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Biochemical journal, ISSN 1470-8728, 04/2015, Volume 467, Issue 3, pp. 365 - 386
.... The CRLs assemble into functional multisubunit complexes using a repertoire of substrate receptors, adaptors, Cullin scaffolds and RING-box proteins... 
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | Index Medicus | MEL26, maternal effect lethal 26 | small molecule | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | structure-based design | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | assembly | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | structure | ubiquitin | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | ubiquitination | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Journal Article
FEBS letters, ISSN 0014-5793, 12/2015, Volume 589, Issue 24, pp. 3760 - 3772
... DA system, and their crosstalk with proteins and signaling pathways associated with PD. 
Rearranged during transfection | Parkinson disease | Drug addiction | Mouse model | Dopaminergic system | Glia cell line-derived neurotrophic factor | MAOA/MAOB | orphan nuclear receptor and transcription factor | cytoplasmic SH2 domain containing protein tyrosine phosphatase | Ras | RRF | COMT | PTEN-induced putative kinase 1 | SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) | PI3K | sorting protein-related receptor with A-type repeats, a member of the mammal Vps10p domain receptor | subunits of the Ca2+-sensitive, voltage gated A-type K+ channel | SH2 domain containing transforming protein 1 | Nurr1 | proprotein convertases | protein kinase B, serine/threonine-specific protein kinase | calcium-calmodulin-dependent protein kinase II β isoform | FRS2 | phosphatase and tensin homolog | catecholamine | SHP-2 | growth factor receptor-bound protein 2, 7 and 10, adaptor proteins | fibroblast growth factor receptor substrate 2, adaptor protein | monoamine oxidases A and B | carbonyl cyanide m-chlorophenyl hydrazone | ERK | brain derived neurotrophic factor | deglycase, oxidative stress sensor and redox-sensitive chaperone and protease | VTA | tyrosines, which can be phosphorylated | cAMP | extracellular-signal-regulated kinases, classical MAPKs | CaMKIIβ | Kv4.3 and KChip3 | GRB2/7/10 | Ser/Thr | SNP | endoplasmatic reticulum | nerve growth factor | monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) | TGF-β | SN | Akt, PKB | phospholipase γ cleaves the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) ppp3R1/ppp3CB, calcineurin subunits | PC5A, PC5B, and PC7 | EGR1 | proprotein convertase subtilisin/kexin type 6 | substantia nigra | phosphotyrosine-interaction domain | BDNF | adaptor protein of the PDZ-LIM family | γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system | Tyr | FosB/ΔFosB | IRS1/2 | LIM | dopamine transporter | enhanced green fluorescent protein | GDNF | DAT | SOS | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | retro-rubal field | transforming growth factor β is a secreted protein that controls proliferation and cellular differentiation | MPTP | GTPase | DA | hypoxia-inducible factor-1alpha | GDNF family of ligands | Ret | GPI | Shank3 | NCAM | Enigma | JNK | (rearranged during transfection) canonical GDNF receptor, a receptor tyrosine kinase | PTEN | 6-OHDA | DJ-1 | (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase | SHC | NF-κB | (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain | phosphotyrosine-binding domains | insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain | Rac1 | GFRα | nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) | catechol-O-methyltransferase | early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor | serine and threonine, which can be phosphorylated | GDNF family receptor α | PKA | protein kinase A, a family of cAMP-dependent protein kinase | MAPK | NGF | ER | SorLA | ventral tegmental area | son of sevenless, family of guanine nucleotide exchange factors that act on Ras | GABA | HIF-1a | Ras-related C3 botulinum toxin substrate 1 (Rho family), a small GTPase, like CDC42 | GAP1/2 | PTB | (Rat sarcoma) family of small membrane-associated GTPase | cycles between an active GTP-bound and an inactive GDP-bound state | glycogen synthase kinase 3β | Src | glia cell line-derived neurotrophic factor | PACE4, PCSK6 | pleckstrin homology domain | co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex | c-Jun N-terminal kinases, members of the MAPK family of proteins | EGFP | cell division control protein 42 homolog, a plasma membrane-associated small GTPase of the Rho family | (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker | CCCP | (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases | DOK1/4/5/6 | (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA | single-nucleotide polymorphism analysis | VPS10P | Rho | MEN2B | phosphatidylinositol-4,5-bisphosphate 3-kinase | 6-hydroxy-dopamine | mitogen-activated protein kinase, can phosphorylate serine, threonine, and tyrosine, e.g. p38MAPK | Cdc42 | docking proteins, have a PH and SH3 domain | GFLs | PDZ | vacuolar protein sorting 10 protein-domain receptors are type 1 transmembrane proteins | PLCγ | GTPase-activating proteins 1 and 2 | 3′,5′-cyclic adenosine monophosphate | neuronal cell adhesion molecule | TIEG | TGF-β-inducible early-response gene, a zinc finger transcription factor Vav2, adaptor protein and guanine nucleotide exchange factor for the Rho family of Ras-related GTPases | PINK1 | PD | Raf | CoREST | PH | PI | multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor | dopaminergic | glycosylphosphatidylinositol | FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form | gsk3β | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Glial Cell Line-Derived Neurotrophic Factor - physiology | Parkinson Disease - pathology | Animals | Proto-Oncogene Proteins c-ret - physiology | Dopamine - physiology | Mesencephalon - metabolism | Humans | Dopaminergic Neurons - physiology | Parkinson Disease - metabolism | Synaptic Transmission | Mesencephalon - pathology | Physiological aspects | Neurons | Parkinson's disease | Index Medicus
Journal Article
Nature cell biology, ISSN 1465-7392, 09/2017, Volume 19, Issue 10, pp. 1226 - 1236
...). Here we report that three anti-apoptotic BCL-2 proteins (MCL-1, BCL-2 and BCL-XL) found untethered from the OMM function as transcriptional regulators of a prosurvival and growth program... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | NIH 3T3 Cells | Transcription, Genetic - drug effects | Cell Proliferation | Zinc Finger Protein GLI1 - metabolism | Humans | Gene Expression Regulation, Neoplastic | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-X Protein - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Molecular Mimicry | Transfection | Neoplasms - genetics | RNA Interference | Time Factors | Tumor Suppressor Proteins - genetics | HEK293 Cells | Female | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - deficiency | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Peptide Fragments - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cell Survival | Zinc Finger Protein GLI1 - genetics | Repressor Proteins - genetics | Genotype | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Mice, Knockout | Neoplasms - drug therapy | Phenotype | Animals | Mice, Nude | CRISPR-Cas Systems | Mice | Neoplasms - pathology | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Genes | Genetic aspects | Genetic transcription | Drug resistance | Binding proteins | Tumors | Protein binding | Regulators | Cell survival | Bcl-2 protein | Transcription | Decision making | Homology | Gene expression | Mcl-1 protein | Proteins | Signaling | Mitochondria | DNA-binding protein | Bcl-x protein | Cell death | Feedforward | Deoxyribonucleic acid--DNA | Cancer | Index Medicus
Journal Article