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Hepatology, ISSN 0270-9139, 05/2018, Volume 67, Issue 5, pp. 1823 - 1841
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2012, Volume 444, Issue 2, pp. 279 - 289
AMOT (angiomotin) is a membrane-associated protein that is expressed in ECs (endothelial cells) and controls migration, TJ (tight junction) formation, cell... 
Degradation | Ubiquitination | Stability | Yes-associated protein (YAP) | Neural-precursor-cell-expressed developmentally down-regulated 4 (Nedd4) | Angiomotin (AMOT) | ubiquitination | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEDIATED DEGRADATION | degradation | neural-precursor-cell-expressed developmentally down-regulated 4 (Nedd4) | angiomotin (AMOT) | stability | Humans | Ubiquitin - metabolism | Endosomal Sorting Complexes Required for Transport - genetics | Molecular Sequence Data | Ubiquitin-Protein Ligases - physiology | Gene Knockdown Techniques | Intercellular Signaling Peptides and Proteins - metabolism | Protein Isoforms - metabolism | Repressor Proteins - deficiency | Proteolysis | HEK293 Cells | Nedd4 Ubiquitin Protein Ligases | Membrane Proteins - metabolism | Amino Acid Sequence | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Repressor Proteins - genetics | Signal Transduction - genetics | Ubiquitin - genetics | Ubiquitin-Protein Ligases - biosynthesis | Endosomal Sorting Complexes Required for Transport - deficiency | Repressor Proteins - biosynthesis | Ubiquitin-Protein Ligases - deficiency | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Endosomal Sorting Complexes Required for Transport - physiology | Protein Isoforms - antagonists & inhibitors | Ubiquitination - genetics | Protein Isoforms - genetics | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2016, Volume 291, Issue 29, pp. 15256 - 15266
YAP signaling pathway plays critical roles in tissue homeostasis, and aberrant activation of YAP signaling has been implicated in cancers. To identify... 
BREAST-CANCER | TARGET | AXIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TISSUE HOMEOSTASIS | HIPPO PATHWAY | ADP-RIBOSYLATION | TUMOR-SUPPRESSOR | DEGRADATION | KRAS | FAMILY PROTEINS | Lung Neoplasms - drug therapy | RNA, Small Interfering - genetics | Humans | Lung Neoplasms - metabolism | Intercellular Signaling Peptides and Proteins - chemistry | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | Tankyrases - antagonists & inhibitors | Intercellular Signaling Peptides and Proteins - metabolism | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | HEK293 Cells | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Tankyrases - genetics | Membrane Proteins - genetics | Down-Regulation | Carcinoma, Non-Small-Cell Lung - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | Tankyrases - chemistry | Phosphoproteins - genetics | Gene Knockout Techniques | Membrane Proteins - chemistry | Signal Transduction - drug effects | Erlotinib Hydrochloride - pharmacology | Protein Stability - drug effects | Adaptor Proteins, Signal Transducing - genetics | CRISPR-Cas Systems | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - drug therapy | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus | CRISPR | Cas | yes-associated protein (YAP) | signal transduction | functional genomics | drug resistance | protein degradation | Cell Biology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2018, Volume 115, Issue 17, pp. E4101 - E4110
During development, ventricular chamber maturation is a crucial step in the formation of a functionally competent postnatal heart. Defects in this process can... 
Cullin 7 | Hippo-YAP signaling | NEDD8 | Cardiomyopathy | Ventricular compaction | YES-ASSOCIATED PROTEIN | MULTIDISCIPLINARY SCIENCES | CARDIOMYOCYTE PROLIFERATION | NONCOMPACTION CARDIOMYOPATHY | DILATED CARDIOMYOPATHY | CLINICAL-FEATURES | ventricular compaction | COP9 SIGNALOSOME | HEART DEVELOPMENT | CARDIAC PROTEINOPATHY | CELL-CYCLE | MISFOLDED PROTEINS | cardiomyopathy | NEDD8 Protein - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Myocardium - pathology | NEDD8 Protein - genetics | Phosphoproteins - genetics | Phosphoproteins - metabolism | Mice, Knockout | Cullin Proteins - genetics | Myocytes, Cardiac - pathology | Animals | Myocardium - metabolism | Tumor Suppressor Proteins - genetics | Adaptor Proteins, Signal Transducing - genetics | Cullin Proteins - metabolism | Myocytes, Cardiac - metabolism | Heart Ventricles - metabolism | Mice | Protein Processing, Post-Translational | Adaptor Proteins, Signal Transducing - metabolism | Heart Ventricles - pathology | Protein-Serine-Threonine Kinases - metabolism | Physiological aspects | Enzymes | Cellular signal transduction | Research | Cardiovascular research | Heart ventricles | Cell proliferation | Ubiquitin | Heart | Cardiac arrhythmia | Postpartum period | Activation | Lethality | Gestation | Kinases | Inactivation | Cullin | Proteins | Clonal deletion | Cell cycle | Deletion | Heart diseases | Ubiquitin-protein ligase | Hypoplasia | Phenotypes | Deactivation | Maturation | Cardiomyocytes | Substrates | Studies | Yes-associated protein | Signaling | Molecular modelling | Ventricle | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, pp. e13952 - e13952
Background: In preimplantation mammalian development the transcription factor Sox2 (SRY-related HMG-box gene 2) forms a complex with Oct4 and functions in... 
PLURIPOTENT STEM-CELLS | DOUBLE-STRANDED-RNA | CELL SELF-RENEWAL | MULTIDISCIPLINARY SCIENCES | TROPHOBLAST DEVELOPMENT | GENE-EXPRESSION | PRIMITIVE ENDODERM | NANOG | TRANSCRIPTIONAL REGULATION | PROTEIN TRANSDUCTION | MOUSE EMBRYO | Immunohistochemistry | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Homeodomain Proteins - metabolism | Apoptosis - genetics | Male | Morula - metabolism | Phosphoproteins - metabolism | RNA, Messenger - metabolism | SOXB1 Transcription Factors - metabolism | DNA-Binding Proteins - metabolism | Octamer Transcription Factor-3 - genetics | Cell Differentiation - genetics | RNA Interference | SOXB1 Transcription Factors - genetics | Gene Expression Regulation, Developmental | Muscle Proteins - metabolism | Female | Trophoblasts - cytology | Cell Lineage - genetics | Trophoblasts - metabolism | RNA, Messenger - genetics | Blastocyst - metabolism | Cells, Cultured | Blastocyst - cytology | Morula - cytology | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Homeodomain Proteins - genetics | Muscle Proteins - genetics | Transcription Factors - metabolism | Microscopy, Confocal | Animals | Octamer Transcription Factor-3 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mice | Adaptor Proteins, Signal Transducing - metabolism | CDX2 Transcription Factor | Embryonic development | Embryo | Fibroblast growth factors | Genetic transcription | RNA | Genes | Neurosciences | Transcription factors | Oct-4 protein | Neurobiology | CDX2 protein | Trophectoderm | Proteins | Embryogenesis | Restoration | Developmental stages | Cell fate | Life sciences | Trends | Growth factors | Fibroblast growth factor receptor 2 | Sox2 protein | RNA-mediated interference | Markers | Zebrafish | Implantation | Blastocysts | siRNA | Mammals | Gene expression | Embryos | Cavitation | Fibroblast growth factor 4 | Yes-associated protein | Ribonucleic acids | Stem cells | Pluripotency | Apoptosis | Index Medicus
Journal Article
Cell Reports, ISSN 2211-1247, 05/2013, Volume 3, Issue 5, pp. 1663 - 1677
Journal Article
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 130, Issue 6, pp. 1120 - 1133
Coordination of cell proliferation and cell death is essential to attain proper organ size during development and for maintaining tissue homeostasis throughout... 
DEVBIO | SIGNALING | YES-ASSOCIATED PROTEIN | APOPTOSIS | DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | TUMOR-SUPPRESSOR | YAP | MICE | CELL | CANCER | CELL BIOLOGY | Protein Kinases - metabolism | Phosphorylation | Cell Proliferation | Large Neutral Amino Acid-Transporter 1 - metabolism | Humans | Liver Neoplasms, Experimental - chemically induced | Homeostasis | Cytoplasm - metabolism | Drosophila Proteins - metabolism | Doxorubicin | Drosophila - enzymology | Liver Neoplasms, Experimental - metabolism | Cell Nucleus - metabolism | Transfection | Trans-Activators - genetics | Active Transport, Cell Nucleus | Liver Neoplasms, Experimental - pathology | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Drosophila - genetics | Cell Line | Mammals - metabolism | Mammals - growth & development | Signal Transduction | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins | Organ Size | Drosophila - cytology | Mice, Transgenic | Nuclear Proteins - metabolism | Transcription Factors - genetics | Serine - metabolism | Transcription Factors - metabolism | Animals | Liver Neoplasms, Experimental - enzymology | Trans-Activators - metabolism | Drosophila - growth & development | Mice | Drosophila - metabolism | Drosophila Proteins - genetics | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Apoptosis | Drosophila | Knowledge-based systems | Index Medicus
Journal Article
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