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1. Full Text Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase- dependent nitric oxide generation
by Zuckerbraun, Brian S and Shiva, Sruti and Ifedigbo, Emeka and Mathier, Michael A and Mollen, Kevin P and Rao, Jayashree and Bauer, Philip M and Choi, Justin J.W and Curtis, Erin and Choi, Augustine M.K and Gladwin, Mark T
Circulation, ISSN 0009-7322, 01/2010, Volume 121, Issue 1, pp. 98 - 109
Background-Pulmonary arterial hypertension is a progressive proliferative vasculopathy of the small pulmonary arteries that is characterized by a primary... 
Hypoxia | Nitric oxide | Pulmonary artery smooth muscle cells | Xanthine oxidoreductase | Monocrotaline sodium | hypoxia | nitric oxide | xanthine oxidoreductase | ISCHEMIA/REPERFUSION INJURY | CARDIAC & CARDIOVASCULAR SYSTEMS | ORGANIC NITRATES | monocrotaline sodium | ACTIVATED-PROTEIN-KINASE | CELL-PROLIFERATION | EXERCISE CAPACITY | pulmonary artery smooth muscle cells | SYNTHASE | L-ARGININE | IN-VIVO | PERIPHERAL VASCULAR DISEASE | ISCHEMIA-REPERFUSION | HEMATOLOGY | EXPRESSION | Xanthine Dehydrogenase - metabolism | Hypoxia - drug therapy | Xanthine Dehydrogenase - antagonists & inhibitors | Male | Hypertension, Pulmonary - chemically induced | Hypoxia - metabolism | Sodium Nitrite - pharmacology | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Hypertension, Pulmonary - drug therapy | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - cytology | Disease Models, Animal | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Administration, Inhalation | Rats | Hypertension, Pulmonary - metabolism | Monocrotaline - toxicity | Rats, Sprague-Dawley | Cell Division - drug effects | Mice, Knockout | Pulmonary Artery - cytology | Animals | Mice | Nitric Oxide - metabolism | Sodium Nitrite - pharmacokinetics | Chronic Disease | Cell proliferation | Control | Nitrites | Physiological aspects | Smooth muscle | Research | Pulmonary hypertension
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2. Full Text Enhanced Vasodilator Activity of Nitrite in Hypertension: Critical Role for Erythrocytic Xanthine Oxidoreductase and Translational Potential
by Ghosh, Suborno M and Kapil, Vikas and Fuentes-Calvo, Isabel and Bubb, Kristen J and Pearl, Vanessa and Milsom, Alexandra B and Khambata, Rayomand and Maleki-Toyserkani, Sheiva and Yousuf, Mubeen and Benjamin, Nigel and Webb, Andrew J and Caulfield, Mark J and Hobbs, Adrian J and Ahluwalia, Amrita
Hypertension, ISSN 0194-911X, 05/2013, Volume 61, Issue 5, pp. 1091 - 1102
Elevation of circulating nitrite (NO2) levels causes vasodilatation and lowers blood pressure in healthy volunteers. Whether these effects and the underpinning... 
red blood cells | nitric oxide | vascular biology | hypertension | CHRONIC HEART-FAILURE | ORAL NITRITE | RESISTANT HYPERTENSION | DIETARY NITRATE | BLOOD-PRESSURE | OXIDE SYNTHASE | L-ARGININE | PERIPHERAL VASCULAR DISEASE | ISCHEMIA-REPERFUSION | HUMAN CIRCULATION | INORGANIC NITRATE | Xanthine Dehydrogenase - antagonists & inhibitors | Humans | Middle Aged | Rats, Inbred WKY | Hypertension - drug therapy | Male | Dose-Response Relationship, Drug | Hypertension - blood | Nitrites - blood | Female | Blood Pressure - drug effects | Blood Pressure - physiology | Erythrocytes - enzymology | Vasodilation - physiology | Disease Models, Animal | Rats, Inbred SHR | Xanthine Dehydrogenase - drug effects | Translational Medical Research | Enzyme Inhibitors - pharmacology | Rats | Nitrites - pharmacology | Hypertension - physiopathology | Nitrites - therapeutic use | Cross-Over Studies | Animals | Xanthine Dehydrogenase - physiology | Allopurinol - pharmacology | Signal Transduction - physiology | Vasodilation - drug effects
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3. Full Text An extremely potent inhibitor of xanthine oxidoreductase: Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition
by Okamoto, Ken and Eger, Bryan T and Nishino, Tomoko and Kondo, Shiro and Pai, Emil F and Nishino, Takeshi
Journal of Biological Chemistry, ISSN 0021-9258, 01/2003, Volume 278, Issue 3, pp. 1848 - 1855
TEI-6720 (2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5thiazolecarboxylic acid) is an extremely potent inhibitor of xanthine oxidoreductase. Steady state kinetics... 
RAT-LIVER | DEHYDROGENASE TYPE | ALLOPURINOL | OXYGEN | PROTEIN | BOVINE-MILK | CONVERSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PURIFICATION | ELECTRON-DENSITY MAPS | OXIDASE INHIBITOR | Milk - enzymology | Febuxostat | Xanthine Dehydrogenase - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Models, Molecular | Spectrometry, Fluorescence | Crystallography, X-Ray | Animals | Cattle | Enzyme Inhibitors - chemistry | Thiazoles - chemistry | Molecular Structure | Thiazoles - pharmacology | Kinetics | Xanthine Dehydrogenase - chemistry
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4. Full Text Dietary nitrate ameliorates pulmonary hypertension: Cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase
by Baliga, Reshma S and Milsom, Alexandra B and Ghosh, Suborno M and Trinder, Sarah L and MacAllister, Raymond J and Ahluwalia, Amrita and Hobbs, Adrian J
Circulation, ISSN 0009-7322, 06/2012, Volume 125, Issue 23, pp. 2922 - 2932
Background-Pulmonary hypertension (PH) is a multifactorial disease characterized by increased pulmonary vascular resistance and right ventricular failure;... 
eNOS | nitric oxide | xanthine oxidase endothelium | vasodilation | pulmonary hypertension | CARDIAC & CARDIOVASCULAR SYSTEMS | HYPOXIA | BLOOD-PRESSURE | REDUCTASE-ACTIVITY | THERAPY | ARTERIAL-HYPERTENSION | IN-VIVO | PERIPHERAL VASCULAR DISEASE | GENERATION | TISSUES | ISCHEMIA-REPERFUSION | HEMATOLOGY | Xanthine Dehydrogenase - metabolism | Antibiotics, Antineoplastic - toxicity | Nitrates - urine | Xanthine Dehydrogenase - antagonists & inhibitors | Nitrates - pharmacology | Male | Cyclic GMP - blood | Hypertension, Pulmonary - chemically induced | Hypertrophy, Right Ventricular - drug therapy | Hypoxia - metabolism | Pulmonary Circulation - physiology | Ventricular Pressure - physiology | Nitrites - blood | Hypoxia - prevention & control | Hypertension, Pulmonary - drug therapy | Nitric Oxide Synthase Type III - metabolism | Hypertrophy, Right Ventricular - metabolism | Bleomycin - toxicity | Disease Models, Animal | Nitrites - urine | Nitrates - blood | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Ventricular Pressure - drug effects | Hypertension, Pulmonary - metabolism | Nitric Oxide Synthase Type III - genetics | Nitrites - pharmacology | Mice, Knockout | Animals | Allopurinol - pharmacology | Mice | Pulmonary Circulation - drug effects | Animal Feed | Care and treatment | Nitric oxide | Development and progression | Research | Oxidoreductases | Xanthine | Health aspects | Pulmonary hypertension | endothelial nitric oxide synthase
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5. Full Text Mammalian xanthine oxidoreductase – mechanism of transition from xanthine dehydrogenase to xanthine oxidase
by Nishino, Tomoko and Okamoto, Ken and Eger, Bryan T and Pai, Emil F and Nishino, Takeshi
The FEBS Journal, ISSN 1742-464X, 07/2008, Volume 275, Issue 13, pp. 3278 - 3289
Reactive oxygen species are generated by various biological systems, including NADPH oxidases, xanthine oxidoreductase, and mitochondrial respiratory enzymes,... 
xanthine dehydrogenase | xanthine oxidoreductase | π‐cation interaction | molybdopterin cofactor | hydrogen peroxide | iron‐sulfur center | reactive oxygen species | superoxide | flavin semiquinone | xanthine oxidase | Reactive oxygen species | Hydrogen peroxide | Iron-sulfur center | Xanthine oxidoreductase | Xanthine dehydrogenase | Xanthine oxidase | Flavin semiquinone | Molybdopterin cofactor | Superoxide | π-cation interaction | RAT-LIVER | O-2-DEPENDENT TYPES | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RHODOBACTER-CAPSULATUS | cation interaction | SUBSTRATE-SPECIFICITY | OXIDATIVE HALF-REACTION | MOLYBDENUM ENZYMES | iron-sulfur center | ADENINE-DINUCLEOTIDE | CATALYTIC MECHANISM | ACTIVE-SITE PROBES | Xanthine Dehydrogenase - metabolism | Amino Acid Sequence | Mitochondria - enzymology | Oxidation-Reduction | Humans | Molecular Conformation | Molecular Sequence Data | Cysteine - chemistry | Xanthine Oxidase - chemistry | Sequence Homology, Amino Acid | Thermodynamics | Animals | Xanthine Dehydrogenase - physiology | Disulfides - chemistry | Models, Biological | Xanthine Dehydrogenase - chemistry | Oxidases | Physiological aspects | Iron compounds | Xanthine | Molybdenum compounds | Enzymes | Chemical reactions | Biochemistry | Biophysics | Mammals | Index Medicus
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6. Full Text Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
by Ives, Annette and Nomura, Johji and Martinon, Fabio and Roger, Thierry and LeRoy, Didier and Miner, Jeffrey N and Simon, Gregoire and Busso, Nathalie and So, Alexander
Nature Communications, ISSN 2041-1723, 03/2015, Volume 6, Issue 1, p. 6555
Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present... 
ALLOPURINOL | OXIDASE | IL-1-BETA PRODUCTION | CONVERSION | MULTIDISCIPLINARY SCIENCES | IDENTIFICATION | HYPERTENSION | INHIBITOR | URIC-ACID | DEHYDROGENASE | NALP3 INFLAMMASOME | Phosphorylation | Calcium - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Xanthine Dehydrogenase - antagonists & inhibitors | Xanthine Dehydrogenase - genetics | Caspase 1 - immunology | Carrier Proteins - drug effects | Autophagy | Gene Knockdown Techniques | Macrophages - secretion | Xanthine Dehydrogenase - immunology | Reactive Oxygen Species - immunology | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | Calcium Phosphates - pharmacology | Carrier Proteins - immunology | Macrophages - immunology | Interleukin-1beta - secretion | Signal Transduction | Mice, Inbred C57BL | Peritonitis - immunology | Xanthine Oxidase - immunology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Uric Acid - immunology | Monocytes | Animals | Lipopolysaccharides - pharmacology | Mice | In Vitro Techniques
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7. Full Text Hyperuricaemia, xanthine oxidoreductase and ribosome-inactivating proteins from plants: The contributions of fiorenzo stirpe to frontline research
by Bolognesi, Andrea and Bortolotti, Massimo and Battelli, Maria Giulia and Polito, Letizia
Molecules, ISSN 1420-3049, 02/2017, Volume 22, Issue 2, p. 206
The enzymes called ribosome-inactivating proteins (RIPs) that are able to depurinate nucleic acids and arrest vital cellular functions, including protein... 
Immunotoxins | Ribosome-inactivating proteins | Toxic lectins | Ricin | Gout | Xanthine oxidoreductase | Hyperuricaemia | toxic lectins | xanthine oxidoreductase | DEHYDROGENASE TYPE D | ricin | CHEMISTRY, ORGANIC | OXIDASE TYPE O | LARGE-CELL LYMPHOMA | HUMAN LIVER-DISEASE | RNA N-GLYCOSIDASES | ADENOSINE GLYCOSIDASE ACTIVITY | IN-VITRO EVALUATION | PHYTOLACCA-DIOICA L | gout | immunotoxins | THY 1.1 ANTIBODY | ribosome-inactivating proteins | hyperuricaemia | CONSTITUENT-PEPTIDE CHAINS | Xanthine Dehydrogenase - metabolism | Plant Proteins - pharmacology | History, 20th Century | Humans | Hyperuricemia - diagnosis | Ribosome Inactivating Proteins - pharmacology | Hyperuricemia - metabolism | Famous Persons | Hyperuricemia - etiology | Fructose - metabolism | Hyperuricemia - drug therapy | Ricin - pharmacology | Translational Medical Research - history | Animals | Research - history | Italy | ribosome‐inactivating proteins | toxic lectins | xanthine oxidoreductase
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8. Full Text Xanthine oxidoreductase in atherosclerosis pathogenesis: Not only oxidative stress
by Battelli, Maria Giulia and Polito, Letizia and Bolognesi, Andrea
Atherosclerosis, ISSN 0021-9150, 2014, Volume 237, Issue 2, pp. 562 - 567
Abstract Endothelial xanthine oxidoreductase (XOR) together with NAD(P)H oxidase and nitric oxide (NO) synthase plays a physiologic role in inflammatory... 
Cardiovascular | Oxidative stress | Uric acid | Cardiovascular diseases | Metabolic syndrome | Atherosclerosis | Xanthine oxidoreductase | CARDIAC & CARDIOVASCULAR SYSTEMS | OXIDASE INHIBITOR FEBUXOSTAT | ENDOTHELIAL DYSFUNCTION | PROTECTION | FREE-RADICAL PRODUCTION | DEHYDROGENASE | NAD(P)H OXIDASE | HYPERURICEMIA | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | HYPERTENSION | URIC-ACID | Xanthine Dehydrogenase - metabolism | Metabolic Syndrome - enzymology | Cardiovascular Diseases - physiopathology | Oxidants - chemistry | Oxidation-Reduction | Oxidative Stress | Humans | Diabetes Mellitus, Type 2 - enzymology | Insulin Resistance | Adipocytes - cytology | Inflammation | Gene Expression Regulation, Enzymologic | Hypertension - blood | Atherosclerosis - enzymology | Hyperuricemia - blood | Animals | Endothelium, Vascular - pathology | Cell Differentiation | Diabetes Complications - enzymology | Mice | Obesity - enzymology | Uric Acid - blood | Cell Movement | Oxidases | Hypertension | Nitric oxide | Insulin resistance | Xanthine
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9. Full Text Untargeted plasma metabolite profiling reveals the broad systemic consequences of xanthine oxidoreductase inactivation in mice
by Chen, Qiuying and Park, Hyeong-Cheon and Goligorsky, Michael S and Chander, Praveen and Fischer, Steven M and Gross, Steven S
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e37149
A major challenge in systems biology is integration of molecular findings for individual enzyme activities into a cohesive high-level understanding of cellular... 
STATIONARY-PHASE | ALLOPURINOL | OXIDATIVE STRESS | METABOLOMICS | LOWERING URIC-ACID | MULTIDISCIPLINARY SCIENCES | REPERFUSION INJURY | KYNURENINE PATHWAY ENZYMES | CHRONIC KIDNEY-DISEASE | MASS-SPECTROMETRY | CHRONIC-RENAL-FAILURE | Xanthine Dehydrogenase - metabolism | Metabolic Networks and Pathways - genetics | Animals | Models, Biological | Gene Deletion | Xanthine Dehydrogenase - genetics | Metabolome | Genotype | Mice | Enzyme Activation - genetics | Cluster Analysis | Mice, Knockout | Enzymes | Metabolites | Gene mutations | Analysis | Tryptophan | Lipids | Information management | Xanthine | Kidney diseases | Oxidative stress | Plasma | Metabolomics | Dehydrogenases | Profiling | Enzyme activity | Syngeneic grafts | Oxidoreductase | Arthritis | Phospholipids | Gene deletion | Multivariate analysis | Inactivation | Proteins | Pyrimidines | Clonal deletion | Enzymatic activity | Rodents | Deletion | Rheumatism | Physiology | Drug dosages | Data analysis | Departments | Deactivation | Data processing | Pharmacology | Uric acid | Metabolism | Gene expression | Fatty acids | Chromatography | Urea | Pathology | Xanthine oxidoreductase | Predictions | Renal failure | Biomarkers | Diabetes | Mutation
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10. Full Text Identification and characterization of oxidoreductase component (NdmD) of methylxanthine oxygenase system in Pseudomonas sp. NCIM 5235
by Retnadhas, Sreeahila and Gummadi, Sathyanarayana N
Applied Microbiology and Biotechnology, ISSN 0175-7598, 9/2018, Volume 102, Issue 18, pp. 7913 - 7926
Pseudomonas sp. NCIM 5235 is a caffeine-degrading bacterial strain that metabolizes caffeine by sequential demethylation using methylxanthine demethylases.... 
Life Sciences | Biotechnology | Rieske proteins | Microbiology | Microbial Genetics and Genomics | Domain swapping | NdmD | Caffeine degradation | PUTIDA CBB5 | 3-HYDROXYLASE | MECHANISM | CRYSTAL-STRUCTURE | DEMETHYLASE | ACINETOBACTER-BAUMANNII | PURINE ALKALOIDS | ELECTRON-TRANSFER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | REDUCTASE | Temperature | Molecular Weight | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Enzyme Stability | Substrate Specificity | Oxygenases - chemistry | Xanthines - metabolism | Pseudomonas - enzymology | Escherichia coli - genetics | Oxygenases - metabolism | Escherichia coli - metabolism | Protein Domains | Bacterial Proteins - metabolism | Oxygenases - genetics | Pseudomonas - chemistry | Pseudomonas - genetics | Hydrogen-Ion Concentration | Physiological aspects | Pseudomonas | Oxidoreductases | Cytochrome | Biodegradation | Reductases | Oxidoreductase | Catalytic activity | Molecular chains | Substrates | Cytochrome c | Proteins | Oxygenase | Demethylation | Clonal deletion | E coli | Substrate specificity | Deletion | Catalysis | Caffeine | Reductase
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11. Full Text Hyperuricemia-related diseases and xanthine oxidoreductase (XOR) inhibitors: An overview
by Chen, Changyi Johnny and Lü, Jian-Ming and Yao, Qizhi
Medical Science Monitor, ISSN 1234-1010, 07/2016, Volume 22, pp. 2501 - 2512
Uric acid is the final oxidation product of purine metabolism in humans. Xanthine oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to... 
Cardiovascular diseases | Hyperuricemia | Gout | MEDICINE, RESEARCH & EXPERIMENTAL | Cardiovascular Diseases | OXIDASE INHIBITORS | TOXIC EPIDERMAL NECROLYSIS | SERUM URIC-ACID | DOSE-RESPONSE METAANALYSIS | ALL-CAUSE MORTALITY | GENERAL-POPULATION | NITRIC-OXIDE | DOUBLE-BLIND | DRUG-DELIVERY SYSTEMS | STEVENS-JOHNSON-SYNDROME | Xanthine Dehydrogenase - metabolism | Animals | Reactive Oxygen Species - metabolism | Xanthine Dehydrogenase - antagonists & inhibitors | Humans | Risk Factors | Enzyme Inhibitors - pharmacology | Allopurinol - pharmacology | Hyperuricemia - therapy | Enzyme Inhibitors - therapeutic use | Hyperuricemia - enzymology | Febuxostat - pharmacology
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12. Full Text The PRY/SPRY/B30.2 domain of butyrophilin 1A1 (BTN1A1) binds to xanthine oxidoreductase. Implications for the function of BTN1A1 in the mammary gland and other tissues
by Jeong, Jaekwang and Rao, Anita U and Xu, Jinling and Ogg, Sherry L and Hathout, Yetrib and Fenselau, Catherine and Mather, Ian H
Journal of Biological Chemistry, ISSN 0021-9258, 08/2009, Volume 284, Issue 33, pp. 22444 - 22456
Butyrophilin 1A1 (BTN1A1) and xanthine oxidoreductase (XOR) are highly expressed in the lactating mammary gland and are secreted into milk associated with the... 
POLYACRYLAMIDE-GELS | CYTOPLASMIC DOMAIN | MYELIN OLIGODENDROCYTE GLYCOPROTEIN | MILK PROTEIN BUTYROPHILIN | IMMUNOGLOBULIN SUPERFAMILY | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | CLASS-I REGION | FAT-GLOBULE-MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BOVINE BUTYROPHILIN | MAMMARY EPITHELIAL-CELLS | Protein Structure, Tertiary | Membrane Glycoproteins - metabolism | Humans | Membrane Glycoproteins - chemistry | Butyrophilins | Cytoplasm - metabolism | Mice, Inbred C3H | Animals | Mammary Glands, Animal - metabolism | Cattle | Protein Binding | Female | Mice | Dimerization | Hydrogen-Ion Concentration | Milk | Xanthine Dehydrogenase - chemistry | Molecular Basis of Cell and Developmental Biology
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13. Full Text Pathophysiology of circulating xanthine oxidoreductase: New emerging roles for a multi-tasking enzyme
by Battelli, Maria Giulia and Bolognesi, Andrea and Polito, Letizia
Biochimica et Biophysica Acta - Molecular Basis of Disease, ISSN 0925-4439, 2014, Volume 1842, Issue 9, pp. 1502 - 1517
The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in the highest uricotelic primates as a rate-limiting enzyme in nucleic... 
Oxidative stress | Uric acid | Cardiovascular diseases | Metabolic syndrome | Endothelium functions | Xanthine oxidoreductase | CHRONIC HEART-FAILURE | NITRIC-OXIDE SYNTHASE | HUMAN LIVER-TRANSPLANTATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE LUNG INJURY | SERUM URIC-ACID | ISCHEMIA-REPERFUSION INJURY | PULMONARY ENDOTHELIAL-CELLS | BIOPHYSICS | THORACIC AORTA OCCLUSION | OXYGEN-FREE-RADICALS | MAMMARY EPITHELIAL-CELLS | Xanthine Dehydrogenase - metabolism | Cardiovascular Diseases - physiopathology | Animals | Humans | Metabolic Syndrome - physiopathology | Oxidases | Physiological aspects | Biological products | Xanthine
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14. Xanthine oxidoreductase in drug metabolism: Beyond a role as a detoxifying enzyme
by Battelli, Maria Giulia and Polito, Letizia and Bortolotti, Massimo and Bolognesi, Andrea
Current Medicinal Chemistry, ISSN 0929-8673, 2016, Volume 23, Issue 35, pp. 4027 - 4036
The enzyme xanthine oxidoreductase (XOR) catalyzes the last two steps of purine catabolism in the highest uricotelic primates. XOR is an enzyme with... 
Anticancer drugs | Antimicrobial drugs | Immunosuppressive drugs | Nitrovasodilators | Purine analogues | Xanthine oxidoreductase | CHEMISTRY, MEDICINAL | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXIDASE-ACTIVATED PRODRUG | CANCER | DEHYDROGENASE | 6-MERCAPTOPURINE | IN-VITRO | 6-DEOXYACYCLOVIR | REDUCTIVE ACTIVATION | ALDEHYDE OXIDASE | PHARMACOLOGY & PHARMACY | PHARMACOGENETICS | Xanthine Dehydrogenase - metabolism | Anti-Infective Agents - metabolism | Purines - metabolism | Humans | Benzoquinones - chemistry | Antineoplastic Agents - chemistry | Antineoplastic Agents - metabolism | Pharmaceutical Preparations - metabolism | Animals | Purines - chemistry | Anti-Infective Agents - chemistry | Va