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Molecular cell, ISSN 1097-2765, 2009, Volume 35, Issue 5, pp. 563 - 573
The target of rapamycin complex 1 (TORC1) is a central regulator of eukaryotic cell growth that is activated by a variety of hormones (e.g., insulin) and... 
CELLBIO | PROTEINS | SIGNALING | YEAST SACCHAROMYCES-CEREVISIAE | CELL-GROWTH CONTROL | SIGNALING PATHWAYS | FUNCTIONAL HOMOLOG | RAG GTPASES | VACUOLE FUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMINO-ACID PERMEASE | COMPONENT | GTP-BINDING PROTEINS | GAP1 PERMEASE | CELL BIOLOGY | Vacuoles - enzymology | Intracellular Membranes - enzymology | Saccharomyces cerevisiae - genetics | Multiprotein Complexes | Adaptor Proteins, Vesicular Transport - genetics | Saccharomyces cerevisiae - drug effects | Guanosine Triphosphate - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Vacuoles - drug effects | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Guanosine Diphosphate - metabolism | Protein Synthesis Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Monomeric GTP-Binding Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Amino Acid Transport Systems - metabolism | Sirolimus - pharmacology | Cycloheximide - pharmacology | Protein Transport | Transcription Factors - metabolism | Monomeric GTP-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Endosomes - enzymology | Intracellular Membranes - drug effects | Mutation | Saccharomyces cerevisiae - growth & development | Proteins | Purines | Amino acids | Gross domestic product | Guanosine
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 330, Issue 6000, pp. 70 - 74
Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific yew tree. Currently, cost-efficient production of Taxol and its... 
Enzymes | Cellular metabolism | Terpenoids | Chemical engineering | Bioreactors | Plasmids | REPORTS | Operons | Biosynthesis | Indoles | Streams | YEAST | CYTOCHROME-P450 | TAXADIENE | CELLS | MULTIDISCIPLINARY SCIENCES | CONSTRUCTION | BIOSYNTHETIC GENES | STEP | OXYGENASES | LYCOPENE PRODUCTION | TERPENOIDS | Metabolomics | NADPH-Ferrihemoprotein Reductase - genetics | Erythritol - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Taxoids - metabolism | Organophosphorus Compounds - metabolism | Recombinant Fusion Proteins - metabolism | Farnesyltranstransferase - metabolism | Escherichia coli K12 - metabolism | Hemiterpenes - metabolism | Indoles - metabolism | Terpenes - metabolism | Erythritol - metabolism | Isomerases - genetics | Diterpenes - metabolism | NADPH-Ferrihemoprotein Reductase - metabolism | Paclitaxel - biosynthesis | Oxidation-Reduction | Fermentation | Taxus - enzymology | Metabolic Networks and Pathways - genetics | Genetic Engineering | Sugar Phosphates - metabolism | Farnesyltranstransferase - genetics | Cytochrome P-450 Enzyme System - genetics | Isomerases - metabolism | Escherichia coli K12 - genetics | Alkenes - metabolism | Escherichia coli K12 - enzymology | Physiological aspects | Research | Health aspects | Escherichia coli | Biological transport | Biochemistry | Pharmacology | E coli
Journal Article
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2012, Volume 337, Issue 6090, pp. 96 - 100
Pyruvate constitutes a critical branch point in cellular carbon metabolism. We have identified two proteins, Mpc1 and Mpc2, as essential for mitochondrial pyruvate transport in yeast, , and humans... 
Yeasts | Mitochondria | Diet | Plasmids | Drosophila | REPORTS | Amino acids | Oxidation | Respiration | Sugars | Medical schools | RAT-LIVER | TRANSPORT | COMPLEX | MECHANISM | IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | Metabolomics | Humans | Molecular Sequence Data | Mitochondrial Proteins - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Anion Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - genetics | Drosophila melanogaster - metabolism | Saccharomyces cerevisiae - metabolism | Amino Acids - metabolism | Biological Transport | Mitochondrial Proteins - metabolism | Pyruvic Acid - metabolism | Amino Acid Sequence | Mitochondrial Membrane Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - metabolism | Oxidation-Reduction | Carbohydrate Metabolism | Mitochondria - metabolism | Drosophila Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Anion Transport Proteins - metabolism | Citric Acid Cycle | Mitochondrial Membranes - metabolism | Point Mutation | Animals | Drosophila melanogaster - chemistry | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Drosophila Proteins - genetics | Anion Transport Proteins - genetics | Saccharomyces cerevisiae Proteins - chemistry | Cell metabolism | Pyruvates | Chemical properties | Research | Molecular biology | Proteins | Yeast | Metabolism | Carriers | Human | Bacteria | Transport | Transporter
Journal Article
Journal Article
The Plant cell, ISSN 1532-298X, 2017, Volume 29, Issue 12, pp. 3234 - 3254
...., 2016). Reactive carbonyl species are highly reactive biological compounds that are unavoidably produced during cellular metabolism in all domains of life... 
RESEARCH ARTICLES | ARABIDOPSIS-THALIANA | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | GLYCATION | D-LACTATE DEHYDROGENASE | PLANT SCIENCES | CELL BIOLOGY | SUBSTRATE-SPECIFICITY | ENCODING GENES | GENOME-WIDE ANALYSIS | METHYLGLYOXAL | GLYOXALASE-I | Inactivation, Metabolic | Arabidopsis - enzymology | Glutathione - metabolism | Eukaryotic Cells - metabolism | RNA, Messenger - metabolism | Arabidopsis Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Protoplasts - metabolism | Pyruvaldehyde - metabolism | Isoenzymes - metabolism | Gene Expression Regulation, Plant | Free Radicals - metabolism | Plant Cells - metabolism | Lactoylglutathione Lyase - metabolism | Stress, Physiological - genetics | Alternative Splicing - genetics | Arabidopsis - cytology | RNA, Messenger - genetics | Mutation - genetics | Subcellular Fractions - metabolism | Chloroplasts - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Metals - metabolism | Plant Leaves - metabolism | Models, Biological | Cytosol - metabolism | Sugars - metabolism | Arabidopsis thaliana | Glucose metabolism | Defense industry | Germination | Glutamine | Alternative splicing | Yeast | Transcription | Splicing | Detoxification | Byproducts | Chemical reactions | Homology | Cytosol | Seedlings | Mitochondria | Developmental stages | Chloroplasts | Coding | Compartments | Isoforms | Glycolysis | Biocompatibility | Lactoylglutathione lyase | Pyruvaldehyde | Species | Sugar | Carbonyls | Index Medicus
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2006, Volume 116, Issue 4, pp. 916 - 928
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 505, Issue 7482, pp. 239 - 243
Journal Article
Nature (London), ISSN 1476-4687, 2019, Volume 572, Issue 7768, pp. 249 - 253
Journal Article
Science (American Association for the Advancement of Science), ISSN 0036-8075, 7/2012, Volume 337, Issue 6091, pp. 195 - 199
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 524, Issue 7566, pp. 481 - 484
Mitochondria are multifunctional organelles whose dysfunction leads to neuromuscular degeneration and ageing. The multifunctionality poses a great challenge... 
YEAST | LIFE-SPAN | COMPLEX | DISEASES | ADENINE-NUCLEOTIDE TRANSLOCATOR | DNA | MULTIDISCIPLINARY SCIENCES | PROTEOMIC ANALYSIS | SACCHAROMYCES-CEREVISIAE | CAP-INDEPENDENT TRANSLATION | ISOBARIC TAGS | Up-Regulation | Proteome - genetics | Saccharomyces cerevisiae - genetics | Stress, Physiological |