunity | Bacteria | Peptides | Kinases | Immune system | Index Medicus | Biological Sciences
Journal Article
International Journal of Oncology, ISSN 1019-6439, 07/2016, Volume 49, Issue 1, pp. 153 - 163
The discovery of the TRAIL protein and its death receptors DR4/5 changed the horizon of cancer research because TRAIL specifically kills cancer cells. However,... 
IAPs | apoptosis | cancer therapy | TRAIL | c-FLIP | drug combination | C-FLIP | Drug combination | Cancer therapy | Apoptosis | LIGAND TRAIL | CASPASE-8 EXPRESSION | ANTITUMOR-ACTIVITY | NEUROBLASTOMA-CELLS | CANCER-THERAPY | DRUG-INDUCED APOPTOSIS | GENE | ONCOLOGY | ANTICANCER THERAPY | IN-VIVO | SENSITIZES | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Benzhydryl Compounds - administration & dosage | Apoptosis - drug effects | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | CASP8 and FADD-Like Apoptosis Regulating Protein - antagonists & inhibitors | Humans | Benzofurans - administration & dosage | CASP8 and FADD-Like Apoptosis Regulating Protein - biosynthesis | TNF-Related Apoptosis-Inducing Ligand - therapeutic use | X-Linked Inhibitor of Apoptosis Protein - genetics | Neoplasms - drug therapy | X-Linked Inhibitor of Apoptosis Protein - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Neoplasms - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Azocines - administration & dosage | Gene Expression Regulation, Neoplastic - drug effects | Neoplasms - pathology | RNA, Small Interfering - administration & dosage | TNF-Related Apoptosis-Inducing Ligand - genetics | X-Linked Inhibitor of Apoptosis Protein - biosynthesis | Transcription factors | Care and treatment | Innovations | Genetic aspects | Drug resistance | Gene expression | Health aspects | Cancer | Studies | Proteins | Immunoglobulins | Chemotherapy | Brain cancer | Rodents | Cytotoxicity | Kinases | Cancer therapies | Tumors
Journal Article