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zm447439 (23) 23
aurora kinases (16) 16
humans (15) 15
protein-serine-threonine kinases - antagonists & inhibitors (13) 13
benzamides - pharmacology (11) 11
quinazolines - pharmacology (11) 11
cancer (10) 10
aurora kinase b (9) 9
index medicus (9) 9
oncology (9) 9
protein-serine-threonine kinases - metabolism (9) 9
mitosis (8) 8
apoptosis (7) 7
cell biology (7) 7
cell line, tumor (7) 7
animals (6) 6
phosphorylation (6) 6
vx-680 (6) 6
apoptosis - drug effects (5) 5
expression (5) 5
overexpression (5) 5
phosphotransferases (5) 5
protein kinase inhibitors - pharmacology (5) 5
analysis (4) 4
aurora kinase (4) 4
aurora kinase a (4) 4
biological phenomena, cell phenomena, and immunity (4) 4
carcinoma (4) 4
chemotherapy (4) 4
cytokinesis (4) 4
hesperadin (4) 4
histones - metabolism (4) 4
in-vivo (4) 4
kinases (4) 4
protein-serine-threonine kinases - genetics (4) 4
proteins (4) 4
small-molecule inhibitor (4) 4
spindle checkpoint (4) 4
benzamides - chemistry (3) 3
binding (3) 3
calcium (3) 3
cell cycle (3) 3
cell proliferation - drug effects (3) 3
cellular biology (3) 3
centromere protein incenp (3) 3
chromosomes (3) 3
embryonic structures (3) 3
kinetochores (3) 3
macromolecular substances (3) 3
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mice (3) 3
mitosis - drug effects (3) 3
mln8054 (3) 3
pharmacology & pharmacy (3) 3
proliferation (3) 3
quinazolines (3) 3
quinazolines - chemistry (3) 3
resistance (3) 3
spindle apparatus - metabolism (3) 3
spindle assembly checkpoint (3) 3
survivin (3) 3
a kinase (2) 2
agents (2) 2
amplification (2) 2
anaphase (2) 2
aneuploidy (2) 2
antineoplastic agents - chemistry (2) 2
antineoplastic agents - pharmacology (2) 2
antitumor-activity (2) 2
aurora (2) 2
aurora a (2) 2
aurora b (2) 2
aurora kinase a - antagonists & inhibitors (2) 2
aurora kinase b - antagonists & inhibitors (2) 2
aurora kinase inhibitor (2) 2
aurora kinase inhibitor zm447439 (2) 2
aurora kinase inhibitors (2) 2
aurora-b (2) 2
azd1152 (2) 2
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biology (2) 2
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blotting, western (2) 2
breast cancer (2) 2
budding yeast (2) 2
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cell (2) 2
cell cycle - drug effects (2) 2
cell cycle proteins (2) 2
cell cycle proteins - metabolism (2) 2
cell division (2) 2
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The Journal of Cell Biology, ISSN 0021-9525, 4/2003, Volume 161, Issue 2, pp. 267 - 280
The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis. Here, we describe ZM447439, a novel selective Aurora kinase... 
Mitotic index | Mitosis | Kinetochores | Microtubules | DNA | Cell lines | HeLa cells | Cultured cells | Chromosomes | Cells | Chemical biology | Aneuploidy | Spindle checkpoint | ZM447439 | KINASE-ACTIVITY | LOCALIZATION | BUDDING YEAST | PHOSPHORYLATION | TENSION | mitosis | MAMMALIAN-CELLS | CELL BIOLOGY | chemical biology | CENTROSOME AMPLIFICATION | HISTONE H3 | aneuploidy | spindle checkpoint | Protein Kinases - metabolism | Protein Kinases - genetics | Paclitaxel - pharmacology | DNA Replication - drug effects | Humans | Chromosome Segregation - drug effects | Mitosis - genetics | Tumor Suppressor Protein p53 - genetics | Aurora Kinase B | Spindle Apparatus - genetics | Eukaryotic Cells - ultrastructure | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Benzamides - pharmacology | Mad2 Proteins | Phosphorylation - drug effects | Calcium-Binding Proteins - metabolism | Eukaryotic Cells - enzymology | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Genes, cdc - drug effects | Aurora Kinases | Tumor Suppressor Protein p53 - drug effects | Anaphase - drug effects | Chromosomal Proteins, Non-Histone - genetics | Anaphase - genetics | Eukaryotic Cells - drug effects | Mitosis - drug effects | DNA Replication - genetics | Repressor Proteins - drug effects | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Quinazolines - pharmacology | Cell Cycle Proteins | Calcium-Binding Proteins - genetics | Chromosome Segregation - genetics | Research | Cytokinesis | Protein kinases | mitosis; spindle checkpoint; chemical biology; aneuploidy; ZM447439
Journal Article
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, ISSN 1226-4512, 09/2019, Volume 23, Issue 5, pp. 393 - 402
Aurora kinases inhibitors, including ZM447439 (ZM), which suppress cell division, have attracted a great deal of attention as potential novel anti-cancer... 
APOPTOSIS | PHYSIOLOGY | Efficacy testing | ZM447439 | TOXICITY | Anticancer agents | Cardiotoxicity | SUPPRESSION | CANCER | BREAST | OVEREXPRESSION | Aurora kinases inhibitor | CALCIUM | OVARIAN | PHARMACOLOGY & PHARMACY | Original | 약리학
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 2015, Volume 5, p. 285
Aurora kinases are essential for cell division and are frequently misregulated in human cancers. Based on their potential as cancer therapeutics, a plethora of... 
MK-8745 | MLN8054 | Aurora kinase inhibitors | AZD1152 | MLN8237 | Hesperadin | ZM447439 | MK-5108 | ALISERTIB MLN8237 | PROTEIN-KINASE | CRYSTAL-STRUCTURE | ANTITUMOR-ACTIVITY | RESISTANT AURORA | SMALL-MOLECULE INHIBITOR | PASSENGER COMPLEX | ONCOLOGY | SELECTIVE INHIBITORS | A KINASE | TIGHT-BINDING INHIBITORS | Care and treatment | Phosphotransferases | Health aspects | Methods | Cancer
Journal Article
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 12/2015, Volume 5
Aurora kinases are essential for cell division and are frequently misregulated in human cancers. Based on their potential as cancer therapeutics, a plethora of... 
kinase | chemical biology tools | kinase inhibitors | aurora | Aurora B | Aurora A
Journal Article
Journal of Cancer Research and Clinical Oncology, ISSN 0171-5216, 3/2012, Volume 138, Issue 3, pp. 405 - 414
Glioblastoma remains one of the most devastating human malignancies, and despite therapeutic advances, there are no drugs that significantly improve the... 
Medicine & Public Health | Hematology | Glioblastoma | Radiation | Internal Medicine | Cancer Research | Oncology | ZM447439 | Temozolomide | Aurora B | Aurora A | TARGET | SURVIVAL | MICROARRAY | TIME QUANTITATIVE PCR | OVEREXPRESSION | ONCOLOGY | POLYPLOIDY | RESISTANT PROSTATE-CANCER | EXPRESSION | CARCINOMA | Glioblastoma - enzymology | Cell Proliferation | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents, Alkylating - pharmacology | RNA, Neoplasm - isolation & purification | Aurora Kinase B | Time Factors | Dacarbazine - pharmacology | Dacarbazine - analogs & derivatives | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Benzamides - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Brain Neoplasms - enzymology | Radiation-Sensitizing Agents - pharmacology | Aurora Kinases | Brain Neoplasms - drug therapy | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Gene Expression Regulation, Enzymologic | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Glioblastoma - drug therapy | Quinazolines - pharmacology | Medical colleges | Oncology, Experimental | Research | Glioblastoma multiforme | Gamma rays | Chemotherapy | Messenger RNA | Nuclear radiation | Cell death | Analysis | Drug therapy, Combination | Health aspects | Phosphotransferases | Cancer
Journal Article
World journal of oncology, ISSN 1920-4531, 10/2017, Volume 8, Issue 5, pp. 151 - 161
The Aurora kinase family is comprised of highly conserved serine/threonine protein kinases that are known to be crucial in the regulation of the cell cycle.... 
Immunohistochemistry | Aurora kinases A, B and C | Migration | Breast cancer | ZM447439 | Metastasis | Proliferation | Original | Adhesion
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 11/2009, Volume 79, Issue 2, p. 122
ZM447439 (ZM) is a potent and selective inhibitor of aurora-A and -B kinase with putative anti-tumoral activity. Inhibitors of aurora kinases were shown to... 
Journal Article
Chinese Journal of Clinical Oncology, ISSN 1000-8179, 11/2011, Volume 38, Issue 22, pp. 1383 - 1386
Journal Article
Cell Cycle, ISSN 1538-4101, 12/2010, Volume 9, Issue 23, pp. 4674 - 4687
Journal Article