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Immunity, ISSN 1074-7613, 02/2012, Volume 36, Issue 2, pp. 215 - 227
Interleukin-1β (IL-1β) is a potent inflammatory cytokine that is usually cleaved and activated by inflammasome-associated caspase-1. To determine whether IL-1β... 
STERILE INFLAMMATORY RESPONSE | PROGRAMMED NECROSIS | CASPASE-8 | IL-1-BETA | NLRP3 INFLAMMASOME | TNF-ALPHA | IMMUNOLOGY | NF-KAPPA-B | CIAP1 | NALP3 INFLAMMASOME | CELL-DEATH | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | X-Linked Inhibitor of Apoptosis Protein - deficiency | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Inhibitor of Apoptosis Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Baculoviral IAP Repeat-Containing 3 Protein | Mitochondrial Proteins - agonists | Carrier Proteins - agonists | Inhibitor of Apoptosis Proteins - deficiency | Molecular Mimicry | Interleukin-1beta - metabolism | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Inhibitor of Apoptosis Proteins - metabolism | Macrophages - immunology | Macrophages - cytology | X-Linked Inhibitor of Apoptosis Protein - genetics | Mice, Knockout | Ubiquitin-Protein Ligases | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | X-Linked Inhibitor of Apoptosis Protein - metabolism | Macrophages - drug effects | Mice | Apoptosis | Proteins | Interleukins | Genes | Membranes | Mammals | Immune system | Caspase-8 | DIABLO protein | Cell activation | IAP protein | Reactive oxygen species | Interleukin 1 | Toll-like receptors | XIAP protein | Inflammation | Macrophages | Caspase-1 | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 04/2017, Volume 7, Issue 1, pp. 46380 - 46380
Journal Article
Cancer Science, ISSN 1347-9032, 08/2017, Volume 108, Issue 8, pp. 1657 - 1666
Chromosomal translocation occurs in some cancer cells, which results in the expression of aberrant oncogenic fusion proteins that include BCR ‐ ABL in chronic... 
BCR | protein knockdown | dasatinib | LCL | E3 ubiquitin ligase | ABL | 161 | LCL161 | BCR-ABL | CHRONIC MYELOGENOUS LEUKEMIA | RNA INTERFERENCE | CANCER-CELLS | UBIQUITIN LIGASE | TYROSINE KINASE | HYBRID SMALL MOLECULES | CHRONIC MYELOID-LEUKEMIA | SMALL-MOLECULE PROTACS | ONCOLOGY | PHILADELPHIA-CHROMOSOME | TARGETED DEGRADATION | Cell Survival - drug effects | Down-Regulation | Humans | Dasatinib - chemistry | Dasatinib - pharmacology | Protein Kinase Inhibitors - chemistry | Ubiquitination - drug effects | Proteolysis | K562 Cells | Cell Line, Tumor | Protein Binding | Ligands | Thiazoles - chemistry | Cell Proliferation - drug effects | Inhibitor of Apoptosis Proteins - metabolism | Protein Kinase Inhibitors - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Fusion Proteins, bcr-abl - metabolism | Ubiquitin | Tyrosine | Snipers | Ligases | Analysis | Leukemia | Drug resistance | Polyols | BCR protein | Phosphorylation | Transcription | XIAP protein | Kinases | Proteins | Cell growth | Polyethylene glycol | Protein-tyrosine kinase | Medical research | Polyethylene | IAP protein | Imatinib | Research & development--R&D | Myeloid leukemia | Abl protein | Stat5 protein | Chronic myeloid leukemia | Proteasomes | Mutation | Binding sites | Apoptosis | Pharmaceuticals | Index Medicus | BCR‐ABL | Original
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 24, pp. 10180 - 10196
We have previously shown that dysbindin is a potent inducer of cardiomyocyte hypertrophy via activation of Rho-dependent serum-response factor (SRF) signaling.... 
COACTIVATOR HTIF1 | SCHIZOPHRENIA-RELATED PROTEIN | NUCLEAR RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC-HYPERTROPHY | IN-VIVO | TRIPARTITE MOTIF | SERUM RESPONSE FACTOR | FAMILY PROTEINS | MUSCLE RING FINGER-1 | E3 UBIQUITIN LIGASE | Serum Response Factor - agonists | Serum Response Factor - genetics | Cardiomyopathy, Dilated - pathology | Rats, Wistar | Serum Response Factor - antagonists & inhibitors | Humans | Ubiquitin-Protein Ligases - antagonists & inhibitors | Recombinant Fusion Proteins - metabolism | Dystrophin-Associated Proteins - genetics | Dystrophin-Associated Proteins - metabolism | RNA Interference | Dystrophin-Associated Proteins - chemistry | Proteolysis | HEK293 Cells | Protein Stability | Peptide Fragments - genetics | Animals, Newborn | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Myocytes, Cardiac - cytology | Signal Transduction | Serum Response Factor - metabolism | Tripartite Motif Proteins - antagonists & inhibitors | Cardiomyopathy, Hypertrophic - metabolism | Carrier Proteins - antagonists & inhibitors | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Rats | Recombinant Proteins - chemistry | Tripartite Motif Proteins - genetics | Transcription Factors - antagonists & inhibitors | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Cardiomyopathy, Dilated - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Myocytes, Cardiac - pathology | Peptide Fragments - chemistry | Animals | Carrier Proteins - metabolism | Myocytes, Cardiac - metabolism | Tripartite Motif Proteins - metabolism | Ubiquitin-Protein Ligases - genetics | Dysbindin | Apoptosis | Cardiomyopathy, Hypertrophic - pathology | Index Medicus | Molecular Bases of Disease | cardiac signaling | cardiomyocyte | TRIM24 | apoptosis | SRF-signaling | cardiac hypertrophy | cardiomyopathy | dysbindin | TRIM32 | X-linked inhibitor of apoptosis protein (XIAP)
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2014, Volume 111, Issue 43, pp. 15532 - 15537
X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is a tumor suppressor that is frequently inactivated in many human cancers. However, the... 
Phosphorylation | HCT116 cells | Ubiquitins | Control loops | Cell lines | Gene expression regulation | Mathematical functions | Tumors | Apoptosis | Cancer | XAF1 | ZNF313 | Siah2 | HIPK2 | P53 | CANCER-CELLS | DOMAIN | HYPERMETHYLATION | X-LINKED INHIBITOR | MULTIDISCIPLINARY SCIENCES | INTERACTING PROTEIN KINASE-2 | IDENTIFICATION | p53 | GENE | XIAP-ASSOCIATED FACTOR-1 | PROSTATE-CANCER | EXPRESSION | Neoplasms - metabolism | Apoptosis - drug effects | Humans | Antineoplastic Agents - therapeutic use | Intracellular Signaling Peptides and Proteins - metabolism | Neoplasm Proteins - metabolism | Proteolysis - drug effects | Protein Isoforms - metabolism | Ubiquitination - drug effects | Protein Binding - drug effects | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-mdm2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | HCT116 Cells | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Neoplasm Proteins - chemistry | Nuclear Proteins - metabolism | Enzyme Activation - drug effects | Phosphoserine - metabolism | Remission Induction | Neoplasms - drug therapy | Carrier Proteins - metabolism | Signal Transduction - drug effects | Intracellular Signaling Peptides and Proteins - chemistry | Models, Biological | Protein Stability - drug effects | Feedback, Physiological - drug effects | Tumor Suppressor Protein p53 - chemistry | Neoplasms - pathology | Physiological aspects | Physiological research | Research | Zinc finger proteins | Tumor proteins | Protein kinases | Proteins | Cell cycle | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14524 - 14529
NOD1 and NOD2 are members of the NOD-like receptor (NLR) protein family that are involved in sensing the presence of pathogens and are a component of the... 
Proteins | HEK293 cells | HCT116 cells | Plasmids | Cell lines | Antibodies | Reporter genes | Ligands | Immunoblotting | Apoptosis | CYTOCHROME-C | NEGATIVE BACTERIAL-INFECTION | ACTIVATION | HOST RECOGNITION | MULTIDISCIPLINARY SCIENCES | ALPHA-DEPENDENT APOPTOSIS | IAP | CELL-SURVIVAL | PROTEIN XIAP | NF-KAPPA-B | DROSOPHILA INHIBITOR | RNA, Small Interfering - genetics | Immunoprecipitation | Luciferases - metabolism | Humans | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Green Fluorescent Proteins - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Nod1 Signaling Adaptor Protein - metabolism | Recombinant Fusion Proteins - metabolism | Luciferases - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Transfection | Interleukin-8 - metabolism | Cell Line | Green Fluorescent Proteins - metabolism | Gene Expression | Enzyme-Linked Immunosorbent Assay | Signal Transduction | HCT116 Cells | Reverse Transcriptase Polymerase Chain Reaction | X-Linked Inhibitor of Apoptosis Protein - genetics | NF-kappa B - genetics | Nod2 Signaling Adaptor Protein - metabolism | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Protein Binding | Recombinant Fusion Proteins - genetics | Mutation | Nod1 Signaling Adaptor Protein - genetics | Research | Immunity | Bacteria | Peptides | Kinases | Immune system | Index Medicus | Biological Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2007, Volume 282, Issue 36, pp. 26202 - 26209
X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is a putative tumor suppressor in which expression is significantly reduced in human cancer... 
CANCER-CELLS | SMAC/DIABLO | HYPERMETHYLATION | PROTEIN | XIAP-ASSOCIATED FACTOR-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | XAF1 EXPRESSION | TRAIL-INDUCED APOPTOSIS | MAMMALIAN-CELLS | UBIQUITIN-PROTEASOME PATHWAY | Microtubule-Associated Proteins - genetics | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Neuronal Apoptosis-Inhibitory Protein - genetics | Ubiquitin - metabolism | Multiprotein Complexes - genetics | Baculoviral IAP Repeat-Containing 3 Protein | Neoplasm Proteins - metabolism | Multiprotein Complexes - metabolism | Tumor Suppressor Proteins - genetics | Inhibitor of Apoptosis Proteins - metabolism | Neoplasm Proteins - genetics | Antiviral Agents - pharmacology | Tumor Suppressor Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Intracellular Signaling Peptides and Proteins | Ubiquitin - genetics | Down-Regulation - drug effects | Neuronal Apoptosis-Inhibitory Protein - metabolism | X-Linked Inhibitor of Apoptosis Protein - genetics | Down-Regulation - physiology | Leupeptins - pharmacology | Mitosis - drug effects | Interferon-beta - pharmacology | Mitosis - physiology | Cysteine Proteinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Index Medicus
Journal Article
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 11/2012, Volume 19, Issue 11, pp. 1791 - 1801
Cellular inhibitor of apoptosis proteins (cIAPs) have emerged as important anti-cell death mediators, particularly in cancer. Although they are known to be... 
macrophage | host-pathogen interactions | innate immunity | inflammation | SURVIVAL | APOPTOSIS | SMAC MIMETICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | CELL-DEATH | CELL BIOLOGY | TNF-INDUCED NECROSIS | CASPASES | RESISTANCE | INFECTION | PROTEINS | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Baculoviral IAP Repeat-Containing 3 Protein | GTPase-Activating Proteins - metabolism | Necrosis | Inhibitor of Apoptosis Proteins - deficiency | RNA Interference | Inhibitor of Apoptosis Proteins - metabolism | Receptors, Tumor Necrosis Factor - metabolism | GTPase-Activating Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Triazoles - pharmacology | Ubiquitin-Protein Ligases | Biomimetic Materials - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Macrophages - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | X-Linked Inhibitor of Apoptosis Protein - metabolism | Macrophages - drug effects | Mice | GTPase-Activating Proteins - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | RNA, Small Interfering - metabolism | Index Medicus | Tumor necrosis factor receptors | DIABLO protein | Pathogens | Post-transcription | Cell activation | Immune response | XIAP protein | Caspase inhibitors | Macrophages | Apoptosis | Cancer | Original Paper | host–pathogen interactions
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, pp. e100960 - e100960
Nilotinib is a selective BCR-ABL tyrosine kinase inhibitor related to imatinib that is more potent than imatinib. Nilotinib is widely used to treat chronic... 
TYROSINE KINASE INHIBITORS | WILD-TYPE P53 | CYTOGENETIC RESPONSES | HEMATOPOIETIC-CELLS | C-ABL | POOR-PROGNOSIS | MULTIDISCIPLINARY SCIENCES | BCR-ABL | IMATINIB | CHILDHOOD LEUKEMIAS | CHRONIC MYELOID-LEUKEMIA | Proto-Oncogene Proteins c-mdm2 - genetics | Apoptosis - drug effects | Humans | Tumor Suppressor Protein p53 - metabolism | Gene Expression Regulation, Leukemic - drug effects | Pyrimidines - pharmacology | Antineoplastic Agents - toxicity | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Fusion Proteins, bcr-abl - genetics | Pyrimidines - toxicity | Protein Processing, Post-Translational - drug effects | Fusion Proteins, bcr-abl - antagonists & inhibitors | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Protein Kinase Inhibitors - toxicity | Antineoplastic Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Ubiquitin | Antimitotic agents | Acute lymphocytic leukemia | Tumor proteins | Antineoplastic agents | BCR protein | Pediatrics | Toxicity | Leukemia | p53 Protein | Cytotoxicity | XIAP protein | Homology | Activation | Kinases | Proteins | Ubiquitination | Cell growth | Cell cycle | Post-translation | Inhibition | Fusion protein | Protein-tyrosine kinase | Chromosomes | Tyrosine | Translation | MDM2 protein | Imatinib | Acute lymphatic leukemia | Myeloid leukemia | Abl protein | Chronic myeloid leukemia | Lymphatic leukemia | Medicine | Gene amplification | Inhibitors | Protein X | Medical prognosis | Cell lines | Blood diseases | Cancer | Apoptosis | Index Medicus
Journal Article