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1. Full Text Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores – A cautionary disclosure
by Acton, Ben and Small, Helen F and Smith, Kate M and McGonagle, Alison and Stowell, Alexandra I.J and James, Dominic I and Hamilton, Niall M and Hamilton, Nicola and Hitchin, James R and Hutton, Colin P and Waddell, Ian D and Ogilvie, Donald J and Jordan, Allan M
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2019, Volume 29, Issue 4, pp. 560 - 562
Fluorination of metabolic hotspots in a molecule is a common medicinal chemistry strategy to improve half-life and exposure and, generally, this strategy... 
Ataxia | Toxicophore | Animal welfare | NNBIAMICHJGJJL-UHFFFAOYSA-N | HUMXMXKZASBHLD-UHFFFAOYSA-N | KFMMUYOIQZVTHD-UHFFFAOYSA-N | VDNPAHSYCDBDLA-UHFFFAOYSA-N | YPJSTCOAXTXCOC-UHFFFAOYSA-N | DCNRZHQYMXKMBD-UHFFFAOYSA-N | PHMBUKPLTWFJTD-UHFFFAOYSA-N | ZOFHEKCMFGZPBH-UHFFFAOYSA-N | URAVBHWPUHHWPE-UHFFFAOYSA-N | YIIIUBIPEMDTEA-FIBGUPNXSA-N | JXROTDVXUCWZRJ-UHFFFAOYSA-N | VQYIPERYJDIKMW-UHFFFAOYSA-N | YIIIUBIPEMDTEA-UHFFFAOYSA-N | CHEMISTRY, ORGANIC | CHEMISTRY, MEDICINAL | GLYCOHYDROLASE | Drug discovery | Sugars | Monosaccharides | PK, Pharmacokinetics | PARG, poly-ADP ribose glycohydrolase | GI, gastrointestinal
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