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Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 7, p. 1508
This study evaluated the protective effect of proanthocyanidins (PCs) on reducing apoptosis in the mouse intestinal epithelial cell model MODE-K exposed to... 
Oxidative damage | Intestinal epithelial cells | Zearalenone | Mice | Apoptosis | Endoplasmic reticulum stress | Proanthocyanidins | VITAMIN-C | intestinal epithelial cells | GRAPE SEED PROANTHOCYANIDINS | OXIDATIVE STRESS | proanthocyanidins | zearalenone | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | oxidative damage | apoptosis | mice | RAPHANUS-SATIVUS | CHEMISTRY, MULTIDISCIPLINARY | endoplasmic reticulum stress | IN-VITRO | SIGNALING PATHWAY | CYTOTOXICITY | EXTRACT | Transcription Factor CHOP - genetics | Superoxide Dismutase - genetics | Epithelial Cells - metabolism | Apoptosis - drug effects | Glutathione - metabolism | Epithelial Cells - drug effects | JNK Mitogen-Activated Protein Kinases - metabolism | Heat-Shock Proteins - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Glutathione - agonists | Malondialdehyde - agonists | Proanthocyanidins - pharmacology | JNK Mitogen-Activated Protein Kinases - genetics | Epithelial Cells - cytology | Superoxide Dismutase - metabolism | bcl-2-Associated X Protein - genetics | Malondialdehyde - metabolism | Cell Line | Cell Survival - drug effects | Glutathione Peroxidase - metabolism | Endoplasmic Reticulum Stress - drug effects | Signal Transduction | Caspase 12 - genetics | Heat-Shock Proteins - metabolism | Estrogens, Non-Steroidal - antagonists & inhibitors | bcl-2-Associated X Protein - metabolism | Glutathione - antagonists & inhibitors | Zearalenone - antagonists & inhibitors | Antioxidants - pharmacology | Caspase 12 - metabolism | Glutathione Peroxidase - genetics | Gene Expression Regulation - drug effects | Animals | Intestine, Small - cytology | Intestine, Small - drug effects | Estrogens, Non-Steroidal - pharmacology | Intestine, Small - metabolism | Malondialdehyde - antagonists & inhibitors | Transcription Factor CHOP - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Zearalenone - pharmacology | Oxidative stress | Transcription factors | Bax protein | Bcl-2 protein | Epithelial cells | Proteinase | Caspase-12 | Superoxide dismutase | Homology | mRNA | CCAAT/enhancer-binding protein | Proteins | Antioxidants | Mouse devices | Intestine | Peroxidase | Inhibition | Glutathione | Glutathione peroxidase | c-Jun protein | Caspase | JNK protein | Gene expression | Malondialdehyde | Endoplasmic reticulum
Journal Article
Cancer Research, ISSN 0008-5472, 01/2013, Volume 73, Issue 4, pp. 1374 - 1385
Clear cell renal cell carcinomas (RCC), the major histologic subtype of RCC accounting for more than 80% of cases, are typified by biallelic inactivation of... 
KINASE SAPK/JNK | HYPOXIA-INDUCIBLE FACTOR | GENE | ONCOLOGY | TUMOR SUPPRESSION | PHOSPHORYLATION | EMBRYONIC STEM-CELLS | E-CADHERIN | VHL | C-JUN | HIPPEL-LINDAU PROTEIN | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Kidney Neoplasms - metabolism | CARD Signaling Adaptor Proteins - genetics | CARD Signaling Adaptor Proteins - metabolism | MAP Kinase Kinase 4 - metabolism | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Female | Von Hippel-Lindau Tumor Suppressor Protein - genetics | JNK Mitogen-Activated Protein Kinases - genetics | Phosphorylation - drug effects | TNF Receptor-Associated Factor 6 - genetics | Carcinoma, Renal Cell - drug therapy | MAP Kinase Kinase Kinases - antagonists & inhibitors | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Carcinoma, Renal Cell - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | MAP Kinase Kinase Kinases - genetics | Proto-Oncogene Proteins c-fos - metabolism | Zearalenone - analogs & derivatives | MAP Kinase Kinase Kinases - metabolism | Anthracenes - pharmacology | Blotting, Western | Xenograft Model Antitumor Assays | Carcinoma, Renal Cell - metabolism | Animals | Mice, Nude | Proto-Oncogene Proteins c-jun - metabolism | B-Cell CLL-Lymphoma 10 Protein | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - metabolism | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | Kidney Neoplasms - pathology | Mice | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | Kidney Neoplasms - drug therapy | Zearalenone - pharmacology
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 12/2013, Volume 219, Issue 3, pp. 243 - 250
Plant-derived estrogens (phytoestrogens, PEs), like endogenous estrogens, affect a diverse array of tissues, including the bone, uterus, mammary gland, and... 
Cell culture | Estrogen receptor | Ovine pituitary cells | Phytoestrogens | FSH | Estradiol | estrogen receptor | SHEEP | phytoestrogens | LUTEINIZING-HORMONE | BETA | EWE | GENE | cell culture | ovine pituitary cells | ENDOCRINOLOGY & METABOLISM | ESTROGEN | PITUITARY | FOLLICLE-STIMULATING-HORMONE | RECEPTORS | estradiol | Receptors, Estrogen - metabolism | Gonadotrophs - cytology | Estrogen Antagonists - pharmacology | Male | Glycoprotein Hormones, alpha Subunit - secretion | Gonadotrophs - metabolism | Food Additives - chemistry | Glycoprotein Hormones, alpha Subunit - biosynthesis | Coumestrol - antagonists & inhibitors | Animal Feed - analysis | Genistein - metabolism | Follicle Stimulating Hormone, beta Subunit - metabolism | Genistein - antagonists & inhibitors | Gonadotrophs - secretion | Gonadotropin-Releasing Hormone - agonists | Coumestrol - metabolism | Estradiol - metabolism | Phytoestrogens - antagonists & inhibitors | Cells, Cultured | Luteinizing Hormone, beta Subunit - metabolism | Luteinizing Hormone, beta Subunit - secretion | Sheep, Domestic - physiology | Receptors, Estrogen - antagonists & inhibitors | Zearalenone - antagonists & inhibitors | Down-Regulation - drug effects | Glycoprotein Hormones, alpha Subunit - metabolism | Up-Regulation - drug effects | Estradiol - chemistry | Animals | Gonadotropin-Releasing Hormone - metabolism | Zearalenone - metabolism | Gonadotrophs - drug effects | Food Additives - metabolism | Phytoestrogens - metabolism | Follicle Stimulating Hormone, beta Subunit - secretion | Luteinizing Hormone, beta Subunit - biosynthesis
Journal Article
Journal Article
Journal Article
Journal of Nutrition, ISSN 0022-3166, 2018, Volume 148, Issue 8, pp. 1209 - 1216
Background: Zearalenone (ZEN) can cause serious defects in development and reproduction in humans and animals. Silymarin shows antioxidant and estrogenic... 
Rats | Zearalenone | Silymarin | Hepatotoxicity | Reproductive toxicity | ENDOCRINE-DISRUPTING CHEMICALS | silymarin | zearalenone | OXIDATIVE DAMAGE | BETA-ZEARALENOL | GROWTH-PERFORMANCE | ALPHA-ZEARALENOL | NUTRITION & DIETETICS | MILK THISTLE | hepatotoxicity | MYCOTOXIN ZEARALENONE | reproductive toxicity | SOYBEAN ISOFLAVONE | rats | EXPOSURE | SELENIUM DEFICIENCY | Uterus - pathology | AMP-Activated Protein Kinases - metabolism | Liver - pathology | Liver - enzymology | Antioxidants - metabolism | Uterus - drug effects | Blood Proteins - metabolism | Liver - drug effects | Malondialdehyde - blood | Milk Thistle - chemistry | ATP-Binding Cassette Transporters - metabolism | Female | Hydroxysteroid Dehydrogenases - metabolism | Ovary - drug effects | Silymarin - pharmacology | Phytotherapy | Chemical and Drug Induced Liver Injury - pathology | Hormones - blood | Chemical and Drug Induced Liver Injury - prevention & control | Glutathione Peroxidase - metabolism | Silymarin - therapeutic use | Ovary - pathology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Antioxidants - pharmacology | Rats, Sprague-Dawley | Reproduction - drug effects | Zearalenone - toxicity | Antioxidants - therapeutic use | Animals | Chemical and Drug Induced Liver Injury - metabolism | Estrogen Receptor alpha - blood | Dietary Supplements | Multidrug Resistance-Associated Proteins - metabolism | Flavonoids | Care and treatment | Liver diseases | Flavones | Bioflavonoids | Dietary supplements | Dosage and administration | Milk thistle | Health aspects
Journal Article
Journal Article
Journal Article