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2012, ISBN 9783527329038, xxix, 724
A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of... 
Toxicology | Biotransformation (Metabolism) | Xenobiotics | Metabolism | Medical | Drugs
Book
Xenobiotica, ISSN 0049-8254, 1971
Journal
2010, 2nd ed., ISBN 9780470742167, xiv, 346
Human Drug Metabolism, An Introduction, Second Editionprovides an accessible introduction to the subject and will be particularly invaluable to those who... 
Drugs | Psychological aspects | toxicity | Pharmaceutical Preparations | Xenobiotics | Metabolism | Physiological effect
Book
2008, Issues in toxicology, ISBN 0854042741, xviii, 521
During half a century, cytochrome P450 in its original uniqueness as an optically "wrong" cytochrome has attracted many investigators, who have contributed to... 
Cytochrome P-450 -- Physiological effect | Xenobiotics -- Metabolism | Biology, life sciences | Cytochrome P-450 | Chemistry | Organic | SCIENCE | Xenobiotics | Metabolism
Book
Toxicology, ISSN 0300-483X, 2005, Volume 216, Issue 2, pp. 154 - 167
Many adverse drug reactions are caused by the cytochrome P450 (CYP) dependent activation of drugs into reactive metabolites. In order to reduce attrition due... 
Reactive metabolites | Cytotoxicity | Metabolism-mediated toxicity | CYP3A4 | In vitro screening | Adverse drug reactions (ADRs) | CYTOCHROME-P450 | MEDIATED CYTOTOXICITY | HUMAN HEPATOCYTE CULTURES | in vitro screening | CARBAMAZEPINE | adverse drug reactions (ADRs) | STABLE EXPRESSION | INDUCTION | metabolism-mediated toxicity | IDIOSYNCRATIC DRUG-REACTIONS | CHINESE-HAMSTER CELLS | HEPG2 CELLS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | reactive metabolites | HUMAN-LIVER-MICROSOMES | cytotoxicity | Microsomes - metabolism | Thiazoles - metabolism | Cytochrome P-450 Enzyme Inhibitors | Cytochrome P-450 CYP3A | Coculture Techniques | Humans | Thiazolidinediones - toxicity | Cytochrome P-450 Enzyme System - metabolism | Isoniazid - toxicity | Xenobiotics - toxicity | Chromans - metabolism | Flutamide - metabolism | Triazolam - toxicity | Microsomes - drug effects | Triazolam - metabolism | Adenosine Triphosphate - metabolism | Carbamazepine - toxicity | Toxicity Tests - methods | Xenobiotics - metabolism | Cell Culture Techniques | Cell Survival - drug effects | Albendazole - toxicity | Tamoxifen - toxicity | Dapsone - metabolism | Dapsone - toxicity | Cell Line, Tumor | Glutathione - chemistry | Troglitazone | Buthionine Sulfoximine - pharmacology | Quinidine - toxicity | Amitriptyline - toxicity | Glutathione - metabolism | Flutamide - toxicity | Substrate Specificity | Piperazines - metabolism | Piperazines - toxicity | Ochratoxins - metabolism | Xenobiotics - chemistry | Tetrazolium Salts - metabolism | Carbamazepine - metabolism | Quinidine - metabolism | Tamoxifen - metabolism | Amitriptyline - metabolism | Glutathione - antagonists & inhibitors | Enzyme Activation - drug effects | Thiazolidinediones - metabolism | Ochratoxins - toxicity | Thiazoles - toxicity | Animals | Albendazole - metabolism | Chromans - toxicity | Isoniazid - metabolism | Phosphates | Metabolites | Ketoconazole | Cytochrome P-450 | Control systems | Xenobiotics | Glutathione | Index Medicus
Journal Article
1984, ISBN 9780850662719, 328
Book
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, pp. e0166110 - e0166110
Journal Article
Biodegradation, ISSN 0923-9820, 1990
Journal
2010, 2nd ed., ISBN 9780470742174
Web Resource
1983, Current reviews in biomedicine, ISBN 0444805109, Volume 3, xii, 185
Book
Comparative Biochemistry and Physiology, Part C, ISSN 1532-0456, 05/2017, Volume 195, pp. 44 - 51
Journal Article
Science, ISSN 0036-8075, 10/2002, Volume 298, Issue 5592, pp. 422 - 424
We have identified the xenobiotic receptor CAR (constitutive androstane receptor) as a key regulator of acetaminophen metabolism and hepatotoxicity. Known CAR... 
Receptors | Animals | Liver | Agonists | Reports | Mice | Automobiles | Dosage | Xenobiotics | Hepatotoxicity | Necrosis | MEDIATED INCREASES | ACTIVATION | POTENTIATION | GLUTATHIONE | MULTIDISCIPLINARY SCIENCES | CYP2B GENE | MOUSE-LIVER | MICE | TOXICITY | INDUCTION | NUCLEAR TRANSLOCATION | Phenobarbital - pharmacology | Acetaminophen - metabolism | Liver - pathology | Oxidoreductases, N-Demethylating - genetics | Cytochrome P-450 CYP3A | Glutathione - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Alanine Transaminase - blood | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | RNA, Messenger - metabolism | Glutathione Transferase - genetics | Analgesics, Non-Narcotic - toxicity | Liver - drug effects | Time Factors | Isoenzymes - metabolism | Cytochrome P-450 CYP1A2 - genetics | Oxidoreductases, N-Demethylating - metabolism | Benzoquinones - metabolism | Acetaminophen - toxicity | Isoenzymes - genetics | Imines - metabolism | Liver - metabolism | RNA, Messenger - genetics | Glutathione Transferase - metabolism | Mice, Transgenic | Transcription Factors - antagonists & inhibitors | Androstanols - pharmacology | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Analgesics, Non-Narcotic - metabolism | Transcription Factors - genetics | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mice, Knockout | Transcription Factors - metabolism | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Acetylcysteine - pharmacology | Cytochrome P-450 Enzyme System - genetics | Glutathione S-Transferase pi | Pyridines - pharmacology | Transcription Factors - agonists | Receptors, Cytoplasmic and Nuclear - metabolism | Liver failure | Dosage and administration | Analgesics | Drug therapy | Acetaminophen | Drug overdose | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 12/2016, Volume 30, Issue 6, pp. 909 - 924
Journal Article