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Journal Article
Toxicology, ISSN 0300-483X, 2005, Volume 216, Issue 2, pp. 154 - 167
Many adverse drug reactions are caused by the cytochrome P450 (CYP) dependent activation of drugs into reactive metabolites. In order to reduce attrition due... 
Reactive metabolites | Cytotoxicity | Metabolism-mediated toxicity | CYP3A4 | In vitro screening | Adverse drug reactions (ADRs) | CYTOCHROME-P450 | MEDIATED CYTOTOXICITY | HUMAN HEPATOCYTE CULTURES | in vitro screening | CARBAMAZEPINE | adverse drug reactions (ADRs) | STABLE EXPRESSION | INDUCTION | metabolism-mediated toxicity | IDIOSYNCRATIC DRUG-REACTIONS | CHINESE-HAMSTER CELLS | HEPG2 CELLS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | reactive metabolites | HUMAN-LIVER-MICROSOMES | cytotoxicity | Microsomes - metabolism | Thiazoles - metabolism | Cytochrome P-450 Enzyme Inhibitors | Cytochrome P-450 CYP3A | Coculture Techniques | Humans | Thiazolidinediones - toxicity | Cytochrome P-450 Enzyme System - metabolism | Isoniazid - toxicity | Xenobiotics - toxicity | Chromans - metabolism | Flutamide - metabolism | Triazolam - toxicity | Microsomes - drug effects | Triazolam - metabolism | Adenosine Triphosphate - metabolism | Carbamazepine - toxicity | Toxicity Tests - methods | Xenobiotics - metabolism | Cell Culture Techniques | Cell Survival - drug effects | Albendazole - toxicity | Tamoxifen - toxicity | Dapsone - metabolism | Dapsone - toxicity | Cell Line, Tumor | Glutathione - chemistry | Troglitazone | Buthionine Sulfoximine - pharmacology | Quinidine - toxicity | Amitriptyline - toxicity | Glutathione - metabolism | Flutamide - toxicity | Substrate Specificity | Piperazines - metabolism | Piperazines - toxicity | Ochratoxins - metabolism | Xenobiotics - chemistry | Tetrazolium Salts - metabolism | Carbamazepine - metabolism | Quinidine - metabolism | Tamoxifen - metabolism | Amitriptyline - metabolism | Glutathione - antagonists & inhibitors | Enzyme Activation - drug effects | Thiazolidinediones - metabolism | Ochratoxins - toxicity | Thiazoles - toxicity | Animals | Albendazole - metabolism | Chromans - toxicity | Isoniazid - metabolism | Phosphates | Metabolites | Ketoconazole | Cytochrome P-450 | Control systems | Xenobiotics | Glutathione
Journal Article
2008, Issues in toxicology, ISBN 0854042741, xviii, 521
During half a century, cytochrome P450 in its original uniqueness as an optically "wrong" cytochrome has attracted many investigators, who have contributed to... 
Cytochrome P-450 -- Physiological effect | Xenobiotics -- Metabolism | Biology, life sciences | Cytochrome P-450 | Chemistry | Organic | SCIENCE | Xenobiotics | Metabolism
Book
Comparative Biochemistry and Physiology, Part C, ISSN 1532-0456, 11/2013, Volume 158, Issue 4, pp. 216 - 224
Journal Article
Toxicological Sciences, ISSN 1096-6080, 03/2017, Volume 156, Issue 1, pp. 109 - 122
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 06/2012, Volume 261, Issue 3, pp. 227 - 235
The mammalian ovary is a heterogeneous organ and contains oocyte-containing follicles at varying stages of development. The most immature follicular stage, the... 
Follicle | Ovotoxicant | Steroidogenesis | HUMAN GRANULOSA-CELLS | FEMALE REPRODUCTIVE-SYSTEM | PHTHALATE SUPPRESSES ESTRADIOL | DIEPOXIDE-INDUCED OVOTOXICITY | HUMAN LIVER-MICROSOMES | DISRUPTOR PESTICIDE-METHOXYCHLOR | VCD-INDUCED OVOTOXICITY | RECEPTOR AGONIST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN | PHARMACOLOGY & PHARMACY | MICROSOMAL EPOXIDE HYDROLASE | TOXICOLOGY | GLUTATHIONE-S-TRANSFERASE | 9,10-Dimethyl-1,2-benzanthracene - toxicity | Inactivation, Metabolic | Benzhydryl Compounds | Ovarian Follicle - growth & development | Phenols - toxicity | Phthalic Acids - toxicity | Humans | Ovarian Diseases - pathology | Xenobiotics - toxicity | Carcinogens - toxicity | Cyclohexenes - toxicity | Environmental Exposure - adverse effects | Methoxychlor - toxicity | Animals | Aging - physiology | Estrogens, Non-Steroidal - toxicity | Oocytes - drug effects | Polychlorinated Dibenzodioxins - toxicity | Female | Ovarian Diseases - chemically induced | Xenobiotics - metabolism | Environmental Pollutants - toxicity | Trichloroethylene - toxicity | Physiological aspects | Xenobiotics | Enzymes | Index Medicus | Solvents | Senescence | Menopause | Organs | Trichloroethylene | Ovaries | Birth | Follicles | Metabolism | Reviews | Developmental stages | 9,10-Dimethyl-1,2-benzanthracene | REVIEWS | XENOBIOTICS | METABOLISM | ENZYMES | OVARIES | OOCYTES | ANTHRACENE | TOXICITY | MENOPAUSE | 60 APPLIED LIFE SCIENCES | ENVIRONMENTAL EXPOSURE | steroidogenesis | follicle
Journal Article