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Journal of Experimental Medicine, ISSN 0022-1007, 2016, Volume 213, Issue 2, pp. 155 - 165
A brother and sister developed a previously undescribed constellation of autoimmune manifestations within their first year of life, with uncontrollable bullous... 
MEDICINE, RESEARCH & EXPERIMENTAL | KINASE-ACTIVITY | ZAP70 | SEVERE COMBINED IMMUNODEFICIENCY | STRUCTURAL BASIS | PATHWAY | T-CELL-RECEPTOR | 22Q11.2 DELETION SYNDROME | IMMUNOLOGY | RECONSTITUTION | CHAIN-ASSOCIATED PROTEIN | DEFICIENCY | ZAP-70 Protein-Tyrosine Kinase - deficiency | T-Lymphocytes - enzymology | Humans | Child, Preschool | Molecular Sequence Data | Infant | Male | Mutation, Missense | Transplantation, Homologous | Autoimmune Diseases - genetics | Base Sequence | ZAP-70 Protein-Tyrosine Kinase - metabolism | Female | Siblings | Amino Acid Sequence | Cell Line | Severe Combined Immunodeficiency - enzymology | Autoimmune Diseases - enzymology | Receptors, Antigen, T-Cell - metabolism | Hemophilia A - immunology | Autoimmune Diseases - immunology | Mutant Proteins - genetics | Hematopoietic Stem Cell Transplantation | Models, Molecular | ZAP-70 Protein-Tyrosine Kinase - genetics | Hemophilia A - enzymology | Mutant Proteins - metabolism | Severe Combined Immunodeficiency - immunology | ZAP-70 Protein-Tyrosine Kinase - chemistry | Pemphigoid, Bullous - genetics | Pemphigoid, Bullous - pathology | Syndrome | Pemphigoid, Bullous - enzymology | Severe Combined Immunodeficiency - genetics | Phenotype | Animals | Pedigree | Mutant Proteins - chemistry | ZAP-70 Protein-Tyrosine Kinase - immunology | Heterozygote | Protein Conformation | T-Lymphocytes - immunology | Hemophilia A - genetics | Mice
Journal Article
Molecular Immunology, ISSN 0161-5890, 05/2016, Volume 73, pp. 19 - 28
The tyrosine kinase Zap-70 is a key regulator of T cell receptor (TCR) signaling downstream of antigen presentation, with coordinated regulation of Zap-70... 
TCR signaling | Ubiquitination | Zap-70
Journal Article
Journal Article