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Journal of Biological Chemistry, ISSN 0021-9258, 02/2004, Volume 279, Issue 7, pp. 5405 - 5412
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2015, Volume 290, Issue 36, pp. 22005 - 22018
Efficient apoptosis requires Bax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP), which releases death-promoting proteins cytochrome c and... 
BCL-2 | DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | IAP | BAX | SMAC | CYTOCHROME-C RELEASE | CLEAVAGE | CHEMOTHERAPY | CELL-DEATH PROTEASES | FAMILY | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | bcl-2 Homologous Antagonist-Killer Protein - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondrial Proteins - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Caspases - metabolism | MCF-7 Cells | Mitochondrial Proteins - metabolism | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | HEK293 Cells | Intracellular Signaling Peptides and Proteins - genetics | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Permeability - drug effects | Cytochromes c - secretion | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Mitochondria - metabolism | Blotting, Western | X-Linked Inhibitor of Apoptosis Protein - genetics | Mice, Knockout | Mitochondrial Membranes - metabolism | Protein Transport | Animals | GTP Phosphohydrolases - metabolism | Embryo, Mammalian - cytology | GTP Phosphohydrolases - genetics | Fibroblasts - drug effects | X-Linked Inhibitor of Apoptosis Protein - metabolism | Enzyme Activation | HeLa Cells | Microscopy, Fluorescence | Index Medicus | tumor necrosis factor (TNF) | dynamin-related protein 1 (Drp1) | cell death | mitochondria | mitochondrial apoptosis | mitochondrial outer membrane permeabilization (MOMP) | E3 ubiquitin ligase | X-linked inhibitor of apoptosis protein (XIAP) | Cell Biology
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2013, Volume 288, Issue 33, pp. 23740 - 23750
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2011, Volume 286, Issue 33, pp. 28749 - 28760
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 18, pp. 15630 - 15640
Journal Article
Radiation Oncology, ISSN 1748-717X, 06/2015, Volume 10, Issue 1, pp. 131 - 131
Background: The mainstay of treatment in rectal cancer is neoadjuvant radio chemotherapy prior to surgery, in an attempt to downstage the tumour, allowing for... 
Rectal cancer | Inhibitor of apoptosis proteins | Neoadjuvant radio chemotherapy | Apoptosis | CELLS | TUMOR PROGRESSION | CASPASE INHIBITION | PREOPERATIVE CHEMORADIOTHERAPY | KAPPA-B | ONCOLOGY | COLORECTAL-CANCER | ALPHA-DEPENDENT APOPTOSIS | CHEMORADIATION | PROGNOSTIC-SIGNIFICANCE | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Apoptosis - drug effects | Apoptosis - radiation effects | Inhibitor of Apoptosis Proteins - genetics | X-Linked Inhibitor of Apoptosis Protein - analysis | Humans | Middle Aged | Male | Rectal Neoplasms - chemistry | Baculoviral IAP Repeat-Containing 3 Protein | Mitochondrial Proteins - genetics | Chemoradiotherapy | Fluorouracil - therapeutic use | Ubiquitin-Protein Ligases - analysis | Adult | Antimetabolites, Antineoplastic - pharmacology | Female | Neoadjuvant Therapy | Rectal Neoplasms - pathology | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Inhibitor of Apoptosis Proteins - analysis | X-Linked Inhibitor of Apoptosis Protein - biosynthesis | Inhibitor of Apoptosis Proteins - biosynthesis | Mitochondrial Proteins - analysis | Biomarkers, Tumor - analysis | Neoplasm Proteins - biosynthesis | Intracellular Signaling Peptides and Proteins - analysis | Mitochondrial Proteins - biosynthesis | Intracellular Signaling Peptides and Proteins - biosynthesis | Rectal Neoplasms - therapy | Ubiquitin-Protein Ligases - biosynthesis | X-Linked Inhibitor of Apoptosis Protein - genetics | Antimetabolites, Antineoplastic - therapeutic use | Radiation Tolerance - physiology | Neoplasm Proteins - analysis | Aged | Biomarkers, Tumor - genetics | Fluorouracil - pharmacology | Gene Expression Regulation, Neoplastic - radiation effects | Ubiquitin-Protein Ligases - genetics | Drug Resistance, Neoplasm - physiology | Biomarkers, Tumor - biosynthesis | Proteins | Colorectal cancer | Adjuvant treatment | Development and progression | Drug therapy | Tumors | Cancer | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 7, pp. e11813 - e11813
Background: XIAP (X-linked inhibitor of apoptosis protein) is one of the most important members of the apoptosis inhibitor family. XIAP is upregulated in... 
CANCER-CELLS | NUDE-MICE | NECROSIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MITOCHONDRIA | RECEPTOR | DEATH | LIGAND | BCL-2 FAMILY | EXPRESSION | In Situ Nick-End Labeling | Caspase 9 - metabolism | Humans | Caspase 3 - metabolism | Apoptosis - genetics | Immunoblotting | Stem Cells - cytology | Fetal Blood - cytology | X-Linked Inhibitor of Apoptosis Protein - genetics | Glioma - metabolism | Glioma - genetics | Cord Blood Stem Cell Transplantation - methods | Animals | Flow Cytometry | Glioma - therapy | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Stem Cells - physiology | Mice | Apoptosis - physiology | Proteins | Metastasis | Gliomas | Analysis | Hematopoietic stem cells | Apoptosis | Cell proliferation | Biotechnology | Flow cytometry | Bax protein | Mesenchyme | Toxicity | Brain tumors | Brain cancer | Glioblastoma | Cytotoxicity | AKT protein | Biology | Activation | Neurosurgery | Caspase-3 | Nuclei | Blood | Metastases | Angiogenesis | Mitochondria | Allografts | Cord blood | Rodents | Glioma cells | Xenografts | Bone marrow | Biocompatibility | Membrane potential | Inhibition | Medical research | Cell survival | Mortality | Caspase | Cultures | Pharmacology | Permeability | Medicine | DIABLO protein | Chemotherapy | Inhibitors | Cell death | Cell lines | Stem cells | Caspase-9 | Spinal cord injuries | Umbilical cord | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2011, Volume 286, Issue 43, pp. 37368 - 37378
Journal Article