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Circulation, ISSN 0009-7322, 2015, Volume 131, Issue 20, pp. 1763 - 1771
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2016, Volume 24, Issue 21, pp. 5462 - 5480
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 09/2012, Volume 40, Issue 9, pp. 1834 - 1845
Negative allosteric modulation (NAM) of metabotropic glutamate receptor subtype 5 (mGlu(5)) represents a therapeutic strategy for the treatment of childhood... 
VITRO | ENZYME | METABOLISM | PHARMACOKINETICS | HUMANS | PHARMACOLOGY & PHARMACY | HUMAN LIVER | TOXICITY | IN VIVO CORRELATION | INHIBITOR | PREDICTION | Raloxifene Hydrochloride - pharmacology | Thiazoles - blood | Injections, Intravenous | Liver - enzymology | Species Specificity | Benzamides - pharmacokinetics | Excitatory Amino Acid Antagonists - pharmacokinetics | Humans | Macaca fascicularis | Male | Metabolic Clearance Rate | Thiazoles - administration & dosage | Thiazoles - pharmacokinetics | Oxygen Isotopes | Tandem Mass Spectrometry | Benzamides - administration & dosage | Liver - drug effects | Biotransformation | Chromatography, Liquid | Receptor, Metabotropic Glutamate 5 | Microsomes, Liver - enzymology | Molecular Structure | Excitatory Amino Acid Antagonists - chemistry | Xanthine Oxidase - antagonists & inhibitors | Benzamides - chemistry | Xanthine Oxidase - metabolism | Hydroxylation | Magnetic Resonance Spectroscopy | Benzamides - blood | Enzyme Inhibitors - pharmacology | Excitatory Amino Acid Antagonists - administration & dosage | Rats | Rats, Sprague-Dawley | Excitatory Amino Acid Antagonists - blood | Aldehyde Oxidase - antagonists & inhibitors | Animals | Models, Biological | Aldehyde Oxidase - metabolism | Allopurinol - pharmacology | Thiazoles - chemistry | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Hepatocytes - enzymology
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 12/2013, Volume 21, Issue 23, pp. 7435 - 7452
Adenosine receptors and monoamine oxidases are drug targets for neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. In the present study we... 
Caffeine derivatives | Monoamine oxidase B inhibitors | Anellated xanthines | Synthesis | Alzheimer’s disease | Tetrahydropyrimido[2,1-f]purinediones | Adenosine A1 receptor antagonists | Adenosine A2A receptor antagonists | Parkinson’s disease | Tricyclic compounds | Parkinson's disease | receptor antagonists | Tetrahydropyrimido[2,1-f] purinediones | Alzheimer's disease | Adenosine A | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CAFFEINE | CHEMISTRY, ORGANIC | ADENOSINE A(2A) RECEPTOR | Adenosine A(2A) receptor antagonists | BIOLOGICAL-ACTIVITY | MOTOR | MONOAMINE-OXIDASE-B | ANIMAL-MODELS | Adenosine A receptor antagonists | INHIBITORS | ANTAGONIST RADIOLIGAND | PARKINSONS-DISEASE | Monoamine Oxidase Inhibitors - pharmacology | Cricetulus | Purines - pharmacology | Humans | Adenosine A1 Receptor Antagonists - pharmacology | Neurodegenerative Diseases - drug therapy | Xanthines - pharmacology | Purinergic P1 Receptor Antagonists - pharmacology | Adenosine A2 Receptor Antagonists - pharmacology | Xanthines - chemistry | Animals | Purines - chemistry | Caffeine - chemistry | Caffeine - pharmacology | Monoamine Oxidase Inhibitors - chemistry | Adenosine A1 Receptor Antagonists - chemistry | Adenosine A2 Receptor Antagonists - chemistry | CHO Cells | Monoamine Oxidase - metabolism | Neurodegenerative Diseases - enzymology | Purinergic P1 Receptor Antagonists - chemistry | Drug therapy | Nervous system diseases
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2011, Volume 51, Issue 7, pp. 1289 - 1301
Reactive oxygen species (ROS) play an important role in physiological and pathological processes. In recent years, a feed-forward regulation of the ROS sources... 
Mitochondria | Free radicals | Mitochondria-targeted antioxidant | NADPH oxidase | Feed-forward regulation | Superoxide | ATP-sensitive potassium channel | VASCULAR OXIDATIVE STRESS | NITRIC-OXIDE SYNTHASE | FACTOR RECEPTOR TRANSACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXYGEN SPECIES GENERATION | ELECTRON-TRANSPORT CHAIN | REACTIVE OXYGEN | RENIN-ANGIOTENSIN SYSTEM | MANGANESE SUPEROXIDE-DISMUTASE | ENDOCRINOLOGY & METABOLISM | SMOOTH-MUSCLE-CELLS | NF-KAPPA-B | Reactive Oxygen Species - metabolism | Humans | NADPH Oxidases - metabolism | Hypertension - drug therapy | Neurodegenerative Diseases - drug therapy | Piperidines - pharmacology | Oxidation-Reduction - drug effects | Organophosphorus Compounds - pharmacology | Nitric Oxide Synthase Type III - metabolism | Superoxide Dismutase - metabolism | Rabbits | Xanthine Oxidase - metabolism | Angiotensin II - pharmacology | Atherosclerosis - drug therapy | Signal Transduction | Atherosclerosis - physiopathology | Diabetes Mellitus - drug therapy | Diabetes Mellitus - metabolism | Rats | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Neurodegenerative Diseases - metabolism | Atherosclerosis - metabolism | Hypertension - physiopathology | Hypertension - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Animals | Neurodegenerative Diseases - physiopathology | Diabetes Mellitus - physiopathology | Mice | Oxidative Stress - drug effects | Aging - metabolism | Antioxidants | Oxidases | Mitochondrial DNA | Atherosclerosis
Journal Article
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 04/2014, Volume 4, Issue 1, p. 4554
Journal Article