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The EMBO Journal, ISSN 0261-4189, 02/2011, Volume 30, Issue 4, pp. 770 - 782
Notch signalling is important for development and tissue homeostasis and activated in many human cancers. Nevertheless, mutations in Notch pathway components... 
miR‐200 | ZEB1 | EMT | Notch | stemness | miR-200 | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | PHENOTYPE | E-CADHERIN | MIR-200 FAMILY | REPRESSORS ZEB1 | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | COLORECTAL-CANCER | Receptors, Notch - metabolism | Humans | Receptors, Notch - genetics | Gene Knockdown Techniques | Intercellular Signaling Peptides and Proteins - physiology | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Neoplasms - genetics | Membrane Proteins - physiology | Serrate-Jagged Proteins | Base Sequence | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Transcription Factors - physiology | DNA-Binding Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Models, Biological | Calcium-Binding Proteins - physiology | Homeodomain Proteins - antagonists & inhibitors | Nuclear Proteins - antagonists & inhibitors | Signal Transduction - physiology | MicroRNAs - genetics | Feedback, Physiological - physiology | MicroRNAs - physiology | Homeodomain Proteins - physiology | Calcium-Binding Proteins - genetics | Zinc Finger E-box-Binding Homeobox 1 | Proteins | Signal transduction | Cellular biology | Molecular biology | Gene expression | Cancer | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 2005, Volume 47, Issue 6, pp. 817 - 831
The molecular mechanisms controlling the differentiation of neural progenitors into distinct subtypes of neurons during neocortical development are unknown.... 
AREA IDENTITY | NEOCORTICAL NEURONS | CELL FATE SPECIFICATION | CEREBRAL CORTICAL DEVELOPMENT | LAYER NEURONS | CENTRAL-NERVOUS-SYSTEM | SUBCORTICAL TARGETS | ZINC-FINGER GENE | SUBVENTRICULAR ZONE | NEUROSCIENCES | ZEBRAFISH FOREBRAIN | Membrane Glycoproteins - metabolism | Embryo, Mammalian | Homeodomain Proteins - metabolism | Nerve Tissue Proteins - deficiency | S100 Proteins - genetics | POU Domain Factors - genetics | Forkhead Transcription Factors - metabolism | In Situ Hybridization - methods | Repressor Proteins - metabolism | Gene Expression Regulation, Developmental - physiology | POU Domain Factors - metabolism | Animals, Newborn | DNA-Binding Proteins - physiology | Motor Neurons - physiology | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | S100 Proteins - metabolism | In Situ Nick-End Labeling - methods | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Immunohistochemistry - methods | Annexin A2 - genetics | Cell Death - physiology | Green Fluorescent Proteins - biosynthesis | Mice | Annexin A2 - metabolism | Age Factors | Phosphopyruvate Hydratase - metabolism | Cell Movement - physiology | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Motor Neurons - cytology | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Membrane Proteins - metabolism | Bromodeoxyuridine - metabolism | Cell Differentiation - physiology | Pyramidal Tracts - physiology | Nerve Tissue Proteins - physiology | Neocortex - growth & development | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Membrane Glycoproteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Cell Count - methods | Neocortex - cytology | Receptors, Antigen, T-Cell, alpha-beta - metabolism | Neurosciences | Neurons | Developmental biology | Stem cells | Studies | Brain | Ultrasonic imaging | Transcription factors | Hybridization | Neurogenesis | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2006, Volume 8, Issue 8, pp. 870 - 876
Journal Article
Developmental Cell, ISSN 1534-5807, 2006, Volume 10, Issue 6, pp. 719 - 729
The Ci/Gli family of transcription factors mediates Hedgehog (Hh) signaling in many key developmental processes. Here we identify a h- nduced MATH and TB... 
SIGNALING | CUBITUS-INTERRUPTUS | ACTIVATOR | KINASE-A | PATHWAY | PHOSPHORYLATION | DEGRADATION | DEVELOPMENTAL BIOLOGY | UBIQUITIN-LIGASE | EYE DEVELOPMENT | KINESIN-RELATED PROTEIN | DROSOPHILA | CELL BIOLOGY | Oncogene Proteins - genetics | Transcription Factors - chemistry | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Oncogene Proteins - physiology | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Hedgehog Proteins | Drosophila Proteins - physiology | Gene Expression Regulation, Developmental | Gene Deletion | Cullin Proteins - metabolism | Drosophila - embryology | Transgenes | Binding Sites | Insect Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Drosophila - genetics | Genes, Insect | Protein Structure, Tertiary | Amino Acid Sequence | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Oncogene Proteins - chemistry | Signal Transduction | Cell Cycle Proteins - metabolism | Oncogene Proteins - metabolism | Glutathione Transferase - metabolism | Insect Proteins - genetics | Drosophila - cytology | Gene Dosage | Drosophila Proteins - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Models, Biological | Embryo, Nonmammalian | Protein Binding | Trans-Activators - metabolism | Zinc Finger Protein GLI1 | Drosophila - metabolism | Drosophila Proteins - genetics | Proteasome Endopeptidase Complex - metabolism | Ubiquitin | DNA binding proteins | Developmental biology | Ligases | Index Medicus
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 06/2010, Volume 17, Issue 6, pp. 718 - 725
Synergism between the RAS and Hedgehog (HH) pathways has been suggested for carcinogenesis in the pancreas, lung and colon. We investigated the molecular... 
GLI1 EXPRESSION | SUPPRESSOR | PANCREATIC DUCTAL ADENOCARCINOMA | ONCOGENIC KRAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADULT MICE | INDUCTION | CELL BIOLOGY | CANCER-CELL | BIOPHYSICS | K-RAS | PATHWAY | PRIMARY CILIA | NIH 3T3 Cells | RNA, Small Interfering - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Pancreatic Neoplasms - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Zinc Finger Protein Gli2 | Zinc Finger Protein Gli3 | Hedgehog Proteins - metabolism | ras Proteins - metabolism | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Protein-Tyrosine Kinases - genetics | Adenocarcinoma - metabolism | Hedgehog Proteins - genetics | Kruppel-Like Transcription Factors - metabolism | Base Sequence | Adenocarcinoma - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Paracrine Communication - genetics | Protein-Serine-Threonine Kinases - genetics | ras Proteins - antagonists & inhibitors | Nuclear Proteins - metabolism | Pancreatic Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Cilia - metabolism | Autocrine Communication - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Models, Biological | RNA, Neoplasm - genetics | Mice | Zinc Finger Protein GLI1 | Mutation | Genes, ras | Kruppel-Like Transcription Factors - genetics | Ras genes | Pancreatic cancer | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Health aspects | Risk factors | Signal transduction | Molecular biology | Kinases | Cancer | Index Medicus
Journal Article
Journal Article
Journal Article
The Plant Journal, ISSN 0960-7412, 04/2018, Volume 94, Issue 2, pp. 232 - 245
SNF 1‐related protein kinase 1 (Sn RK 1) is a central regulator of plant growth during energy starvation. The FCS ‐like zinc finger ( FLZ ) proteins have... 
Arabidopsis thaliana | 1‐related protein kinase 1 | sugar availability | FCS | like zinc finger | SNF | adaptive growth | energy signalling | target of rapamycin | SNF1-related protein kinase 1 | FCS-like zinc finger | PHOSPHORYLATION | PROTEIN-KINASE | SUGAR | PLANT SCIENCES | THALIANA | TOR | GENE-EXPRESSION | AMPK | ENDOPLASMIC-RETICULUM | STRESS | PLANT-GROWTH | Arabidopsis Proteins - physiology | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Signal Transduction | Protein-Serine-Threonine Kinases - physiology | Endoplasmic Reticulum - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Arabidopsis - metabolism | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Gene Expression Regulation, Plant | Intracellular Signaling Peptides and Proteins - physiology | Protein-Serine-Threonine Kinases - metabolism | Physiological aspects | Protein biosynthesis | DNA binding proteins | Protein kinases | Analysis | TOR protein | Adaptor proteins | Growth conditions | Starvation | Genes | Rapamycin | Kinases | Promotion | Gene expression | Zinc | Mutants | Proteins | Ribosomal protein S6 kinase | Signaling | Plant growth | Repressors | Protein synthesis | Protein kinase | Cell cycle | Zinc finger proteins | Catalysis | Endoplasmic reticulum | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2007, Volume 282, Issue 50, pp. 36177 - 36189
As a multifunctional protein, KRAB domain-associated protein 1 (KAP1) is reportedly subjected to multiple protein posttranslational modifications, including... 
CELLS | DEPENDENT TRANSCRIPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ZINC-FINGER PROTEINS | DNA-DAMAGE | MDM2 INTERACTION | SUMO MODIFICATION | G CHECKPOINT | C-JUN | CANCER | P53 | Transcription, Genetic - drug effects | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Humans | bcl-2-Associated X Protein - biosynthesis | Mutation, Missense | Proto-Oncogene Proteins - biosynthesis | Tripartite Motif-Containing Protein 28 | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | DNA Damage - physiology | SUMO-1 Protein - genetics | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Cell Cycle Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Phosphorylation - drug effects | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | bcl-2-Associated X Protein - genetics | Apoptosis Regulatory Proteins - biosynthesis | DNA Damage - drug effects | Cell Line | Cysteine Endopeptidases | Endopeptidases - metabolism | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Serine - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Serine - metabolism | Transcription, Genetic - physiology | Endopeptidases - genetics | Cell Cycle - physiology | SUMO-1 Protein - metabolism | Apoptosis - physiology | Cell Cycle - drug effects | Proto-Oncogene Proteins c-bcl-2 - genetics | Doxorubicin - pharmacology | Index Medicus
Journal Article
CELL, ISSN 0092-8674, 02/2000, Volume 100, Issue 4, pp. 423 - 434
Ci/Gli zinc finger proteins mediate the transcriptional effects of Hedgehog protein signals. In Drosophila, Ci action as transcriptional repressor or activator... 
PROTEIN-KINASE-A | VENTRAL NEURAL-TUBE | CUBITUS-INTERRUPTUS | FLOOR PLATE | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TERMINAL CLEAVAGE PRODUCT | PATTERNING ACTIVITY | TRANSCRIPTION FACTOR | GREIG CEPHALOPOLYSYNDACTYLY SYNDROME | SONIC-HEDGEHOG | CELL BIOLOGY | Phosphorylation | Humans | Repressor Proteins | Zinc Finger Protein Gli2 | Zinc Finger Protein Gli3 | Molecular Sequence Data | DNA-Binding Proteins - metabolism | Hedgehog Proteins | Gene Expression Regulation, Developmental | Base Sequence | Body Patterning | Antibodies - immunology | Transcription, Genetic | Transcription Factors - immunology | Cyclic AMP-Dependent Protein Kinases - metabolism | DNA-Binding Proteins - immunology | Trans-Activators | Nerve Tissue Proteins | Transcription Factors - genetics | Xenopus Proteins | DNA-Binding Proteins - genetics | Chick Embryo | Limb Buds - embryology | Nuclear Proteins | Kruppel-Like Transcription Factors | Transcription Factors - metabolism | Animals | Proteins - metabolism | Mice | Protein Processing, Post-Translational | COS Cells | DNA, Complementary | Vertebrates | Carrier proteins | Physiological aspects | Genetic aspects | Research | Genetic transcription | Cytochemistry | Cell migration | Extremities (Anatomy) | Gli3 gene | Hedgehog protein | Cubitus interruptus protein | Sonic hedgehog protein | Gli3 protein | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 09/2017, Volume 19, Issue 10, pp. 1226 - 1236
Direct interactions between pro-and anti-apoptotic BCL-2 family members form the basis of cell death decision-making at the outer mitochondrial membrane (OMM).... 
SIGNAL | APOPTOSIS | ACTIVATION | SONIC HEDGEHOG | PATHWAY | MCL-1 | GENOMIC ANALYSIS | RESISTANCE | PROLIFERATION | MEDULLOBLASTOMA | CELL BIOLOGY | Neoplasms - metabolism | NIH 3T3 Cells