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Journal of Clinical Investigation, ISSN 0021-9738, 08/2015, Volume 125, Issue 8, pp. 2935 - 2951
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2009, Volume 284, Issue 46, pp. 31523 - 31531
Journal Article
Oncogene, ISSN 0950-9232, 03/2017, Volume 36, Issue 13, pp. 1849 - 1861
BRAF inhibitor (BRAFi) therapy for melanoma patients harboring the V600E mutation is initially highly effective, but almost all patients relapse within a few... 
TGF-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACQUIRED-RESISTANCE | DRUG-RESISTANCE | MESENCHYMAL TRANSITION | MEK INHIBITORS | CELL BIOLOGY | METASTATIC MELANOMA | GROWTH-FACTOR-BETA | IN-VITRO | ONCOLOGY | GENETICS & HEREDITY | BRAF INHIBITOR RESISTANCE | UP-REGULATION | Zinc Finger Protein GLI1 - metabolism | Humans | Zinc Finger Protein Gli2 | Hedgehog Proteins - metabolism | Drug Resistance, Neoplasm | Gene Knockdown Techniques | Kruppel-Like Transcription Factors - metabolism | Melanoma - genetics | Zinc Finger Protein GLI1 - antagonists & inhibitors | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Melanoma - metabolism | Cell Survival - drug effects | Cellular Senescence - genetics | Gene Expression | Zinc Finger Protein GLI1 - genetics | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Kruppel-Like Transcription Factors - antagonists & inhibitors | Kruppel-Like Transcription Factors - genetics | Care and treatment | Melanoma | Genetic aspects | Research | Transforming growth factors | Health aspects | Cancer | Signal transduction | Oncology | Transcription factors | Mutation | Index Medicus | Original
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 30, pp. 13432 - 13437
Aberrant Hedgehog (Hh) pathway activation has been implicated in cancers of diverse tissues and organs, and the tumor growth-inhibiting effects of pathway... 
Hedgehogs | Arsenic | NIH 3T3 cells | Medulloblastoma | Medical treatment | Genes | Tumors | Cancer | Arsenic compounds | Cilia | Primary cilium | Hedgehog antagonist | Arsenic trioxide | Smoothened | SMOOTHENED MUTATION | STEM-CELLS | TRIOXIDE | smoothened | arsenic trioxide | MULTIDISCIPLINARY SCIENCES | RAR-ALPHA | primary cilium | SIGNALING PATHWAY | MEDIATED TRANSCRIPTION | SMALL-MOLECULE INHIBITORS | BASAL-CELL CARCINOMA | cancer | HUMAN HOMOLOG | Arsenites - pharmacology | Cerebellar Neoplasms - prevention & control | NIH 3T3 Cells | Luciferases - metabolism | Zinc Finger Protein Gli2 | Hedgehog Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Transplantation, Homologous | Tumor Suppressor Protein p53 - genetics | Luciferases - genetics | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Transfection | Hedgehog Proteins - genetics | Kruppel-Like Transcription Factors - metabolism | Medulloblastoma - pathology | Cerebellar Neoplasms - pathology | Medulloblastoma - genetics | Arsenic Trioxide | Arsenicals - pharmacology | Medulloblastoma - prevention & control | Neoplasms, Experimental - prevention & control | Cerebellar Neoplasms - genetics | Sodium Compounds - pharmacology | Tumor Suppressor Protein p53 - deficiency | Mice, Knockout | Oxides - pharmacology | Animals | Signal Transduction - drug effects | Mice, Nude | Protein Stability - drug effects | Recombinant Fusion Proteins - genetics | Luminescent Proteins - genetics | Mice | Kruppel-Like Transcription Factors - genetics | Luminescent Proteins - metabolism | Physiological aspects | Genetic transcription | Properties | Cilia and ciliary motion | Hedgehog proteins | Biological Sciences
Journal Article
Science, ISSN 0036-8075, 04/2017, Volume 356, Issue 6335, pp. eaal3485 - eaal3485
The stem cell niche is a complex local signaling microenvironment that sustains stem cell activity during organ maintenance and regeneration. The mammary gland... 
HORMONE DEFICIENCY | IGF-I | MULTIDISCIPLINARY SCIENCES | MOUSE | RECEPTOR | DIFFERENTIATION | TRANSCRIPTION FACTOR | EXPRESSION | GLAND DEVELOPMENT | HEDGEHOG | GROWTH-FACTOR-I | Epithelial Cells - metabolism | Hedgehog Proteins - metabolism | Mammary Glands, Animal - growth & development | Prolactin - metabolism | Epithelial Cells - physiology | Insulin-Like Growth Factor II - genetics | Wnt Proteins - genetics | Hedgehog Proteins - genetics | Female | Epithelial Cells - cytology | Estrogens - metabolism | Stem Cell Niche - genetics | Zinc Finger Protein Gli2 - genetics | Gene Expression | Growth Hormone - blood | Sexual Maturation - genetics | Growth Hormone - metabolism | Stromal Cells - metabolism | Signal Transduction - genetics | Growth Hormone - deficiency | Mammary Glands, Animal - cytology | Zinc Finger Protein Gli2 - physiology | Animals | Mammary Glands, Animal - metabolism | Mice | Peptides | Disease | Pathogenesis | Estrogens | Disorders | Hormones | Delay | Distension | Fragmentation | Signal transduction | Efficiency | Entrainment | Mammary gland | Failure | Constitution | Fragments | Maintenance | Epithelium | Releasing | Ablation | Diseases | Stem cells | Growth hormone | Fibroblast growth factor | Flow cytometry | Transcription | Insulin-like growth factor I | Gene regulation | Glands | Homeostasis | Fluorescence | Effector cells | Insulin-like growth factors | Tissues | Defects | Morphogenesis | Control | Allografts | Rodents | Implants | Extracellular matrix | Combined pituitary hormone deficiency | Puberty | Pituitary hormones | Organs | Hedgehog protein | Pituitary | Green fluorescent protein | Breast | Growth hormones | Receptor mechanisms | Effectors | Mammary glands
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 7, pp. 732 - 740
Journal Article