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ym-254890 (34) 34
index medicus (11) 11
animals (8) 8
depsipeptide (7) 7
fr900359 (7) 7
cyclic peptide (6) 6
g proteins (6) 6
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inhibitor (5) 5
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chromobacterium sp qs3666 (4) 4
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protein (3) 3
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structure–activity relationships (3) 3
thrombosis (3) 3
wu-07047 (3) 3
adenylate-cyclase (2) 2
alpha-subunits (2) 2
ardisia - chemistry (2) 2
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cas (2) 2
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cyclic depsipeptides (2) 2
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gtp-binding protein alpha subunit (2) 2
gtp-binding protein alpha subunits, gq-g11 - antagonists & inhibitors (2) 2
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gtp-binding protein alpha subunits, gq-g11 - metabolism (2) 2
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ireland–claisen rearrangement (2) 2
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SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 09/2017, Volume 9, Issue 407
Obstructive lung diseases are common causes of disability and death worldwide. A hallmark feature is aberrant activation of G(q) protein-dependent signaling... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | SMOOTH-MUSCLE | YM-254890 | THROMBOSIS | DISEASE | PROTEIN-COUPLED RECEPTORS | MICE | GUINEA-PIGS | AGONISTS | CELL BIOLOGY
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 04/2019, Volume 294, Issue 15, pp. 5747 - 5758
Transmembrane signals initiated by a range of extracellular stimuli converge on members of the Gq family of heterotrimeric G proteins, which relay these... 
Index Medicus | CRISPR | label-free | Signal Transduction | Cas | YM-254890 | pharmacology | G protein-coupled receptor (GPCR) | DMR | FR900359 | G protein
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 11/2004, Volume 279, Issue 46, pp. 47438 - 47445
YM-254890, which was isolated from the culture broth of Chromobacterium sp., inhibits ADP-induced platelet aggregation and has antithrombotic and thrombolytic... 
ALPHA-SUBUNITS | G(Q/11) INHIBITOR | ADP RECEPTORS | CELLS | ACTIVATION | YM-254890 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPASE-C | IN-VIVO | G-PROTEIN ANTAGONISTS | GTP HYDROLYSIS
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 15, pp. 5747 - 5758
Transmembrane signals initiated by a range of extracellular stimuli converge on members of the Gq family of heterotrimeric G proteins, which relay these... 
CYCLASE | CRISPR | label-free | ACTIVATION | YM-254890 | MECHANISM | signal transduction | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DMR | RECEPTOR | G-ALPHA(Q) | Cas | TRANSDUCERS | STRUCTURAL BASIS | pharmacology | G protein-coupled receptor (GPCR) | FR900359 | G protein | INSIGHTS
Journal Article
CHEMMEDCHEM, ISSN 1860-7179, 04/2019, Volume 14, Issue 8, pp. 865 - 870
G proteins act as molecular switches in G protein-coupled receptor signaling pathways and are key mediators for numerous important physiological processes. The... 
CHEMISTRY, MEDICINAL | G protein-coupled receptors | structure-activity relationships | YM-254890 | TOXIN | ADP-RIBOSYLATION | PHARMACOLOGY & PHARMACY | G protein inhibitors | G proteins
Journal Article
Cellular Signalling, ISSN 0898-6568, 11/2018, Volume 51, pp. 59 - 71
Previous research from our laboratory has demonstrated a novel phenomenon whereby GPCRs play a role in inhibiting cytokine-mediated c-Jun N-terminal kinase... 
Inflammation | G-protein coupled receptors | Purinergic receptors | C-Jun N-terminal kinase | Interleukin-1β | YM-254890 (PubChem CID: 9919454) | H-89 (PubChem CID: 449241) | NF340 (PubChem CID: 73755007) | ZM241385 (PubChem CID: 176407) | MRS2179 (PubChem CID: 24867852)
Journal Article
ChemMedChem, ISSN 1860-7179, 04/2019, Volume 14, Issue 8, pp. 865 - 870
G proteins act as molecular switches in G protein‐coupled receptor signaling pathways and are key mediators for numerous important physiological processes. The... 
G protein-coupled receptors | G proteins | YM-254890 | structure–activity relationships | G protein inhibitors | Physiological aspects | Synthesis | G proteins | Membrane proteins | Organic compounds | Proteins | Molecular machines | Signaling | Inhibitors | Natural products | Switches | Pharmacology
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2018, Volume 57, Issue 3, pp. 836 - 840
Journal Article
PHARMACOLOGICAL RESEARCH, ISSN 1043-6618, 03/2019, Volume 141, pp. 264 - 275
Augmented vasoconstriction is a hallmark of hypertension and is mediated partly by hyper-stimulation of G protein couple receptors (GPCRs) and downstream... 
Calcium signaling | PHYSIOLOGY | YM-254890 | Cyclic depsipeptides | VASCULAR SMOOTH-MUSCLE | BLOOD-PRESSURE | G(q/11) inhibitor ligands | REGULATOR | CHANNEL | STRUCTURAL BASIS | CA2 | NA+ | PHARMACOLOGY & PHARMACY | Blood pressure | G proteins | L-type calcium channel | HYPERTENSION
Journal Article
ChemMedChem, ISSN 1860-7179, 06/2017, Volume 12, Issue 11, pp. 785 - 785
The front cover picture shows the X‐ray crystal structure of the natural product, cyclic depsipeptide YM‐254890 bound to the Gαi/q protein (PDB: 3AH8).... 
G protein-coupled receptors | biological activity | YM-254890 | structure–activity relationships | peptide synthesis | Proteins | Signal transduction | Inhibitors | Equivalence | Natural products | Inhibition | Information dissemination | Crystal structure | GDP/GTP exchange factors
Journal Article
CHEMMEDCHEM, ISSN 1860-7179, 06/2017, Volume 12, Issue 11, pp. 830 - 834
Extracellular signals perceived by Gprotein-coupled receptors are transmitted via Gproteins, and subsequent intracellular signaling cascades result in a... 
ACTIVATION | CHEMISTRY, MEDICINAL | biological activity | PLATELET-AGGREGATION INHIBITOR | YM-254890 | TOXIN | CHROMOBACTERIUM SP QS3666 | CYSTEINE | MECHANISMS | Gprotein-coupled receptors | G(Q/11) INHIBITOR | structure-activity relationships | ADP-RIBOSYLATION | PHARMACOLOGY & PHARMACY | ADENYLATE-CYCLASE | peptide synthesis
Journal Article
PLATELETS, ISSN 0953-7104, 2015, Volume 26, Issue 8, pp. 771 - 778
G alpha(q) plays an important role in platelet activation by agonists such as thrombin, adenosine diphosphate (ADP) and thromboxane. The significance of G... 
PATHWAYS | ACTIVATION | GTP-binding protein alpha subunit | YM-254890 | PHOSPHORYLATION | RELEASE | G-PROTEIN | platelets | platelet aggregation | CELL BIOLOGY | specificity | GENERATION | G(12/13) | RECEPTORS | HEMATOLOGY
Journal Article
Nature Chemistry, ISSN 1755-4330, 11/2016, Volume 8, Issue 11, pp. 1035 - 1041
Journal Article
Journal Article
Thrombosis and Haemostasis, ISSN 0340-6245, 09/2003, Volume 90, Issue 3, pp. 406 - 413
Journal Article
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