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Cell reports (Cambridge), ISSN 2211-1247, 2016, Volume 16, Issue 10, pp. 2576 - 2592
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
Journal of virology, ISSN 0022-538X, 2016, Volume 90, Issue 21, pp. 9683 - 9692
RNA viruses present an extraordinary threat to human health, given their sudden and unpredictable appearance, the potential for rapid spread among the human population, and their ability to evolve... 
DRUG | EFLORNITHINE | REPLICATION | VIROLOGY | ALPHA-DIFLUOROMETHYLORNITHINE | DEPLETION | INFECTION | TRANSLATION | MAMMALIAN-CELLS | RESPIRATORY SYNDROME CORONAVIRUS | SPERMIDINE | Zika Virus Infection - drug therapy | Acetyltransferases - metabolism | Ebolavirus - metabolism | Chikungunya virus - metabolism | Humans | Eflornithine - pharmacology | Ebolavirus - drug effects | Zika Virus Infection - virology | Disease Outbreaks | RNA Viruses - drug effects | Hemorrhagic Fever, Ebola - virology | Hemorrhagic Fever, Ebola - drug therapy | Spermine - analogs & derivatives | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Mice, Inbred C57BL | Chikungunya Fever - drug therapy | Zika Virus - drug effects | Chikungunya Fever - virology | Polyamines - metabolism | Chikungunya virus - drug effects | Animals | Spermine - pharmacology | Mice | Spermine/analogs & derivatives | Virus Replication/drug effects | Hemorrhagic Fever, Ebola/virology | Life Sciences | Zika Virus/drug effects | Immunology | Chikungunya virus/metabolism | Chikungunya Fever/drug therapy | Zika Virus Infection/drug therapy | Ebolavirus/drug effects | Acetyltransferases/metabolism | Chikungunya virus/drug effects | Eflornithine/pharmacology | Spermine/pharmacology | Polyamines/metabolism | Chikungunya Fever/virology | Hemorrhagic Fever, Ebola/drug therapy | Virology | Microbiology and Parasitology | Zika Virus Infection/virology | Ebolavirus/metabolism | Antiviral Agents/pharmacology | RNA Viruses/drug effects
Journal Article
Journal Article
Lancet, The, ISSN 0140-6736, 2016, Volume 387, Issue 10027, pp. 1531 - 1539
Summary Background Between October, 2013, and April, 2014, French Polynesia experienced the largest Zika virus outbreak ever described at that time... 
Internal Medicine | DENGUE | CRITERIA | DIAGNOSIS | MEDICINE, GENERAL & INTERNAL | CHIKUNGUNYA | INFLUENZA | CAMPYLOBACTER | Polynesia - epidemiology | Humans | Middle Aged | Male | Disease Outbreaks - statistics & numerical data | Zika Virus - isolation & purification | Severe Dengue - epidemiology | Case-Control Studies | Severe Dengue - complications | Zika Virus Infection - epidemiology | Guillain-Barre Syndrome - epidemiology | Zika Virus Infection - complications | Adult | Female | Guillain-Barre Syndrome - virology | Dengue Virus - isolation & purification | Virus diseases | Autoimmunity | Medical research | Guillain-Barre syndrome | Dengue viruses | Medicine, Experimental | Development and progression | Immunochemistry | Health aspects | Epidemiology | Epidemics | Zika virus | Patients | Viral infections | Immunoglobulin M | Intensive care | Disease | Control methods | Immunoglobulin G | Viral diseases | Antibodies | Viruses | Outbreaks | Infections | Family medical history | Neuropathy | Microcephaly | Enzyme-linked immunosorbent assay | Vector-borne diseases | Signs and symptoms | Immunoglobulins | Dengue | Dengue fever | Disease control | Polymerase chain reaction | Infectious diseases | Combinatorial analysis | Cold remedies | Zika Virus | Zika Virus Infection | Guillain-Barre Syndrome | Dengue Virus | Severe Dengue | Virology | Life Sciences | Microbiology and Parasitology | Disease Outbreaks | Polynesia | Santé publique et épidémiologie
Journal Article
Nature immunology, ISSN 1529-2916, 2016, Volume 17, Issue 9, pp. 1102 - 1108
Zika virus (ZIKV) was discovered in 1947 and was thought to lead to relatively mild disease... 
NEUTRALIZING ANTIBODIES | IMMUNOLOGY | CHIKUNGUNYA VIRUS | OUTBREAK | BRAZIL | BRAIN | Immunodominant Epitopes - immunology | Antibody-Dependent Enhancement | Epitope Mapping | Humans | Child, Preschool | Male | Antibodies, Viral - blood | Microcephaly - epidemiology | Antibodies, Monoclonal - blood | Antibodies, Neutralizing - immunology | South America - epidemiology | Immunodominant Epitopes - metabolism | Guillain-Barre Syndrome - epidemiology | Viral Envelope Proteins - metabolism | Female | Dengue - immunology | Child | Antibodies, Monoclonal - immunology | Zika Virus - physiology | Cells, Cultured | Dengue - epidemiology | Cross Reactions | Zika Virus Infection - epidemiology | Virus Replication | Adolescent | Protein Binding | Zika Virus Infection - immunology | Antibodies, Viral - immunology | Dengue Virus - physiology | Viral Envelope Proteins - immunology | Antibodies, Neutralizing - blood | Medical research | Immune response | Comorbidity | Dengue | Medicine, Experimental | Development and progression | Research | Observations | South America | Populations and Evolution | Viral Envelope Proteins | Zika Virus Infection | Microcephaly | Guillain-Barre Syndrome | Life Sciences | Computer Science | Genetics | Bioinformatics | Antibodies, Neutralizing | Parasitology | Quantitative Methods | Zika Virus | Antibodies, Monoclonal | Antibodies, Viral | Dengue Virus | Virology | Microbiology and Parasitology | Santé publique et épidémiologie | Immunodominant Epitopes | Human genetics
Journal Article
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2017, Volume 61, Issue 3
As new pathogenic viruses continue to emerge, it is paramount to have intervention strategies that target a common denominator in these pathogens... 
Envelope protein | Antiviral | Zika virus | Virus entry | Chikungunya virus | Resistant mutant | LYSOSOMAL FUNCTION | envelope protein | MICROBIOLOGY | SEMLIKI-FOREST-VIRUS | chikungunya virus | CHLOROQUINE | FULL-LENGTH CDNA | IN-VITRO | antiviral | virus entry | PHARMACOLOGY & PHARMACY | INFECTION | resistant mutant | MUTATIONS | CELL ENTRY | ANTIVIRALS | Zika Virus - genetics | Chikungunya virus - genetics | Membrane Glycoproteins - metabolism | Epithelial Cells - drug effects | Humans | Yellow fever virus - growth & development | Semliki forest virus - growth & development | Virus Internalization - drug effects | Endosomes - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Lysosomes - metabolism | West Nile virus - genetics | Hydrogen-Ion Concentration - drug effects | Endosomes - drug effects | Viral Envelope Proteins - metabolism | Cell Membrane - drug effects | Hepatocytes - drug effects | Membrane Fusion - drug effects | Lysosomes - drug effects | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Cricetinae | Gene Expression | Viral Envelope Proteins - genetics | Zika Virus - growth & development | West Nile virus - growth & development | Zika Virus - drug effects | West Nile virus - drug effects | Chikungunya virus - growth & development | Membrane Glycoproteins - genetics | Chikungunya virus - drug effects | Drug Resistance, Viral - genetics | Pyrroles - pharmacology | Yellow fever virus - drug effects | Animals | Semliki forest virus - genetics | Neutral Red - metabolism | Epithelial Cells - virology | Semliki forest virus - drug effects | Hepatocytes - virology | Cell Membrane - virology | Mutation | Proto-Oncogene Proteins c-bcl-2 - genetics | Yellow fever virus - genetics
Journal Article