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Biochemical journal, ISSN 1470-8728, 2010, Volume 427, Issue 1, pp. 69 - 78
More than 200 phosphorylated 14-3-3-binding sites in the literature were analysed to define 14-3-3 specificities, identify relevant protein kinases, and give insights into how cellular 14-3-3... 
Evolution | 14-3-3 protein | Disrupted-in-schizophrenia 1 (DISC1) | calmodulin-dependent protein kinase | AGC protein kinase | NEURONAL MIGRATION | SIGNALING PATHWAYS | MEMBRANE H+-ATPASE | REGULATING 14-3-3 BINDING | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | EUKARYOTIC PROTEIN-KINASES | evolution | NUCLEAR-LOCALIZATION | EXOENZYME-S | STRUCTURAL BASIS | Ca2+/calmodulin-dependent protein kinase | disrupted-in-schizophrenia 1 (DISC1) | ENDOPLASMIC-RETICULUM | Protein Kinases - metabolism | Phosphorylation | Immunoprecipitation | Humans | RNA, Messenger - genetics | Cells, Cultured | Computational Biology | Kidney - cytology | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | 14-3-3 Proteins - metabolism | Nerve Tissue Proteins - metabolism | Kidney - metabolism | Carrier Proteins - metabolism | Protein Binding | Binding Sites | Dimerization | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | 14-3-3 Proteins - genetics | Bcl-2-associated death promoter | AANAT, serotonin acetyltransferase | FOXO, Forkhead box O | KLC, kinesin light chain | CDK5, cyclin-dependent kinase 5 | HEK, human embryonic kidney | MARK, microtubule affinity-regulating kinase | AMPK, AMP-activated protein kinase | EST, expressed sequence tag | PKB, protein kinase B | RSK, ribosomal S6 kinase | CaMK, Ca2 | GLUT4, glucose transporter 4 | protein kinase G | GST, glutathione transferase | HDAC, histone deacetylase | HAP1A, Huntingtin-associated protein 1A | DIG, digoxigenin | PKC, protein kinase C | BAD, Bcl-XL | PP2A, protein phosphatase 2A | DSTT, Division of Signal Transduction Therapy | HA, haemagglutinin | AGC, protein kinase A | Ca2 | PI4K, phosphoinositide 4-kinase | DISC1, disrupted-in-schizophrenia 1 | protein kinase C family kinase | YAP1, yes-associated protein 1
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 43, pp. 17368 - 17373
Large tumor suppressor (LATS)1/2 protein kinases transmit Hippo signaling in response to intercellular contacts and serum levels to limit cell growth via the inhibition of Yes-associated protein (YAP... 
Cell growth | Phosphorylation | Starvation | Epithelial cells | Cell lines | Actins | Gene expression regulation | Breast cancer | Cellular immunity | Endothelial cells | Itch | Growth control | YES-ASSOCIATED PROTEIN | MIGRATION | REGULATOR | COMPLEX | DOMAIN | ACTIN | MULTIDISCIPLINARY SCIENCES | growth control | breast cancer | HIPPO PATHWAY REGULATION | FAMILY PROTEINS | Transcription, Genetic - drug effects | Humans | Phosphoproteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | MCF-7 Cells | RNA Interference | Tumor Suppressor Proteins - genetics | HEK293 Cells | Membrane Proteins - metabolism | Phosphorylation - drug effects | Culture Media, Serum-Free - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | 14-3-3 Proteins - genetics | Amino Acid Sequence | Cell Line | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Repressor Proteins - genetics | Serine - genetics | Binding Sites - genetics | Phosphoproteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Serine - metabolism | Blotting, Western | 14-3-3 Proteins - metabolism | Microscopy, Confocal | Animals | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Protein Binding | Cell Proliferation - drug effects | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Cell proliferation | Physiological aspects | Genetic transcription | Research | Protein kinases | Biological Sciences
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 08/2016, Volume 291, Issue 34, pp. 17988 - 18005
We examined the regulation of Yes-associated protein (YAP) localization, phosphorylation, and transcriptional activity in intestinal epithelial cells... 
yes-associated protein (YAP) | ANG-II | G(Q)-COUPLED RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEAR EXPORT SIGNALS | HIPPO PATHWAY | DNA-SYNTHESIS | ANTITUMOR-ACTIVITY | protein kinase D (PKD) | ACTIVATION LOOP SER | LYSOPHOSPHATIDIC ACID | angiotensin II | protein kinase C (PKC) | IN-VIVO | G protein-coupled receptor (GPCR) | PHORBOL ESTERS | Protein Kinase C - genetics | Receptors, G-Protein-Coupled - metabolism | Enterocytes - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Cytoplasm - metabolism | Protein Transport - drug effects | Receptors, G-Protein-Coupled - agonists | Phosphorylation - genetics | Cell Nucleus - metabolism | Protein Kinase C - metabolism | Amyloid beta-Protein Precursor - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoplasm - genetics | Phosphorylation - drug effects | Peptide Fragments - genetics | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Peptide Fragments - metabolism | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Rats | Protein Kinase C - antagonists & inhibitors | Thiazepines - pharmacology | Pyrimidines - pharmacology | Transcription Factors - genetics | Protein Transport - genetics | Apoptosis Regulatory Proteins - metabolism | Transcription Factors - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Cell Nucleus - genetics | Receptors, G-Protein-Coupled - genetics | Cell Biology
Journal Article
Nature cell biology, ISSN 1465-7392, 2017, Volume 19, Issue 8, pp. 996 - 1002
The Hippo pathway controls organ size and tissue homeostasis, with deregulation leading to cancer. The core Hippo components in mammals are composed of the... 
LOCALIZATION | HOMEOSTASIS | PHOSPHORYLATION | YAP/TAZ | YAP | STRESS | NLK | TAZ | CANCER | KINASES | CELL BIOLOGY | Osmotic Pressure | Phosphorylation | Cell Proliferation | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Transfection | Neoplasms - genetics | Time Factors | HEK293 Cells | Muscle Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cytoplasm - enzymology | Signal Transduction | Neoplasms - enzymology | p38 Mitogen-Activated Protein Kinases - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Protein Transport | Muscle Proteins - genetics | Transcription Factors - metabolism | Animals | Mice, Nude | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Protein Binding | Adaptor Proteins, Signal Transducing - metabolism | Neoplasms - pathology | Smad protein | Deregulation | Transcription factors | Gene regulation | Serine | Homeostasis | Dephosphorylation | NF-AT protein | Kinases | Inactivation | Signal transduction | Localization | Deoxyribonucleic acid--DNA | Translocation | Transducers | Deactivation | Threonine | MAP kinase | Gene expression | Nuclear transport | Environmental stress | Yes-associated protein | Tea | Signaling | Cancer
Journal Article
Genes & development, ISSN 0890-9369, 2007, Volume 21, Issue 21, pp. 2747 - 2761
.... Here we show that in mammalian cells, the transcription coactivator YAP ( Yes-associated protein... 
Contact inhibition | Lats | YAP | NF2 | Hippo | Mst | YES-ASSOCIATED PROTEIN | hippo | PROLIFERATION ARREST | SIZE CONTROL | lats | DEVELOPMENTAL BIOLOGY | mst | CELL BIOLOGY | ORGAN SIZE | SIGNALING PATHWAY | CYCLE EXIT | GENETICS & HEREDITY | IMAGINAL DISC | contact inhibition | BANTAM MICRORNA | TUMOR-SUPPRESSOR PATHWAY | PROMOTES APOPTOSIS | Protein Kinases - metabolism | NIH 3T3 Cells | Phosphorylation | Cell Proliferation | Cell Count | Humans | Drosophila Proteins - metabolism | Trans-Activators - chemistry | Contact Inhibition - genetics | Trans-Activators - physiology | Drosophila Proteins - physiology | Drosophila Proteins - antagonists & inhibitors | Drosophila - genetics | Amino Acid Sequence | Protein-Serine-Threonine Kinases - physiology | Cells, Cultured | Intracellular Signaling Peptides and Proteins | Nuclear Proteins - metabolism | Cell Communication - genetics | Drosophila Proteins - chemistry | Nuclear Proteins - chemistry | Amino Acid Motifs | Protein Transport | 14-3-3 Proteins - metabolism | Animals | Models, Biological | Nuclear Proteins - antagonists & inhibitors | Protein Binding | Signal Transduction - physiology | Trans-Activators - metabolism | Drosophila - growth & development | Mice | Nuclear Proteins - physiology | HeLa Cells | Trans-Activators - antagonists & inhibitors | Cell proliferation | Drosophila | Tumor suppressor genes | Genetic aspects | Research | Genetic transcription | Apoptosis | Research Paper
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2011, Volume 286, Issue 9, pp. 7018 - 7026
The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by phosphorylating them for cytoplasmic sequestration or degradation. In... 
YES-ASSOCIATED PROTEIN | EPITHELIAL-MESENCHYMAL TRANSITION | CELL CONTACT INHIBITION | WW DOMAIN | GROWTH-CONTROL | ORGAN SIZE CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ONCOGENIC TRANSFORMATION | BINDING | CANCER | Adaptor Proteins, Signal Transducing - chemistry | Protein Interaction Domains and Motifs - physiology | Humans | Intercellular Signaling Peptides and Proteins - chemistry | Cytoplasm - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Intercellular Signaling Peptides and Proteins - metabolism | HEK293 Cells | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein Structure, Tertiary | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Phosphoproteins - genetics | Cell Division - physiology | Transcription, Genetic - physiology | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Connective Tissue Growth Factor - genetics | Adaptor Proteins, Signal Transducing - metabolism | Connective Tissue Growth Factor - metabolism | Gene Transcription | Transcription Coactivators | Signal Transduction | AmotL1 | YAP | Transcription Factors | Serine Threonine Protein Kinase | Hippo Pathway | TAZ | Amot
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 10, p. e75483
Ras association domain family protein 1A (RASSF1A) is a tumor suppressor gene silenced in cancer... 
YES-ASSOCIATED PROTEIN | APOPTOSIS | C-ABL | DNA METHYLTRANSFERASE-1 | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | YAP | STEM-CELL PROLIFERATION | NF-KAPPA-B | PROMOTES | P53 | Inflammation - pathology | Apoptosis - drug effects | Colitis, Ulcerative - genetics | Colon - drug effects | NF-kappa B - metabolism | Intestinal Mucosa - drug effects | Tumor Suppressor Proteins - deficiency | Colitis, Ulcerative - drug therapy | Toll-Like Receptors - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Colon - pathology | bcl-2-Associated X Protein - metabolism | Epithelial Cells - pathology | Colitis, Ulcerative - pathology | Pyrimidines - pharmacology | Piperazines - pharmacology | Colon - metabolism | Mice, Knockout | Tumor Protein p73 | Toll-Like Receptors - genetics | Mice | Intestinal Mucosa - pathology | Inflammation - chemically induced | Dextran Sulfate | Intestinal Mucosa - metabolism | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Phosphoproteins - metabolism | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Inflammation - drug therapy | Tumor Suppressor Proteins - genetics | Benzamides - pharmacology | Nuclear Proteins - genetics | bcl-2-Associated X Protein - genetics | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Phosphoproteins - genetics | DNA-Binding Proteins - genetics | Imatinib Mesylate | Proto-Oncogene Proteins c-abl - pharmacology | Animals | NF-kappa B - genetics | Colitis, Ulcerative - chemically induced | Adaptor Proteins, Signal Transducing - genetics | Inflammation - genetics | Cell Proliferation - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Tyrosine | Genes | Inflammation | Permeability | Dextran | Cell death | Gastrointestinal diseases | Genetic aspects | Genetic engineering | Colitis | Tumor proteins | Tumors | Cancer | Pediatrics | p53 Protein | Biochemistry | Proteins | Physiology | Tumorigenesis | Inhibition | Damage accumulation | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Imatinib | Mortality | Gene expression | Survival | Yes-associated protein | Inflammatory bowel disease | Cell injury | Sodium | Pharmacy | TNF inhibitors | Oxidative stress | Phosphorylation | Inflammatory bowel diseases | Bax protein | Epithelial cells | Gene regulation | DNA damage | Homeostasis | Kinases | Accumulation | Intestine | Rodents | Cell cycle | DNA methylation | Toll-like receptors | Injuries | Pharmaceutical sciences | Immune system | Cell survival | Gordon, Marilyn | Dentistry | Medicine | Lymphocytes B | Epigenetics | Tumor suppressor genes | Kidney diseases | Diabetes | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 424 - 15
Transition from pluripotency to differentiation is a pivotal yet poorly understood developmental step. Here, we show that the tumour suppressor RASSF1A is a... 
GATA FACTORS | DNA METHYLATION DYNAMICS | ZYGOTIC GENE-EXPRESSION | TGF-BETA | PROTEIN | PATHWAY | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | TRANSCRIPTION | SELF-RENEWAL | PREIMPLANTATION MOUSE DEVELOPMENT | Embryonic Stem Cells - cytology | Humans | Tumor Protein p73 - genetics | Male | Phosphoproteins - metabolism | Wnt Proteins - metabolism | Tumor Protein p73 - metabolism | DNA-Binding Proteins - metabolism | Octamer Transcription Factor-3 - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Tumor Suppressor Proteins - genetics | Mice, Inbred CBA | Female | Cell Differentiation | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Phosphoproteins - genetics | beta Catenin - metabolism | Embryonic Stem Cells - physiology | Transcription Factors - metabolism | Animals | Octamer Transcription Factor-3 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cell Cycle Proteins | Wnt protein | Quaternary | Oct-4 protein | Yes-associated protein | GATA-1 protein | β-catenin | Demethylation | Signaling | Cell fate | Stem cells | Differentiation | Pluripotency | Tumors
Journal Article
PLoS biology, ISSN 1545-7885, 2019, Volume 17, Issue 10, p. e3000509
The Hippo signalling pathway restricts cell proliferation in animal tissues by inhibiting Yes-associated protein (YAP or YAP1... 
DROSOPHILA HOMOLOG | FACTOR-I IGF-1 | PROTEIN-KINASE-B | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | INSULIN-LIKE PEPTIDES | YORKIE PHOSPHORYLATION | WING IMAGINAL DISC | CELL-GROWTH | PHOSPHOINOSITIDE 3-KINASE | TUMOR-SUPPRESSOR PATHWAY | Cell Polarity | Wings, Animal - cytology | Cell Proliferation | Epithelial Cells - metabolism | Humans | Insulin-Like Growth Factor I - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Proto-Oncogene Proteins c-akt - genetics | Drosophila melanogaster - metabolism | Cell Nucleus - metabolism | Wings, Animal - growth & development | Gene Expression Regulation, Developmental | Receptor, Insulin - genetics | Larva - growth & development | Trans-Activators - genetics | Female | Larva - genetics | Epithelial Cells - cytology | Nuclear Proteins - genetics | Ovarian Follicle - cytology | Proto-Oncogene Proteins c-akt - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Ovarian Follicle - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Protein-Serine-Threonine Kinases - metabolism | 3-Phosphoinositide-Dependent Protein Kinases - genetics | Ovarian Follicle - growth & development | Larva - metabolism | Drosophila melanogaster - cytology | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | 3-Phosphoinositide-Dependent Protein Kinases - metabolism | Cell Nucleus - ultrastructure | Larva - cytology | Protein Transport | Mechanotransduction, Cellular | Wings, Animal - metabolism | Biomechanical Phenomena | Animals | Phosphatidylinositol 3-Kinase - genetics | Drosophila melanogaster - growth & development | Receptor, Insulin - metabolism | Trans-Activators - metabolism | Mice | Drosophila Proteins - genetics | Insulin-Like Growth Factor I - metabolism | Cell proliferation | Phosphorylation | Authorship | Laboratories | Insulin-like growth factor I | Epithelial cells | Homology | AKT protein | Biology | Insulin-like growth factors | Kinases | Proteins | Signal transduction | Mechanics (physics) | Cell growth | Animal tissues | Polarity | Growth factors | Deoxyribonucleic acid--DNA | Cues | Inositol | Cell division | Crick, Francis | RNA polymerase | Epithelium | Insulin | 1-Phosphatidylinositol 3-kinase | Feeding | Yes-associated protein | Signaling | Insects | Skin | Nuclei (cytology) | Cytoplasm | Tumors | Cancer | Apoptosis | Deoxyribonucleic acid | Drosophila | DNA
Journal Article