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Cancer Discovery, ISSN 2159-8274, 04/2013, Volume 3, Issue 4, pp. 388 - 398
Chimeric antigen receptors (CAR) are recombinant receptors that provide both antigen-binding and T-cell-activating functions. A multitude of CARs has been... 
LONG-TERM | CLINICAL-TRIAL | ONCOLOGY | CLONAL EXPANSION | CD28 | MODIFIED T-CELLS | ZETA-CHAIN | ANTITUMOR-ACTIVITY | GENETIC-MODIFICATION | ADOPTIVE IMMUNOTHERAPY | LYMPHOCYTES | Neoplasms - therapy | Animals | Receptors, Antigen - metabolism | Immunotherapy, Adoptive | Signal Transduction | Humans | T-Lymphocytes - immunology | Recombinant Fusion Proteins - metabolism
Journal Article
Cancer discovery, ISSN 2159-8274, 10/2018, Volume 8, Issue 10, pp. 1219 - 26
Emerging data from chimeric antigen receptor (CAR) T-cell trials in B-cell malignancies demonstrate that a common mechanism of resistance to this novel class... 
SUSTAINED REMISSIONS | B-CELL | ONCOLOGY | IMMUNOTHERAPY | RECEPTOR ZETA-CHAIN | ACUTE LYMPHOBLASTIC-LEUKEMIA | RESISTANCE | TERM-FOLLOW-UP | LINEAGE SWITCH | SURFACE-ANTIGEN | ACUTE MYELOID-LEUKEMIA
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2019, Volume 476, Issue 2, pp. 405 - 419
Type II phosphatidylinositol 4-kinase beta (PtdIns 4-kinase II beta) is an enigma among the phosphatidylinositol 4-kinase family. The role of PtdIns 4-kinase... 
ACTIVATION | PROTEIN | INHIBITION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRAFFICKING | ALPHA | DEGRADATION | SUPPRESSES | ZETA-CHAIN | PAR-4
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 10/2004, Volume 53, Issue 10, pp. 865 - 878
The ζ chain is a 16-kDa molecule associated with the T-cell receptor (TCR)-CD3 complex in T lymphocytes and FcγRIII in CD3−CD56+CD16+ natural killer (NK... 
Medicine | T lymphocytes | Zeta-chain expression | Cancer | T-cell signaling
Journal Article
Nature Reviews Rheumatology, ISSN 1759-4790, 12/2016, Volume 12, Issue 12, pp. 716 - 730
Journal Article
Pathology - Research and Practice, ISSN 0344-0338, 06/2019, Volume 215, Issue 6, p. 152383
Arginase-1 (Arg-1) metabolizes -arginine to -ornithine and urea. It has been documented to have a role in various malignancies. However, the relationship... 
Immunohistochemistry | Prognosis | Arginase-1 | Colorectal cancer | ARGININE | ZETA-CHAIN | PATHOLOGY | EXPRESSION | BLOOD
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 09/2017, Volume 199, Issue 5, pp. 1555 - 1560
For the ab or gamma delta TCR chains to integrate extracellular stimuli into the appropriate intracellular cellular response, they must use the 10 ITAMs found... 
COMPLEX | ACTIVATION MOTIFS | MEMBRANE-BINDING | RETROGENIC MICE | CD3-EPSILON | T-CELL-RECEPTOR | GENERATION | ZETA-CHAIN | IMMUNOLOGY | SELECTION | ANTIGEN
Journal Article
Blood, ISSN 0006-4971, 02/2007, Volume 109, Issue 4, pp. 1568 - 1573
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 05/2018, Volume 200, Issue 9, pp. 3077 - 3086
Cytotoxic function and cytokine profile of NK cells are compromised in patients with systemic lupus erythematosus (SLE). CD3 zeta, an important molecule for NK... 
DEPENDENT CELLULAR CYTOTOXICITY | NATURAL-KILLER-CELLS | FC-GAMMA-RIII | SIGNALING ABNORMALITIES | MEDIATED CYTOTOXICITY | ACTIVATING RECEPTORS | MECHANISMS | ZETA-CHAIN | IMMUNOLOGY | EXPRESSION | T-CELLS
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 06/2010, Volume 184, Issue 12, pp. 6938 - 6949
Chimeric Ag receptors (CARs) expressed in T cells permit the redirected lysis of tumor cells in an MHC-unrestricted manner. In the Jurkat T cell model system,... 
ZETA-CHAIN DIMERIZATION | PROTEIN | IMMUNE RECEPTORS | TCR-ZETA | 2D IR | T-CELL-RECEPTOR | RESONANCE ENERGY-TRANSFER | ENDOPLASMIC-RETICULUM | IMMUNOLOGY | GAMMA-SUBUNIT | LYMPHOCYTES
Journal Article
Nature Immunology, ISSN 1529-2908, 11/2006, Volume 7, Issue 11, pp. 1139 - 1142
The 'lipid raft' hypothesis has been a contentious topic over the past 5 years, with much of the immunology community divided into 'believers' and... 
MDCK CELLS | ACTIVATION | MICRODOMAINS | CHOLESTEROL | RECEPTOR ZETA-CHAIN | CELL-SURFACE MOLECULES | TYROSINE KINASES | IMMUNOLOGY | PLASMA-MEMBRANE | DOMAINS | GPI-ANCHORED PROTEINS | Proteins - physiology | Animals | Humans | Membrane Microdomains - chemistry | Membrane Microdomains - physiology | Lipid Bilayers - chemistry | Proteins - chemistry
Journal Article