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Cancer Research, ISSN 0008-5472, 04/2005, Volume 65, Issue 7, pp. 2840 - 2845
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 06/2013, Volume 33, Issue 11, pp. 2188 - 2201
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 2017, Volume 24, Issue 12, pp. 1155 - 1163
Journal Article
PLoS ONE, ISSN 1932-6203, 2012, Volume 7, Issue 11, pp. e49284 - e49284
This study provides a comprehensive computational procedure for the discovery of novel urea-based antineoplastic kinase inhibitors while focusing on... 
FAMILY KINASE | SYK KINASE | SPLEEN TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | BIOLOGICAL-ACTIVITY | T-CELL-RECEPTOR | GENE-EXPRESSION | INTERACTION MAP | ANTICANCER DRUG DISCOVERY | PHARMACOLOGICAL EVALUATION | POTENT INHIBITORS | Protein-Tyrosine Kinases - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Support Vector Machine | Urea - chemistry | Protein Kinase Inhibitors - chemistry | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Antineoplastic Agents - classification | Syk Kinase | Cyclin-Dependent Kinase 2 - metabolism | Protein Kinase Inhibitors - chemical synthesis | Protein Kinase Inhibitors - classification | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Models, Molecular | Antineoplastic Agents - chemistry | Drug Discovery | Algorithms | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Ligands | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Cell Cycle - drug effects | Electrons | Protein-Tyrosine Kinases - antagonists & inhibitors | Urea | Protein kinases | Analysis | Profiling | Similarity | Cytotoxicity | Selectivity | ZAP-70 protein | Electron distribution | Kinases | Anticancer properties | Filters | Cell cycle | Trees | Spleen | Feasibility studies | Pharmacology | Tumor cell lines | Src protein | Chemistry | Protein arrays | Inhibitors | Computation | Protein kinase | Searching | Pharmacy | Cell lines | Computer applications | Antitumor activity | Syk protein | Bayesian analysis | Cancer | Structural analysis | Pharmaceuticals | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2013, Volume 288, Issue 10, pp. 7338 - 7350
The inducible T cell kinase-spleen tyrosine kinase (ITK-SYK) oncogene consists of the Tec homology-pleckstrin homology domain of ITK and the kinase domain of... 
ZAP-70 | DOMAIN | ACTIVATION | COMPLEX | STRUCTURAL BASIS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATION | RECEPTOR | TRANSDUCTION | LYMPHOMA | Oncogene Proteins, Fusion - metabolism | Phosphorylation | Protein-Tyrosine Kinases - metabolism | Glutamic Acid - genetics | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | Antigens, CD - metabolism | Lectins, C-Type - metabolism | Protein-Tyrosine Kinases - genetics | Flow Cytometry | T-Lymphocytes - metabolism | HEK293 Cells | ZAP-70 Protein-Tyrosine Kinase - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Interleukin-2 - metabolism | Phenylalanine - metabolism | Signal Transduction | Jurkat Cells | Lymphocyte Activation | Antigens, Differentiation, T-Lymphocyte - metabolism | ZAP-70 Protein-Tyrosine Kinase - genetics | Phosphoproteins - genetics | Blotting, Western | Tyrosine - metabolism | Animals | Oncogene Proteins, Fusion - genetics | Phenylalanine - genetics | Adaptor Proteins, Signal Transducing - genetics | Glutamic Acid - metabolism | Mutation | Adaptor Proteins, Signal Transducing - metabolism | COS Cells | Amino Acid Substitution | Tyrosine - genetics | Index Medicus | Immunology | SLP-76 | SYK | Molecular Cell Biology | Cell Signaling | Phosphotyrosine Signaling | ITK-SYK | Lymphoma | Cell Biology
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2008, Volume 16, Issue 20, pp. 9247 - 9260
The conversion of 1,2,4-triazolo[4,3- ]pyrimidine to a imidazo[1,2- ]pyrimidine derivative improves in vivo efficacy of suppression of both passive cutaneous... 
Protein tyrosine kinases (PTKs) | ZAP-70 | Syk family kinases | Syk | Syk and/or ZAP-70 kinase inhibitor | Autoimmune diseases | autoimmune diseases | DRUG | COMPLEX | ACTIVATION | CHEMISTRY, MEDICINAL | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | PROTEIN-TYROSINE KINASE | BIOAVAILABILITY | SOLUBILITY | LCK | INFLAMMATION | protein tyrosine kinases (PTKs) | ABSORPTION | Protein-Tyrosine Kinases - metabolism | Pyrimidines - chemical synthesis | Humans | Imidazoles - chemistry | Protein-Tyrosine Kinases - classification | Crystallography, X-Ray | Intracellular Signaling Peptides and Proteins - metabolism | Structure-Activity Relationship | Pyrimidines - chemistry | Protein Kinase Inhibitors - chemistry | Inhibitory Concentration 50 | ZAP-70 Protein-Tyrosine Kinase - antagonists & inhibitors | ZAP-70 Protein-Tyrosine Kinase - metabolism | Molecular Structure | Syk Kinase | Protein Kinase Inhibitors - chemical synthesis | Administration, Oral | Pyrimidines - administration & dosage | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Models, Molecular | Enzyme Activation - drug effects | Intracellular Signaling Peptides and Proteins - classification | Mice, Inbred ICR | Protein Kinase Inhibitors - administration & dosage | Animals | Mice | Protein-Tyrosine Kinases - antagonists & inhibitors | Phosphotransferases | Pyrimidines | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2016, Volume 17, Issue 5, pp. 574 - 582
Journal Article