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Journal of Neuroscience, ISSN 0270-6474, 10/2012, Volume 32, Issue 40, pp. 13819 - 13840
Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Recent efforts in protein engineering have significantly increased... 
2-PHOTON EXCITATION | GREEN FLUORESCENT PROTEIN | DROSOPHILA-MELANOGASTER | CELLULAR RESOLUTION | IN-VIVO | NETWORK ACTIVITY | MOTOR CORTEX | BARREL CORTEX | NEUROSCIENCES | MOUSE VISUAL-CORTEX | CA2+ INDICATORS | Olfactory Receptor Neurons - physiology | Hippocampus - chemistry | Humans | Peptides - genetics | Recombinant Fusion Proteins - analysis | Crystallography, X-Ray | Green Fluorescent Proteins - genetics | Neuromuscular Junction - chemistry | Neuropil - ultrastructure | Neurons - ultrastructure | Lasers | Astrocytes - chemistry | Green Fluorescent Proteins - isolation & purification | Neuroimaging - methods | Neuropil - physiology | Neurons - chemistry | Genes, Synthetic | Models, Molecular | Rats | Recombinant Fusion Proteins - chemistry | Astrocytes - ultrastructure | Olfactory Receptor Neurons - chemistry | Caenorhabditis elegans | Larva | Retinal Bipolar Cells - ultrastructure | Recombinant Fusion Proteins - genetics | Drosophila melanogaster - growth & development | Protein Conformation | Mice | Peptides - analysis | Fluorescent Dyes - analysis | Fluorometry - methods | Olfactory Receptor Neurons - ultrastructure | Synaptic Transmission | Retinal Bipolar Cells - physiology | Neurons - physiology | Female | Green Fluorescent Proteins - chemistry | Calcium Signaling | Fluorescent Dyes - chemistry | Green Fluorescent Proteins - analysis | Mutagenesis, Site-Directed | Peptides - chemistry | Neuropil - chemistry | Retinal Bipolar Cells - chemistry | HEK293 Cells - chemistry | Hippocampus - cytology | HEK293 Cells - ultrastructure | Neuromuscular Junction - ultrastructure | Zebrafish - growth & development | Animals | Genetic Vectors | Photic Stimulation | Index Medicus | GCaMP5 | functional imaging | genetically encoded calcium indicator | GECI | GCaMP3
Journal Article
Science, ISSN 0036-8075, 2016, Volume 353, Issue 6302, pp. aad8266 - aad8266
Journal Article
Science, ISSN 0036-8075, 3/2011, Volume 331, Issue 6021, pp. 1196 - 1199
Journal Article
BMC Evolutionary Biology, ISSN 1471-2148, 2007, Volume 7, Issue 1, pp. 103 - 103
Background: Septins are cytoskeletal GTPase proteins first discovered in the fungus Saccharomyces cerevisiae where they organize the septum and link nuclear... 
P-LOOP | ORGANIZATION | PHYLOGENY | EVOLUTIONARY BIOLOGY | YEAST SEPTINS | GENE | SEQUENCE | GENETICS & HEREDITY | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | BINDING | COILED COILS | Consensus Sequence | Fungal Proteins - chemistry | Gene Duplication | Multigene Family | Species Specificity | Cytoskeletal Proteins - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Cell Cycle Proteins - classification | Phylogeny | Protozoan Proteins - genetics | Fungi - genetics | Cell Cycle Proteins - chemistry | GTP Phosphohydrolases - chemistry | Profilins - genetics | Protein Isoforms - chemistry | Cell Cycle Proteins - genetics | Conserved Sequence | Microsporidia - genetics | Protozoan Proteins - chemistry | Microsporidia - enzymology | Protein Structure, Tertiary | Zebrafish Proteins - chemistry | Fungi - enzymology | Insect Proteins - genetics | Rats | Terminology as Topic | Cytoskeletal Proteins - chemistry | Cytoskeletal Proteins - classification | Drosophila Proteins - chemistry | Fungal Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Fungal Proteins - classification | Sequence Homology, Amino Acid | Sequence Alignment | Animals | GTP Phosphohydrolases - genetics | Profilins - chemistry | GTP Phosphohydrolases - classification | Insect Proteins - chemistry | Mice | Drosophila Proteins - genetics | Zebrafish Proteins - genetics | Amino Acid Motifs - genetics | Caenorhabditis elegans Proteins - genetics | Evolution, Molecular | Protein Isoforms - genetics | Saccharomyces cerevisiae Proteins - chemistry | Amino acid sequence | Genetic aspects | Yeast fungi | Guanosine triphosphatase | Analysis | Index Medicus
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2017, Volume 474, Issue 23, pp. 3963 - 3984
Journal Article
eLife, ISSN 2050-084X, 2013, Volume 2, pp. e01340 - e01340
The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target... 
oxysterol | Hedgehog signaling | Zebrafish | cysteine rich domain | smoothened | MAXIMUM-LIKELIHOOD | STEM-CELLS | PROTEIN | SONIC HEDGEHOG | CYSTEINE-RICH DOMAINS | CRYSTAL-STRUCTURE | PATHWAY ACTIVITY | BIOLOGY | N-TERMINAL DOMAIN | MAMMALIAN-CELLS | PRIMARY CILIUM | Hedgehog Proteins - chemistry | Receptors, G-Protein-Coupled - metabolism | Hedgehog Proteins - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Hedgehog Proteins - genetics | Gene Expression Regulation, Developmental | Smoothened Receptor | Escherichia coli - metabolism | Binding Sites | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Protein Structure, Secondary | Signal Transduction | Zebrafish Proteins - chemistry | Sterols - chemistry | Zebrafish Proteins - metabolism | Zebrafish Proteins - antagonists & inhibitors | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Zebrafish - growth & development | Zebrafish - genetics | Animals | Escherichia coli - genetics | Zebrafish - metabolism | Embryo, Nonmammalian | Receptors, G-Protein-Coupled - antagonists & inhibitors | Protein Binding | Ligands | Mice | Receptors, G-Protein-Coupled - genetics | Zebrafish Proteins - genetics | Receptors, G-Protein-Coupled - chemistry | Wnt protein | Frizzled protein | Genes | Lipids | Biology | Hydrophobicity | Chromatography | Membrane proteins | Medicine | Proteins | Hedgehog protein | Binding sites | Crystal structure | Structure-function relationships | Index Medicus
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 09/2013, Volume 20, Issue 9, pp. 1047 - 1053
Polo-like kinase 1 (PLK1) is a master regulator of mitosis and is considered a potential drug target for cancer therapy. PLK1 is characterized by an N-terminal... 
PHOSPHORYLATION | TYROSINE KINASE | CRYSTAL-STRUCTURE | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLK1 | CANCER-THERAPY | CELL BIOLOGY | BIOPHYSICS | MITOTIC ENTRY | SPINDLE CHECKPOINT ARREST | BOX DOMAIN | BINDING | Microtubule-Associated Proteins - chemistry | Microtubule-Associated Proteins - genetics | Humans | Molecular Sequence Data | Crystallography, X-Ray | Multiprotein Complexes - genetics | Proto-Oncogene Proteins - chemistry | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - chemistry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Protein Interaction Domains and Motifs | Amino Acid Sequence | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Zebrafish Proteins - chemistry | Zebrafish Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Models, Molecular | Proto-Oncogene Proteins - genetics | Drosophila Proteins - chemistry | Sequence Homology, Amino Acid | Multiprotein Complexes - chemistry | Animals | Models, Biological | Protein Conformation | Protein-Serine-Threonine Kinases - chemistry | Drosophila Proteins - genetics | Zebrafish Proteins - genetics | Care and treatment | Physiological aspects | Research | Structure | Protein kinases | Health aspects | Cancer | Phosphorylation | Kinases | Molecular biology | Binding sites | Crystal structure | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1472 - 14
Heat shock protein 90 (Hsp90) is a dimeric molecular chaperone that undergoes large conformational changes during its functional cycle. It has been established... 
ATP HYDROLYSIS | STRUCTURAL BIOLOGY | PROTEIN | TYROSINE PHOSPHORYLATION | TERMINAL DOMAIN | MULTIDISCIPLINARY SCIENCES | MACHINERY | ESCHERICHIA-COLI HSP90 | CONFORMATIONAL DYNAMICS | SACCHAROMYCES-CEREVISIAE | BINDING | Caenorhabditis elegans - chemistry | Humans | Tryptophan - chemistry | Crystallography, X-Ray | Tryptophan - metabolism | Cloning, Molecular | Escherichia coli - metabolism | HSP90 Heat-Shock Proteins - chemistry | HSP90 Heat-Shock Proteins - genetics | Lysine - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Genetic Vectors - chemistry | Adenosine Triphosphatases - metabolism | Genetic Vectors - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Molecular Dynamics Simulation | Saccharomyces cerevisiae - chemistry | Sequence Alignment | Animals | Protein Conformation, beta-Strand | Escherichia coli - genetics | Zebrafish - metabolism | HSP90 Heat-Shock Proteins - metabolism | Protein Binding | Adenosine Triphosphatases - chemistry | Ligands | Adenosine Triphosphatases - genetics | Mice | Structural Homology, Protein | Mutation | Lysine - chemistry | Amino Acid Substitution | Proteins | Hsp90 protein | Lysine | Tryptophan | Heat shock proteins | Heat shock | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e62721 - e62721
Growth factor signaling pathways are tightly regulated by phosphorylation and include many important kinase targets of interest for drug discovery. Small... 
TARGET | CRYSTALLIZATION | CELL-MEMBRANE | TGF-BETA | ZEBRAFISH | MULTIDISCIPLINARY SCIENCES | ATHEROSCLEROSIS | PROMOTE PROTEIN STABILITY | RECEPTOR | BONE | FIBRODYSPLASIA OSSIFICANS PROGRESSIVA | Activin Receptors, Type I - antagonists & inhibitors | Body Patterning - drug effects | Bone Morphogenetic Proteins - antagonists & inhibitors | Neovascularization, Physiologic - drug effects | Humans | Molecular Conformation | Models, Molecular | Zebrafish | Pyrimidines - pharmacology | Aminopyridines - chemistry | Bone Morphogenetic Proteins - metabolism | Protein Kinase Inhibitors - chemistry | Animals | Signal Transduction - drug effects | Aminopyridines - pharmacology | Protein Binding | Phenols - chemistry | Protein Kinase Inhibitors - pharmacology | Bone Morphogenetic Proteins - chemistry | Smad Proteins - metabolism | Activin Receptors, Type I - chemistry | Phenols - pharmacology | Pyrazoles - pharmacology | Analysis | Crystals | Bone morphogenetic proteins | Drug discovery | Transforming growth factors | Structure | Phosphotransferases | Phosphorylation | Smad protein | Laboratories | Genomics | Identification | Kinases | Medical schools | Optimization | Proteins | Consortia | Signal transduction | Neurodegeneration | Crystal structure | Recombinant | Medical research | Complementarity | Research & development--R&D | Pharmacology | Myositis ossificans | Embryos | Signaling | Hospitals | Inhibitors | Phenols | Pharmacokinetics | Cancer | Index Medicus | Research & development | R&D
Journal Article