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Quantitative structure-activity relationships including molecular modelling and applications of computer graphics in pharmacology, chemistry, and biology, ISSN 0931-8771, 1985
Journal
The Journal of Clinical Pharmacology, ISSN 0091-2700, 12/2006, Volume 46, Issue 12, pp. 1426 - 1438
Cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of drugs such as bupropion, efavirenz, propofol, and selegiline, among others. More than 200... 
HPLC/MS/MS | P450 2B6 | rhCYP2B6 | Drug‐drug interactions | in vitro | Drug-drug interactions | In vitro | Raloxifene Hydrochloride - pharmacology | Cytochrome P-450 Enzyme Inhibitors | Humans | Microsomes, Liver - metabolism | Sertraline - chemistry | Bupropion - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Antifungal Agents - chemistry | Xenobiotics - pharmacology | Reverse Transcriptase Inhibitors - chemistry | Xenobiotics - classification | Clotrimazole - metabolism | Platelet Aggregation Inhibitors - pharmacology | Oxazines - pharmacology | Antifungal Agents - pharmacology | Itraconazole - metabolism | Serotonin Uptake Inhibitors - metabolism | Clotrimazole - pharmacology | Serotonin Uptake Inhibitors - chemistry | Antidepressive Agents, Second-Generation - pharmacology | Clotrimazole - chemistry | Itraconazole - chemistry | Selective Estrogen Receptor Modulators - metabolism | Ticlopidine - analogs & derivatives | Raloxifene Hydrochloride - metabolism | Platelet Aggregation Inhibitors - chemistry | Oxazines - chemistry | Kinetics | Serotonin Uptake Inhibitors - pharmacology | Selective Estrogen Receptor Modulators - pharmacology | Bupropion - metabolism | Ticlopidine - pharmacology | Area Under Curve | Reverse Transcriptase Inhibitors - pharmacology | Ticlopidine - chemistry | Benzoxazines | Xenobiotics - pharmacokinetics | Itraconazole - pharmacology | Oxazines - metabolism | Microsomes, Liver - drug effects | Antifungal Agents - metabolism | Ticlopidine - metabolism | Molecular Structure | Platelet Aggregation Inhibitors - metabolism | Sertraline - metabolism | Sertraline - pharmacology | Selective Estrogen Receptor Modulators - chemistry | Algorithms | Bupropion - pharmacology | Reverse Transcriptase Inhibitors - metabolism | Antidepressive Agents, Second-Generation - metabolism | Raloxifene Hydrochloride - chemistry | Cytochrome P-450 CYP2B6 | Cytochromes | Research | Health aspects | Drug interactions | Index Medicus
Journal Article
1976, Monographs in pharmacology and physiology, ISBN 9780470150214, Volume 1, 401
Book
Trends in Pharmacological Sciences, ISSN 0165-6147, 07/2019, Volume 40, Issue 7, pp. 495 - 505
Our bodies each possess a unique and dynamic collection of microbes and viruses, collectively the ‘microbiome’, with distinct metabolic capacities from our... 
microbiome | pharmacodynamics | xenobiotics | pharmacology
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, pp. e0168837 - e0168837
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2008, Volume 584, Issue 1, pp. 57 - 65
The pregnane X receptor is a ligand-activated transcription factor that is abundantly expressed in hepatocytes. Numerous drugs are pregnane X receptor ligands.... 
Organic anion transporting polypeptide | Hepatocyte | Nuclear receptor ligand | Drug–drug interaction | Drug-drug interaction | ORGANIC ANION TRANSPORTER | hepatocyte | ORPHAN NUCLEAR RECEPTORS | organic anion transporting polypeptide | HEPATIC-UPTAKE | RIFAMYCIN SV | SLCO1B3 GENE | IDENTIFICATION | POLYPEPTIDES | nuclear receptor ligand | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | HUMAN LIVER | drug-drug interaction | Organic Anion Transporters, Sodium-Independent - genetics | Estradiol - analogs & derivatives | Paclitaxel - pharmacology | Receptors, Steroid - metabolism | Cricetulus | Humans | Xenobiotics - pharmacology | Organic Anion Transporters - metabolism | Dose-Response Relationship, Drug | Organic Anion Transporters - genetics | Drug Interactions | Transfection | Chromans - pharmacology | Organic Anion Transporters, Sodium-Independent - metabolism | Organic Anion Transporters, Sodium-Independent - drug effects | Thiazolidinediones - pharmacology | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Estradiol - metabolism | Cricetinae | Clotrimazole - pharmacology | Receptors, Steroid - drug effects | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Ligands | Kinetics | Rifampin - pharmacology | Mifepristone - pharmacology | Solute Carrier Organic Anion Transporter Family Member 1b1 | Organic Anion Transporters - drug effects | Hormones, Sex | Antagonists | Progesterone | Drug interactions | Analysis | Index Medicus | drug-drug interactions | hepatocytes | nuclear receptor ligands
Journal Article
Human Reproduction, ISSN 0268-1161, 05/2006, Volume 21, Issue 5, pp. 1184 - 1193
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2006, Volume 34, Issue 1, pp. 75 - 83
Most human hepatocyte cell lines lack a substantial set of liver-specific functions, especially major cytochrome P450 (P450)-related enzyme activities, making... 
MAINTENANCE | RAT HEPATOCYTES | ADULT HUMAN HEPATOCYTES | LIVER | LINE | CULTURED HUMAN HEPATOCYTES | PHARMACOLOGY & PHARMACY | AFLATOXIN B-1 | DIMETHYL-SULFOXIDE | INDUCTION | DRUG-METABOLIZING-ENZYMES | Aflatoxin B1 - pharmacology | Cell Survival - drug effects | Gene Expression - drug effects | Isoenzymes - genetics | Humans | RNA, Messenger - genetics | RNA, Messenger - analysis | Chlorpromazine - pharmacology | Dimethyl Sulfoxide - pharmacology | Gene Expression Profiling | Receptors, Cytoplasmic and Nuclear - genetics | Hepatocytes - metabolism | Xenobiotics - pharmacology | Glucuronosyltransferase - genetics | Hepatocytes - cytology | Acetaminophen - pharmacology | Carcinoma, Hepatocellular - genetics | Reverse Transcriptase Polymerase Chain Reaction - methods | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Inhibitory Concentration 50 | Hepatocytes - drug effects | Amiodarone - pharmacology | Index Medicus | Gene Expression | Isoenzymes | Cell Survival | Amiodarone | Reverse Transcriptase Polymerase Chain Reaction | Receptors, Cytoplasmic and Nuclear | Chlorpromazine | Cytochrome P-450 Enzyme System | Life Sciences | Microbiology and Parasitology | Hepatocytes | Acetaminophen | Aflatoxin B1 | Dimethyl Sulfoxide | Carcinoma, Hepatocellular | Xenobiotics | RNA, Messenger | Glucuronosyltransferase
Journal Article
Molecular BioSystems, ISSN 1742-206X, 2010, Volume 6, Issue 7, pp. 1195 - 1206
Journal Article
Journal of Biochemical and Molecular Toxicology, ISSN 1095-6670, 09/2018, Volume 32, Issue 9, pp. e22196 - n/a
Glutathione‐ S ‐transferases (GSTs) have a function in xenobiotic metabolism. They are a significant multifunctional family with a wide variety of catalytic... 
inhibition | transferase | Van Lake fish | pesticides | glutathione | purification | glutathione-S-transferase | CHALCALBURNUS-TARICHII PALLAS | CHLORPYRIFOS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOXICOLOGY | HISTOPATHOLOGY | Glycine - analogs & derivatives | Glycine - metabolism | Liver - enzymology | Molecular Weight | Nitriles - pharmacology | Species Specificity | Glutathione Transferase - isolation & purification | Dimethylamines - pharmacology | Fish Proteins - isolation & purification | Pyrethrins - pharmacology | Fungicides, Industrial - pharmacology | Liver - growth & development | Dimethylamines - metabolism | Fungicides, Industrial - metabolism | Glutathione Transferase - antagonists & inhibitors | Enzyme Inhibitors - toxicity | Fish Proteins - antagonists & inhibitors | Pesticides - metabolism | Pyrethrins - metabolism | 2,4-Dichlorophenoxyacetic Acid - metabolism | Binding, Competitive | Nitriles - metabolism | Enzyme Inhibitors - metabolism | Fish Proteins - chemistry | Water Pollutants, Chemical - pharmacology | 2,4-Dichlorophenoxyacetic Acid - pharmacology | Fish Proteins - metabolism | Glutathione Transferase - metabolism | Glutathione Transferase - chemistry | Dichlorvos - pharmacology | Water Pollutants, Chemical - metabolism | Animals | Pyridines - metabolism | Turkey | Glycine - pharmacology | Saline Waters | Lakes | Pyridines - pharmacology | Kinetics | Cyprinidae - growth & development | Dichlorvos - metabolism | Pesticides - pharmacology | Herbicides | Glutathione transferase | Analysis | Liver | Pesticides | Physiological aspects | Xenobiotics | Chromatography | Enzyme activity | Metabolism | Glyphosate | Enzymatic activity | Dichlorvos | Dichlorophenoxyacetic acid | Fish | Catalysis | Inhibition | Glutathione | Cyhalothrin | Index Medicus
Journal Article
2002, Current toxicology series., ISBN 9780471894667, viii, 578
This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each... 
Drugs | Enzymes | Physiology | Xenobiotics | Metabolism
Book
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2007, Volume 222, Issue 2, pp. 129 - 140
Xenobiotics may cause long-term adverse effects in humans, especially at the embryonic level, raising questions about their levels of exposure, combined... 
Pesticides | Endocrine disrupters | Cytochrome P450 reductase | PCB | Bisphenol A | Combined effects | Aromatase | Equine testis | Diethylstilbestrol | Human 293 embryonic cells | Steroidogenesis | Nonylphenol | Xenobiotics | human 293 embryonic cells | nonylphenol | TESTICULAR CANCER | REPRODUCTIVE HEALTH | ESTROGEN-RECEPTOR | ENVIRONMENTAL XENOESTROGENS | cytochrome P450 reductase | pesticides | SEXUAL-DIFFERENTIATION | CHEMICAL-MIXTURES | PHARMACOLOGY & PHARMACY | ACTIVITY IN-VITRO | TOXICOLOGY | ACTIVITY MODULATION | HUMAN PLACENTAL MICROSOMES | aromatase | xenobiotics | steroidogenesis | combined effects | endocrine disrupters | diethylstilbestrol | PROTEIN EXPRESSION | equine testis | bisphenol A | Microsomes - metabolism | Aromatase Inhibitors - pharmacology | Humans | Aromatase Inhibitors - chemistry | Aromatase - metabolism | Male | Xenobiotics - chemistry | Xenobiotics - pharmacology | Chlordecone - pharmacology | Microsomes - drug effects | Aromatase - genetics | Diethylstilbestrol - pharmacology | Endocrine Disruptors - pharmacology | Transfection | Testis - enzymology | Chlordecone - chemistry | Trialkyltin Compounds - chemistry | Female | Molecular Structure | Diethylstilbestrol - chemistry | Phenols - pharmacology | Cell Line | Cell Survival - drug effects | Trialkyltin Compounds - pharmacology | Benzhydryl Compounds | Endocrine Disruptors - chemistry | Microsomes - enzymology | Androstenedione - pharmacology | Pregnancy | Catalysis - drug effects | Animals | Horses | Androstenedione - chemistry | Phenols - chemistry | Bisphenol-A | Physiological aspects | Index Medicus | HUMAN POPULATIONS | BIOLOGICAL ACCUMULATION | ENVIRONMENT | POLYCHLORINATED BIPHENYLS | TOXICITY | 60 APPLIED LIFE SCIENCES | SYNERGISM | CHRONIC EXPOSURE | XENOBIOTICS | INHIBITION | METABOLISM | DDT | ENZYMES | MICROSOMES | EMBRYONIC CELLS | OXIDES | ANDROGENS
Journal Article