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apoptosis (203) 203
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caspases - metabolism (27) 27
inhibitor of apoptosis proteins - metabolism (27) 27
genes (26) 26
kinases (25) 25
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lymphoproliferative disorders - genetics (23) 23
phosphorylation (23) 23
adult (22) 22
apoptosis - physiology (22) 22
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down-regulation (22) 22
infant (22) 22
inhibitor (22) 22
structural basis (22) 22
cytotoxicity (21) 21
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apoptosis - genetics (20) 20
medicine, research & experimental (20) 20
patients (20) 20
x-linked inhibitor of apoptosis protein (20) 20
alpha-dependent apoptosis (19) 19
antineoplastic agents - pharmacology (19) 19
cell proliferation (19) 19
crohns-disease (19) 19
inhibitor of apoptosis proteins - genetics (19) 19
x-linked inhibitor of apoptosis protein - deficiency (19) 19
cell line (18) 18
iap (18) 18
inflammatory bowel disease (18) 18
lymphohistiocytosis, hemophagocytic - diagnosis (18) 18
mortality (18) 18
protein binding (18) 18
resistance (18) 18
sap (18) 18
stem-cell transplantation (18) 18
biochemistry (17) 17
in-vivo (17) 17
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transplantation (17) 17
ubiquitin (17) 17
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Gut, ISSN 0017-5749, 06/2017, Volume 66, Issue 6, pp. 1060 - 1073
ObjectivePatients with Niemann–Pick disease type C1 (NPC1), a lysosomal lipid storage disorder that causes neurodegeneration and liver damage, can present with... 
IBD-GENETICS | IBD CLINICAL | IMMUNODEFICIENCY | IBD BASIC RESEARCH | Crohn'S DISEASE | MIGLUSTAT THERAPY | PATHOGENESIS | APOPTOSIS | DENDRITIC CELLS | MACROPHAGES | SUSCEPTIBILITY | ILEAL MUCOSA | PHAGOSOME PROTEOME | GASTROENTEROLOGY & HEPATOLOGY | BOWEL-DISEASE | INNATE IMMUNITY | Tumor Necrosis Factor-alpha - metabolism | Crohn Disease - genetics | X-Linked Inhibitor of Apoptosis Protein - deficiency | Humans | Child, Preschool | Lysosomes | Male | Nod2 Signaling Adaptor Protein - genetics | Leukocytes, Mononuclear | Pyridazines - pharmacology | Niemann-Pick Disease, Type C - physiopathology | Autophagy - drug effects | Crohn Disease - complications | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Young Adult | Gentamicins - pharmacology | Adult | Bacteria | Female | Genetic Diseases, X-Linked - genetics | Autophagy - genetics | Child | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Macrophages - physiology | Granuloma - genetics | Cells, Cultured | Chlorpromazine - pharmacology | Imidazoles - pharmacology | Acetylmuramyl-Alanyl-Isoglutamine - metabolism | X-Linked Inhibitor of Apoptosis Protein - genetics | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Granuloma - pathology | Nod2 Signaling Adaptor Protein - metabolism | Crohn Disease - pathology | Dopamine Antagonists - pharmacology | Adolescent | X-Linked Inhibitor of Apoptosis Protein - metabolism | Macrophages - drug effects | Anti-Bacterial Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | Mutation | Niemann-Pick Disease, Type C - complications | Niemann-Pick Disease, Type C - genetics | Autophagy (Cytology) | Inflammatory bowel diseases | Gastrointestinal diseases | Causes of | Colorectal diseases | Crohn's disease | Research | Niemann-Pick disease | Salmonella | Granuloma | Muramyl dipeptide | Liver | XIAP protein | Kinases | Macrophages | Autophagy | Defects | Genotype & phenotype | Cell activation | Intestine | Neurodegeneration | Npc1 protein | Age | NOD2 protein | Oligomerization | Dendritic cells | Cytokines | Blood & organ donations | Inflammation | Patients | Crohns disease | Studies | Inflammatory bowel disease | Monocytes | Proteomics | Colitis | Adapter proteins | Phagocytosis | Apoptosis | Index Medicus | Abridged Index Medicus | IBD - GENETICS | CROHN'S DISEASE | Inflammatory Bowel Disease | 1506
Journal Article
Blood, ISSN 0006-4971, 02/2011, Volume 117, Issue 5, pp. 1522 - 1529
Journal Article
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 129, Issue 3, pp. 787 - 793.e6
Background CD27 is a lymphocyte costimulatory molecule that regulates T-cell, natural killer (NK) cell, B-cell, and plasma cell function, survival, and... 
Allergy and Immunology | phenotype | B cell | T cell | EBV | CD27 | immunodeficiency | hypogammaglobulinemia | natural killer cell | viremia | LINKED LYMPHOPROLIFERATIVE SYNDROME | DENDRITIC CELLS | IMMUNOLOGY | CD8(+) T-CELLS | HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS | MEMORY | ALLERGY | B-CELL ACTIVATION | CD27-CD70 INTERACTIONS | XIAP DEFICIENCY | INFECTION | EPSTEIN-BARR-VIRUS | Gram-Positive Bacterial Infections - immunology | Anemia, Aplastic - virology | Humans | Male | Gram-Positive Bacterial Infections - virology | Severe Combined Immunodeficiency - physiopathology | Young Adult | Severe Combined Immunodeficiency - virology | T-Lymphocytes - metabolism | Fatal Outcome | Epstein-Barr Virus Infections - genetics | Gram-Positive Bacterial Infections - genetics | Herpesvirus 4, Human - pathogenicity | B-Lymphocytes - pathology | T-Lymphocytes - pathology | Gram-Positive Bacterial Infections - complications | Anemia, Aplastic - complications | Anemia, Aplastic - genetics | B-Lymphocytes - metabolism | Siblings | Epstein-Barr Virus Infections - physiopathology | Gram-Positive Bacterial Infections - physiopathology | Epstein-Barr Virus Infections - virology | Epstein-Barr Virus Infections - immunology | Immunity, Humoral - genetics | Cells, Cultured | Herpesvirus 4, Human - immunology | Viremia - genetics | Severe Combined Immunodeficiency - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 7 - genetics | Mutation - genetics | Agammaglobulinemia - etiology | Anemia, Aplastic - physiopathology | Severe Combined Immunodeficiency - complications | Severe Combined Immunodeficiency - genetics | B-Lymphocytes - immunology | Viremia - virology | Pedigree | Epstein-Barr Virus Infections - complications | T-Lymphocytes - immunology | Viremia - immunology | Consanguinity | Anemia, Aplastic - immunology | Antigens | Genes | Staphylococcus aureus infections | T cells | Diseases | Virus diseases | Lymphocytes | Virus diseases in children | Medical genetics | Cross infection | Children | Tetanus | Nosocomial infections | Mitogens | Ligands | Infections | T cell receptors | Family medical history | Patients | Age | Viral infections | Fever | Immune system | Index Medicus | Abridged Index Medicus | CD27 antigen | Immunoglobulins | Cell survival | Viremia | Aplastic anemia | Immunodeficiency | Hypogammaglobulinemia | Lymphocytes T | Costimulator | Infection | Lymphocytes B | Plasma cells | Sepsis | Mutation | Natural killer cells | Differentiation | NK cell
Journal Article
Journal of Clinical Immunology, ISSN 0271-9142, 6/2012, Volume 32, Issue 3, pp. 411 - 420
Deficiency of X-linked inhibitor of apoptosis (XIAP) caused by XIAP/BIRC4 gene mutations is an inherited immune defect recognized as X-linked... 
Medical Microbiology | Biomedicine | Immunology | Internal Medicine | Infectious Diseases | hemophagocytic lymphohistiocytosis | invariant natural killer T cell | X-linked lymphoproliferative syndrome | X-linked inhibitor of apoptosis | Epstein–Barr virus | Epstein-Barr virus | APOPTOSIS | SEVERE COMBINED IMMUNODEFICIENCY | FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS | ENCODING GENE | IMMUNOLOGY | LINKED LYMPHOPROLIFERATIVE-DISEASE | NKT-CELL-DEVELOPMENT | FLOW-CYTOMETRY | MUTATIONS | T-LYMPHOCYTES | GRANZYME-B | T-Lymphocytes, Cytotoxic - immunology | X-Linked Inhibitor of Apoptosis Protein - deficiency | Humans | Japan | Child, Preschool | Lymphohistiocytosis, Hemophagocytic - diagnosis | Infant | Male | Lymphoproliferative Disorders - genetics | Lymphoproliferative Disorders - immunology | X-Linked Inhibitor of Apoptosis Protein - immunology | X-Linked Inhibitor of Apoptosis Protein - genetics | Lymphoproliferative Disorders - diagnosis | Leukocytes, Mononuclear - immunology | Adolescent | Lymphocyte Count | Mutation | Lymphohistiocytosis, Hemophagocytic - genetics | Child | Lymphohistiocytosis, Hemophagocytic - immunology | Natural Killer T-Cells - immunology | Virus diseases | Medical colleges | Anopheles | Gene mutations | Lymphocytes | Genes | Genetic research | Universities and colleges | Colitis | T cells | Health aspects | Apoptosis | Index Medicus | CD8 antigen | Recurrent infection | X chromosome | Cytotoxicity | XIAP protein | Lymphocytes T | Histiocytosis | Cord blood | Point mutation | Children | Natural killer cells | Lymphocytosis
Journal Article
Journal of Clinical Immunology, ISSN 0271-9142, 1/2017, Volume 37, Issue 1, pp. 85 - 91
Journal Article
European Journal of Immunology, ISSN 0014-2980, 03/2019, Volume 49, Issue 3, pp. 504 - 507
Journal Article
Journal of Immunological Methods, ISSN 0022-1759, 10/2010, Volume 362, Issue 1-2, pp. 1 - 9
Journal Article
Journal Article