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ISSN 0890-9369, 2016
$\textit{PAXX}$ was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its physiological roles, we... 
development | XLF | PAXX | synthetic lethality | ATM | NHEJ
Journal Article
Journal Article
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2018, Volume 9
PAXX is a recently identified component of the nonhomologous end joining (NHEJ) DNA repair pathway. The molecular mechanisms of PAXX action remain largely... 
XLF | XRCC4 | CHROMATIN | INTERACTS | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | POL-MU | ENDS | DEPENDENT PROTEIN-KINASE | DOUBLE-STRAND BREAKS
Journal Article
Journal of Veterinary Medical Science, ISSN 0916-7250, 2015
Clinically, many chemotherapeutics and ionizing radiation (IR) have been applied for the treatment of various types of human and animal malignancies. These... 
Ku70 | XLF | DNA damage | domestic animal | cattle
Journal Article
NATURE STRUCTURAL & MOLECULAR BIOLOGY, ISSN 1545-9993, 06/2018, Volume 25, Issue 6, pp. 482 - 482
Repairing DNA double-strand breaks (DSBs) by nonhomologous end joining (NKEJ) requires multiple proteins to recognize and bind DNA ends, process them for... 
XRCC4-DNA LIGASE-IV | COMPLEX | XLF | BIOPHYSICS | PAXX | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | NHEJ | BINDING | PKCS | CELL BIOLOGY
Journal Article
Translational Cancer Research, ISSN 2218-676X, 06/2013, Volume 2, Issue 3, pp. 130 - 143
DNA double-stranded breaks (DSB) are among the most dangerous forms of DNA damage. Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas... 
DNA-Ligase IV | DNA-PKcs | Ku70/80 | XLF | XRCC4 | Non-homologous end-joining | DNA double strand breaks | non-homologous end-joining | ONCOLOGY | Ku70
Journal Article
Current Opinion in Structural Biology, ISSN 0959-440X, 04/2019, Volume 55, pp. 154 - 160
Summarizing image: individual components were solved mainly using X-ray crystallography; hybrid approaches might help to describe larger assemblies executing... 
RECRUITMENT | XRCC4-DNA LIGASE-IV | PROTEIN INTERACTIONS | XLF | MECHANISM | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIGATION | CRYO-EM STRUCTURE | PKCS | CELL BIOLOGY
Journal Article
Journal of Veterinary Medical Science, ISSN 0916-7250, 2016
Understanding the molecular mechanisms of DNA double-strand break (DSB) repair processes, especially nonhomologous DNA-end joining (NHEJ), is critical for... 
XLF | canine | companion animal | DNA double-strand break
Journal Article
Journal Article
by Lieber, MR and Lu, H and Gu, J and Schwarz, K
CELL RESEARCH, ISSN 1001-0602, 01/2008, Volume 18, Issue 1, pp. 125 - 133
Nonhomologous DNA end joining (NHEJ) is the primary pathway for repair of double-strand DNA breaks in human cells and in multicellular eukaryotes. The causes... 
DNA-PKcs | ligase IV | artemis | STRAND BREAK REPAIR | XRCC4 | SOMATIC HYPERMUTATION | IV-COMPLEX | V(D)J RECOMBINATION | MU | DEPENDENT PROTEIN-KINASE | Ku | nonhomologous DNA end joining (NHEJ) | cernunnos/XLF | XRCC4 PROTEIN | CELL BIOLOGY | polymerase lambda | polymerase mu | HUMAN XLF | CLASS-SWITCH RECOMBINATION
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2017, Volume 141, Issue 1, pp. 322 - 328.e10
Abstract Background Rare DNA breakage-repair disorders predispose to infection and lympho-reticular malignancies. Hematopoietic cell transplantation (HCT) is... 
Allergy and Immunology | Ataxia-Telangiectasia | DNA Ligase 4 deficiency | Nijmegen Breakage syndrome | DNA repair disorders | Hematopoietic stem cell transplantation | Cernunnos-XLF deficiency
Journal Article
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