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1. Full Text The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells
by Brabletz, Simone and Meidhof, Simone and Faller, Gerhard and Dimmler, Arno and Schubert, Jörg and Brabletz, Thomas and Bajdak, Karolina and Burk, Ulrike and Niedermann, Gabriele and Firat, Elke and Wellner, Ulrich
The EMBO Journal, ISSN 0261-4189, 02/2011, Volume 30, Issue 4, pp. 770 - 782
Notch signalling is important for development and tissue homeostasis and activated in many human cancers. Nevertheless, mutations in Notch pathway components... 
miR‐200 | ZEB1 | EMT | Notch | stemness | miR-200 | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | PHENOTYPE | E-CADHERIN | MIR-200 FAMILY | REPRESSORS ZEB1 | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | COLORECTAL-CANCER | Receptors, Notch - metabolism | Humans | Receptors, Notch - genetics | Gene Knockdown Techniques | Intercellular Signaling Peptides and Proteins - physiology | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Neoplasms - genetics | Membrane Proteins - physiology | Serrate-Jagged Proteins | Base Sequence | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Transcription Factors - physiology | DNA-Binding Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Models, Biological | Calcium-Binding Proteins - physiology | Homeodomain Proteins - antagonists & inhibitors | Nuclear Proteins - antagonists & inhibitors | Signal Transduction - physiology | MicroRNAs - genetics | Feedback, Physiological - physiology | MicroRNAs - physiology | Homeodomain Proteins - physiology | Calcium-Binding Proteins - genetics | Zinc Finger E-box-Binding Homeobox 1 | Proteins | Signal transduction | Cellular biology | Molecular biology | Gene expression | Cancer | Index Medicus
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2. Full Text Fezl Is Required for the Birth and Specification of Corticospinal Motor Neurons
by Molyneaux, Bradley J and Arlotta, Paola and Hirata, Tustomu and Hibi, Masahiko and Macklis, Jeffrey D
Neuron, ISSN 0896-6273, 2005, Volume 47, Issue 6, pp. 817 - 831
The molecular mechanisms controlling the differentiation of neural progenitors into distinct subtypes of neurons during neocortical development are unknown.... 
AREA IDENTITY | NEOCORTICAL NEURONS | CELL FATE SPECIFICATION | CEREBRAL CORTICAL DEVELOPMENT | LAYER NEURONS | CENTRAL-NERVOUS-SYSTEM | SUBCORTICAL TARGETS | ZINC-FINGER GENE | SUBVENTRICULAR ZONE | NEUROSCIENCES | ZEBRAFISH FOREBRAIN | Membrane Glycoproteins - metabolism | Embryo, Mammalian | Homeodomain Proteins - metabolism | Nerve Tissue Proteins - deficiency | S100 Proteins - genetics | POU Domain Factors - genetics | Forkhead Transcription Factors - metabolism | In Situ Hybridization - methods | Repressor Proteins - metabolism | Gene Expression Regulation, Developmental - physiology | POU Domain Factors - metabolism | Animals, Newborn | DNA-Binding Proteins - physiology | Motor Neurons - physiology | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | S100 Proteins - metabolism | In Situ Nick-End Labeling - methods | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Immunohistochemistry - methods | Annexin A2 - genetics | Cell Death - physiology | Green Fluorescent Proteins - biosynthesis | Mice | Annexin A2 - metabolism | Age Factors | Phosphopyruvate Hydratase - metabolism | Cell Movement - physiology | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Motor Neurons - cytology | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Membrane Proteins - metabolism | Bromodeoxyuridine - metabolism | Cell Differentiation - physiology | Pyramidal Tracts - physiology | Nerve Tissue Proteins - physiology | Neocortex - growth & development | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Membrane Glycoproteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Cell Count - methods | Neocortex - cytology | Receptors, Antigen, T-Cell, alpha-beta - metabolism | Neurosciences | Neurons | Developmental biology | Stem cells | Studies | Brain | Ultrasonic imaging | Transcription factors | Hybridization | Neurogenesis | Index Medicus
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3. Full Text Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway
by Ziv, Yael and Galanty, Yaron and Lukas, Claudia and Lukas, Jiri and Shiloh, Yosef and Schultz, David C and Taya, Yoichi and Bartek, Jiri and Bielopolski, Dana and Bekker-Jensen, Simon
Nature Cell Biology, ISSN 1465-7392, 08/2006, Volume 8, Issue 8, pp. 870 - 876
The cellular DNA-damage response is a signaling network that is vigorously activated by cytotoxic DNA lesions, such as double-strand breaks (DSBs). The DSB... 
CELLS | REPAIR | COREPRESSOR | REPRESSOR DOMAIN | ZINC-FINGER PROTEINS | IN-VIVO | TRANSCRIPTION | DAMAGE | GENOME | CELLULAR-RESPONSE | CELL BIOLOGY | Chromatin - metabolism | Phosphorylation | Nucleic Acid Synthesis Inhibitors - pharmacology | Humans | Cell Survival - genetics | Tripartite Motif-Containing Protein 28 | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Repressor Proteins - physiology | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Cell Line | Cell Survival - drug effects | DNA-Binding Proteins - physiology | Tumor Suppressor Proteins - metabolism | Zinostatin - pharmacology | Protein-Serine-Threonine Kinases - physiology | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Mutation - genetics | Blotting, Western | Tumor Suppressor Proteins - physiology | Cell Line, Tumor | Signal Transduction - physiology | DNA Damage | Cell Cycle Proteins - physiology | Microscopy, Fluorescence | Physiological aspects | DNA polymerases | Chromatin | Genetic aspects | Research | DNA damage | Index Medicus
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4. Full Text A Hedgehog-Induced BTB Protein Modulates Hedgehog Signaling by Degrading Ci/Gli Transcription Factor
by Zhang, Qing and Zhang, Lei and Wang, Bing and Ou, Chan-Yen and Chien, Cheng-Ting and Jiang, Jin
Developmental Cell, ISSN 1534-5807, 2006, Volume 10, Issue 6, pp. 719 - 729
The Ci/Gli family of transcription factors mediates Hedgehog (Hh) signaling in many key developmental processes. Here we identify a h- nduced MATH and TB... 
SIGNALING | CUBITUS-INTERRUPTUS | ACTIVATOR | KINASE-A | PATHWAY | PHOSPHORYLATION | DEGRADATION | DEVELOPMENTAL BIOLOGY | UBIQUITIN-LIGASE | EYE DEVELOPMENT | KINESIN-RELATED PROTEIN | DROSOPHILA | CELL BIOLOGY | Oncogene Proteins - genetics | Transcription Factors - chemistry | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Oncogene Proteins - physiology | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Hedgehog Proteins | Drosophila Proteins - physiology | Gene Expression Regulation, Developmental | Gene Deletion | Cullin Proteins - metabolism | Drosophila - embryology | Transgenes | Binding Sites | Insect Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Drosophila - genetics | Genes, Insect | Protein Structure, Tertiary | Amino Acid Sequence | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Oncogene Proteins - chemistry | Signal Transduction | Cell Cycle Proteins - metabolism | Oncogene Proteins - metabolism | Glutathione Transferase - metabolism | Insect Proteins - genetics | Drosophila - cytology | Gene Dosage | Drosophila Proteins - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Models, Biological | Embryo, Nonmammalian | Protein Binding | Trans-Activators - metabolism | Zinc Finger Protein GLI1 | Drosophila - metabolism | Drosophila Proteins - genetics | Proteasome Endopeptidase Complex - metabolism | Ubiquitin | DNA binding proteins | Developmental biology | Ligases | Index Medicus
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5. Full Text DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS
by Jin, Qianren and Lauth, Matthias and Shimokawa, Takashi and Toftgård, Rune and Fendrich, Volker and Barbacid, Mariano and Bergström, Åsa and Tostar, Ulrica and Guerra, Carmen
Nature Structural & Molecular Biology, ISSN 1545-9993, 06/2010, Volume 17, Issue 6, pp. 718 - 725
Synergism between the RAS and Hedgehog (HH) pathways has been suggested for carcinogenesis in the pancreas, lung and colon. We investigated the molecular... 
GLI1 EXPRESSION | SUPPRESSOR | PANCREATIC DUCTAL ADENOCARCINOMA | ONCOGENIC KRAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADULT MICE | INDUCTION | CELL BIOLOGY | CANCER-CELL | BIOPHYSICS | K-RAS | PATHWAY | PRIMARY CILIA | NIH 3T3 Cells | RNA, Small Interfering - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Pancreatic Neoplasms - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Zinc Finger Protein Gli2 | Zinc Finger Protein Gli3 | Hedgehog Proteins - metabolism | ras Proteins - metabolism | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Protein-Tyrosine Kinases - genetics | Adenocarcinoma - metabolism | Hedgehog Proteins - genetics | Kruppel-Like Transcription Factors - metabolism | Base Sequence | Adenocarcinoma - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Paracrine Communication - genetics | Protein-Serine-Threonine Kinases - genetics | ras Proteins - antagonists & inhibitors | Nuclear Proteins - metabolism | Pancreatic Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Cilia - metabolism | Autocrine Communication - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Models, Biological | RNA, Neoplasm - genetics | Mice | Zinc Finger Protein GLI1 | Mutation | Genes, ras | Kruppel-Like Transcription Factors - genetics | Ras genes | Pancreatic cancer | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Health aspects | Risk factors | Signal transduction | Molecular biology | Kinases | Cancer | Index Medicus
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6. Full Text The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking
by Liem Jr, Karel F and Ashe, Alyson and He, Mu and Satir, Peter and Moran, Jennifer and Beier, David and Wicking, Carol and Anderson, Kathryn V
Journal of Cell Biology, ISSN 0021-9525, 06/2012, Volume 197, Issue 6, pp. 789 - 800
Two intraflagellar transport (IFT) complexes, IFT-A and IFT-B, build and maintain primary cilia and are required for activity of the Sonic hedgehog (Shh)... 
LOCALIZATION | CAENORHABDITIS-ELEGANS | GENE | CHLAMYDOMONAS-REINHARDTII | MOUSE | TULP3 | MUTATIONS | CILIOGENESIS | INTRAFLAGELLAR TRANSPORT PROTEIN | HEDGEHOG | CELL BIOLOGY | Signal Transduction | Membrane Proteins - genetics | Mice, Inbred C57BL | Zinc Finger Protein Gli2 | Hedgehog Proteins - metabolism | Repressor Proteins - genetics | Male | Intracellular Signaling Peptides and Proteins - metabolism | Microscopy, Electron | Cilia - metabolism | Kinesin - metabolism | Proteins - genetics | Animals | Flagella - metabolism | Proteins - metabolism | Hedgehog Proteins - genetics | Kruppel-Like Transcription Factors - metabolism | Cilia - ultrastructure | Kinesin - genetics | Membrane Proteins - metabolism | Mice | Intracellular Signaling Peptides and Proteins - genetics | Kruppel-Like Transcription Factors - genetics | Repressor Proteins - metabolism | Physiological aspects | Research | Cilia and ciliary motion | Hedgehog proteins | Membrane proteins | Proteins | Membranes | Mutation | Genes | Index Medicus
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7. Full Text Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal
by Di Marcotullio, L and Greco, A and Mazzà, D and Canettieri, G and Pietrosanti, L and Infante, P and Coni, S and Moretti, M and De Smaele, E and Ferretti, E and Screpanti, I and Gulino, A
Oncogene, ISSN 0950-9232, 01/2011, Volume 30, Issue 1, pp. 65 - 76
Hedgehog pathway regulates tissue patterning and cell proliferation. Gli1 transcription factor is the major effector of Hedgehog signaling and its deregulation... 
Numb | Hedgehog | Itch | Gli1 | medulloblastoma | ubiquitination | WW DOMAINS | FINGER PROTEIN | UBIQUITIN-PROTEIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | FAMILY | CELL BIOLOGY | IN-VITRO | ENZYME | ONCOLOGY | GENETICS & HEREDITY | TARGETS | NIH 3T3 Cells | Signal Transduction | Humans | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Hedgehog Proteins - metabolism | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Membrane Proteins - metabolism | Mice | Zinc Finger Protein GLI1 | Ubiquitin-Protein Ligases - genetics | Repressor Proteins - metabolism | Ubiquitin | Care and treatment | Gliomas | Ligases | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Proteins | Signal transduction | Oncology | Genetics | Cellular biology | Index Medicus | Repressor Proteins | Nerve Tissue Proteins | Hedgehog Proteins | Ubiquitin-Protein Ligases | Membrane Proteins | Life Sciences | Transcription Factors | Cancer
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8. Full Text FCS‐like zinc finger 6 and 10 repress SnRK1 signalling in Arabidopsis
by Jamsheer K, Muhammed and Sharma, Manvi and Singh, Dhriti and Mannully, Chanchal T and Jindal, Sunita and Shukla, Brihaspati N and Laxmi, Ashverya
The Plant Journal, ISSN 0960-7412, 04/2018, Volume 94, Issue 2, pp. 232 - 245
SNF 1‐related protein kinase 1 (Sn RK 1) is a central regulator of plant growth during energy starvation. The FCS ‐like zinc finger ( FLZ ) proteins have... 
Arabidopsis thaliana | 1‐related protein kinase 1 | sugar availability | FCS | like zinc finger | SNF | adaptive growth | energy signalling | target of rapamycin | SNF1-related protein kinase 1 | FCS-like zinc finger | PHOSPHORYLATION | PROTEIN-KINASE | SUGAR | PLANT SCIENCES | THALIANA | TOR | GENE-EXPRESSION | AMPK | ENDOPLASMIC-RETICULUM | STRESS | PLANT-GROWTH | Arabidopsis Proteins - physiology | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Signal Transduction | Protein-Serine-Threonine Kinases - physiology | Endoplasmic Reticulum - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Arabidopsis - metabolism | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Gene Expression Regulation, Plant | Intracellular Signaling Peptides and Proteins - physiology | Protein-Serine-Threonine Kinases - metabolism | Physiological aspects | Protein biosynthesis | DNA binding proteins | Protein kinases | Analysis | TOR protein | Adaptor proteins | Growth conditions | Starvation | Genes | Rapamycin | Kinases | Promotion | Gene expression | Zinc | Mutants | Proteins | Ribosomal protein S6 kinase | Signaling | Plant growth | Repressors | Protein synthesis | Protein kinase | Cell cycle | Zinc finger proteins | Catalysis | Endoplasmic reticulum | Index Medicus
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9. Full Text Role for KAP1 Serine 824 Phosphorylation and Sumoylation/Desumoylation Switch in Regulating KAP1-mediated Transcriptional Repression
by Xu Li and Yung-Kang Lee and Jen-Chong Jeng and Yun Yen and David C. Schultz and Hsiu-Ming Shih and David K. Ann
Journal of Biological Chemistry, ISSN 0021-9258, 12/2007, Volume 282, Issue 50, pp. 36177 - 36189
As a multifunctional protein, KRAB domain-associated protein 1 (KAP1) is reportedly subjected to multiple protein posttranslational modifications, including... 
CELLS | DEPENDENT TRANSCRIPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ZINC-FINGER PROTEINS | DNA-DAMAGE | MDM2 INTERACTION | SUMO MODIFICATION | G CHECKPOINT | C-JUN | CANCER | P53 | Transcription, Genetic - drug effects | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Humans | bcl-2-Associated X Protein - biosynthesis | Mutation, Missense | Proto-Oncogene Proteins - biosynthesis | Tripartite Motif-Containing Protein 28 | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | DNA Damage - physiology | SUMO-1 Protein - genetics | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Cell Cycle Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Phosphorylation - drug effects | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | bcl-2-Associated X Protein - genetics | Apoptosis Regulatory Proteins - biosynthesis | DNA Damage - drug effects | Cell Line | Cysteine Endopeptidases | Endopeptidases - metabolism | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Serine - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Serine - metabolism | Transcription, Genetic - physiology | Endopeptidases - genetics | Cell Cycle - physiology | SUMO-1 Protein - metabolism | Apoptosis - physiology | Cell Cycle - drug effects | Proto-Oncogene Proteins c-bcl-2 - genetics | Doxorubicin - pharmacology | Index Medicus
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10. Full Text Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
by Wang, BL and Fallon, JF and Beachy, PA
CELL, ISSN 0092-8674, 02/2000, Volume 100, Issue 4, pp. 423 - 434
Ci/Gli zinc finger proteins mediate the transcriptional effects of Hedgehog protein signals. In Drosophila, Ci action as transcriptional repressor or activator... 
PROTEIN-KINASE-A | VENTRAL NEURAL-TUBE | CUBITUS-INTERRUPTUS | FLOOR PLATE | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TERMINAL CLEAVAGE PRODUCT | PATTERNING ACTIVITY | TRANSCRIPTION FACTOR | GREIG CEPHALOPOLYSYNDACTYLY SYNDROME | SONIC-HEDGEHOG | CELL BIOLOGY | Phosphorylation | Humans | Repressor Proteins | Zinc Finger Protein Gli2 | Zinc Finger Protein Gli3 | Molecular Sequence Data | DNA-Binding Proteins - metabolism | Hedgehog Proteins | Gene Expression Regulation, Developmental | Base Sequence | Body Patterning | Antibodies - immunology | Transcription, Genetic | Transcription Factors - immunology | Cyclic AMP-Dependent Protein Kinases - metabolism | DNA-Binding Proteins - immunology | Trans-Activators | Nerve Tissue Proteins | Transcription Factors - genetics | Xenopus Proteins | DNA-Binding Proteins - genetics | Chick Embryo | Limb Buds - embryology | Nuclear Proteins | Kruppel-Like Transcription Factors | Transcription Factors - metabolism | Animals | Proteins - metabolism | Mice | Protein Processing, Post-Translational | COS Cells | DNA, Complementary | Vertebrates | Carrier proteins | Physiological aspects | Genetic aspects | Research | Genetic transcription | Cytochemistry | Cell migration | Extremities (Anatomy) | Gli3 gene | Hedgehog protein | Cubitus interruptus protein | Sonic hedgehog protein | Gli3 protein | Index Medicus
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11. Full Text Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor
by Wu, Xiaofeng and Zhang, Li-Shu and Toombs, Jason and Kuo, Yi-Chun and Piazza, John Tyler and Tuladhar, Rubina and Barrett, Quinn and Fan, Chih-Wei and Zhang, Xuewu and Walensky, Loren D and Kool, Marcel and Cheng, Steven Y and Brekken, Rolf and Opferman, Joseph T and Green, Douglas R and Moldoveanu, Tudor and Lum, Lawrence
Nature Cell Biology, ISSN 1465-7392, 09/2017, Volume 19, Issue 10, pp. 1226 - 1236
Direct interactions between pro-and anti-apoptotic BCL-2 family members form the basis of cell death decision-making at the outer mitochondrial membrane (OMM).... 
SIGNAL | APOPTOSIS | ACTIVATION | SONIC HEDGEHOG | PATHWAY | MCL-1 | GENOMIC ANALYSIS | RESISTANCE | PROLIFERATION | MEDULLOBLASTOMA | CELL BIOLOGY | Neoplasms - metabolism | NIH 3T3 Cells