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MOLECULAR MICROBIOLOGY, ISSN 0950-382X, 08/2019, Volume 112, Issue 2, pp. 374 - 384
This year marks the 50(th) anniversary of the discovery of sigma(70) as a protein factor that was needed for bacterial RNA polymerase to accurately transcribe... 
OXIDATIVE-STRESS | GENE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | STREPTOMYCES-COELICOLOR | SINGLET OXYGEN | MICROBIOLOGY | ZINC-BINDING | TRANSCRIPTIONAL RESPONSE | BACTERIAL RESPONSES | RNA-POLYMERASE
Journal Article
Journal Article
Current Drug Targets, ISSN 1389-4501, 2015, Volume 16, Issue 14, pp. 1634 - 1644
Journal Article
Tetrahedron, ISSN 0040-4020, 01/2019, Volume 75, Issue 4, pp. 486 - 509
The Zn -dependent bacterial deacetylase LpxC is a promising target for the development of novel antibiotics. Most of the known LpxC inhibitors carry a... 
Hydroxamic acids | Antibacterials | Metabolic stability | Zn2+-chelating groups | LpxC inhibitors | THERAPEUTIC APPLICATION | ESCHERICHIA-COLI | CHEMISTRY, ORGANIC | ANTIBACTERIAL AGENTS | ACID-DERIVATIVES | IN-VITRO | DEPENDENT DEACETYLASE LPXC | METABOLISM | BIOLOGICAL EVALUATION | ZINC-BINDING GROUPS
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2008, Volume 16, Issue 9, pp. 4839 - 4853
Histone deacetylase (HDAC) inhibition is a recent, clinically validated therapeutic strategy for cancer treatment. Small molecule HDAC inhibitors identified so... 
Histone deacetylase (HDAC) | SAHA-like hydroxamates, 1,2,3-triazole | Trichostatin A (TSA) | AutoDock | Click chemistry | Histone deacetylase-like protein (HDLP) | Suberoylanilide hydroxamic acid (SAHA) | Zinc-binding group (ZBG) | Molecular docking | HYDROXAMIC ACID | trichostatin A (TSA) | DESIGN | CHEMISTRY, MEDICINAL | AZIDES | BIOCHEMISTRY & MOLECULAR BIOLOGY | zinc-binding group (ZBG) | SOLID-PHASE | CHEMISTRY, ORGANIC | histone deacetylase ( HDAC) | click chemistry | TERMINAL ALKYNES | histone deacetylase-like protein (HDLP) | ALCOHOLS | suberoylanilide hydroxamic acid ( SAHA) | molecular docking | CYCLOADDITIONS | GROWTH | SAHA-like hydroxamates | 1,2,3-triazole | Cell Survival - drug effects | Molecular Weight | Stereoisomerism | Triazoles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Enzyme Inhibitors - pharmacology | Hydroxamic Acids - chemistry | Models, Molecular | Crystallography, X-Ray | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Enzyme Inhibitors - chemical synthesis | Dose-Response Relationship, Drug | Triazoles - pharmacology | Enzyme Inhibitors - chemistry | Triazoles - chemical synthesis | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Histone Deacetylase Inhibitors | Molecular Structure | Tumor Cells, Cultured | Drug Screening Assays, Antitumor
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2012, Volume 51, pp. 271 - 276
Journal Article
Scientia Pharmaceutica, ISSN 2218-0532, 10/2019, Volume 87, Issue 4, p. 28
Histone deacetylase inhibitors with zinc binding groups often exhibit drawbacks like non-selectivity or toxic effects. Thus, there are continuous efforts to... 
zinc binding group | distance from zinc ion | acyl thiourea derivatives | histone deacetylase inhibitors
Journal Article
ACS Medicinal Chemistry Letters, 05/2012, Volume 3, Issue 6, pp. 505 - 508
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 06/2012, Volume 3, Issue 6, pp. 505 - 508
Natural and synthetic histone deacetylase (HDAC) inhibitors generally derive their strong binding affinity and high potency from a key functional group that... 
cancer therapy | CHEMISTRY, MEDICINAL | apicidin | zinc binding group | STRATEGY | SLOW | BINDING INHIBITOR | HDAC inhibitors | HISTONE DEACETYLASE INHIBITORS | tetrapeptide
Journal Article
Molecules, ISSN 1420-3049, 11/2012, Volume 17, Issue 12, pp. 13740 - 13758
Within this study, a unique 3D structure-based pharmacophore model of the enzyme glyoxalase-1 (Glo-1) has been revealed. Glo-1 is considered a zinc... 
CDOCKER | GOLD | molecular docking | glyoxlase-1 enzyme | zinc binding group | 2D similarity search
Journal Article
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