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Journal of Biological Chemistry, ISSN 0021-9258, 10/2012, Volume 287, Issue 41, pp. 34149 - 34156
Dectin-1 is a pattern recognition receptor that is important for innate immune responses against fungi in humans and mice. Dectin-1 binds to beta-glucans in... 
YEAST | CELLS | RESPONSES | PHAGOCYTOSIS | ACTIVATION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-GLUCAN RECOGNITION | RECEPTOR | AUTOPHAGY | DECTIN-1 | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Lectins, C-Type - immunology | NADPH Oxidases - immunology | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Lectins, C-Type - genetics | Enzyme Activation - immunology | Protein-Tyrosine Kinases - immunology | CD4-Positive T-Lymphocytes - immunology | Lectins, C-Type - metabolism | Phagosomes - immunology | Protein-Tyrosine Kinases - genetics | Bone Marrow Cells - immunology | NADPH Oxidases - genetics | Histocompatibility Antigens Class II - metabolism | beta-Glucans - immunology | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Macrophages - immunology | Cell Line | Bone Marrow Cells - cytology | Antigens, Fungal - metabolism | CD4-Positive T-Lymphocytes - cytology | Phagosomes - metabolism | CD4-Positive T-Lymphocytes - metabolism | Antigens, Fungal - immunology | Macrophages - cytology | Mice, Knockout | Microtubule-Associated Proteins - immunology | beta-Glucans - metabolism | Animals | Histocompatibility Antigens Class II - immunology | Autophagy-Related Protein 5 | Protein Binding | Dendritic Cells - cytology | Mice | Histocompatibility Antigens Class II - genetics | Enzyme Activation - genetics | Antigen Presentation - physiology | Phagosomes - genetics | Lectin | Dectin-1 | Immunology | Dendritic Cells | Innate Immunity | Macrophages | Phagocytosis
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2012, Volume 8, Issue 7, p. 24
Vaccines may help reduce the growing incidence of fungal infections in immune-suppressed patients. We have found that, even in the absence of CD4(+) T-cell... 
DEFENSE | ACTIVATION | MICROBIOLOGY | IL-23 | DECTIN-1 | RESPONSES | PNEUMOCYSTIS-CARINII | VIROLOGY | INTERLEUKIN-17 | IL-17 | PARASITOLOGY | TH17 CELLS | ANTIGEN | Lung - microbiology | Receptors, CCR6 - biosynthesis | Interleukin-17 - immunology | Fungal Vaccines - immunology | Blastomycosis - immunology | Lung Diseases, Fungal - microbiology | Histoplasmosis - immunology | CD4-Positive T-Lymphocytes - immunology | Lectins, C-Type - metabolism | Histoplasma - pathogenicity | Receptors, Immunologic - biosynthesis | Receptors, CCR6 - metabolism | Pneumonia - immunology | Blastomyces - pathogenicity | Immunologic Deficiency Syndromes - immunology | Immunologic Memory - immunology | Interleukin-12 - biosynthesis | Lung Diseases, Fungal - immunology | Signal Transduction | Mice, Inbred C57BL | Receptors, CXCR3 - biosynthesis | Hepatocyte Nuclear Factor 1-alpha | Neutrophils - immunology | Pneumonia - microbiology | Interleukin-17 - biosynthesis | Mice, Knockout | Histoplasma - immunology | Cell Differentiation - immunology | T Cell Transcription Factor 1 - biosynthesis | Animals | Interleukin-6 - immunology | Interleukin-6 - biosynthesis | Th17 Cells - immunology | Blastomyces - immunology | Mice | Immunocompromised Host | CD8-Positive T-Lymphocytes - immunology | Lung - immunology | Fungi | Medical research | Flow cytometry | Pneumonia | Cytokines | Lymphocytes | Rodents | Cytotoxicity | Vaccines | Fungal infections | Experiments
Journal Article
Vaccine, ISSN 0264-410X, 2015, Volume 33, Issue 10, pp. 1274 - 1283
Journal Article
PLoS Pathogens, ISSN 1553-7366, 01/2010, Volume 6, Issue 1, p. e1000714
Journal Article
PLoS Pathogens, ISSN 1553-7366, 05/2018, Volume 14, Issue 5, p. e1007069
The opportunistic fungal pathogen Candida albicans frequently causes diseases such as oropharyngeal candidiasis (OPC) in immunocompromised individuals.... 
FUNGAL-INFECTION | MICROBIOLOGY | CHRONIC MUCOCUTANEOUS CANDIDIASIS | LANGERHANS CELLS | HYPER-IGE SYNDROME | VIROLOGY | IL-17-PRODUCING T-CELLS | HOST-DEFENSE | STAT1 MUTATIONS | CONVENTIONAL DENDRITIC CELLS | LYMPHOID-CELLS | PARASITOLOGY | TH17 CELLS | Mononuclear Phagocyte System - immunology | Spleen - immunology | Dendritic Cells - immunology | Lectins, C-Type - immunology | Tongue - microbiology | Male | Leukocytes - immunology | Flow Cytometry | Female | Tongue - cytology | Interleukin-1beta - biosynthesis | Cytokines - immunology | Mouth Mucosa - cytology | Mouth Mucosa - microbiology | Tongue - immunology | Specific Pathogen-Free Organisms | Thy-1 Antigens - immunology | Mice, Inbred C57BL | Mouth Mucosa - immunology | Neutrophils - immunology | Spleen - cytology | Interleukin-17 - biosynthesis | Candida albicans - immunology | Interleukin-23 - immunology | Candidiasis, Oral - immunology | Animals | Mannose-Binding Lectins - immunology | Candidiasis, Oral - microbiology | Interleukin-23 - biosynthesis | Interleukin-6 - biosynthesis | Mice | Antigens, Surface - immunology | Candidiasis | Tongue | Mucosal immunity | Fungicides | Cytokines | Dendritic cells | Mucosa | Opportunist infection | Interleukin 23 | Infections | Lymphocytes T | Inflammation | Leukocytes | Macrophages | Immunity | Interleukin 17 | Interleukin 6 | White blood cells | CD90 antigen | Monocytes | Immunology | Lymphocytes | Rodents | Population
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e68434
Glycoprotein gp43 is an immunodominant diagnostic antigen for paracoccidioidomycosis caused by Paracoccidioides brasiliensis. It is abundantly secreted in... 
PROTEOLYTIC ACTIVITY | FUNGUS | MAJOR DIAGNOSTIC ANTIGEN | MULTIDISCIPLINARY SCIENCES | IMMUNODIFFUSION TESTS | 43-KILODALTON GLYCOPROTEIN | EXOCELLULAR COMPONENTS | 43 KDA GLYCOPROTEIN | INFLAMMATORY RESPONSE | BALB/C MICE | YEAST PHASE | Paracoccidioides - immunology | Tumor Necrosis Factor-alpha - metabolism | Lung - microbiology | Virulence Factors - genetics | Gene Expression - genetics | Tumor Necrosis Factor-alpha - genetics | Glycoproteins - metabolism | Paracoccidioidomycosis - metabolism | Virulence Factors - immunology | Mutation - immunology | Paracoccidioidomycosis - genetics | Fungal Proteins - immunology | Paracoccidioides - metabolism | Antigens, Fungal - genetics | Gene Expression - immunology | Paracoccidioidomycosis - immunology | Tumor Necrosis Factor-alpha - immunology | Paracoccidioides - genetics | Lung - metabolism | Interleukin-6 - metabolism | Glycoproteins - genetics | Genetic Vectors - immunology | Interleukin-6 - genetics | Antigens, Fungal - metabolism | Genetic Vectors - metabolism | RNA, Antisense - immunology | Antigens, Fungal - immunology | Fungal Proteins - genetics | Mutation - genetics | Genetic Vectors - genetics | Glycoproteins - immunology | Animals | Paracoccidioidomycosis - microbiology | Interleukin-6 - immunology | Virulence Factors - metabolism | Mice | Mice, Inbred BALB C | Lung - immunology | Fungal Proteins - metabolism | RNA, Antisense - genetics | Infection | Viral antibodies | Fibronectins | Antigens | Genetically modified organisms | Antibodies | Antisense RNA | B cells | Health aspects | Protein binding | Cell culture | Transformation | Yeast | Virulence | Cytology | Immunoblotting | Infections | Biology | Macrophages | Fibronectin | Fungi | Interleukin 6 | Proteins | Laminin | Extracellular matrix | Genetic modification | Killing | Pathogens | Glycoprotein gp43 | Immune response | Cytokines | Glycoprotein | Tumor necrosis factor-α | Gene expression | Ribonucleic acid--RNA | Mutants | Pathogenicity | Chemotherapy | Lungs | γ-Interferon | Monoclonal antibodies | Interferon | Diagnostic systems | South American blastomycosis | RNA | Ribonucleic acid
Journal Article
PLoS One, ISSN 1932-6203, 2014, Volume 9, Issue 11, p. e112472
The commensal yeast Candida albicans is part of the human intestinal microflora and is considered a "pathobiont", a resident microbe with pathogenic potential... 
YEAST | FUNGI | BOWEL DISEASES | MULTIDISCIPLINARY SCIENCES | DISTINCT | INDUCED COLITIS | MICROBIOTA | CELL DEVELOPMENT | LINEAGE | DECTIN-1 | Immunohistochemistry | Spleen - immunology | Protein-Tyrosine Kinases - metabolism | Colitis - genetics | Humans | Interleukin-17 - immunology | Colon - immunology | Intestines - metabolism | Candidiasis - microbiology | Intestines - immunology | Protein-Tyrosine Kinases - immunology | Host-Pathogen Interactions - immunology | Protein-Tyrosine Kinases - genetics | Inflammation Mediators - metabolism | Interleukin-10 - metabolism | Candida albicans - physiology | Candidiasis - immunology | Colitis - immunology | Spleen - pathology | Macrophages - immunology | Macrophages - microbiology | Cytokines - immunology | Inflammation Mediators - immunology | Transforming Growth Factor beta - immunology | Cytokines - metabolism | Colon - pathology | Candida albicans - immunology | Colon - metabolism | Mice, Knockout | Candidiasis - metabolism | Interleukin-17 - metabolism | Macrophages - metabolism | Animals | Colitis - microbiology | Intestines - microbiology | Spleen - metabolism | Dextran Sulfate - immunology | Organ Size - immunology | Interleukin-10 - immunology | Transforming Growth Factor beta - metabolism | Tyrosine | Enzymes | Microbiota (Symbiotic organisms) | Antifungal agents | Inflammation | Transforming growth factors | Sulfates | Dextran | Analysis | Gastrointestinal system | Phenols | Bone morphogenetic proteins | Colitis | Drinking water | Biomedical research | Yeast | Fungicides | Microflora | Infections | Macrophages | Immunity | Experiments | Fungi | Receptors | Microbiota | Lymphocytes | Intestine | Rodents | Sodium sulfate | Colon | Intestinal microflora | Protein-tyrosine kinase | Spleen | Medical research | Immunoglobulins | Cytokines | Neutrophils | Histology | Gastrointestinal tract | Adaptive immunity | Clustering | Bruton's tyrosine kinase | Crohns disease | Inflammatory bowel disease | Signaling | Antibiotics | Sodium | Correlation analysis | Interleukin 10 | Mice | Infiltration | Sulfate | Laboratory animals | Colonization
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 2, pp. 558 - 567.e11
Background Allergen immunotherapy (AIT) is the only curative treatment for allergy. AIT faces pitfalls related to efficacy, security, duration, and patient... 
Allergy and Immunology | immunomodulation | dendritic cells | regulatory T cells | vaccines | neoglycans | mannan | Allergen immunotherapy | allergoids | INTRALYMPHATIC IMMUNOTHERAPY | TOLERANCE | CONSENSUS | RECEPTOR | NECROSIS-FACTOR-ALPHA | MICROBIOTA | LECTINS | IMMUNOLOGY | regulatory T cells | RESPONSES | FRAGMENTS | ALLERGY | IMMUNE REGULATION | Poaceae - immunology | T-Lymphocytes, Regulatory - metabolism | Cytokines - metabolism | Rhinitis, Allergic, Seasonal - metabolism | Adjuvants, Immunologic | Plant Extracts | Dendritic Cells - immunology | Humans | Vaccines - immunology | Pollen - immunology | Allergens - metabolism | Rhinitis, Allergic, Seasonal - immunology | T-Lymphocytes, Regulatory - immunology | B7-H1 Antigen - metabolism | Animals | Allergens - immunology | Immune Tolerance - immunology | Mannans | Antibodies, Blocking - immunology | Antibodies - immunology | Mice | Dendritic Cells - metabolism | Allergy | Medical colleges | Allergens | Dendritic cells | Immunotherapy | Vaccines | T cells | Molecular biology | Allergic reaction | Patient compliance | Medical research | Crosslinked polymers | Immunoglobulin E | Medicine, Experimental | Nuclear magnetic resonance--NMR | Yeast | Cytokines | Clinical trials | Grasses | Experiments | Patients | Allergies | Asthma | Human subjects | Ethics | Ligands | Software | Oxidation
Journal Article