Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (768) 768
xanthine oxidase - antagonists & inhibitors (467) 467
male (407) 407
rats (388) 388
index medicus (364) 364
humans (335) 335
xanthine oxidase - metabolism (310) 310
enzyme inhibitors - pharmacology (230) 230
xanthine oxidase (227) 227
biochemistry & molecular biology (226) 226
pharmacology & pharmacy (218) 218
oxidative stress (214) 214
allopurinol (197) 197
allopurinol - pharmacology (185) 185
xanthine-oxidase (176) 176
xanthine dehydrogenase - antagonists & inhibitors (164) 164
oxidases (153) 153
mice (148) 148
female (136) 136
xanthine (129) 129
xanthine dehydrogenase - metabolism (127) 127
free radicals (119) 119
reactive oxygen species - metabolism (116) 116
rats, sprague-dawley (115) 115
kinetics (111) 111
dehydrogenase (106) 106
rats, wistar (106) 106
molybdenum compounds (105) 105
uric acid (105) 105
iron compounds (100) 100
gout (99) 99
oxidation-reduction (97) 97
liver - enzymology (95) 95
purines (95) 95
cells, cultured (88) 88
hyperuricemia (88) 88
nitric oxide (87) 87
superoxide (85) 85
in vitro techniques (84) 84
time factors (84) 84
dose-response relationship, drug (82) 82
febuxostat (80) 80
inhibition (79) 79
antioxidants - pharmacology (78) 78
oxidative stress - drug effects (78) 78
cell biology (76) 76
free-radicals (75) 75
reactive oxygen species (74) 74
disease models, animal (71) 71
cattle (69) 69
superoxides - metabolism (69) 69
analysis (68) 68
uric acid - blood (68) 68
allopurinol - therapeutic use (67) 67
liver - drug effects (67) 67
mechanism (67) 67
antioxidants (66) 66
physiology (66) 66
chemistry, medicinal (65) 65
enzyme inhibitors - therapeutic use (65) 65
xanthines - pharmacology (64) 64
cardiac & cardiovascular systems (61) 61
ischemia (61) 61
lipid-peroxidation (61) 61
liver - metabolism (61) 61
injury (60) 60
metabolism (59) 59
nitric-oxide (59) 59
uric acid - metabolism (58) 58
xanthine oxidoreductase (58) 58
enzyme inhibitors - chemistry (55) 55
enzymes (55) 55
liver (55) 55
oxidoreductase (55) 55
xanthine dehydrogenase (55) 55
hyperuricemia - drug therapy (53) 53
uric-acid (53) 53
neurosciences (52) 52
physiological aspects (52) 52
nitric oxide - metabolism (51) 51
research (50) 50
toxicology (50) 50
rodents (49) 49
inflammation (47) 47
care and treatment (46) 46
lipid peroxidation - drug effects (45) 45
hypertension (44) 44
structure-activity relationship (44) 44
superoxide dismutase - metabolism (44) 44
endocrinology & metabolism (43) 43
hypoxia (43) 43
ischemia-reperfusion (43) 43
l-lactate dehydrogenase - metabolism (43) 43
reperfusion injury (42) 42
nadph oxidase (41) 41
oxygen (41) 41
adult (40) 40
metabolites (40) 40
research article (40) 40
activation (39) 39
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1065) 1065
German (5) 5
Japanese (4) 4
Spanish (4) 4
Russian (2) 2
Chinese (1) 1
Portuguese (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase
by Takano, Yasuhiro and Hase-Aoki, Kumiko and Horiuchi, Hideki and Zhao, Lin and Kasahara, Yoshinori and Kondo, Shiro and Becker, Michael A
Life Sciences, ISSN 0024-3205, 2005, Volume 76, Issue 16, pp. 1835 - 1847
The purine analogue, allopurinol, has been in clinical use for more than 30 years as an inhibitor of xanthine oxidase (XO) in the treatment of hyperuricemia... 
Pyrimidine metabolism | Xanthine oxidase inhibitor | Febuxostat | Purine metabolism | MEDICINE, RESEARCH & EXPERIMENTAL | TEI-6720 | xanthine oxidase inhibitor | purine metabolism | NUCLEOSIDE-PHOSPHORYLASE | ALLOPURINOL HYPERSENSITIVITY SYNDROME | OROTIDYLATE DECARBOXYLASE | OXIDASE INHIBITOR | KINETIC-PROPERTIES | pyrimidine metabolism | THERAPY | RENAL-FAILURE | PHARMACOLOGY & PHARMACY | febuxostat | PHOSPHORIBOSYLTRANSFERASE | ENZYMATIC SYNTHESIS | Animals | Milk - enzymology | Xanthine Dehydrogenase - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Enzyme Inhibitors - pharmacology | Thiazoles - chemistry | Molecular Structure | Thiazoles - pharmacology | Kinetics | Xanthine Oxidase - antagonists & inhibitors | Oxidases | Care and treatment | Biological products | Iron compounds | Metabolites | Molybdenum compounds | Heterocyclic compounds | Gout | Physiological aspects | Phosphorylase
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Enhanced Vasodilator Activity of Nitrite in Hypertension: Critical Role for Erythrocytic Xanthine Oxidoreductase and Translational Potential
by Ghosh, Suborno M and Kapil, Vikas and Fuentes-Calvo, Isabel and Bubb, Kristen J and Pearl, Vanessa and Milsom, Alexandra B and Khambata, Rayomand and Maleki-Toyserkani, Sheiva and Yousuf, Mubeen and Benjamin, Nigel and Webb, Andrew J and Caulfield, Mark J and Hobbs, Adrian J and Ahluwalia, Amrita
Hypertension, ISSN 0194-911X, 05/2013, Volume 61, Issue 5, pp. 1091 - 1102
Elevation of circulating nitrite (NO2) levels causes vasodilatation and lowers blood pressure in healthy volunteers. Whether these effects and the underpinning... 
red blood cells | nitric oxide | vascular biology | hypertension | CHRONIC HEART-FAILURE | ORAL NITRITE | RESISTANT HYPERTENSION | DIETARY NITRATE | BLOOD-PRESSURE | OXIDE SYNTHASE | L-ARGININE | PERIPHERAL VASCULAR DISEASE | ISCHEMIA-REPERFUSION | HUMAN CIRCULATION | INORGANIC NITRATE | Xanthine Dehydrogenase - antagonists & inhibitors | Humans | Middle Aged | Rats, Inbred WKY | Hypertension - drug therapy | Male | Dose-Response Relationship, Drug | Hypertension - blood | Nitrites - blood | Female | Blood Pressure - drug effects | Blood Pressure - physiology | Erythrocytes - enzymology | Vasodilation - physiology | Disease Models, Animal | Rats, Inbred SHR | Xanthine Dehydrogenase - drug effects | Translational Medical Research | Enzyme Inhibitors - pharmacology | Rats | Nitrites - pharmacology | Hypertension - physiopathology | Nitrites - therapeutic use | Cross-Over Studies | Animals | Xanthine Dehydrogenase - physiology | Allopurinol - pharmacology | Signal Transduction - physiology | Vasodilation - drug effects
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
by Ives, Annette and Nomura, Johji and Martinon, Fabio and Roger, Thierry and LeRoy, Didier and Miner, Jeffrey N and Simon, Gregoire and Busso, Nathalie and So, Alexander
Nature Communications, ISSN 2041-1723, 03/2015, Volume 6, Issue 1, p. 6555
Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present... 
ALLOPURINOL | OXIDASE | IL-1-BETA PRODUCTION | CONVERSION | MULTIDISCIPLINARY SCIENCES | IDENTIFICATION | HYPERTENSION | INHIBITOR | URIC-ACID | DEHYDROGENASE | NALP3 INFLAMMASOME | Phosphorylation | Calcium - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Xanthine Dehydrogenase - antagonists & inhibitors | Xanthine Dehydrogenase - genetics | Caspase 1 - immunology | Carrier Proteins - drug effects | Autophagy | Gene Knockdown Techniques | Macrophages - secretion | Xanthine Dehydrogenase - immunology | Reactive Oxygen Species - immunology | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | Calcium Phosphates - pharmacology | Carrier Proteins - immunology | Macrophages - immunology | Interleukin-1beta - secretion | Signal Transduction | Mice, Inbred C57BL | Peritonitis - immunology | Xanthine Oxidase - immunology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Uric Acid - immunology | Monocytes | Animals | Lipopolysaccharides - pharmacology | Mice | In Vitro Techniques
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Diminishing Inflammation by Reducing Oxidant Generation: Nitrated Fatty Acid-Mediated Inactivation of Xanthine Oxidoreductase
by Kelley, Eric E
Advances in experimental medicine and biology, ISSN 0065-2598, 2019, Volume 1127, p. 59
Inhibition of xanthine oxidoreductase (XOR) has proven beneficial in a plethora of inflammatory disease processes due to a net reduction in pro-inflammatory... 
Nitrates - chemistry | Oxidants - chemistry | Xanthine Dehydrogenase - antagonists & inhibitors | Humans | Inflammation | Fatty Acids - pharmacology
Journal Article
Details down arrow
5. Full Text A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease
by Chi, Thomas and Kim, Man Su and Lang, Sven and Bose, Neelanjan and Kahn, Arnold and Flechner, Lawrence and Blaschko, Sarah D and Zee, Tiffany and Muteliefu, Gulinuer and Bond, Nichole and Kolipinski, Marysia and Fakra, Sirine C and Mandel, Neil and Miller, Joe and Ramanathan, Arvind and Killilea, David W and Brückner, Katja and Kapahi, Pankaj and Stoller, Marshall L
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0124150
Ectopic calcification is a driving force for a variety of diseases, including kidney stones and atherosclerosis, but initiating factors remain largely unknown.... 
MALPIGHIAN TUBULES | NANOBACTERIA | XANTHINE OXIDOREDUCTASE | MEDICAL-MANAGEMENT | MULTIDISCIPLINARY SCIENCES | CALCIUM | GROWTH | RISK | CALCIFICATION | PLAQUE | INSIGHTS | Xanthine Dehydrogenase - metabolism | RNA, Small Interfering - genetics | Cation Transport Proteins - antagonists & inhibitors | Kidney - pathology | Xanthine Dehydrogenase - antagonists & inhibitors | Zinc - metabolism | Humans | Xanthine Dehydrogenase - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Malpighian Tubules - chemistry | Drosophila melanogaster - metabolism | Kidney - metabolism | Cation Transport Proteins - metabolism | Dietary Proteins - pharmacology | Cation Transport Proteins - genetics | Malpighian Tubules - drug effects | Drosophila Proteins - antagonists & inhibitors | Disease Models, Animal | X-Ray Absorption Spectroscopy | Gene Expression | Kidney - drug effects | Chelating Agents - pharmacology | Kidney Calculi - metabolism | Kidney Calculi - pathology | Ethylenediamines - pharmacology | Animals | Dogs | Allopurinol - pharmacology | Drosophila Proteins - genetics | Malpighian Tubules - pathology | Kidney Calculi - genetics | Kidney Calculi - prevention & control | RNA, Small Interfering - metabolism | Care and treatment | Drosophila | Fossilization | Diagnosis | Research | Risk factors | Zinc | Kidney stones | Calcification (ectopic) | Dehydrogenases | Disease | Xanthine dehydrogenase | Biology | Hydroxyapatite | Stone | Urology | Etiology | Mineralization | Rodents | Atherosclerosis | Aging | Physiology | Inhibition | Plaques | Spectroscopy | Kidneys | Pharmacology | Xanthine | Metabolism | Zinc transporter | Diet | Insects | Arteriosclerosis | Calcification | Lithiasis | Trace elements | Mutation | Transporter | Kidney transplantation
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Enhanced XOR activity in eNOS-deficient mice: Effects on the nitrate-nitrite-NO pathway and ROS homeostasis
by Peleli, Maria and Zollbrecht, Christa and Montenegro, Marcelo F and Hezel, Michael and Zhong, Jianghong and Persson, Erik G and Holmdahl, Rikard and Weitzberg, Eddie and Lundberg, Jon O and Carlström, Mattias and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinsk cellbiologi
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2016, Volume 99, pp. 472 - 484
Xanthine oxidoreductase (XOR) is generally known as the final enzyme in purine metabolism and as a source of reactive oxygen species (ROS). In addition, this... 
Hypertension | Oxidative stress | Endothelial nitric oxide synthase | Reactive oxygen species | Nitrate | Febuxostat | Nitric oxide | Xanthine oxidoreductase | Xanthine oxidase | Superoxide | Nitrite | Uric acid | NADPH OXIDASE | METABOLIC SYNDROME | OXIDASE INHIBITOR FEBUXOSTAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLOOD-PRESSURE | REACTIVE SPECIES GENERATION | INDUCED HYPERTENSION | SYNTHASE ACTIVITY | ENDOCRINOLOGY & METABOLISM | DIETARY INORGANIC NITRATE | Xanthine Dehydrogenase - metabolism | Xanthine Dehydrogenase - antagonists & inhibitors | Xanthine Dehydrogenase - genetics | Nitrates - pharmacology | Male | Nitric Oxide Synthase Type III - deficiency | Febuxostat - pharmacology | Nitric Oxide Synthase Type II - antagonists & inhibitors | Nitric Oxide Synthase Type I - antagonists & inhibitors | Nitrites - blood | Superoxides - metabolism | Blood Pressure - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Nitrates - blood | Nitric Oxide - blood | Oxidation-Reduction | Signal Transduction | Nitric Oxide Synthase Type II - deficiency | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Nitric Oxide Synthase Type III - genetics | Nitrites - pharmacology | Mice, Knockout | Nitric Oxide Synthase Type I - deficiency | Nitric Oxide Synthase Type III - antagonists & inhibitors | Animals | Nitric Oxide Synthase Type II - genetics | Mice | Nitric Oxide Synthase Type I - genetics | Oxidases | Iron compounds | Homeostasis | Biological Sciences | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Cell Biology | Clinical Medicine | Naturvetenskap | Endokrinologi och diabetes | Biologiska vetenskaper | Natural Sciences | Cellbiologi | Endocrinology and Diabetes
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Mechanisms Underlying Erythrocyte and Endothelial Nitrite Reduction to Nitric Oxide in Hypoxia: Role for Xanthine Oxidoreductase and Endothelial Nitric Oxide Synthase
by Webb, Andrew J and Milsom, Alexandra B and Rathod, Krishnaraj S and Chu, Wai Lum and Qureshi, Shehla and Lovell, Matthew J and Lecomte, Florence M.J and Perrett, David and Raimondo, Carmelo and Khoshbin, Espeed and Ahmed, Zubair and Uppal, Rakesh and Benjamin, Nigel and Hobbs, Adrian J and Ahluwalia, Amrita
Circulation Research, ISSN 0009-7330, 10/2008, Volume 103, Issue 9, pp. 957 - 964
Reduction of nitrite (NO2) provides a major source of nitric oxide (NO) in the circulation, especially in hypoxemic conditions. Our previous studies suggest... 
Blood vessels | Hypoxia | Cardiovascular research | Nitric oxide | HEMOGLOBIN | hypoxia | nitric oxide | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | blood vessels | INDUCED VASODILATION | cardiovascular research | ISCHEMIA-REPERFUSION INJURY | IN-VIVO | S-NITROSOTHIOLS | MEDIATED DECOMPOSITION | PERIPHERAL VASCULAR DISEASE | RED-BLOOD-CELLS | REDUCES NITRITE | HEMATOLOGY | Xanthine Dehydrogenase - metabolism | Rats, Wistar | Xanthine Dehydrogenase - antagonists & inhibitors | Humans | Nitrites - metabolism | Male | omega-N-Methylarginine - pharmacology | Fluorometry | Cell Hypoxia | Nitrite Reductases - antagonists & inhibitors | Nitrites - blood | Erythrocytes - enzymology | Nitric Oxide Synthase Type III - metabolism | Aorta - enzymology | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - blood | Oxidation-Reduction | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Xanthine Dehydrogenase - blood | Erythrocytes - drug effects | Nitric Oxide Synthase Type III - antagonists & inhibitors | Xanthine - metabolism | Nitric Oxide Synthase Type III - blood | Animals | Allopurinol - pharmacology | Nitric Oxide - metabolism | Endothelial Cells - enzymology | Arginine - metabolism | Endothelial Cells - drug effects | Hydrogen-Ion Concentration | Nitric Oxide Synthase Type II - metabolism | Nitrite Reductases - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. FYX-051: A novel and potent hybrid-type inhibitor of xanthine oxidoreductase
by Matsumoto, Koji and Okamoto, Ken and Ashizawa, Naoki and Nishino, Takeshi
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 01/2011, Volume 336, Issue 1, pp. 95 - 103
4-[5-(Pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile (FYX-051) is a potent inhibitor of bovine milk xanthine oxidoreductase (XOR). Steady-state... 
ALLOPURINOL | TEI-6720 | ACID | MECHANISM | CRYSTAL-STRUCTURE | PURIFICATION | OXIDASE INHIBITOR | PHARMACOLOGY & PHARMACY | DEHYDROGENASE | Xanthine Dehydrogenase - metabolism | Nitriles - pharmacology | Rats, Wistar | Pyridines - chemistry | Xanthine Dehydrogenase - antagonists & inhibitors | Rats | Crystallography, X-Ray | Male | Structure-Activity Relationship | Binding, Competitive - drug effects | Animals | Cattle | Nitriles - chemistry | Xanthine Dehydrogenase - isolation & purification | Pyridines - pharmacology
Journal Article
Details down arrow
9. Full Text Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans
by Arif, Sayqa and Borgognone, Alessandra and Lin, Erica Lai‐Sze and O'Sullivan, Aine G and Sharma, Vishal and Drury, Nigel E and Menon, Ashvini and Nightingale, Peter and Mascaro, Jorge and Bonser, Robert S and Horowitz, John D and Feelisch, Martin and Frenneaux, Michael P and Madhani, Melanie
British Journal of Pharmacology, ISSN 0007-1188, 07/2015, Volume 172, Issue 13, pp. 3341 - 3352
Background and Purpose Hypoxic conditions favour the reduction of nitrite to nitric oxide (NO) to elicit vasodilatation, but the mechanism(s) responsible for... 
XANTHINE OXIDOREDUCTASE | OXIDE | CONCISE GUIDE | MECHANISM | PHARMACOLOGY | TOLERANCE | NITROGLYCERIN | PHARMACOLOGY & PHARMACY | DIETARY NITRATE | GLYCERYL TRINITRATE | BLOOD | Aldehyde Dehydrogenase - antagonists & inhibitors | Aldehyde Dehydrogenase, Mitochondrial | Humans | Middle Aged | Heart Failure - physiopathology | Male | Nitroglycerin - pharmacology | Aldehyde Dehydrogenase - physiology | Regional Blood Flow - drug effects | Arteries - physiology | Aldehydes - pharmacology | Forearm - blood supply | Female | Nitric Oxide Donors - pharmacology | Vasodilation - physiology | Spermine - analogs & derivatives | Vasodilator Agents - pharmacology | Mitochondrial Proteins - antagonists & inhibitors | Mitochondrial Proteins - physiology | Arteries - drug effects | Nitrites - pharmacology | Rats, Sprague-Dawley | Animals | Spermine - pharmacology | Hypoxia - physiopathology | Aged | Cyanamide - pharmacology | In Vitro Techniques | Heart failure | Heart | Dilatation | Vasodilators | Nitric oxide | Blood vessels | Nitrates | Aldehydes | Hypoxia | Coronary vessels | Dehydrogenases | Research Papers
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Hyperuricemia-related diseases and xanthine oxidoreductase (XOR) inhibitors: An overview
by Chen, Changyi Johnny and Lü, Jian-Ming and Yao, Qizhi
Medical Science Monitor, ISSN 1234-1010, 07/2016, Volume 22, pp. 2501 - 2512
Uric acid is the final oxidation product of purine metabolism in humans. Xanthine oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to... 
Cardiovascular diseases | Hyperuricemia | Gout | MEDICINE, RESEARCH & EXPERIMENTAL | Cardiovascular Diseases | OXIDASE INHIBITORS | TOXIC EPIDERMAL NECROLYSIS | SERUM URIC-ACID | DOSE-RESPONSE METAANALYSIS | ALL-CAUSE MORTALITY | GENERAL-POPULATION | NITRIC-OXIDE | DOUBLE-BLIND | DRUG-DELIVERY SYSTEMS | STEVENS-JOHNSON-SYNDROME | Xanthine Dehydrogenase - metabolism | Animals | Reactive Oxygen Species - metabolism | Xanthine Dehydrogenase - antagonists & inhibitors | Humans | Risk Factors | Enzyme Inhibitors - pharmacology | Allopurinol - pharmacology | Hyperuricemia - therapy | Enzyme Inhibitors - therapeutic use | Hyperuricemia - enzymology | Febuxostat - pharmacology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Effects of topiroxostat and febuxostat on urinary albumin excretion and plasma xanthine oxidoreductase activity in db/db mice
by Nakamura, Takashi and Murase, Takayo and Nampei, Mai and Morimoto, Nobutaka and Ashizawa, Naoki and Iwanaga, Takashi and Sakamoto, Ryusuke
European Journal of Pharmacology, ISSN 0014-2999, 06/2016, Volume 780, pp. 224 - 231
Topiroxostat, a xanthine oxidoreductase (XOR) inhibitor, has been shown to decrease the urinary albumin-to-creatinine ratio compared with placebo in... 
Diabetic nephropathy | Albuminuria | Topiroxostat | Xanthine oxidoreductase | Diabetic Nephropathies - urine | Diabetic Nephropathies - enzymology | Nitriles - pharmacology | Xanthine Dehydrogenase - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Pyridines - pharmacokinetics | Male | Diabetic Nephropathies - blood | Xanthine Dehydrogenase - blood | Nitriles - pharmacokinetics | Febuxostat - pharmacology | Animals | Enzyme Inhibitors - pharmacokinetics | Febuxostat - pharmacokinetics | Mice | Pyridines - pharmacology | Albuminuria - urine | Alkaloids | Chronic kidney failure | Analysis | Liver | Albumin | Xanthine | Uric acid | Diabetic nephropathies
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text The treatment of hyperuricemia
by Gliozzi, Micaela and Malara, Natalia and Muscoli, Saverio and Mollace, Vincenzo
International Journal of Cardiology, ISSN 0167-5273, 2015, Volume 213, pp. 23 - 27
Abstract Hyperuricemia has long been established as the major etiologic factor in gout. Alongside with an inflammatory state triggered by urate crystal... 
Cardiovascular | Oxidative stress | Hyperuricemia | Xanthine oxidase inhibitors | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | GOUT | OXIDOREDUCTASE | FEBUXOSTAT | ALLOPURINOL | HEART | COLCHICINE | INFLAMMATION | CARDIOVASCULAR-DISEASE | XANTHINE-OXIDASE INHIBITION | Gout Suppressants - therapeutic use | Uric Acid - metabolism | Xanthine Dehydrogenase - antagonists & inhibitors | Humans | Enzyme Inhibitors - pharmacology | Oxidative Stress - drug effects | Enzyme Inhibitors - therapeutic use | Hyperuricemia - drug therapy | Heart failure | Hypertension | Enzymes | Care and treatment | Physiological aspects | Uric acid | Oxidases | Iron compounds | Safety and security measures | Food
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and Atherosclerosis Development
by Kushiyama, Akifumi and Okubo, Hirofumi and Sakoda, Hideyuki and Kikuchi, Takako and Fujishiro, Midori and Sato, Hirokazu and Kushiyama, Sakura and Iwashita, Misaki and Nishimura, Fusanori and Fukushima, Toshiaki and Nakatsu, Yusuke and Kamata, Hideaki and Kawazu, Shoji and Higashi, Yukihito and Kurihara, Hiroki and Asano, Tomoichiro
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2012, Volume 32, Issue 2, pp. 291 - 298
OBJECTIVE—Hyperuricemia is common in patients with metabolic syndrome. We investigated the role of xanthine oxidoreductase (XOR) in atherosclerosis... 
atherosclerosis | macrophages | xanthine oxidoreductase | cytokines | cell physiology | METABOLIC SYNDROME | MYOCARDIAL-INFARCTION | HIGH-FAT DIET | SERUM URIC-ACID | APOLIPOPROTEIN-E | PERCUTANEOUS CORONARY INTERVENTION | OXIDASE | PPAR-GAMMA | PERIPHERAL VASCULAR DISEASE | ANIMAL-MODEL | HEMATOLOGY | TRANSGENIC MICE | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Apolipoproteins E - deficiency | Xanthine Dehydrogenase - antagonists & inhibitors | Humans | Foam Cells - drug effects | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | ATP Binding Cassette Transporter 1 | Cell Differentiation - physiology | Foam Cells - pathology | Foam Cells - metabolism | Disease Models, Animal | Xanthine Dehydrogenase - drug effects | Cytokines - metabolism | Macrophages - pathology | Atherosclerosis - physiopathology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Atherosclerosis - metabolism | Mice, Knockout | Macrophages - metabolism | Animals | Xanthine Dehydrogenase - physiology | Apolipoproteins E - genetics | Lipid Metabolism - drug effects | Allopurinol - pharmacology | Macrophages - drug effects | Mice
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
14. Full Text Investigation of the transport of xanthine dehydrogenase inhibitors by the urate transporter ABCG2
by Nakamura, Makiko and Fujita, Kyoko and Toyoda, Yu and Takada, Tappei and Hasegawa, Hiroshi and Ichida, Kimiyoshi
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 02/2018, Volume 33, Issue 1, pp. 77 - 81
Hyperuricemia induces gout and kidney stones and accelerates the progression of renal and cardiovascular diseases. Adenosine 5′-triphosphate-binding cassette... 
Hyperuricemia therapy | Oxypurinol | Febuxostat | Allopurinol | A serum uric acid lowering drug | GOUT | RESISTANCE PROTEIN TRANSPORTER | RISK | LOCI | BCRP/ABCG2 | PHARMACOKINETICS | KIDNEY-FUNCTION | PHARMACOLOGY & PHARMACY | URIC-ACID | GENOME-WIDE ASSOCIATION | Xanthine Dehydrogenase - metabolism | Oxypurinol - metabolism | Enzyme Inhibitors - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism | Xanthine Dehydrogenase - antagonists & inhibitors | Humans | Hyperuricemia - metabolism | Neoplasm Proteins - metabolism | Hep G2 Cells | HEK293 Cells | Biological Transport - physiology | Cell Membrane - metabolism | Allopurinol - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
15. Full Text An extremely potent inhibitor of xanthine oxidoreductase: Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition
by Okamoto, Ken and Eger, Bryan T and Nishino, Tomoko and Kondo, Shiro and Pai, Emil F and Nishino, Takeshi
Journal of Biological Chemistry, ISSN 0021-9258, 01/2003, Volume 278, Issue 3, pp. 1848 - 1855
TEI-6720 (2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5thiazolecarboxylic acid) is an extremely potent inhibitor of xanthine oxidoreductase. Steady state kinetics... 
RAT-LIVER | DEHYDROGENASE TYPE | ALLOPURINOL | OXYGEN | PROTEIN | BOVINE-MILK | CONVERSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PURIFICATION | ELECTRON-DENSITY MAPS | OXIDASE INHIBITOR | Milk - enzymology | Febuxostat | Xanthine Dehydrogenase - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Models, Molecular | Spectrometry, Fluorescence | Crystallography, X-Ray | Animals | Cattle | Enzyme Inhibitors - chemistry | Thiazoles - chemistry | Molecular Structure | Thiazoles - pharmacology | Kinetics | Xanthine Dehydrogenase - chemistry
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights