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Journal Article
Development (Cambridge), ISSN 0950-1991, 03/2018, Volume 145, Issue 5, pp. dev159467 - dev159467
Animal cells are thought to sense mechanical forces via the transcriptional co-activators YAP (or YAP1) and TAZ (or WWTR1), the sole Drosophila homolog of... 
Hippo pathway | Cell shape | Yorkie | Mechanosensing | Drosophila | TISSUE-GROWTH | GROWTH-CONTROL | ACTIVATION | PROTEIN | YORKIE PHOSPHORYLATION | CELL-PROLIFERATION | DEVELOPMENTAL BIOLOGY | APICAL-DOMAIN SIZE | KIBRA | SIGNALING PATHWAY | TUMOR-SUPPRESSOR PATHWAY | Drosophila melanogaster - embryology | Stress, Mechanical | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Mechanotransduction, Cellular - physiology | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Cell Nucleus - metabolism | Gene Expression Regulation, Developmental | Imaginal Discs - embryology | Trans-Activators - genetics | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Wings, Animal - embryology | Animals, Genetically Modified | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Signal Transduction - genetics | Protein Transport - genetics | Transcription Factors - metabolism | Wings, Animal - metabolism | Animals | Embryo, Nonmammalian | Imaginal Discs - metabolism | Trans-Activators - metabolism | Drosophila Proteins - genetics | Body Patterning - genetics | Cell culture | Transcription factors | Transcription | Epithelial cells | Epithelium | Kinases | Nuclear transport | Mammalian cells | Yes-associated protein | Warts | Signal transduction | Insects | Transcription activation | Physiology | Mechanical stimuli | Localization | Cytoplasm | Index Medicus
Journal Article
Cellular Signalling, ISSN 0898-6568, 2014, Volume 26, Issue 5, pp. 1048 - 1059
Emerging studies have revealed that Malat1 is overexpressed in many malignant diseases, including liver cancer, and contributes to enhancing cell migration or... 
Promoter | RNA stability | Hippo/YAP pathway | Wnt pathway | Angiomotin (AMOT) | YES-ASSOCIATED PROTEIN | HIPPO PATHWAY | INTERCHROMATIN GRANULE CLUSTERS | SPLICING FACTOR-SF2 | CELL BIOLOGY | HEPATOCELLULAR-CARCINOMA | MESSENGER-RNA | SIGNALING PATHWAY | SR PROTEINS | GENE-EXPRESSION | TRANSCRIPTION FACTOR | RNA-Binding Proteins - genetics | Up-Regulation | Humans | Transplantation, Heterologous | Phosphoproteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Cell Nucleus - metabolism | HEK293 Cells | Liver Neoplasms - pathology | Transcription, Genetic | Membrane Proteins - metabolism | Nuclear Proteins - genetics | RNA-Binding Proteins - antagonists & inhibitors | Promoter Regions, Genetic | Transcription Factor 4 | Nuclear Proteins - metabolism | RNA, Long Noncoding - genetics | beta Catenin - metabolism | Hep G2 Cells | Transcription Factors - metabolism | Animals | Cell Transformation, Neoplastic | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Liver Neoplasms - metabolism | Serine-Arginine Splicing Factors | Cell Line, Tumor | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | RNA, Long Noncoding - metabolism | RNA-Binding Proteins - metabolism | RNA | Liver cancer | Analysis | Index Medicus
Journal Article
eLife, ISSN 2050-084X, 03/2017, Volume 6
We hypothesized that human genes and disease-associated alleles might be systematically functionally annotated using morphological profiling of cDNA... 
KAPPA-B ACTIVATION | PATHWAY | PHOSPHORYLATION | GENOME-WIDE RNAI | PROTEIN-KINASE | BIOLOGY | SCREENS | MUTATIONS | DIFFERENTIATION | CANCER | EXPRESSION | Staining and Labeling - methods | Optical Imaging | Multigene Family | Humans | TNF Receptor-Associated Factor 2 - genetics | Endoplasmic Reticulum - metabolism | Proto-Oncogene Proteins c-rel - metabolism | NF-kappa B - metabolism | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | Mitochondria - ultrastructure | Endoplasmic Reticulum - ultrastructure | Cell Nucleus - metabolism | Cell Transformation, Neoplastic - genetics | HEK293 Cells | Golgi Apparatus - ultrastructure | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Fluorescent Dyes - chemistry | Signal Transduction | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | TNF Receptor-Associated Factor 2 - metabolism | Mitochondria - metabolism | Phosphoproteins - genetics | Cell Nucleus - ultrastructure | Cell Transformation, Neoplastic - metabolism | Osteoblasts - pathology | Image Processing, Computer-Assisted | NF-kappa B - genetics | Proto-Oncogene Proteins c-rel - genetics | Adaptor Proteins, Signal Transducing - genetics | Alleles | Cell Line, Tumor | Golgi Apparatus - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Cell Transformation, Neoplastic - pathology | Osteoblasts - metabolism | Allelomorphism | Physiological aspects | Nucleotide sequencing | Gene expression | Observations | Methods | DNA sequencing | NF-κB protein | Disease | Gene clusters | Transcription | Cloning | Extracellular signal-regulated kinase | Raf protein | Genomes | Yes-associated protein | TRAF2 protein | Annotations | Morphology | Index Medicus
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 09/2012, Volume 26, Issue 17, pp. 1959 - 1971
Journal Article
Cancer Letters, ISSN 0304-3835, 2017, Volume 402, pp. 61 - 70
Abstract KRAS mutation is the most common genetic event in pancreatic cancer. Whereas KRAS itself has proven difficult to inhibit, agents that target key... 
Hematology, Oncology and Palliative Medicine | RAF inhibitor | Verteporfin | Yes-associated protein (YAP) | Pancreatic ductal adenocarcinoma (PDAC) | Combinational therapy | SURVIVAL | CELLS | DUCTAL ADENOCARCINOMA | BRAF | PROLIFERATION | TAZ | METASTATIC MELANOMA | ONCOLOGY | HIPPO | RESISTANCE | TUMORIGENESIS | Immunohistochemistry | Genetic Testing | Proto-Oncogene Proteins p21(ras) - genetics | Tissue Array Analysis | raf Kinases - antagonists & inhibitors | Humans | Middle Aged | Male | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | raf Kinases - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Carcinoma, Pancreatic Ductal - genetics | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | Transfection | RNA Interference | Time Factors | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-akt - metabolism | Pancreatic Neoplasms - pathology | Kaplan-Meier Estimate | Pancreatic Neoplasms - enzymology | Pancreatic Neoplasms - genetics | Phosphoproteins - genetics | Porphyrins - pharmacology | Pyrimidines - pharmacology | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Pancreatic Ductal - enzymology | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Disease-Free Survival | Phenotype | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Phenylurea Compounds - pharmacology | Protein Kinase Inhibitors - pharmacology | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Prevention | Epidermal growth factor | Research | Oncology, Experimental | Pancreatic cancer | Cancer | Cell proliferation | Raf protein | AKT protein | Activation | Kinases | K-Ras protein | Anticancer properties | Proteins | Signal transduction | Gastroenterology | Inhibition | Cell survival | Pharmacology | Patients | Survival | Yes-associated protein | Inhibitors | Plasmids | Medical prognosis | Antitumor activity | Combinatorial analysis | Tumors | Index Medicus
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 01/2018, Volume 44, Issue 5, pp. 2073 - 2089
Background/Aims: The Hippo-Yap pathway is associated with tumor development and progression. However, little evidence is available concerning its role in... 
Original Paper | F-actin | HtrA2/Omi | Lamellipodia | JNK | Migration | Cofilin | Yap | Mitochondrial fission | Apoptosis | Drp1 | YES-ASSOCIATED PROTEIN | PHYSIOLOGY | HIPPO PATHWAY | INJURY | MICROVASCULAR ENDOTHELIAL-CELLS | ANTITUMOR-ACTIVITY | CELL BIOLOGY | IN-VITRO | GASTRIC-CANCER | SIGNALING PATHWAY | SERINE-PROTEASE | TUMORIGENESIS | Mitochondrial Dynamics | Phosphorylation | Caspase 9 - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Caspase 3 - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | RNA Interference | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Mitochondrial Proteins - metabolism | Membrane Potential, Mitochondrial | Protein Domains | Rectal Neoplasms - pathology | Signal Transduction | JNK Mitogen-Activated Protein Kinases - chemistry | Phosphoproteins - genetics | High-Temperature Requirement A Serine Peptidase 2 - metabolism | GTP Phosphohydrolases - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Cytoskeleton - metabolism | Protein Binding | Rectal Neoplasms - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Cell Movement | RNA, Small Interfering - metabolism | Melatonin | Tissue engineering | Colorectal cancer | Homeostasis | Mitochondrial DNA | Kinases | Experiments | Proteins | Mitochondria | Hypoxia | Laboratory animals | Cytoplasm | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 01/2013, Volume 304, Issue 1, pp. E41 - E50
Hulmi JJ, Oliveira BM, Silvennoinen M, Hoogaars WM, Ma H, Pierre P, Pasternack A, Kainulainen H, Ritvos O. Muscle protein synthesis, mTORC1/MAPK/Hippo... 
Mammalian target of rapamycin complex 1 | Exercise | Hippo | Mitogen-activated protein kinase | Muscle hypertrophy | Myostatin | Muscle dystrophy | YES-ASSOCIATED PROTEIN | PHYSIOLOGY | KINASE | HIPPO PATHWAY | exercise | IIB RECEPTOR | MYOTUBE SIZE | myostatin | MDX MICE | mitogen-activated protein kinase | SKELETAL-MUSCLE | muscle dystrophy | MOUSE MODEL | ENDOCRINOLOGY & METABOLISM | DUCHENNE MUSCULAR-DYSTROPHY | MATURE MICE | muscle hypertrophy | mammalian target of rapamycin complex 1 | TOR Serine-Threonine Kinases - metabolism | Cell Count | Activins - antagonists & inhibitors | Capillaries - drug effects | Male | Multiprotein Complexes - genetics | Muscle, Skeletal - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Mechanistic Target of Rapamycin Complex 1 | Muscle Proteins - biosynthesis | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Muscle, Skeletal - drug effects | Muscle Proteins - metabolism | TOR Serine-Threonine Kinases - physiology | Protein Biosynthesis - genetics | Extracellular Signal-Regulated MAP Kinases - physiology | Protein-Serine-Threonine Kinases - metabolism | Protein-Serine-Threonine Kinases - physiology | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Multiprotein Complexes - physiology | Myostatin - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Capillaries - cytology | Intercellular Signaling Peptides and Proteins - pharmacology | Protein Biosynthesis - drug effects | Mice | Angiogenesis | Phosphorylation | Protein synthesis | Rodents | Blood vessels | Muscular system | Muscular dystrophy | Index Medicus
Journal Article
Genome Biology, ISSN 1474-7596, 12/2017, Volume 18, Issue 1, pp. 237 - 237
Background: Circular RNAs are a class of endogenous RNAs with various functions in eukaryotic cells. Worthy of note, circular RNAs play a critical role in... 
Mut-p53 | TEAD | CircPVT1 | HNSCC | PVT1 | MiR-497-5p | YAP | BIOMARKER | miR-497-5p | mut-p53 | BIOGENESIS | GASTRIC-CANCER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GROWTH | GENETICS & HEREDITY | MUTATIONAL LANDSCAPE | circPVT1 | OVARIAN | P53 PROTEINS | EXPRESSION | CIRCULAR RNA MOLECULES | EXON CIRCULARIZATION | Cell Proliferation | Prognosis | RNA | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Multiprotein Complexes | Gene Expression Regulation, Neoplastic | RNA, Long Noncoding - blood | Phosphoproteins - metabolism | Biomarkers, Tumor | Head and Neck Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Squamous Cell Carcinoma of Head and Neck | Carcinoma, Squamous Cell - mortality | Oncogenes - genetics | Promoter Regions, Genetic | RNA Transport | Carcinogenesis - genetics | Tumor Suppressor Protein p53 - metabolism | RNA, Long Noncoding - genetics | Phosphoproteins - genetics | Phenotype | Models, Biological | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Protein Binding | Head and Neck Neoplasms - genetics | MicroRNAs - genetics | Head and Neck Neoplasms - mortality | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Cell proliferation | Phenotypes | Squamous cell carcinoma | Transcription | p53 Protein | Genomes | Breast cancer | Chromosome 5 | Gene expression | Datasets | Yes-associated protein | Proteins | MicroRNAs | Cell lines | Head and neck cancer | Neck | Chromosomes | Tumors | Index Medicus
Journal Article
Journal Article
Journal Article