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AIDS, ISSN 0269-9370, 09/2007, Volume 21, Issue 14, pp. 1899 - 1907
Objectives: To describe first dose and steady state antiretroviral drug exposure in the female genital tract. Design: Non-blinded, single center, open-label... 
Women | Genital tract | HIV | Prophylaxis | Sexual transmission | Pharmacokinetics | Antiretroviral therapy | genital tract | INFECTIOUS DISEASES | sexual transmission | antiretroviral therapy | EMTRICITABINE | IMMUNOLOGY | CEREBROSPINAL-FLUID | prophylaxis | BACTERIAL VAGINOSIS | PROTEASE INHIBITOR | TRICHOMONAS-VAGINALIS | HIV-INFECTION | THERAPY | VIROLOGY | LIQUID-CHROMATOGRAPHY | SIMIAN IMMUNODEFICIENCY VIRUS | pharmacokinetics | MACAQUES | women | Lamivudine - administration & dosage | Humans | Deoxycytidine - blood | Zidovudine - administration & dosage | Tenofovir | Deoxycytidine - pharmacokinetics | HIV Protease Inhibitors - pharmacokinetics | Atazanavir Sulfate | Genitalia, Female - metabolism | Emtricitabine | HIV Infections - blood | HIV Protease Inhibitors - blood | Adenine - analogs & derivatives | Pyridines - administration & dosage | Benzoxazines - administration & dosage | Administration, Oral | Anti-Retroviral Agents - pharmacokinetics | Deoxycytidine - administration & dosage | Lopinavir | HIV Protease Inhibitors - administration & dosage | Adenine - pharmacokinetics | Pyrimidinones - blood | Anti-Retroviral Agents - administration & dosage | Oligopeptides - administration & dosage | Pyrimidinones - administration & dosage | Zidovudine - blood | Deoxycytidine - analogs & derivatives | Reverse Transcriptase Inhibitors - blood | Zidovudine - pharmacokinetics | Pyridines - pharmacokinetics | Reverse Transcriptase Inhibitors - administration & dosage | Adenine - blood | Reverse Transcriptase Inhibitors - pharmacokinetics | Benzoxazines - pharmacokinetics | Adult | Benzoxazines - blood | Female | Organophosphonates - blood | Anti-Retroviral Agents - blood | Drug Therapy, Combination | Oligopeptides - blood | Oligopeptides - pharmacokinetics | Lamivudine - blood | Lamivudine - pharmacokinetics | Adenine - administration & dosage | Organophosphonates - pharmacokinetics | Organophosphonates - administration & dosage | Pyridines - blood | Pyrimidinones - pharmacokinetics | HIV Infections - drug therapy
Journal Article
Journal Article
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 9/1999, Volume 16, Issue 9, pp. 1366 - 1372
Purpose. Previous studies demonstrated that inhibition of P glycoprotein (P-gp) by Pluronic P85 (P85) block copolymer increases apical (AP) to basolateral (BL)... 
Biochemistry, general | Biomedical Engineering | blood brain barrier | Biomedicine | P-gp | intestinal barrier | Pharmacy | Medical Law | Pluronic block copolymer | MRP | Pharmacology/Toxicology | Intestinal barrier | Blood brain barrier | SYSTEM | PROTEIN | MICELLES | BLOOD-BRAIN-BARRIER | CHEMISTRY, MULTIDISCIPLINARY | P-GLYCOPROTEIN | TRANSPORT | EFFLUX | ENDOTHELIAL-CELLS | RESISTANCE | PHARMACOLOGY & PHARMACY | EXPRESSION | Endothelium, Vascular - cytology | Valproic Acid - pharmacokinetics | Antimetabolites, Antineoplastic - pharmacokinetics | Humans | Intestinal Absorption - drug effects | Zidovudine - pharmacokinetics | Contrast Media - pharmacokinetics | Drug Resistance, Neoplasm | Endothelium, Vascular - drug effects | Tritium | Paclitaxel - pharmacokinetics | Fluorescein - pharmacokinetics | Microcirculation - drug effects | Loperamide - pharmacokinetics | Poloxamer - pharmacology | Enzyme Inhibitors - pharmacokinetics | Cattle | Micelles | Caco-2 Cells - metabolism | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents, Phytogenic - pharmacokinetics | Antidiarrheals - pharmacokinetics | Blood-Brain Barrier - drug effects | Doxorubicin - pharmacokinetics | Caco-2 Cells - drug effects | ATP Binding Cassette Transporter, Subfamily B, Member 1 - pharmacokinetics | Animals | Endothelium, Vascular - metabolism | Excipients - pharmacology | Etoposide - pharmacokinetics
Journal Article
JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 04/2011, Volume 56, Issue 5, pp. 412 - 419
BACKGROUND:Few data are available describing atazanavir exposure during pregnancy, especially when used in combination with tenofovir, whose coadministration... 
pharmacokinetics | HIV | atazanavir | tenofovir | mother to child transmission | pregnancy | INDINAVIR | INFECTIOUS DISEASES | EFFICACY | SAFETY | SAQUINAVIR | IMMUNOLOGY | NELFINAVIR | WOMEN | LAMIVUDINE | ZIDOVUDINE | LOPINAVIR EXPOSURE | RITONAVIR | HIV Infections - prevention & control | Pregnancy Complications, Infectious - virology | Prospective Studies | Humans | Pyridines - pharmacokinetics | Postpartum Period | Reverse Transcriptase Inhibitors - administration & dosage | Pregnancy Trimester, Third | Anti-HIV Agents - administration & dosage | Tenofovir | Reverse Transcriptase Inhibitors - pharmacokinetics | HIV Protease Inhibitors - pharmacokinetics | Atazanavir Sulfate | Female | HIV Infections - transmission | Drug Therapy, Combination | Adenine - analogs & derivatives | Pyridines - administration & dosage | Drug Administration Schedule | Ritonavir - administration & dosage | HIV-1 - drug effects | HIV Infections - virology | Oligopeptides - pharmacokinetics | Treatment Outcome | HIV Protease Inhibitors - administration & dosage | Adenine - pharmacokinetics | Adenine - administration & dosage | Organophosphonates - pharmacokinetics | Pregnancy | Organophosphonates - administration & dosage | Ritonavir - pharmacokinetics | Anti-HIV Agents - pharmacokinetics | Pregnancy Complications, Infectious - drug therapy | HIV Infections - drug therapy | Oligopeptides - administration & dosage | Drug Monitoring | Infectious Disease Transmission, Vertical - prevention & control
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 04/2008, Volume 65, Issue s1, pp. 27 - 37
Journal Article
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 2003, Volume 42, Issue 14, pp. 1179 - 1191
Adherence to therapy is of critical importance for the long-term success of the treatment of HIV infection. Once-daily administration of antiretroviral agents... 
Saquinavir, pharmacokinetics | Lamivudine, pharmacokinetics | Nucleoside reverse transcriptase inhibitors, pharm | Didanosine, pharmacokinetics | Atazanavir, pharmacokinetics | Stavudine, pharmacokinetics | Emtricitabine, pharmacokinetics | Nevirapine, pharmacokinetics | Nelfinavir, pharmacokinetics | Abacavir, pharmacokinetics | Indinavir, pharmacokinetics | HIV infections | Efavirenz, pharmacokinetics | Protease inhibitors, pharmacokinetics | Non nucleoside reverse transcriptase inhibitors, p | Amprenavir, pharmacokinetics | Lopinavir, pharmacokinetics | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | STEADY-STATE PHARMACOKINETICS | TENOFOVIR DISOPROXIL FUMARATE | PLUS ZIDOVUDINE | PROTEASE INHIBITOR THERAPY | COMBINATION THERAPY | LOW-DOSE RITONAVIR | NAIVE HIV-1-INFECTED ADULTS | A-DAY | PHARMACOLOGY & PHARMACY | HIV-INFECTED PATIENTS | PLASMA PHARMACOKINETICS | Drug Administration Schedule | Area Under Curve | Humans | Clinical Trials as Topic | HIV Protease Inhibitors - administration & dosage | Reverse Transcriptase Inhibitors - administration & dosage | Anti-HIV Agents - administration & dosage | Antiretroviral Therapy, Highly Active | Reverse Transcriptase Inhibitors - pharmacokinetics | HIV Protease Inhibitors - pharmacokinetics | Anti-HIV Agents - pharmacokinetics | HIV Infections - drug therapy | Patient Compliance | HIV Infections - metabolism
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2014, Volume 58, Issue 10, pp. 6287 - 6289
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 01/2015, Volume 104, Issue 1, pp. 244 - 256
In this study, we aimed to determine the modulatory effects of warfarin (an extensively used anticoagulant drug) and its metabolites on... 
UGT | zidovudine | bioavailability | drug–drug interactions | pharmacokinetics | warfarin | phase II metabolism | Warfarin | Drug-drug interactions | Bioavailability | Phase II metabolism | Pharmacokinetics | Zidovudine | CHEMISTRY, MEDICINAL | VIVO | GLUCURONIDATION | RATS | MECHANISMS | HUMAN LIVER-MICROSOMES | CHEMISTRY, MULTIDISCIPLINARY | drug-drug interactions | IN-VITRO | INHIBITION | PHARMACOLOGY & PHARMACY | BINDING | 2B7 UGT2B7 | DRUG-METABOLISM | Anti-HIV Agents - pharmacology | Gene Expression Regulation, Enzymologic - drug effects | Zidovudine - metabolism | Liver - enzymology | Humans | Microsomes, Liver - metabolism | Zidovudine - pharmacokinetics | Warfarin - adverse effects | Biological Availability | Male | Isoenzymes - chemistry | Glucuronides - blood | Warfarin - pharmacology | Glucuronosyltransferase - genetics | Drug Interactions | Glucuronides - metabolism | Liver - drug effects | Anticoagulants - chemistry | Isoenzymes - metabolism | Microsomes, Liver - drug effects | Microsomes, Liver - enzymology | Anti-HIV Agents - blood | Anti-HIV Agents - metabolism | Recombinant Proteins - metabolism | Hydroxylation | Isoenzymes - genetics | Liver - metabolism | Zidovudine - pharmacology | Random Allocation | Anticoagulants - adverse effects | Rats, Sprague-Dawley | Warfarin - analogs & derivatives | Animals | Glucuronosyltransferase - chemistry | Glucuronosyltransferase - metabolism | Models, Biological | Anti-HIV Agents - pharmacokinetics | Anticoagulants - pharmacology | Biotransformation - drug effects | Kinetics | Zidovudine - blood | Enzymes | Metabolites | Analysis
Journal Article