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1. Pharmacokinetics and toxicokinetics
by Boroujerdi, Mehdi
2015, 2015, ISBN 1482221349, xix, 530
Pharmacokinetics and Toxicokinetics provides an overview of pharmacokinetics and toxicokinetics in a comprehensible, interrelated, and applied manner. It... 
Drugs | Pharmacokinetics | Toxicology | Other branches of medicine | Mathematical Modeling | Pharmaceutical Science
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2. Physiologically based pharmacokinetic modeling
: science and applications
by Reddy, Micaela B and Yang, Raymond S. H and Andersen, Melvin E and Clewell, III, Harvey J
2005, ISBN 0471478148, xix, 420
Presents an overview of the underlying principles of PBPK model development. This book provides a compendium of PBPK modeling information, including historical... 
Chemistry | SCIENCE | Industrial & Technical | Pharmacokinetics | Xenobiotics | Toxicology
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3. Full Text Modeling pharmacokinetics
by Bois, Frederic Y and Brochot, Céline
Methods in Molecular Biology, ISSN 1064-3745, 2016, Volume 1425, pp. 37 - 62
Pharmacokinetics is the study of the fate of xenobiotics in a living organism. Physiologically based pharmacokinetic (PBPK) models provide realistic... 
PBPK | R software | Numerical integration | 1,3-Butadiene | Monte carlo simulations | Butadienes - pharmacology | Computational Biology - methods | Animals | Models, Biological | Humans | Butadienes - pharmacokinetics | Software | Monte Carlo Method | Life Sciences | Toxicology
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4. Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone
by Kodaira, Hiroshi and Kusuhara, Hiroyuki and Ushiki, Junko and Fuse, Eiichi and Sugiyama, Yuichi
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 06/2010, Volume 333, Issue 3, pp. 788 - 796
breast cancer resistance protein (Bcrp)/Abcg2 was reported to limit the brain penetration of their common substrates. This study investigated this based on... 
BCRP | EFFLUX | TRANSPORTERS | TISSUE DISTRIBUTION | BILIARY-EXCRETION | BARRIER | INVOLVEMENT | MOUSE | PHARMACOLOGY & PHARMACY | CAPILLARY ENDOTHELIAL-CELLS | ABCG2 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Erlotinib Hydrochloride | Testis - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Quinazolines - pharmacokinetics | Male | Neoplasm Proteins - metabolism | Brain - metabolism | Tissue Distribution | Dantrolene - pharmacokinetics | ATP-Binding Cassette Transporters - genetics | Quinidine - pharmacokinetics | ATP-Binding Cassette Transporters - metabolism | Piperidines - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Xenobiotics - metabolism | Neoplasm Proteins - genetics | Protein Kinase Inhibitors - pharmacokinetics | Antimalarials - pharmacokinetics | Blood-Brain Barrier - drug effects | Flavonoids - pharmacokinetics | Mice, Knockout | Muscle Relaxants, Central - pharmacokinetics | Algorithms | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | ATP Binding Cassette Transporter, Sub-Family B | Mice | Kinetics | Mitoxantrone - pharmacokinetics
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5. Full Text Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101)
by Gaillard, Pieter J and Appeldoorn, Chantal C. M and Dorland, Rick and Van Kregten, Joan and Manca, Francesca and Vugts, Danielle J and Windhorst, Bert and Van Dongen, Guus A. M. S and De Vries, Helga E and Maussang, David and Van Tellingen, Olaf
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e82331
Brain cancer is a devastating disease affecting many people worldwide. Effective treatment with chemotherapeutics is limited due to the presence of the... 
MALIGNANT GLIOMA | CELLS | TRANSPORT | MULTIDISCIPLINARY SCIENCES | BARRIER | METASTASES | ADRIAMYCIN | BIODISTRIBUTION | MODEL | CHEMOTHERAPY | PACLITAXEL | Doxorubicin - blood | Glutathione - pharmacokinetics | Doxorubicin - therapeutic use | Capillaries - pathology | Humans | Brain Neoplasms - pathology | Body Weight - drug effects | Polyethylene Glycols - therapeutic use | Drug Delivery Systems | Brain - blood supply | Glutathione - pharmacology | Time Factors | Doxorubicin - analogs & derivatives | Female | Polyethylene Glycols - pharmacology | Glutathione - therapeutic use | Tissue Distribution - drug effects | Glutathione - analogs & derivatives | Endothelial Cells - metabolism | Polyethylene Glycols - pharmacokinetics | Treatment Outcome | Brain Neoplasms - drug therapy | Doxorubicin - pharmacokinetics | Brain - drug effects | Animals | Mice, Nude | Glioblastoma - pathology | Survival Analysis | Brain - pathology | Cell Proliferation - drug effects | Mice | Brain Neoplasms - ultrastructure | Endothelial Cells - pathology | Glioblastoma - drug therapy | Doxorubicin - pharmacology | Glutathione - blood | Drugs | Plasma physics | Drug delivery systems | Anthracyclines | Thiols | Gliomas | Brain tumors | Drug therapy | Cancer | Vehicles | Nuclear medicine | Bioluminescence | Neurosciences | Brain cancer | Glioblastoma | Drug delivery | Metastasis | Cancer therapies | Doxorubicin | Antioxidants | Blood-brain barrier | Inhibition | Xenobiotics | Glutathione | Medical treatment | Pharmacology | Breast cancer | Disease control | Endothelial cells | Studies | Chemotherapy | Brain research | Diffusion barriers | Medical prognosis | Pharmacokinetics | Tumors
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6. Full Text Separating host and microbiome contributions to drug pharmacokinetics and toxicity
by Zimmermann, Michael and Zimmermann-Kogadeeva, Maria and Wegmann, Rebekka and Goodman, Andrew L
Science, ISSN 0036-8075, 02/2019, Volume 363, Issue 6427, pp. 600 - 600
The gut microbiota is implicated in the metabolism of many medical drugs, with consequences for interpersonal variation in drug efficacy and toxicity. However,... 
5-FLUOROURACIL | CATABOLISM | INTESTINAL MICROFLORA | CLONAZEPAM | MECHANISM | DIHYDROPYRIMIDINE DEHYDROGENASE | MULTIDISCIPLINARY SCIENCES | (E)-5-(2-BROMOVINYL)URACIL | HUMAN GUT SYMBIONT | SORIVUDINE | EXPRESSION | Drugs | Microbiota (Symbiotic organisms) | Physiological aspects | Transformation | Animal models | Physiological effects | Toxicity | Medical services | Microbiomes | Microorganisms | Microbiota | Absorption | Metabolites | Antidepressants | Intestine | Compartments | Animal tissues | Drug metabolism | Genetics | Biocompatibility | Oxidation | Xenobiotics | Digestive tract | Food | Enzymes | Gnotobiotics | Effectiveness | Computer simulation | Digestive system | Exposure | Pharmacology | Bioavailability | Clonazepam | Metabolism | Conversion | Benzodiazepines | Organic chemistry | Computer applications | Nucleosides | Transformations | In vivo methods and tests | Mice | Kinetics | Pharmacokinetics | Variation | Nucleoside analogs
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7. Full Text Similarity of Bisphenol A Pharmacokinetics in Rhesus Monkeys and Mice: Relevance for Human Exposure
by Julia A. Taylor and Frederick S. vom Saal and Wade V. Welshons and Bertram Drury and George Rottinghaus and Patricia A. Hunt and Pierre-Louis Toutain and Céline M. Laffont and Catherine A. VandeVoort
Environmental Health Perspectives, ISSN 0091-6765, 4/2011, Volume 119, Issue 4, pp. 422 - 430
Objective: Daily adult human exposure to bisphenol A (BPA) has been estimated at < 1 μg/kg, with virtually complete first-pass conjugation in the liver in... 
Business publications audits | Reviews | Bisphenols | Rodents | Oral administration | Administered dose | Adults | Mice | Dosage | Female animals | Human resources | Endocrine disruption | Bisphenol A | Xenobiotic metabolism | Biomonitoring | Pharmacokinetics | ROUTE | biomonitoring | RATS | MECHANISMS | EXCRETION | xenobiotic metabolism | endocrine disruption | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | CD1 MICE | IN-VIVO | LIVER | pharmacokinetics | bisphenol A | TOXICOLOGY | RISK-ASSESSMENT | UDP-GLUCURONOSYLTRANSFERASE ACTIVITIES | Endocrine Disruptors - metabolism | Benzhydryl Compounds | Species Specificity | Humans | Liver - metabolism | Endocrine Disruptors - blood | Macaca mulatta | Environmental Exposure - analysis | Environmental Pollutants - metabolism | Phenols - metabolism | Environmental Pollutants - blood | Animals | Phenols - blood | Environmental Exposure - statistics & numerical data | Usage | Bisphenol-A | Primates | Physiological aspects | Research | Health aspects | Biological monitoring | Human | Cadmium | Monkeys | Females | Serums | Life Sciences | Review
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8. Full Text Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review
by Stingl, J.C and Bartels, H and Viviani, R and Lehmann, M.L and Brockmöller, J
Pharmacology and Therapeutics, ISSN 0163-7258, 01/2014, Volume 141, Issue 1, pp. 92 - 116
UDP-glucuronosyltransferases (UGT) catalyze the biotransformation of many endobiotics and xenobiotics, and are coded by polymorphic genes. However, knowledge... 
Drug metabolism | UDP-glucuronosyltransferases | Pharmacogenetics | Pharmacogenetics-based dose adjustments | UGT1A1 | Polymorphism | UGT2B7 GENETIC POLYMORPHISMS | MYCOPHENOLIC-ACID PHARMACOKINETICS | HUMAN LIVER-MICROSOMES | GLUCURONIDATION POTENTIAL ROLE | METASTATIC COLORECTAL-CANCER | RENAL-TRANSPLANT RECIPIENTS | CELL LUNG-CANCER | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | IN-VITRO CHARACTERIZATION | IRINOTECAN-INDUCED NEUTROPENIA | PHARMACOLOGY & PHARMACY | Psychotropic Drugs - pharmacokinetics | Humans | Analgesics - metabolism | Analgesics - pharmacokinetics | Antihypertensive Agents - metabolism | Antihypertensive Agents - pharmacokinetics | Uridine Diphosphate - metabolism | Polymorphism, Genetic | Antineoplastic Agents - metabolism | Glucuronosyltransferase - genetics | Pharmaceutical Preparations - metabolism | Glucuronosyltransferase - metabolism | Anti-HIV Agents - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Psychotropic Drugs - metabolism | Anti-HIV Agents - metabolism | Pharmaceutical Preparations - administration & dosage | Pharmacokinetics | Physiological aspects | Xenobiotics | Index Medicus
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9. Full Text Drug transport in corneal epithelium and blood–retina barrier: Emerging role of transporters in ocular pharmacokinetics
by Mannermaa, Eliisa and Vellonen, Kati-Sisko and Urtti, Arto
Advanced Drug Delivery Reviews, ISSN 0169-409X, 2006, Volume 58, Issue 11, pp. 1136 - 1163
Corneal epithelium and blood–retina barrier (i.e. retinal capillaries and retinal pigment epithelium (RPE)) are the key membranes that regulate the access of... 
Corneal epithelium | Retinal capillaries | Transporter | Ocular drug delivery | Retinal pigment epithelium | Ocular pharmacokinetics | ORGANIC ANION TRANSPORTER | ocular pharmacokinetics | ocular drug delivery | MULTIDRUG-RESISTANCE PROTEIN | PIGMENTED RABBIT CONJUNCTIVA | corneal epithelium | retinal capillaries | AMINO-ACID TRANSPORTER | HUMAN P-GLYCOPROTEIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | DEPENDENT NUCLEOSIDE TRANSPORTER | transporter | BETA-LACTAM ANTIBIOTICS | CACO-2 CELL MONOLAYERS | PHARMACOLOGY & PHARMACY | GLYCOPROTEIN-MEDIATED-TRANSPORT | retinal pigment epithelium | Pharmaceutical Preparations - metabolism | Animals | Blood-Retinal Barrier - physiology | Humans | Epithelium, Corneal - metabolism | Pharmacokinetics | Membrane Transport Proteins - physiology | Drug Delivery Systems | Drugs | Animal pigments | Drug delivery systems | Universities and colleges | Xenobiotics | Epithelium | Vehicles
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10. Full Text Dissecting the relative contribution of OATP1B1-mediated uptake of xenobiotics into human hepatocytes using siRNA
by Williamson, B and Soars, A. C and Owen, A and White, P and Riley, R. J and Soars, M. G
Xenobiotica, ISSN 0049-8254, 10/2013, Volume 43, Issue 10, pp. 920 - 931
Abstract 1. Organic anion transporting polypeptide 1B1 plays a pivotal role in the disposition of many anionic drugs. Significant overlap in substrate... 
drug transporters | organic anion polypeptides | drug-drug interactions | Cytochrome P450 | pharmacokinetics | siRNA | hepatocytes | OATP1B1 | Hepatocytes | Organic anion polypeptides | Drug-drug interactions | Pharmacokinetics | SiRNA | Drug transporters | PHARMACOKINETIC INTERACTION | ANGIOTENSIN-II AT1-RECEPTOR | TRANSPLANT RECIPIENTS | HEPATIC-UPTAKE | SANDWICH-CULTURED RAT | MOUSE VASCULAR ENDOTHELIUM | SMALL INTERFERING RNA | ANION-TRANSPORTING POLYPEPTIDE | IN-VITRO MODEL | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Fluorobenzenes - pharmacokinetics | Valsartan | Humans | Molecular Sequence Data | Male | Hepatocytes - metabolism | Imidazoles - pharmacokinetics | Xenobiotics - pharmacokinetics | Organic Anion Transporters - metabolism | Quinolines - pharmacokinetics | Organic Anion Transporters - genetics | Drug Interactions | Base Sequence | Female | Hepatocytes - drug effects | Valine - pharmacokinetics | Valine - analogs & derivatives | Cells, Cultured | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Estrone - analogs & derivatives | Cytochrome P-450 CYP3A - metabolism | Pyrimidines - pharmacokinetics | Liver-Specific Organic Anion Transporter 1 | Estrone - pharmacokinetics | RNA, Small Interfering - administration & dosage | Tetrazoles - pharmacokinetics | Index Medicus
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11. Full Text Representative sinusoids for hepatic four-scale pharmacokinetics simulations
by Schwen, Lars Ole and Schenk, Arne and Kreutz, Clemens and Timmer, Jens and Rodríguez, María Matilde Bartolomé and Kuepfer, Lars and Preusser, Tobias
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0133653
The mammalian liver plays a key role for metabolism and detoxification of xenobiotics in the body. The corresponding biochemical processes are typically... 
1ST-PASS ELIMINATION | LOCALIZED ADJOINT METHODS | ARTERIAL BUFFER RESPONSE | CYTOCHROME-P450 EXPRESSION | IN-VIVO EXTRAPOLATION | MULTIDISCIPLINARY SCIENCES | PERFUSED-RAT-LIVER | NONALCOHOLIC STEATOHEPATITIS | PULSATILE INSULIN-SECRETION | DRUG-METABOLIZING-ENZYMES | BLOOD-FLOW | Fatty Liver - metabolism | Humans | Liver - metabolism | Male | Caffeine - pharmacokinetics | Regeneration | Liver - blood supply | Animals | Models, Biological | Liver - physiology | Adult | Liver - cytology | Mice | Pharmacokinetics | Insulin - pharmacokinetics | Blood Circulation | Drug metabolism | Xenobiotics | Detoxification therapy (Alternative medicine) | Health aspects | Analysis | Thoracic surgery | Animal models | Liver | Spatial discrimination | Biology | Rodents | Mathematical models | Caffeine | Data analysis | Computer simulation | Detoxification | Pharmacology | Metabolism | Gene expression | Insulin | Hepatocytes | Spatial variations | Computer applications | Spatial heterogeneity | Ordinary differential equations | Inhomogeneity | Diabetes | Midazolam | Variation | Veins & arteries
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