Hypertension, ISSN 0194-911X, 06/2017, Volume 70, Issue 2, pp. 347 - 356
Ca drives aldosterone synthesis in the cytosolic and mitochondrial compartments of the adrenal zona glomerulosa cell. Membrane potential across each of these...
hyperaldosteronism | zona glomerulosa | aldosterone | mitochondria | ion channels | ANGIOTENSIN SYSTEM | REDOX STATE | POTASSIUM CHANNELS | PLASMA-MEMBRANE | BLOOD-PRESSURE | TASK CHANNELS | ACUTE REGULATORY PROTEIN | CALCIUM | PERIPHERAL VASCULAR DISEASE | K+ CHANNEL | Zona Glomerulosa - physiology | Aldosterone - biosynthesis | Humans | Potassium Channels, Tandem Pore Domain - physiology | Cells, Cultured | Membrane Potential, Mitochondrial - physiology | Hyperaldosteronism - metabolism | Mitochondria - physiology | leak potassium channels | membrane potential
hyperaldosteronism | zona glomerulosa | aldosterone | mitochondria | ion channels | ANGIOTENSIN SYSTEM | REDOX STATE | POTASSIUM CHANNELS | PLASMA-MEMBRANE | BLOOD-PRESSURE | TASK CHANNELS | ACUTE REGULATORY PROTEIN | CALCIUM | PERIPHERAL VASCULAR DISEASE | K+ CHANNEL | Zona Glomerulosa - physiology | Aldosterone - biosynthesis | Humans | Potassium Channels, Tandem Pore Domain - physiology | Cells, Cultured | Membrane Potential, Mitochondrial - physiology | Hyperaldosteronism - metabolism | Mitochondria - physiology | leak potassium channels | membrane potential
Journal Article
Hypertension, ISSN 0194-911X, 11/2019, Volume 74, Issue 5, pp. 1152 - 1159
Microarray comparison of the transcriptomes of human adrenal zona glomerulosa (ZG) and zona fasciculata found several ZG-specific genes that negatively...
Zona glomerulosa | CHLORIDE CURRENT | PROTEIN | cell proliferation | aldosterone | ANGIOTENSIN-II | CHANNEL DELETION | anoctamins | SOMATIC MUTATIONS | FAMILY | TMEM16 | chloride channel | CALCIUM | COMMON | PERIPHERAL VASCULAR DISEASE | ADENOMAS | 10111 | Original
Zona glomerulosa | CHLORIDE CURRENT | PROTEIN | cell proliferation | aldosterone | ANGIOTENSIN-II | CHANNEL DELETION | anoctamins | SOMATIC MUTATIONS | FAMILY | TMEM16 | chloride channel | CALCIUM | COMMON | PERIPHERAL VASCULAR DISEASE | ADENOMAS | 10111 | Original
Journal Article
Hypertension, ISSN 0194-911X, 05/2015, Volume 65, Issue 5, pp. 1103 - 1110
Common somatic mutations in CACNAID and ATP1A1 may define a subgroup of smaller, zona glomerulosa (70) like aldosterone-producing adenomas. We have therefore...
hyperaldosteronism | zona glomerulosa | DACH1 protein human | transforming growth factor beta | aldosterone | CELLS | CYCLIN D1 | DACH1 protein, human | CANCER | TRANSCRIPTOME ANALYSIS | GROWTH-FACTOR-BETA-1 INHIBITS ALDOSTERONE | PERIPHERAL VASCULAR DISEASE | MUTATIONS | FATE DETERMINATION FACTOR | WNT | EXPRESSION | ADENOMAS | Immunohistochemistry | Signal Transduction | Adrenocortical Carcinoma - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Aldosterone - secretion | Zona Glomerulosa - pathology | Male | Transcription Factors - biosynthesis | Zona Glomerulosa - metabolism | Transcription Factors - genetics | Transforming Growth Factor beta - biosynthesis | Disease Progression | Adrenocortical Carcinoma - pathology | Transforming Growth Factor beta - genetics | Adrenocortical Carcinoma - metabolism | RNA, Neoplasm - genetics | Female | Eye Proteins - genetics | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Eye Proteins - biosynthesis | Original
hyperaldosteronism | zona glomerulosa | DACH1 protein human | transforming growth factor beta | aldosterone | CELLS | CYCLIN D1 | DACH1 protein, human | CANCER | TRANSCRIPTOME ANALYSIS | GROWTH-FACTOR-BETA-1 INHIBITS ALDOSTERONE | PERIPHERAL VASCULAR DISEASE | MUTATIONS | FATE DETERMINATION FACTOR | WNT | EXPRESSION | ADENOMAS | Immunohistochemistry | Signal Transduction | Adrenocortical Carcinoma - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Aldosterone - secretion | Zona Glomerulosa - pathology | Male | Transcription Factors - biosynthesis | Zona Glomerulosa - metabolism | Transcription Factors - genetics | Transforming Growth Factor beta - biosynthesis | Disease Progression | Adrenocortical Carcinoma - pathology | Transforming Growth Factor beta - genetics | Adrenocortical Carcinoma - metabolism | RNA, Neoplasm - genetics | Female | Eye Proteins - genetics | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Eye Proteins - biosynthesis | Original
Journal Article
Hypertension, ISSN 0194-911X, 09/2017, Volume 70, Issue 5, pp. 867 - 874
HUMAN TISSUES | ADRENAL-CORTEX | ADRENOCORTICAL-CELLS | POTASSIUM CHANNELS | K+ CHANNEL MUTATIONS | GENE-EXPRESSION | KCNJ5 MUTATIONS | PERIPHERAL VASCULAR DISEASE | MONOCLONAL-ANTIBODIES | SOMATIC MUTATIONS | CONNS ADENOMA | Biomarkers - metabolism | Humans | Hyperaldosteronism - pathology | Zona Glomerulosa - pathology | Hyperaldosteronism - metabolism | Zona Glomerulosa - metabolism | Adrenal Cortex Neoplasms - pathology | Adenoma - metabolism | Aldosterone - metabolism | Animals | Adenoma - pathology | Signal Transduction - physiology | Adrenal Cortex Neoplasms - metabolism | Index Medicus | zona glomerulosa | adrenal | CYP11B2 | biomarkers | aldosterone | aldosterone producing adenoma
Journal Article
Developmental Cell, ISSN 1534-5807, 09/2013, Volume 26, Issue 6, pp. 666 - 673
Lineage conversion of differentiated cells in response to hormonal feedback has yet to be described. To investigate this, we studied the adrenal cortex, which...
ADRENAL-CORTEX | BETA-CELLS | MICE | ALDOSTERONE | DEVELOPMENTAL BIOLOGY | FETAL | EXPRESSION | STEROIDOGENIC FACTOR-I | GLAND | NUCLEAR RECEPTOR | X-ZONE | CELL BIOLOGY | Embryonic Stem Cells - metabolism | Zona Glomerulosa - growth & development | Embryonic Stem Cells - cytology | Homeostasis | Steroidogenic Factor 1 - genetics | Zona Glomerulosa - metabolism | Zona Fasciculata - cytology | Zona Glomerulosa - cytology | Cell Lineage | Feedback, Physiological | Animals | Hormones - metabolism | Zona Fasciculata - growth & development | Gene Expression Regulation, Developmental | Gene Deletion | Transcription, Genetic | Zona Fasciculata - metabolism | Cell Differentiation | Mice | Steroidogenic Factor 1 - metabolism | Physiological aspects | Stem cells
ADRENAL-CORTEX | BETA-CELLS | MICE | ALDOSTERONE | DEVELOPMENTAL BIOLOGY | FETAL | EXPRESSION | STEROIDOGENIC FACTOR-I | GLAND | NUCLEAR RECEPTOR | X-ZONE | CELL BIOLOGY | Embryonic Stem Cells - metabolism | Zona Glomerulosa - growth & development | Embryonic Stem Cells - cytology | Homeostasis | Steroidogenic Factor 1 - genetics | Zona Glomerulosa - metabolism | Zona Fasciculata - cytology | Zona Glomerulosa - cytology | Cell Lineage | Feedback, Physiological | Animals | Hormones - metabolism | Zona Fasciculata - growth & development | Gene Expression Regulation, Developmental | Gene Deletion | Transcription, Genetic | Zona Fasciculata - metabolism | Cell Differentiation | Mice | Steroidogenic Factor 1 - metabolism | Physiological aspects | Stem cells
Journal Article
The Journal of Physiology, ISSN 0022-3751, 10/2016, Volume 594, Issue 20, pp. 5851 - 5860
Zona glomerulosa cells (ZG) of the adrenal gland constantly integrate fluctuating ionic, hormonal and paracrine signals to control the synthesis and secretion...
PHYSIOLOGY | SLEEP SPINDLE DENSITY | RESISTANT HYPERTENSION | PROTEIN-KINASE | KCNJ5 MUTATIONS | ANGIOTENSIN-II | T-TYPE | CYTOSOLIC CALCIUM | NEUROSCIENCES | SOMATIC MUTATIONS | CA2+ OSCILLATIONS | KINASE-II | Aldosterone - metabolism | Animals | Calcium Channels - metabolism | Calcium - metabolism | Humans | Adrenal Cortex - metabolism | Zona Glomerulosa - metabolism | Calcium channels | Corticosteroids | Aldosterone | Angiotensin | Symposium Review | Symposium section reviews | Cellular and Molecular Physiology | Voltage‐gated calcium channels ‐ from basic mechanisms to disease | Endocrinology and Metabolism
PHYSIOLOGY | SLEEP SPINDLE DENSITY | RESISTANT HYPERTENSION | PROTEIN-KINASE | KCNJ5 MUTATIONS | ANGIOTENSIN-II | T-TYPE | CYTOSOLIC CALCIUM | NEUROSCIENCES | SOMATIC MUTATIONS | CA2+ OSCILLATIONS | KINASE-II | Aldosterone - metabolism | Animals | Calcium Channels - metabolism | Calcium - metabolism | Humans | Adrenal Cortex - metabolism | Zona Glomerulosa - metabolism | Calcium channels | Corticosteroids | Aldosterone | Angiotensin | Symposium Review | Symposium section reviews | Cellular and Molecular Physiology | Voltage‐gated calcium channels ‐ from basic mechanisms to disease | Endocrinology and Metabolism
Journal Article
Blood Pressure, ISSN 0803-7051, 09/2018, Volume 27, Issue 5, pp. 304 - 312
Background: Primary aldosteronism (PA) is the most common cause of secondary hypertension and bilateral adrenal hyperplasia (BAH) and aldosterone-producing...
Primary aldosteronism | adrenal cortex insufficiency | chronic kidney failure | hyperkalemia | ALDOSTERONE-PRODUCING ADENOMA | PRESSURE | POSTOPERATIVE HYPERKALEMIA | PERIPHERAL VASCULAR DISEASE | HYPERTENSION | HYPOKALEMIA | Adrenal Cortex - physiopathology | Fludrocortisone - therapeutic use | Anti-Inflammatory Agents | Adrenalectomy - adverse effects | Humans | Zona Glomerulosa - physiopathology | Hyperaldosteronism - complications | Hypertension - complications | Male | Aged | Renal Insufficiency - etiology | Hyperkalemia - etiology
Primary aldosteronism | adrenal cortex insufficiency | chronic kidney failure | hyperkalemia | ALDOSTERONE-PRODUCING ADENOMA | PRESSURE | POSTOPERATIVE HYPERKALEMIA | PERIPHERAL VASCULAR DISEASE | HYPERTENSION | HYPOKALEMIA | Adrenal Cortex - physiopathology | Fludrocortisone - therapeutic use | Anti-Inflammatory Agents | Adrenalectomy - adverse effects | Humans | Zona Glomerulosa - physiopathology | Hyperaldosteronism - complications | Hypertension - complications | Male | Aged | Renal Insufficiency - etiology | Hyperkalemia - etiology
Journal Article
Endocrine Reviews, ISSN 0163-769X, 12/2018, Volume 39, Issue 6, pp. 1029 - 1056
The identification of several germline and somatic ion channel mutations in aldosterone-producing adenomas (APAs) and detection of cell clusters that can be...
RESISTANT HYPERTENSION | POTASSIUM CHANNELS | HYPERALDOSTERONISM TYPE-III | K+ CHANNEL MUTATIONS | ENDOCRINOLOGY & METABOLISM | ANGIOTENSIN-II | FETAL ADRENAL-CORTEX | MONOCLONAL-ANTIBODIES | SOMATIC MUTATIONS | CELL CLUSTERS | PROTEIN-KINASE-II | Adrenocortical Adenoma - diagnosis | Humans | Hyperaldosteronism - pathology | Zona Glomerulosa - pathology | Hyperaldosteronism - metabolism | Zona Glomerulosa - metabolism | Adrenal Cortex Neoplasms - pathology | Adrenocortical Adenoma - pathology | Adrenocortical Adenoma - metabolism | Aging - pathology | Hyperaldosteronism - diagnosis | Adrenal Cortex Neoplasms - diagnosis | Aldosterone - metabolism | Adrenal Cortex Neoplasms - metabolism | Aging - metabolism
RESISTANT HYPERTENSION | POTASSIUM CHANNELS | HYPERALDOSTERONISM TYPE-III | K+ CHANNEL MUTATIONS | ENDOCRINOLOGY & METABOLISM | ANGIOTENSIN-II | FETAL ADRENAL-CORTEX | MONOCLONAL-ANTIBODIES | SOMATIC MUTATIONS | CELL CLUSTERS | PROTEIN-KINASE-II | Adrenocortical Adenoma - diagnosis | Humans | Hyperaldosteronism - pathology | Zona Glomerulosa - pathology | Hyperaldosteronism - metabolism | Zona Glomerulosa - metabolism | Adrenal Cortex Neoplasms - pathology | Adrenocortical Adenoma - pathology | Adrenocortical Adenoma - metabolism | Aging - pathology | Hyperaldosteronism - diagnosis | Adrenal Cortex Neoplasms - diagnosis | Aldosterone - metabolism | Adrenal Cortex Neoplasms - metabolism | Aging - metabolism
Journal Article
Endocrinology, ISSN 0013-7227, 01/2018, Volume 159, Issue 1, pp. 238 - 247
Hyperaldosteronism is associated with hypertension, cardiac hypertrophy, and congestive heart failure. Steroidogenic factors facilitate aldosterone secretion...
STEROIDOGENESIS | ALDOSTERONE RELEASE | STEROID-SECRETION | ENDOCRINOLOGY & METABOLISM | RAT ADRENALS | AMINOPEPTIDASE | MEDIUM FLOW-RATE | BLOOD-FLOW | RECEPTORS | GLAND | ENDOTHELIAL NITRIC-OXIDE | Endothelium, Vascular - cytology | Gene Expression Regulation, Enzymologic - drug effects | Abattoirs | Muscle, Smooth, Vascular - metabolism | Zona Glomerulosa - drug effects | Adrenal Cortex - metabolism | Endothelium, Vascular - drug effects | Peptide Fragments - pharmacology | Protease Inhibitors - pharmacology | Aldosterone - metabolism | Cattle | Adrenal Cortex - drug effects | Aminopeptidases - metabolism | Arterioles - cytology | Muscle, Smooth, Vascular - drug effects | Aminopeptidases - genetics | Angiotensin II - pharmacology | Peptide Fragments - metabolism | Angiotensin II - metabolism | Cells, Cultured | Zona Glomerulosa - metabolism | Adrenal Cortex - blood supply | Aminopeptidases - antagonists & inhibitors | Angiotensin II - analogs & derivatives | Angiotensin I - metabolism | Muscle, Smooth, Vascular - cytology | Arterioles - drug effects | Zona Glomerulosa - cytology | Angiotensin III - metabolism | Angiotensin II - chemistry | Animals | Arterioles - metabolism | Endothelium, Vascular - metabolism | Peptide Fragments - antagonists & inhibitors | Vasodilation - drug effects | In Vitro Techniques | Angiotensin I - antagonists & inhibitors | Heart | Enzyme activity | Angiotensin III | Adrenal glands | Eicosanoids | Congestive heart failure | Aldosterone | Arteries | Receptors | Enzymatic activity | Metabolites | Adrenal gland | Angiotensin II | Hypertension | Peptidase | Secretion | Cortex | Mass spectroscopy | Liquid chromatography | Metabolism | Blood flow | Angiotensin | Aminopeptidase | Mass spectrometry | Adrenal metabolism | Hypertrophy | Veins & arteries
STEROIDOGENESIS | ALDOSTERONE RELEASE | STEROID-SECRETION | ENDOCRINOLOGY & METABOLISM | RAT ADRENALS | AMINOPEPTIDASE | MEDIUM FLOW-RATE | BLOOD-FLOW | RECEPTORS | GLAND | ENDOTHELIAL NITRIC-OXIDE | Endothelium, Vascular - cytology | Gene Expression Regulation, Enzymologic - drug effects | Abattoirs | Muscle, Smooth, Vascular - metabolism | Zona Glomerulosa - drug effects | Adrenal Cortex - metabolism | Endothelium, Vascular - drug effects | Peptide Fragments - pharmacology | Protease Inhibitors - pharmacology | Aldosterone - metabolism | Cattle | Adrenal Cortex - drug effects | Aminopeptidases - metabolism | Arterioles - cytology | Muscle, Smooth, Vascular - drug effects | Aminopeptidases - genetics | Angiotensin II - pharmacology | Peptide Fragments - metabolism | Angiotensin II - metabolism | Cells, Cultured | Zona Glomerulosa - metabolism | Adrenal Cortex - blood supply | Aminopeptidases - antagonists & inhibitors | Angiotensin II - analogs & derivatives | Angiotensin I - metabolism | Muscle, Smooth, Vascular - cytology | Arterioles - drug effects | Zona Glomerulosa - cytology | Angiotensin III - metabolism | Angiotensin II - chemistry | Animals | Arterioles - metabolism | Endothelium, Vascular - metabolism | Peptide Fragments - antagonists & inhibitors | Vasodilation - drug effects | In Vitro Techniques | Angiotensin I - antagonists & inhibitors | Heart | Enzyme activity | Angiotensin III | Adrenal glands | Eicosanoids | Congestive heart failure | Aldosterone | Arteries | Receptors | Enzymatic activity | Metabolites | Adrenal gland | Angiotensin II | Hypertension | Peptidase | Secretion | Cortex | Mass spectroscopy | Liquid chromatography | Metabolism | Blood flow | Angiotensin | Aminopeptidase | Mass spectrometry | Adrenal metabolism | Hypertrophy | Veins & arteries
Journal Article
10.
Full Text
Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electrical oscillators
Journal of Clinical Investigation, ISSN 0021-9738, 06/2012, Volume 122, Issue 6, pp. 2046 - 2053
Aldosterone, which plays a central role in the regulation of blood pressure, is produced by zona glomerulosa (ZG) cells of the adrenal gland. When...
MEDICINE, RESEARCH & EXPERIMENTAL | VOLTAGE | CALCIUM-CHANNELS | ALDOSTERONE SECRETION | CA2+ CHANNELS | ANGIOTENSIN-II | T-TYPE | POTASSIUM | SENSORY NEURONS | KINASE-II | Kidney Diseases - physiopathology | Potassium - metabolism | Cardiovascular Diseases - physiopathology | Angiotensin II - metabolism | Calcium Channels - metabolism | Cardiovascular Diseases - metabolism | Calcium - metabolism | Kidney Diseases - pathology | Zona Glomerulosa - pathology | Male | Zona Glomerulosa - metabolism | Cardiovascular Diseases - pathology | Animals | Membrane Potentials | Mice | Biological Clocks | Kidney Diseases - metabolism | Calcium channels | Adrenal cortex | Physiological aspects | Electrophysiology | Research | Properties | Aldosterone | Health aspects
MEDICINE, RESEARCH & EXPERIMENTAL | VOLTAGE | CALCIUM-CHANNELS | ALDOSTERONE SECRETION | CA2+ CHANNELS | ANGIOTENSIN-II | T-TYPE | POTASSIUM | SENSORY NEURONS | KINASE-II | Kidney Diseases - physiopathology | Potassium - metabolism | Cardiovascular Diseases - physiopathology | Angiotensin II - metabolism | Calcium Channels - metabolism | Cardiovascular Diseases - metabolism | Calcium - metabolism | Kidney Diseases - pathology | Zona Glomerulosa - pathology | Male | Zona Glomerulosa - metabolism | Cardiovascular Diseases - pathology | Animals | Membrane Potentials | Mice | Biological Clocks | Kidney Diseases - metabolism | Calcium channels | Adrenal cortex | Physiological aspects | Electrophysiology | Research | Properties | Aldosterone | Health aspects
Journal Article
Hypertension, ISSN 0194-911X, 11/2010, Volume 56, Issue 5, pp. 885 - 892
Primary aldosteronism is the most common form of secondary hypertension with hypokalemia and suppressed renin-angiotensin system caused by autonomous...
aldosterone-producing adenoma | potassium | secondary hypertension | zona glomerulosa hyperplasia | adrenal cortex remodeling | aldosterone | transcriptome | HYPERALDOSTERONISM | ADENOMA | PERIPHERAL VASCULAR DISEASE | EXPRESSION | TUMORS | Immunohistochemistry | Adenoma - genetics | Aldosterone - biosynthesis | Humans | Hyperaldosteronism - pathology | Middle Aged | Adrenal Cortex - metabolism | Zona Glomerulosa - pathology | Male | Hyperaldosteronism - metabolism | Adrenal Cortex - pathology | Steroid 11-beta-Hydroxylase - genetics | Adenoma - metabolism | In Situ Hybridization | Adult | Female | Adrenal Cortex Neoplasms - metabolism | Cytochrome P-450 CYP11B2 - metabolism | Hyperaldosteronism - genetics | Zona Glomerulosa - metabolism | Adrenal Cortex Neoplasms - pathology | Adrenal Cortex Neoplasms - genetics | Hyperplasia - pathology | Steroid 11-beta-Hydroxylase - metabolism | Adenoma - pathology | Cytochrome P-450 CYP11B2 - genetics | Adrenal Cortex | Aldosterone Synthase | Hyperaldosteronism | Steroid 11-beta-Hydroxylase | Hyperplasia | Adenoma | Aldosterone | Life Sciences | Human health and pathology | Adrenal Cortex Neoplasms | Zona Glomerulosa
aldosterone-producing adenoma | potassium | secondary hypertension | zona glomerulosa hyperplasia | adrenal cortex remodeling | aldosterone | transcriptome | HYPERALDOSTERONISM | ADENOMA | PERIPHERAL VASCULAR DISEASE | EXPRESSION | TUMORS | Immunohistochemistry | Adenoma - genetics | Aldosterone - biosynthesis | Humans | Hyperaldosteronism - pathology | Middle Aged | Adrenal Cortex - metabolism | Zona Glomerulosa - pathology | Male | Hyperaldosteronism - metabolism | Adrenal Cortex - pathology | Steroid 11-beta-Hydroxylase - genetics | Adenoma - metabolism | In Situ Hybridization | Adult | Female | Adrenal Cortex Neoplasms - metabolism | Cytochrome P-450 CYP11B2 - metabolism | Hyperaldosteronism - genetics | Zona Glomerulosa - metabolism | Adrenal Cortex Neoplasms - pathology | Adrenal Cortex Neoplasms - genetics | Hyperplasia - pathology | Steroid 11-beta-Hydroxylase - metabolism | Adenoma - pathology | Cytochrome P-450 CYP11B2 - genetics | Adrenal Cortex | Aldosterone Synthase | Hyperaldosteronism | Steroid 11-beta-Hydroxylase | Hyperplasia | Adenoma | Aldosterone | Life Sciences | Human health and pathology | Adrenal Cortex Neoplasms | Zona Glomerulosa
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 05/2012, Volume 97, Issue 5, pp. E819 - E829
Context: Aldosterone-producing adenomas (APA) are heterogeneous. The recent finding of somatic KCNJ5 mutations suggests a genetic explanation. Objectives: The...
CELLS | ENDOCRINOLOGY & METABOLISM | UPRIGHT POSTURE | EXPRESSION PROFILES | MUTATIONS | HYPERTENSION | RECEPTORS | ANGIOTENSIN | BLOOD-PRESSURE | GENOME-WIDE ASSOCIATION | Adenoma - genetics | Aldosterone - biosynthesis | Humans | Hyperaldosteronism - pathology | Middle Aged | Hyperaldosteronism - genetics | Zona Glomerulosa - pathology | Genotype | Male | Hyperaldosteronism - metabolism | Zona Glomerulosa - metabolism | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Adenoma - metabolism | Phenotype | Adenoma - pathology | Adrenal Gland Neoplasms - metabolism | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Zona Fasciculata - pathology | Adult | Female | Zona Fasciculata - metabolism | Aged | Adrenal Gland Neoplasms - genetics | Adrenal Gland Neoplasms - pathology
CELLS | ENDOCRINOLOGY & METABOLISM | UPRIGHT POSTURE | EXPRESSION PROFILES | MUTATIONS | HYPERTENSION | RECEPTORS | ANGIOTENSIN | BLOOD-PRESSURE | GENOME-WIDE ASSOCIATION | Adenoma - genetics | Aldosterone - biosynthesis | Humans | Hyperaldosteronism - pathology | Middle Aged | Hyperaldosteronism - genetics | Zona Glomerulosa - pathology | Genotype | Male | Hyperaldosteronism - metabolism | Zona Glomerulosa - metabolism | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Adenoma - metabolism | Phenotype | Adenoma - pathology | Adrenal Gland Neoplasms - metabolism | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Zona Fasciculata - pathology | Adult | Female | Zona Fasciculata - metabolism | Aged | Adrenal Gland Neoplasms - genetics | Adrenal Gland Neoplasms - pathology
Journal Article
Endocrinology, ISSN 0013-7227, 04/2014, Volume 155, Issue 4, pp. 1363 - 1372
Aldosterone is the primary adrenocortical hormone regulating sodium retention, and its production is under the control of the renin-angiotensin-aldosterone...
CELLS | ALDOSTERONE-PRODUCING ADENOMAS | ENZYMES | TRANSCRIPTION | ENDOCRINOLOGY & METABOLISM | FASCICULATA | ADRENOCORTICAL CARCINOMA | RECEPTOR | ONTOLOGY | ANGIOTENSIN-II | RAPID RESPONSE GENES | Oligonucleotide Array Sequence Analysis | Gene Expression Regulation | Transcriptome | Rats | Male | Zona Glomerulosa - metabolism | Sodium Chloride, Dietary | Rats, Sprague-Dawley | Cholesterol - chemistry | Sodium - deficiency | Aldosterone - metabolism | Animals | Adrenal Glands - metabolism | Time Factors | Diet, Sodium-Restricted | Steroids - chemistry | Glucocorticoids-CRH-ACTH-Adrenal
CELLS | ALDOSTERONE-PRODUCING ADENOMAS | ENZYMES | TRANSCRIPTION | ENDOCRINOLOGY & METABOLISM | FASCICULATA | ADRENOCORTICAL CARCINOMA | RECEPTOR | ONTOLOGY | ANGIOTENSIN-II | RAPID RESPONSE GENES | Oligonucleotide Array Sequence Analysis | Gene Expression Regulation | Transcriptome | Rats | Male | Zona Glomerulosa - metabolism | Sodium Chloride, Dietary | Rats, Sprague-Dawley | Cholesterol - chemistry | Sodium - deficiency | Aldosterone - metabolism | Animals | Adrenal Glands - metabolism | Time Factors | Diet, Sodium-Restricted | Steroids - chemistry | Glucocorticoids-CRH-ACTH-Adrenal
Journal Article
Hypertension, ISSN 0194-911X, 08/2017, Volume 70, Issue 2, pp. 357 - 364
Heterogeneity among aldosterone-producing adenomas (APAs) has been highlighted by the discovery of somatic mutations. KCNJ5 mutations predominate in large zona...
mutation | cell proliferation | adrenal cortex | dopamine | aldosterone | LOCALIZATION | D2 DOPAMINE-RECEPTOR | PHENOTYPE | PROLIFERATION | METOCLOPRAMIDE | SOMATIC MUTATIONS | MESSENGER-RIBONUCLEIC-ACID | ADENOMA | PERIPHERAL VASCULAR DISEASE | EXPRESSION | GLAND | Dopamine Agonists - pharmacology | Zona Glomerulosa - physiology | Adenoma - genetics | Aldosterone - biosynthesis | Humans | Cell Proliferation - physiology | Gene Expression Regulation | Hyperaldosteronism - metabolism | Zona Fasciculata - physiology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Hypertension - metabolism | Receptors, Dopamine D1 - metabolism | Neurofilament Proteins - genetics | Adenoma - complications | Hyperaldosteronism - etiology | Receptors, Dopamine D1 - agonists | Adenoma - pathology | Adrenal Gland Neoplasms - complications | Cell Line, Tumor | Neurofilament Proteins - metabolism | Adrenal Gland Neoplasms - genetics | Dopamine Agonists - metabolism | Adrenal Gland Neoplasms - pathology
mutation | cell proliferation | adrenal cortex | dopamine | aldosterone | LOCALIZATION | D2 DOPAMINE-RECEPTOR | PHENOTYPE | PROLIFERATION | METOCLOPRAMIDE | SOMATIC MUTATIONS | MESSENGER-RIBONUCLEIC-ACID | ADENOMA | PERIPHERAL VASCULAR DISEASE | EXPRESSION | GLAND | Dopamine Agonists - pharmacology | Zona Glomerulosa - physiology | Adenoma - genetics | Aldosterone - biosynthesis | Humans | Cell Proliferation - physiology | Gene Expression Regulation | Hyperaldosteronism - metabolism | Zona Fasciculata - physiology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Hypertension - metabolism | Receptors, Dopamine D1 - metabolism | Neurofilament Proteins - genetics | Adenoma - complications | Hyperaldosteronism - etiology | Receptors, Dopamine D1 - agonists | Adenoma - pathology | Adrenal Gland Neoplasms - complications | Cell Line, Tumor | Neurofilament Proteins - metabolism | Adrenal Gland Neoplasms - genetics | Dopamine Agonists - metabolism | Adrenal Gland Neoplasms - pathology
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 11/2012, Volume 97, Issue 11, pp. 3965 - 3973
Context: Unilateral adrenalectomy is the therapy of choice in aldosterone-producing adenoma (APA). Zona glomerulosa (ZG) insufficiency causing hyperkalemia...
PRIMARY HYPERALDOSTERONISM | DIAGNOSIS | IDIOPATHIC ALDOSTERONISM | ENDOCRINOLOGY & METABOLISM | GERMAN CONNS REGISTRY | ADENOMA | SPONTANEOUS REMISSION | UNILATERAL ADRENALECTOMY | KIDNEY | LONG-TERM TREATMENT | BLOOD-PRESSURE | Kidney - physiology | Adrenal Cortex Neoplasms - complications | Adenoma - surgery | Humans | Middle Aged | Adrenal Cortex Neoplasms - surgery | Hyperaldosteronism - complications | Male | Adrenalectomy | Adenoma - complications | Zona Glomerulosa - surgery | Adult | Female | Hyperaldosteronism - surgery | Aged | Blood Pressure - physiology | Retrospective Studies | Hyperkalemia - etiology
PRIMARY HYPERALDOSTERONISM | DIAGNOSIS | IDIOPATHIC ALDOSTERONISM | ENDOCRINOLOGY & METABOLISM | GERMAN CONNS REGISTRY | ADENOMA | SPONTANEOUS REMISSION | UNILATERAL ADRENALECTOMY | KIDNEY | LONG-TERM TREATMENT | BLOOD-PRESSURE | Kidney - physiology | Adrenal Cortex Neoplasms - complications | Adenoma - surgery | Humans | Middle Aged | Adrenal Cortex Neoplasms - surgery | Hyperaldosteronism - complications | Male | Adrenalectomy | Adenoma - complications | Zona Glomerulosa - surgery | Adult | Female | Hyperaldosteronism - surgery | Aged | Blood Pressure - physiology | Retrospective Studies | Hyperkalemia - etiology
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2004, Volume 217, Issue 1, pp. 23 - 26
The adrenal glomerulosa cells is the cell type most sensitive to extracellular K in the mammalian organism. Its sensitivity to physiological increases in K...
TASK channel | Glomerulosa cells | T-type Ca 2+ channel | Pyridine nucleotides | NAD(P)H | Aldosterone | Potassium | Mitochondrial calcium | K + conductance | Cell swelling | T-type Ca | channel | conductance | potassium | K+ conductance | T-type Ca2+ channel | FASCICULATA CELLS | REDOX STATE | aldosterone | glomerulosa cells | ANGIOTENSIN-II | cell swelling | mitochondrial calcium | CELL BIOLOGY | ACUTE REGULATORY PROTEIN | ZONA GLOMERULOSA | ALDOSTERONE SECRETION | CALCIUM | ENDOCRINOLOGY & METABOLISM | CA2+ CHANNEL | RAT ADRENAL GLOMERULOSA | pyridine nucleotides | Extracellular Space - physiology | Potassium - metabolism | Potassium Channels, Tandem Pore Domain - metabolism | Animals | Zona Glomerulosa - physiology | Calcium Signaling - physiology | Humans | Mitochondria - metabolism | Cell Membrane - physiology | Membrane Potentials - physiology | Phosphoproteins - metabolism | Pyrimidine Nucleotides - metabolism
TASK channel | Glomerulosa cells | T-type Ca 2+ channel | Pyridine nucleotides | NAD(P)H | Aldosterone | Potassium | Mitochondrial calcium | K + conductance | Cell swelling | T-type Ca | channel | conductance | potassium | K+ conductance | T-type Ca2+ channel | FASCICULATA CELLS | REDOX STATE | aldosterone | glomerulosa cells | ANGIOTENSIN-II | cell swelling | mitochondrial calcium | CELL BIOLOGY | ACUTE REGULATORY PROTEIN | ZONA GLOMERULOSA | ALDOSTERONE SECRETION | CALCIUM | ENDOCRINOLOGY & METABOLISM | CA2+ CHANNEL | RAT ADRENAL GLOMERULOSA | pyridine nucleotides | Extracellular Space - physiology | Potassium - metabolism | Potassium Channels, Tandem Pore Domain - metabolism | Animals | Zona Glomerulosa - physiology | Calcium Signaling - physiology | Humans | Mitochondria - metabolism | Cell Membrane - physiology | Membrane Potentials - physiology | Phosphoproteins - metabolism | Pyrimidine Nucleotides - metabolism
Journal Article