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Neuron, ISSN 0896-6273, 2005, Volume 47, Issue 6, pp. 817 - 831
The molecular mechanisms controlling the differentiation of neural progenitors into distinct subtypes of neurons during neocortical development are unknown.... 
AREA IDENTITY | NEOCORTICAL NEURONS | CELL FATE SPECIFICATION | CEREBRAL CORTICAL DEVELOPMENT | LAYER NEURONS | CENTRAL-NERVOUS-SYSTEM | SUBCORTICAL TARGETS | ZINC-FINGER GENE | SUBVENTRICULAR ZONE | NEUROSCIENCES | ZEBRAFISH FOREBRAIN | Membrane Glycoproteins - metabolism | Embryo, Mammalian | Homeodomain Proteins - metabolism | Nerve Tissue Proteins - deficiency | S100 Proteins - genetics | POU Domain Factors - genetics | Forkhead Transcription Factors - metabolism | In Situ Hybridization - methods | Repressor Proteins - metabolism | Gene Expression Regulation, Developmental - physiology | POU Domain Factors - metabolism | Animals, Newborn | DNA-Binding Proteins - physiology | Motor Neurons - physiology | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | S100 Proteins - metabolism | In Situ Nick-End Labeling - methods | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Immunohistochemistry - methods | Annexin A2 - genetics | Cell Death - physiology | Green Fluorescent Proteins - biosynthesis | Mice | Annexin A2 - metabolism | Age Factors | Phosphopyruvate Hydratase - metabolism | Cell Movement - physiology | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Motor Neurons - cytology | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Membrane Proteins - metabolism | Bromodeoxyuridine - metabolism | Cell Differentiation - physiology | Pyramidal Tracts - physiology | Nerve Tissue Proteins - physiology | Neocortex - growth & development | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Membrane Glycoproteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Cell Count - methods | Neocortex - cytology | Receptors, Antigen, T-Cell, alpha-beta - metabolism | Neurosciences | Neurons | Developmental biology | Stem cells | Studies | Brain | Ultrasonic imaging | Transcription factors | Hybridization | Neurogenesis | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2015, Volume 17, Issue 3, pp. 228 - 240
Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11-Rab8 cascade... 
EHD PROTEINS | TRANSPORT | COMPLEX | BIOGENESIS | PRIMARY CILIOGENESIS | MEMBRANE | DOCKING | GTPASE RAB8 | DISTINCT ROLES | MOTHER CENTRIOLE | CELL BIOLOGY | RNA, Small Interfering - genetics | Retinal Pigment Epithelium - metabolism | Epithelial Cells - metabolism | Axoneme - metabolism | Vesicular Transport Proteins - metabolism | Humans | Qb-SNARE Proteins - metabolism | Qb-SNARE Proteins - genetics | rab GTP-Binding Proteins - genetics | Vesicular Transport Proteins - antagonists & inhibitors | Qc-SNARE Proteins - metabolism | Retinal Pigment Epithelium - ultrastructure | Axoneme - ultrastructure | Gene Expression Regulation, Developmental | Cilia - ultrastructure | Centrioles - ultrastructure | rab GTP-Binding Proteins - metabolism | Cell Line | Kidney Tubules, Collecting - ultrastructure | Morphogenesis - genetics | Signal Transduction | Vesicular Transport Proteins - genetics | Carrier Proteins - antagonists & inhibitors | Epithelial Cells - ultrastructure | Zebrafish | Cilia - metabolism | Carrier Proteins - genetics | Kidney Tubules, Collecting - metabolism | Animals | Carrier Proteins - metabolism | Transport Vesicles - metabolism | Embryo, Nonmammalian | Qc-SNARE Proteins - genetics | Mice | Centrioles - metabolism | Transport Vesicles - ultrastructure | RNA, Small Interfering - metabolism | Cell research | Cilia and ciliary motion | Physiological aspects | Cell organelles | Research | Properties | Formation | Membrane proteins | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 484, Issue 7397, pp. 195 - 202
Journal Article
Science, ISSN 0036-8075, 3/2010, Volume 327, Issue 5971, pp. 1345 - 1350
Half a century ago, thalidomide was widely prescribed to pregnant women as a sedative but was found to be teratogenic, causing multiple birth defects. Today,... 
Receptors | Messenger RNA | Delta cells | Ubiquitins | Substrate specificity | Teratogenicity | HeLa cells | Pectorals | Cellular immunity | Embryos | Research Article | MULTIPLE-MYELOMA | CELLS | LIMB DEFECTS | ORIGIN | ZEBRAFISH | UBIQUITIN LIGASE | PATHWAY | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | OUTGROWTH | EXPRESSION | Teratogens - toxicity | Thalidomide - metabolism | Peptide Hydrolases - genetics | Forelimb - embryology | Humans | Fibroblast Growth Factors - genetics | Ubiquitin-Protein Ligases - antagonists & inhibitors | Zebrafish - embryology | Embryo, Nonmammalian - drug effects | DNA-Binding Proteins - metabolism | Fibroblast Growth Factors - metabolism | Ubiquitination | Forelimb - abnormalities | Gene Expression Regulation, Developmental | Cullin Proteins - metabolism | Peptide Hydrolases - metabolism | Zebrafish Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Mutant Proteins - metabolism | Chick Embryo | Thalidomide - toxicity | Zebrafish - genetics | Animals | Carrier Proteins - metabolism | HeLa Cells | Zebrafish Proteins - genetics | Embryonic Development - drug effects | Teratogens - metabolism | Dosage and administration | Research | Teratogenic agents | Thalidomide | Protein binding | Pharmacology | Birth defects | Developmental biology | DNA damage | Binding sites | Index Medicus
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2013, Volume 202, Issue 7, pp. 1023 - 1039
Chromosome pairing is an essential meiotic event that ensures faithful haploidization and recombination of the genome. Pairing of homologous chromosomes is... 
STRUCTURED ILLUMINATION | FISSION YEAST | ZEBRAFISH ZYGOTE | LINC COMPLEX | SPINDLE POLE BODY | ENVELOPE | ACTIN CYTOSKELETON | NUCLEAR-MEMBRANE PROTEIN | C. ELEGANS | BOUQUET FORMATION | CELL BIOLOGY | Meiosis - physiology | RNA, Small Interfering - genetics | Spermatocytes - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Molecular Sequence Data | Male | Immunoenzyme Techniques | Cell Cycle Proteins - antagonists & inhibitors | Telomere-Binding Proteins - genetics | Microtubules - metabolism | Cell Nucleus - metabolism | HEK293 Cells | Cell Cycle Proteins - genetics | Female | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Telomere-Binding Proteins - metabolism | Real-Time Polymerase Chain Reaction | Cytoplasmic Dyneins - metabolism | Telomere - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Membrane Proteins - genetics | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Cells, Cultured | Cytoplasmic Dyneins - genetics | In Situ Hybridization, Fluorescence | Nuclear Proteins - metabolism | Microtubule-Associated Proteins - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Telomere-Binding Proteins - antagonists & inhibitors | Blotting, Western | Sequence Homology, Amino Acid | Nuclear Envelope - metabolism | Animals | Cell Nucleus - genetics | Membrane Proteins - antagonists & inhibitors | Nuclear Proteins - antagonists & inhibitors | Cytoskeleton - metabolism | Spermatocytes - cytology | Mice | HeLa Cells | Chromosome Pairing | Chromosomes | Analysis | Dynein | Protein binding | Proteins | Membranes | Rodents | Zebrafish | Genomes | Cytoplasm | Index Medicus | s
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2015, Volume 47, Issue 8, pp. 926 - 932
Dominant optic atrophy (DOA)(1,2) and axonal peripheral neuropathy (Charcot-Marie-Tooth type 2, or CMT2)(3) are hereditary neurodegenerative disorders most... 
MEMBRANE-FUSION | MITOCHONDRIAL FUSION | OUTER-MEMBRANE | RECRUITMENT | ZEBRAFISH | OPA1 | MITOFUSIN-2 | GENETICS & HEREDITY | DYNAMICS | CARRIER PROTEIN | MOTONEURONS | Humans | Optic Atrophy, Autosomal Dominant - metabolism | Embryo, Nonmammalian - metabolism | Phosphate Transport Proteins - metabolism | Cercopithecus aethiops | Embryo, Nonmammalian - embryology | Male | Mitochondrial Proteins - genetics | Zebrafish - embryology | Charcot-Marie-Tooth Disease - genetics | RNA Interference | Mitochondrial Proteins - metabolism | HEK293 Cells | Muscle Proteins - metabolism | Female | Membrane Proteins - metabolism | Optic Atrophy, Autosomal Dominant - pathology | Phosphate Transport Proteins - genetics | Charcot-Marie-Tooth Disease - metabolism | Microscopy, Electron, Transmission | Genetic Predisposition to Disease - genetics | Animals, Genetically Modified | Membrane Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Sequence Analysis, DNA | Mitochondrial Membranes - metabolism | Muscle Proteins - genetics | Microscopy, Confocal | Exome - genetics | Animals | Pedigree | Embryo, Nonmammalian - ultrastructure | Zebrafish - metabolism | Optic Atrophy, Autosomal Dominant - genetics | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Mutation | COS Cells | Development and progression | Genetic aspects | Optic atrophy | Gene mutations | Identification and classification | Health aspects | Proteins | Neurodegeneration | Genes | Neurological disorders | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 07/2012, Volume 14, Issue 7, pp. 697 - 706
Ciliogenesis requires the removal of CP110 from the mother centriole; actin dynamics also influence ciliation, at least partly by affecting the centrosomal... 
MOLECULAR CHARACTERIZATION | KUPFFERS VESICLE | MIGRATING CELLS | PROTEIN | ZEBRAFISH | EPITHELIAL-CELLS | ARP2/3 COMPLEX | CILIOGENESIS | MICRORNAS | SIGNALING CENTER | CELL BIOLOGY | Retinal Pigment Epithelium - metabolism | Cell Proliferation | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Actins - metabolism | Molecular Sequence Data | MicroRNAs - metabolism | LIM Domain Proteins - metabolism | Phosphoproteins - metabolism | Zebrafish - embryology | Gene Knockdown Techniques | Morphogenesis | Transfection | Time Factors | Gene Expression Regulation, Developmental | Base Sequence | HEK293 Cells | Cell Cycle Proteins - genetics | Conserved Sequence | Actin-Related Protein 2 - metabolism | Microfilament Proteins - metabolism | 3' Untranslated Regions | Binding Sites | Microfilament Proteins - genetics | Genes, Reporter | Actin Cytoskeleton - metabolism | RNA Processing, Post-Transcriptional | Signal Transduction | Cell Cycle Proteins - metabolism | Phosphoproteins - genetics | Actin-Related Protein 2 - genetics | Cilia - metabolism | Zebrafish - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Pronephros - metabolism | LIM Domain Proteins - genetics | Mice | Centrioles - metabolism | Physiological aspects | MicroRNA | Research | Actin | Cilia and ciliary motion | Index Medicus
Journal Article
Genes and Development, ISSN 0890-9369, 11/2011, Volume 25, Issue 22, pp. 2347 - 2360
The membrane of the primary cilium is a highly specialized compartment that organizes proteins to achieve spatially ordered signaling. Disrupting ciliary... 
UNC119 | ARL3 | Myristoylation | NPHP | RETINAL DEGENERATION | NERVOUS-SYSTEM | PROTEIN | myristoylation | PHOTORECEPTOR | DEVELOPMENTAL BIOLOGY | SENSORY NEURONS | CELL BIOLOGY | DELTA-SUBUNIT | CAENORHABDITIS-ELEGANS | GENE | PDE-DELTA | GENETICS & HEREDITY | C-ELEGANS | Caenorhabditis elegans Proteins - chemistry | Caenorhabditis elegans Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Zebrafish - embryology | Gene Knockdown Techniques | Kinesin - genetics | Cilia - enzymology | Intracellular Signaling Peptides and Proteins - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - genetics | Zebrafish Proteins - metabolism | Monomeric GTP-Binding Proteins - genetics | Cilia - metabolism | Zebrafish - genetics | Kinesin - metabolism | Protein Transport | Phenotype | Sequence Alignment | Animals | GTP Phosphohydrolases - metabolism | Monomeric GTP-Binding Proteins - metabolism | GTP Phosphohydrolases - genetics | Zebrafish - metabolism | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Mutation | Zebrafish Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Caenorhabditis elegans - enzymology | Care and treatment | Kidney, Cystic | Neural tube | Abnormalities | Index Medicus | Research Paper
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2012, Volume 45, Issue 3, pp. 330 - 343
Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian... 
TRANSFORMATION | MAINTENANCE | ADULT HEMATOPOIESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEMATOPOIETIC STEM-CELLS | CBFA2 | MEGAKARYOCYTE | MICE | DIFFERENTIATION | RUNX1 | HAPLOINSUFFICIENCY | CELL BIOLOGY | Chromatin - metabolism | Thymocytes - metabolism | Protein Multimerization | Gene Expression Profiling | Core Binding Factor beta Subunit - genetics | Zebrafish - embryology | Gene Knockdown Techniques | T-Lymphocytes - metabolism | Hematopoietic Stem Cells - physiology | Repressor Proteins - isolation & purification | Megakaryocytes - metabolism | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Core Binding Factor beta Subunit - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | Core Binding Factor Alpha 2 Subunit - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Polycomb-Group Proteins | Zebrafish - genetics | Mice, Knockout | Animals | Chromatography, Affinity | Polycomb Repressive Complex 1 | Protein Binding | Mice | Ubiquitin-Protein Ligases - genetics | Core Binding Factor Alpha 2 Subunit - genetics | Cluster Analysis | Computer science | Employee recruitment | Chromatin | Genomics | Genes | Stem cells | Chemical properties | DNA binding proteins | Artificial intelligence | Genetic research | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2006, Volume 440, Issue 7080, pp. 96 - 100
Iron has a fundamental role in many metabolic processes, including electron transport, deoxyribonucleotide synthesis, oxygen transport and many essential redox... 
YEAST |