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1. Full Text Enhanced Vasodilator Activity of Nitrite in Hypertension: Critical Role for Erythrocytic Xanthine Oxidoreductase and Translational Potential
by Ghosh, Suborno M and Kapil, Vikas and Fuentes-Calvo, Isabel and Bubb, Kristen J and Pearl, Vanessa and Milsom, Alexandra B and Khambata, Rayomand and Maleki-Toyserkani, Sheiva and Yousuf, Mubeen and Benjamin, Nigel and Webb, Andrew J and Caulfield, Mark J and Hobbs, Adrian J and Ahluwalia, Amrita
Hypertension (Dallas, Tex. 1979), ISSN 0194-911X, 05/2013, Volume 61, Issue 5, pp. 1091 - 1102
red blood cells | nitric oxide | vascular biology | hypertension | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Biological and medical sciences | Arterial hypertension. Arterial hypotension | Medical sciences | Blood and lymphatic vessels | Xanthine Dehydrogenase - antagonists & inhibitors | Humans | Middle Aged | Rats, Inbred WKY | Hypertension - drug therapy | Male | Dose-Response Relationship, Drug | Hypertension - blood | Nitrites - blood | Female | Blood Pressure - drug effects | Blood Pressure - physiology | Erythrocytes - enzymology | Vasodilation - physiology | Disease Models, Animal | Rats, Inbred SHR | Xanthine Dehydrogenase - drug effects | Translational Medical Research | Enzyme Inhibitors - pharmacology | Rats | Nitrites - pharmacology | Hypertension - physiopathology | Nitrites - therapeutic use | Cross-Over Studies | Animals | Xanthine Dehydrogenase - physiology | Allopurinol - pharmacology | Signal Transduction - physiology | Vasodilation - drug effects | Index Medicus
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2. Full Text An extremely potent inhibitor of xanthine oxidoreductase: Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition
by Okamoto, Ken and Eger, Bryan T and Nishino, Tomoko and Kondo, Shiro and Pai, Emil F and Nishino, Takeshi
The Journal of biological chemistry, ISSN 0021-9258, 01/2003, Volume 278, Issue 3, pp. 1848 - 1855
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Milk - enzymology | Febuxostat | Xanthine Dehydrogenase - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Models, Molecular | Spectrometry, Fluorescence | Crystallography, X-Ray | Animals | Cattle | Enzyme Inhibitors - chemistry | Thiazoles - chemistry | Molecular Structure | Thiazoles - pharmacology | Kinetics | Xanthine Dehydrogenase - chemistry | Index Medicus
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3. Full Text Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
by Ives, Annette and Nomura, Johji and Martinon, Fabio and Roger, Thierry and LeRoy, Didier and Miner, Jeffrey N and Simon, Gregoire and Busso, Nathalie and So, Alexander
Nature communications, ISSN 2041-1723, 03/2015, Volume 6, Issue 1, pp. 6555 - 6555
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Phosphorylation | Calcium - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Xanthine Dehydrogenase - antagonists & inhibitors | Xanthine Dehydrogenase - genetics | Caspase 1 - immunology | Carrier Proteins - drug effects | Autophagy | Gene Knockdown Techniques | Macrophages - secretion | Xanthine Dehydrogenase - immunology | Reactive Oxygen Species - immunology | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | Calcium Phosphates - pharmacology | Carrier Proteins - immunology | Macrophages - immunology | Interleukin-1beta - secretion | Signal Transduction | Mice, Inbred C57BL | Peritonitis - immunology | Xanthine Oxidase - immunology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Uric Acid - immunology | Monocytes | Animals | Lipopolysaccharides - pharmacology | Mice | In Vitro Techniques | Index Medicus
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4. Full Text Mammalian xanthine oxidoreductase – mechanism of transition from xanthine dehydrogenase to xanthine oxidase
by Nishino, Tomoko and Okamoto, Ken and Eger, Bryan T and Pai, Emil F and Nishino, Takeshi
The FEBS journal, ISSN 1742-464X, 07/2008, Volume 275, Issue 13, pp. 3278 - 3289
xanthine dehydrogenase | xanthine oxidoreductase | π‐cation interaction | molybdopterin cofactor | hydrogen peroxide | iron‐sulfur center | reactive oxygen species | superoxide | flavin semiquinone | xanthine oxidase | Reactive oxygen species | Hydrogen peroxide | Iron-sulfur center | Xanthine oxidoreductase | Xanthine dehydrogenase | Xanthine oxidase | Flavin semiquinone | Molybdopterin cofactor | Superoxide | π-cation interaction | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Xanthine Dehydrogenase - metabolism | Amino Acid Sequence | Mitochondria - enzymology | Oxidation-Reduction | Humans | Molecular Conformation | Molecular Sequence Data | Cysteine - chemistry | Xanthine Oxidase - chemistry | Sequence Homology, Amino Acid | Thermodynamics | Animals | Xanthine Dehydrogenase - physiology | Disulfides - chemistry | Models, Biological | Xanthine Dehydrogenase - chemistry | Oxidases | Physiological aspects | Iron compounds | Xanthine | Molybdenum compounds | Enzymes | Chemical reactions | Biochemistry | Biophysics | Mammals | Index Medicus
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5. Full Text Xanthine oxidoreductase in atherosclerosis pathogenesis: Not only oxidative stress
by Battelli, Maria Giulia and Polito, Letizia and Bolognesi, Andrea
Atherosclerosis, ISSN 0021-9150, 2014, Volume 237, Issue 2, pp. 562 - 567
Cardiovascular | Oxidative stress | Uric acid | Cardiovascular diseases | Metabolic syndrome | Atherosclerosis | Xanthine oxidoreductase | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Xanthine Dehydrogenase - metabolism | Metabolic Syndrome - enzymology | Cardiovascular Diseases - physiopathology | Oxidants - chemistry | Oxidation-Reduction | Oxidative Stress | Humans | Diabetes Mellitus, Type 2 - enzymology | Insulin Resistance | Adipocytes - cytology | Inflammation | Gene Expression Regulation, Enzymologic | Hypertension - blood | Atherosclerosis - enzymology | Hyperuricemia - blood | Animals | Endothelium, Vascular - pathology | Cell Differentiation | Diabetes Complications - enzymology | Mice | Obesity - enzymology | Uric Acid - blood | Cell Movement | Oxidases | Hypertension | Nitric oxide | Insulin resistance | Xanthine | Index Medicus
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6. Full Text Xanthine Oxidoreductase-Derived Reactive Species: Physiological and Pathological Effects
by Battelli, Maria Giulia and Polito, Letizia and Bortolotti, Massimo and Bolognesi, Andrea
Oxidative medicine and cellular longevity, ISSN 1942-0900, 12/2015, Volume 2016, pp. 3527579 - 8
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Human Umbilical Vein Endothelial Cells | Xanthine Dehydrogenase - metabolism | Xanthine Oxidase - metabolism | Phosphorylation | Reactive Oxygen Species - metabolism | Antioxidants - chemistry | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Free Radicals - chemistry | Humans | Protein Tyrosine Phosphatases - metabolism | Inflammation | Vanadates - chemistry | Cell Adhesion | Endothelial Cells - cytology | Enzyme Inhibitors - chemistry | Nitric Oxide - metabolism | Apoptosis | Enzymes | Ischemia | Nitric oxide | Physiological aspects | Development and progression | Peroxides | Superoxide | B cells | Xanthine | Uric acid | Endothelium | Transcription factors | Free radicals | Dehydrogenases | Cytokines | Cytotoxicity | Mammals | Gene expression | Molybdenum | Cell adhesion & migration | Proteins | Angiogenesis | Hypoxia | Oxidation | Physiology | Sulfur | Cancer | Index Medicus | Review
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7. Full Text Hyperuricaemia, xanthine oxidoreductase and ribosome-inactivating proteins from plants: The contributions of fiorenzo stirpe to frontline research
by Bolognesi, Andrea and Bortolotti, Massimo and Battelli, Maria Giulia and Polito, Letizia
Molecules (Basel, Switzerland), ISSN 1420-3049, 02/2017, Volume 22, Issue 2, p. 206
Immunotoxins | Ribosome-inactivating proteins | Toxic lectins | Ricin | Gout | Xanthine oxidoreductase | Hyperuricaemia | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Xanthine Dehydrogenase - metabolism | Plant Proteins - pharmacology | History, 20th Century | Humans | Hyperuricemia - diagnosis | Ribosome Inactivating Proteins - pharmacology | Hyperuricemia - metabolism | Famous Persons | Hyperuricemia - etiology | Fructose - metabolism | Hyperuricemia - drug therapy | Ricin - pharmacology | Translational Medical Research - history | Animals | Research - history | Italy | Index Medicus | ribosome‐inactivating proteins | toxic lectins | ricin | gout | immunotoxins | hyperuricaemia | xanthine oxidoreductase
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8. Full Text Pathophysiology of circulating xanthine oxidoreductase: New emerging roles for a multi-tasking enzyme
by Battelli, Maria Giulia and Bolognesi, Andrea and Polito, Letizia
Biochimica et biophysica acta. Molecular basis of disease, ISSN 0925-4439, 09/2014, Volume 1842, Issue 9, pp. 1502 - 1517
Oxidative stress | Uric acid | Cardiovascular diseases | Metabolic syndrome | Endothelium functions | Xanthine oxidoreductase | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Xanthine Dehydrogenase - metabolism | Cardiovascular Diseases - physiopathology | Animals | Humans | Metabolic Syndrome - physiopathology | Oxidases | Physiological aspects | Biological products | Xanthine
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