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AIDS, ISSN 0269-9370, 09/2007, Volume 21, Issue 14, pp. 1899 - 1907
Objectives: To describe first dose and steady state antiretroviral drug exposure in the female genital tract. Design: Non-blinded, single center, open-label... 
Women | Genital tract | HIV | Prophylaxis | Sexual transmission | Pharmacokinetics | Antiretroviral therapy | genital tract | INFECTIOUS DISEASES | sexual transmission | antiretroviral therapy | EMTRICITABINE | IMMUNOLOGY | CEREBROSPINAL-FLUID | prophylaxis | BACTERIAL VAGINOSIS | PROTEASE INHIBITOR | TRICHOMONAS-VAGINALIS | HIV-INFECTION | THERAPY | VIROLOGY | LIQUID-CHROMATOGRAPHY | SIMIAN IMMUNODEFICIENCY VIRUS | pharmacokinetics | MACAQUES | women | Lamivudine - administration & dosage | Humans | Deoxycytidine - blood | Zidovudine - administration & dosage | Tenofovir | Deoxycytidine - pharmacokinetics | HIV Protease Inhibitors - pharmacokinetics | Atazanavir Sulfate | Genitalia, Female - metabolism | Emtricitabine | HIV Infections - blood | HIV Protease Inhibitors - blood | Adenine - analogs & derivatives | Pyridines - administration & dosage | Benzoxazines - administration & dosage | Administration, Oral | Anti-Retroviral Agents - pharmacokinetics | Deoxycytidine - administration & dosage | Lopinavir | HIV Protease Inhibitors - administration & dosage | Adenine - pharmacokinetics | Pyrimidinones - blood | Anti-Retroviral Agents - administration & dosage | Oligopeptides - administration & dosage | Pyrimidinones - administration & dosage | Zidovudine - blood | Deoxycytidine - analogs & derivatives | Reverse Transcriptase Inhibitors - blood | Zidovudine - pharmacokinetics | Pyridines - pharmacokinetics | Reverse Transcriptase Inhibitors - administration & dosage | Adenine - blood | Reverse Transcriptase Inhibitors - pharmacokinetics | Benzoxazines - pharmacokinetics | Adult | Benzoxazines - blood | Female | Organophosphonates - blood | Anti-Retroviral Agents - blood | Drug Therapy, Combination | Oligopeptides - blood | Oligopeptides - pharmacokinetics | Lamivudine - blood | Lamivudine - pharmacokinetics | Adenine - administration & dosage | Organophosphonates - pharmacokinetics | Organophosphonates - administration & dosage | Pyridines - blood | Pyrimidinones - pharmacokinetics | HIV Infections - drug therapy
Journal Article
Journal Article
Journal Article
Antiviral Research, ISSN 0166-3542, 05/2009, Volume 82, Issue 2, pp. A99 - A109
The advent of highly active antiretroviral therapy (HAART), which constitutes HIV protease inhibitors, nucleoside reverse transcriptase inhibitors,... 
Choroid plexus | Antiretroviral drugs | HIV | Transporters | P-Glycoprotein | Blood–brain barrier | HAART | Blood-brain barrier | MICROVESSEL ENDOTHELIAL-CELLS | P-GLYCOPROTEIN EXPRESSION | NECROSIS-FACTOR-ALPHA | PLURONIC BLOCK-COPOLYMERS | HUMAN-IMMUNODEFICIENCY-VIRUS | ORGANIC ANION TRANSPORTERS | RESISTANCE-ASSOCIATED PROTEINS | BRAIN-BARRIER | REVERSE-TRANSCRIPTASE INHIBITORS | VIROLOGY | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | Animals | Biological Transport | Anti-HIV Agents - pharmacokinetics | Humans | Anti-HIV Agents - therapeutic use | HIV Infections - drug therapy | Membrane Transport Proteins - metabolism | Blood-Brain Barrier - drug effects | Blood-Nerve Barrier - drug effects | HIV Infections - metabolism | Highly active antiretroviral therapy | Polypeptides | Protease inhibitors | Proteases | DNA polymerases | Reverse transcriptase inhibitors | HIV (Viruses) | Health aspects | Mitogens | HIV infection | Zidovudine | Dementia | P-gp, P-glycoprotein | PIs, protease inhibitors | NNRTIs, non-nucleoside reverse transcriptase inhibitors | MRP, multi-drug resistance associated protein | AZT, zidovudine | Review | OATP, organic anion-transporting polypeptide | OAT, organic anion transporter | ddI, 2′,3′-dideoxyinosine | NRTIs, nucleoside reverse transcriptase inhibitors | MDR-1, multi-drug resistance gene 1 | HAD, HIV-associated dementia | SLC, solute carrier superfamily | ENT, equilibrative nucleoside transporter | ABC, ATP binding cassette | ddC, 2′3′-dideoxycytidine | BBB, blood–brain barrier | ET-1, endothelin-1 | CNT, concentrative nucleoside transporter | HAART, highly active antiretroviral therapy | AIDS, acquired immunodeficiency syndrome | MND, mild neurocognitive disorder | BCRP, breast cancer resistance protein | CNS, central nervous system | HIVE, HIV encephalitis | NtRTIs, nucleotide reverse transcriptase inhibitors | LPS, lipopolysaccharide | 3TC, (−)-2′-deoxy-3′-thiacytidine | CSF, cerebrospinal fluid
Journal Article
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 04/2011, Volume 50, Issue 7, pp. 801 - 810
The era of highly active antiretroviral therapy (HAART) has controlled AIDS and its related disorders considerably; however, the prevalence of HIV-1-associated... 
Oxidative stress | Mitochondrial dysfunction | Free radicals | N-acetylcysteine amide | AZT | Indinavir | HAART | Blood–brain barrier | Bloodbrain barrier | ACQUIRED-IMMUNODEFICIENCY-SYNDROME | CANCER-CELLS | APOPTOSIS | LIPID-PEROXIDATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYTOCHROME-C | Blood-brain barrier | AIDS DEMENTIA COMPLEX | GLUTATHIONE | HIV-POSITIVE PATIENTS | ENDOCRINOLOGY & METABOLISM | INFECTION | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Antiretroviral Therapy, Highly Active - adverse effects | Indinavir - pharmacology | Membrane Potential, Mitochondrial - drug effects | HIV Protease Inhibitors - pharmacology | Cytochromes c - biosynthesis | Malondialdehyde - analysis | Acetylcysteine - analogs & derivatives | Glutathione - analysis | Caspase 3 - biosynthesis | Acetylcysteine - therapeutic use | HIV Protease Inhibitors - adverse effects | HIV-1 - metabolism | Zidovudine - adverse effects | Endothelial Cells - metabolism | Adenosine Triphosphate - analysis | Zidovudine - pharmacology | Mitochondria - metabolism | Cytochromes c - analysis | Mitochondria - drug effects | Blood-Brain Barrier - metabolism | Endothelial Cells - cytology | Acetylcysteine - pharmacology | Caspase 3 - analysis | HIV Infections - drug therapy | Oxidative Stress - drug effects | Indinavir - adverse effects | Cell Line, Transformed | Endothelial Cells - drug effects | HIV Infections - metabolism | Drugs | Reactive oxygen species | amides | Thiols | Acetylcysteine | Cytotoxicity | Cognition | Caspase-3 | Endothelial cells | Malondialdehyde | Antioxidants | Cytochrome c | Mitochondria | Acquired immune deficiency syndrome | highly active antiretroviral therapy | Membrane potential | ATP | Zidovudine | Apoptosis | Glutathione | blood-brain barrier | indinavir | mitochondrial dysfunction | oxidative stress
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e96750
Journal Article
JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 12/2012, Volume 61, Issue 5, pp. 593 - 599
OBJECTIVE:Phase 0 studies can provide initial pharmacokinetics (PKs) data in humans and help to facilitate early drug development, but their predictive value... 
Tenofovir-diphosphate | Microdose | Pharmacokinetics | INFECTIOUS DISEASES | ACTIVATION | VIRUS | IMMUNOLOGY | ACCELERATOR MASS-SPECTROMETRY | BLOOD MONONUCLEAR-CELLS | NUCLEOTIDES | METABOLISM | PHARMACOLOGY | tenofovir-diphosphate | pharmacokinetics | microdose | LAMIVUDINE-TRIPHOSPHATE | SAMPLES | SOLID-PHASE EXTRACTION | Phosphorylation | Reverse Transcriptase Inhibitors - blood | Humans | Middle Aged | Zidovudine - pharmacokinetics | Biological Availability | Male | Reverse Transcriptase Inhibitors - administration & dosage | Zidovudine - administration & dosage | Adenine - blood | Anti-HIV Agents - administration & dosage | Tenofovir | Dideoxynucleotides - pharmacokinetics | Reverse Transcriptase Inhibitors - pharmacokinetics | Dideoxynucleotides - blood | Mass Spectrometry | Adult | Female | Organophosphonates - blood | Anti-HIV Agents - blood | Adenine - analogs & derivatives | CD4-Positive T-Lymphocytes - metabolism | Thymine Nucleotides - blood | Adenine - pharmacokinetics | Adenine - administration & dosage | Organophosphonates - pharmacokinetics | Organophosphonates - administration & dosage | Anti-HIV Agents - pharmacokinetics | Zidovudine - analogs & derivatives | Dideoxynucleotides - administration & dosage | Thymine Nucleotides - administration & dosage | Thymine Nucleotides - pharmacokinetics | Zidovudine - blood | Carbon Radioisotopes | Tenofovir diphosphate
Journal Article