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Frontiers in oncology, ISSN 2234-943X, 2019, Volume 9, p. 85
Esophageal cancer (EC) is a very aggressive tumor, and no reliable prognostic markers exist especially for resectable advanced neoplasia. The principal aim of... 
PREDICTIVE ROLE | esophageal cancer | VARIANTS | ERCC1 C8002A | SUSCEPTIBILITY | RISK | ERCC2/XPD rs1799793 | XPD | NUCLEOTIDE EXCISION-REPAIR | POLYMORPHISMS | ONCOLOGY | GENES | overall survival | germline variants | XPD Asp312Asn | DNA-REPAIR | ERCC1 re3212986 | MODULATION | Logistic regression | Usage | Chemotherapy | Genetic aspects | Diagnosis | Research | Esophageal cancer | Risk factors | Genetic polymorphisms | Cancer | ERCC1 rs3212986
Journal Article
Development (Cambridge), ISSN 0950-1991, 01/2018, Volume 145, Issue 2, pp. dev156802 - dev156802
Mms19 encodes a cytosolic iron-sulphur assembly component. We found that Drosophila Mms19 is also essential for mitotic divisions and for the proliferation of... 
Mms19 | Cdk-activating kinase | Drosophila development | Xpd | Mitotic gene | SYSTEM | COMPLEX | PROTEIN | DEVELOPMENTAL BIOLOGY | SACCHAROMYCES-CEREVISIAE | MUTANTS | XERODERMA-PIGMENTOSUM | HELICASE | Cyclin-dependent kinase | Cell proliferation | Transcription | Mitosis | Metaphase | Cell cycle | XPD protein | Imaginal discs | Kinases | Sulfur
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e33200
Purpose: Xeroderma pigmentosum group D (XPD) codes for a DNA helicase involved in nucleotide excision repair thatremoves platinum-induced DNA damage. Genetic... 
EXCISION-REPAIR | SURVIVAL | POPULATION | PROGNOSTIC-FACTORS | CISPLATIN | BIOLOGY | RISK | REPAIR GENE XPD | ASSOCIATION | CARCINOMA | SINGLE NUCLEOTIDE POLYMORPHISMS | Haplotypes | Lung Neoplasms - drug therapy | Lung Neoplasms - ethnology | Multivariate Analysis | Prognosis | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Male | Cisplatin - administration & dosage | China | Aged, 80 and over | Adult | Female | Lung Neoplasms - genetics | Xeroderma Pigmentosum Group D Protein - genetics | Drug Administration Schedule | Carcinoma, Non-Small-Cell Lung - genetics | Gene Frequency | Carboplatin - administration & dosage | Carcinoma, Non-Small-Cell Lung - ethnology | Genotype | Treatment Outcome | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Polymorphism, Single Nucleotide | Carcinoma, Non-Small-Cell Lung - drug therapy | Medical research | Care and treatment | Patient outcomes | DNA damage | Lung cancer, Small cell | Lung cancer, Non-small cell | DNA repair | Genetic polymorphisms | Chemotherapy | Ionization | Medicine, Experimental | Genetic aspects | Rankings | Mass spectrometry | Glutamine | Cancer | Adenocarcinoma | Disease | Laboratories | Lung cancer | Multiple myeloma | Xeroderma pigmentosum | Oncology | Epidemiology | Cancer therapies | Clinical outcomes | Skin cancer | DNA helicase | Platinum | XPD protein | Life sciences | Repair | Genotypes | Deoxyribonucleic acid--DNA | Melanoma | Non-small cell lung carcinoma | Nucleotide excision repair | Mass spectroscopy | Patients | Survival | Experimental design | Medical prognosis | Respiratory diseases | Influence | Genetic engineering | Genetic testing | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 549, Issue 7672, pp. 414 - 417
Human transcription factor IIH (TFIIH) is part of the general transcriptional machinery required by RNA polymerase II for the initiation of eukaryotic gene... 
GENERAL TRANSCRIPTION | XPD HELICASE | DOMAIN | MOLECULAR-REPLACEMENT | XERODERMA-PIGMENTOSUM | CRYSTAL-STRUCTURE | TFIIH | MULTIDISCIPLINARY SCIENCES | DNA-REPAIR | CRYO-EM STRUCTURE | NUCLEOTIDE EXCISION-REPAIR | Transcription Factor TFIIH - ultrastructure | Humans | RNA Polymerase II - ultrastructure | Adenosine Triphosphatases - metabolism | Models, Molecular | Transcription Factor TFIIH - chemistry | RNA Polymerase II - metabolism | Protein Subunits - metabolism | Transcription Factor TFIIH - genetics | Cryoelectron Microscopy | Adenosine Triphosphate - metabolism | Transcription Factor TFIIH - metabolism | Adenosine Triphosphatases - chemistry | Adenosine Triphosphatases - genetics | Protein Subunits - chemistry | Adenosine Triphosphatases - ultrastructure | Mutation | Transcription Initiation, Genetic | RNA Polymerase II - chemistry | Protein Subunits - genetics | Transcription factors | Research | Molecular structure | Structure | Cryoelectron microscopy | Conformational analysis | Cockayne syndrome | Trichothiodystrophy | Xeroderma pigmentosum | Nucleotide excision repair | Electron microscopy | Kinases | Ribonucleic acid--RNA | DNA-directed RNA polymerase | DNA repair | Proteins | Polymerase | Transmission electron microscopy | XPD protein | Binding sites | RNA polymerase II | Deoxyribonucleic acid--DNA | Cellular structure | Cancer | Crystal structure | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY | Transcription | BASIC BIOLOGICAL SCIENCES | Supramolecular assembly
Journal Article
Nature structural & molecular biology, ISSN 1545-9985, 2019, Volume 26, Issue 6, pp. 397 - 406
Transcription preinitiation complexes (PICs) are vital assemblies whose function underlies the expression of protein-encoding genes. Cryo-EM advances have... 
RNA-POLYMERASE-II | MOLECULAR-DYNAMICS | TERMINAL DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | GENERAL TRANSCRIPTION | XPD HELICASES | BIOPHYSICS | XERODERMA-PIGMENTOSUM | BASAL TRANSCRIPTION | TFIIH | DNA-REPAIR | INITIATION COMPLEX | Transcription Factors - chemistry | Humans | Cell Cycle Proteins - metabolism | Models, Molecular | Transcription Factor TFIIH - chemistry | DNA - metabolism | Protein Subunits - metabolism | Protein Interaction Maps | Cell Cycle Proteins - chemistry | DNA - genetics | Transcription Factors - metabolism | Transcription Factors, TFII - chemistry | Transcription Factor TFIIH - metabolism | Transcription Factors, TFII - metabolism | Protein Subunits - chemistry | Transcription Initiation, Genetic | Transcription factors | Genetic disorders | Research | Gene mutations | Gene expression | RNA polymerases | Cockayne syndrome | Transcription | Computer simulation | Communities | Trichothiodystrophy | Xeroderma pigmentosum | Supercoiling | Mapping | Locks | Rigging | Clustering | Substrates | DNA helicase | Proteins | Functional morphology | XPD protein | Mutation | Gene mapping | Protein interaction | Deoxyribonucleic acid--DNA | Binding sites | Structure-function relationships | Biochemistry & Molecular Biology | Biophysics | Cell Biology | Global protein dynamics | ERCC3 | Gene regulation | ERCC2 | Molecular dynamics | RNA polymerase | NUPR1 | Transcription initiation | Community network analysis
Journal Article
Pathology oncology research, ISSN 1532-2807, 2018, Volume 25, Issue 3, pp. 1035 - 1045
The combination of cisplatin and gemcitabine is still one of the most frequently used first-line chemotherapy scheme in patients with advanced non-small cell... 
Biomedicine, general | Pathology | Biomedicine | Immunology | Non-small cell lung cancer | Cancer Research | Oncology | XPD, chemotherapy | DNA repair | Polymorphism | CELL LUNG-CANCER | SURVIVAL | TRIAL | ONCOLOGY | THERAPIES | PATHOLOGY | XPD | chemotherapy | Carcinoma, Large Cell - drug therapy | Lung Neoplasms - drug therapy | Endonucleases - genetics | Adenocarcinoma - pathology | Prognosis | Follow-Up Studies | Carcinoma, Large Cell - pathology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Cisplatin - administration & dosage | Adult | Female | Adenocarcinoma - genetics | Carcinoma, Large Cell - genetics | Nuclear Proteins - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Xeroderma Pigmentosum Group D Protein - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Deoxycytidine - administration & dosage | Xeroderma Pigmentosum Group A Protein - genetics | Survival Rate | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Adenocarcinoma - drug therapy | Carcinoma, Squamous Cell - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Biomarkers, Tumor - genetics | Carcinoma, Non-Small-Cell Lung - drug therapy | Deoxycytidine - analogs & derivatives | Tyrosine | Medical research | Care and treatment | Gemcitabine | Genes | Lung cancer, Non-small cell | Cisplatin | Chemotherapy | Physiological aspects | Medicine, Experimental | Genetic research | Genetic aspects | Single nucleotide polymorphisms | Cancer | Toxicity | Lung cancer | Non-small cell lung carcinoma | Nucleotide excision repair | Single-nucleotide polymorphism | Kinases | Patients | Genotyping | Correlation analysis | XPD protein | ERCC1 protein | XPC protein | ERCC2 gene | Protein-tyrosine kinase | Genotypes | Nucleotides | Original
Journal Article
Frontiers in genetics, ISSN 1664-8021, 2018, Volume 9, p. 218
The aim of the present study was to define the potential relationship between xeroderma pigmentosum group D (XPD) Lys751Gln polymorphisms and the risk of... 
meta-analysis | leukemia | polymorphism | XPD | ERCC2
Journal Article