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1. Full Text A novel GLI3 mutation affecting the zinc finger domain leads to preaxial-postaxial polydactyly-syndactyly complex
by Volodarsky, Michael and Langer, Yshaia and Birk, Ohad S
BMC medical genetics, ISSN 1471-2350, 09/2014, Volume 15, Issue 1, pp. 110 - 110
Background: Polydactyly is a highly common congenital limb defect. Extra digits may appear as an isolated anomaly or as a part of a syndrome. Mutations in GLI3... 
C2H2 | Zinc finger | Polydactyly | Syndactyly | Mutation | GCPS | GLI3 | GENETICS & HEREDITY | Protein Structure, Tertiary | Syndactyly - complications | Polydactyly - genetics | Genetic Association Studies | Polydactyly - complications | Humans | Zinc Finger Protein Gli3 | Histidine - genetics | Genotype | Male | Syndactyly - pathology | Mutation, Missense | Nerve Tissue Proteins - genetics | Jews - genetics | Genetic Variation | Phenotype | Morocco | Pedigree | Arginine - genetics | Female | Kruppel-Like Transcription Factors - genetics | Polydactyly - pathology | Syndactyly - genetics | Gene mutations | Abnormalities | Bones | Development and progression | Genetic aspects | Zinc finger proteins | Identification and classification
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2. Full Text MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression
by Hyun, Jeongeun and Wang, Sihyung and Kim, Jieun and Rao, Kummara Madhusudana and Park, Soo Yong and Chung, Ildoo and Ha, Chang-Sik and Kim, Sang-Woo and Yun, Yang H and Jung, Youngmi
Nature Communications, ISSN 2041-1723, 03/2016, Volume 7, Issue 1, p. 10993
Hedgehog (Hh) signalling regulates hepatic fibrogenesis. MicroRNAs (miRNAs) mediate various cellular processes; however, their role in liver fibrosis is... 
RAT-LIVER | TARGET | HEPATOCELLULAR-CARCINOMA | POLYPHOSPHATE | BIOGENESIS | MULTIDISCIPLINARY SCIENCES | MICE | NF-KAPPA-B | HEDGEHOG PATHWAY ACTIVATION | CANCER | L-TYROSINE | Protein Binding - genetics | Nanoparticles - chemistry | Receptors, G-Protein-Coupled - metabolism | Carbon Tetrachloride | Humans | Zinc Finger Protein Gli2 | Zinc Finger Protein Gli3 | Hepatic Stellate Cells - metabolism | Molecular Sequence Data | Male | MicroRNAs - metabolism | RNA, Messenger - metabolism | Kruppel-Like Transcription Factors - metabolism | Base Sequence | Carcinoma, Hepatocellular - genetics | Smoothened Receptor | Liver Cirrhosis - genetics | Down-Regulation | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Expression Regulation | Methionine | Nerve Tissue Proteins - genetics | Ethionine | Nerve Tissue Proteins - metabolism | Animals | Transcription Factor RelA - metabolism | Choline | Liver Cirrhosis - pathology | MicroRNAs - genetics | Chronic Disease | Kruppel-Like Transcription Factors - genetics
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3. Full Text Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
by Haycraft, Courtney J and Banizs, Boglarka and Aydin-Son, Yesim and Zhang, Qihong and Michaud, Edward J and Yoder, Bradley K
PLoS Genetics, ISSN 1553-7390, 2005, Volume 1, Issue 4, pp. 0480 - 0488
Intraflagellar transport (IFT) proteins are essential for cilia assembly and have recently been associated with a number of developmental processes, such as... 
Nerve Tissue Proteins - physiology | Tumor Suppressor Proteins - metabolism | Mice, Inbred C57BL | Zinc Finger Protein Gli2 | Zinc Finger Protein Gli3 | Kruppel-Like Transcription Factors - physiology | Nerve Tissue Proteins - genetics | Extremities - embryology | Hedgehog Proteins | Transcription Factors - metabolism | Animals | Flagella - metabolism | Models, Biological | Trans-Activators - metabolism | Mice | Mice, Inbred BALB C | Kruppel-Like Transcription Factors - genetics | Proteins | Signal transduction | Transmission electron microscopy | Colleges & universities | Defects
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4. Full Text Kinetics of Hedgehog-Dependent Full-Length Gli3 Accumulation in Primary Cilia and Subsequent Degradation
by Xiaohui Wen and Cary K. Lai and Marie Evangelista and Jo-Anne Hongo and Frederic J. de Sauvage and Suzie J. Scales
Molecular and Cellular Biology, ISSN 0270-7306, 04/2010, Volume 30, Issue 8, pp. 1910 - 1922
OA  Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+... 
PROTEIN-KINASE-A | INTRAFLAGELLAR TRANSPORT PROTEINS | SIGNAL-TRANSDUCTION | TRANSCRIPTION FACTORS | SONIC HEDGEHOG | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDEPENDENT REGULATION | MONOCLONAL-ANTIBODIES | CUBITUS-INTERRUPTUS PROTEIN | NEGATIVE REGULATOR | CELL BIOLOGY | RNA, Small Interfering - genetics | Receptors, G-Protein-Coupled - metabolism | Humans | Zinc Finger Protein Gli2 | Zinc Finger Protein Gli3 | Hedgehog Proteins - metabolism | Hedgehog Proteins - genetics | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | Cilia - ultrastructure | Patched Receptors | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | Receptors, Cell Surface - metabolism | Nerve Tissue Proteins - genetics | Cilia - metabolism | Nerve Tissue Proteins - metabolism | Animals | Signal Transduction - physiology | Mice | Mice, Inbred BALB C | Receptors, G-Protein-Coupled - genetics | Proteasome Endopeptidase Complex - metabolism | Kruppel-Like Transcription Factors - genetics | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics
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5. Full Text MiR-506 acts as a tumor suppressor by directly targeting the hedgehog pathway transcription factor Gli3 in human cervical cancer
by Wen, S.-Y and Lin, Y and Yu, Y.-Q and Cao, S.-J and Zhang, R and Yang, X.-M and Li, J and Zhang, Y.-L and Wang, Y.-H and Ma, M.-Z and Sun, W.-W and Lou, X.-L and Wang, J.-H and Teng, Y.-C and Zhang, Z.-G
Oncogene, ISSN 0950-9232, 02/2015, Volume 34, Issue 6, pp. 717 - 725
Although significant advances have recently been made in the diagnosis and treatment of cervical carcinoma, the long-term survival rate for advanced cervical... 
CELLS | ONCOLOGY | SONIC HEDGEHOG | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | REGULATORY NETWORK | DIFFERENTIATION | MICRORNAS | UP-REGULATION | EXPRESSION | CELL BIOLOGY | Kruppel-Like Transcription Factors - biosynthesis | Nerve Tissue Proteins - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Zinc Finger Protein Gli3 | MicroRNAs - metabolism | Uterine Cervical Neoplasms - drug therapy | Uterine Cervical Neoplasms - pathology | Signal Transduction - genetics | Uterine Cervical Neoplasms - genetics | Nerve Tissue Proteins - genetics | G1 Phase Cell Cycle Checkpoints - genetics | Xenograft Model Antitumor Assays | Animals | Nerve Tissue Proteins - biosynthesis | Cell Line, Tumor | Female | Ki-67 Antigen - biosynthesis | Mice | MicroRNAs - genetics | Genes, Tumor Suppressor | Kruppel-Like Transcription Factors - antagonists & inhibitors | Kruppel-Like Transcription Factors - genetics | Care and treatment | Transcription factors | Tumor suppressor genes | Genetic aspects | Research | Health aspects | Cervical cancer | Risk factors | Chemotherapy | Pathogenesis | MicroRNAs
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6. Full Text The ciliary EVC/EVC2 complex interacts with smo and controls hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia
by Caparrós-Martín, Jose A and Valencia, María and Reytor, Edel and Pacheco, María and Fernandez, Margarita and Perez-Aytes, Antonio and Gean, Esther and Lapunzina, Pablo and Peters, Heiko and Goodship, Judith A and Ruiz-Perez, Victor L
Human Molecular Genetics, ISSN 0964-6906, 01/2013, Volume 22, Issue 1, pp. 124 - 139
Hedgehog (Hh) signaling is involved in patterning and morphogenesis of most organs in the developing mammalian embryo. Despite many advances in understanding... 
VAN-CREVELD-SYNDROME | SIGNAL-TRANSDUCTION | ACTIVATION | PROTEIN | EVC | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | GENETICS & HEREDITY | IHH | MUTATIONS | INTRAFLAGELLAR TRANSPORT | VERTEBRATE LIMB | Receptors, G-Protein-Coupled - metabolism | Zinc Finger Protein Gli3 | Hedgehog Proteins - metabolism | Cilia - metabolism | Protein Transport | Nerve Tissue Proteins - metabolism | Animals | Kruppel-Like Transcription Factors - metabolism | Membrane Proteins - physiology | Mice, Mutant Strains | Smoothened Receptor | Membrane Proteins - metabolism | Mice | Chondrocytes - metabolism | Repressor Proteins - metabolism
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7. Full Text New insights into genotype-phenotype correlation for GLI3 mutations
by Démurger, Florence and Ichkou, Amale and Mougou-Zerelli, Soumaya and Le Merrer, Martine and Goudefroye, Géraldine and Delezoide, Anne-Lise and Quélin, Chloé and Manouvrier, Sylvie and Baujat, Geneviève and Fradin, Mélanie and Pasquier, Laurent and Megarbané, André and Faivre, Laurence and Baumann, Clarisse and Nampoothiri, Sheela and Roume, Joëlle and Isidor, Bertrand and Lacombe, Didier and Delrue, Marie-Ange and Mercier, Sandra and Philip, Nicole and Schaefer, Elise and Holder, Muriel and Krause, Amanda and Laffargue, Fanny and Sinico, Martine and Amram, Daniel and André, Gwenaelle and Liquier, Alain and Rossi, Massimiliano and Amiel, Jeanne and Giuliano, Fabienne and Boute, Odile and Dieux-Coeslier, Anne and Jacquemont, Marie-Line and Afenjar, Alexandra and Van Maldergem, Lionel and Lackmy-Port-Lis, Marylin and Vincent- Delorme, Catherine and Chauvet, Marie-Liesse and Cormier-Daire, Valérie and Devisme, Louise and Geneviève, David and Munnich, Arnold and Viot, Géraldine and Raoul, Odile and Romana, Serge and Gonzales, Marie and Encha-Razavi, Ferechte and Odent, Sylvie and Vekemans, Michel and Attie-Bitach, Tania
European Journal of Human Genetics, ISSN 1018-4813, 01/2015, Volume 23, Issue 1, pp. 92 - 102
The phenotypic spectrum of GLI3 mutations includes autosomal dominant Greig cephalopolysyndactyly syndrome (GCPS) and Pallister-Hall syndrome (PHS). PHS was... 
POINT MUTATIONS | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACROCALLOSAL SYNDROME | GENETICS & HEREDITY | PALLISTER-HALL-SYNDROME | CONGENITAL HYPOTHALAMIC HAMARTOBLASTOMA | SPECTRUM | DIAGNOSTIC-CRITERIA | IMPERFORATE ANUS | EXPRESSION | GREIG CEPHALOPOLYSYNDACTYLY SYNDROME | Gene Expression | Genetic Association Studies | Humans | Zinc Finger Protein Gli3 | In Situ Hybridization, Fluorescence | Acrocephalosyndactylia - genetics | Nerve Tissue Proteins - genetics | Haploinsufficiency | Phenotype | DNA Mutational Analysis | Abnormalities, Multiple - diagnosis | Gene Rearrangement | Acrocephalosyndactylia - diagnosis | Family | Mutation | Kruppel-Like Transcription Factors - genetics | Abnormalities, Multiple - genetics | Cohort Studies | Epiglottis | Phenotypes | Greig cephalopolysyndactyly syndrome | Fetuses | Lethality | Hypothalamus | Gene expression | Gene deletion | Gli3 protein | Corpus callosum | Proteins | Clonal deletion | Polydactyly | Genetics | Neoplasia | Genotypes | Life Sciences
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8. Full Text Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors
by Wang, Chengbing and Pan, Yong and Wang, Baolin
Development, ISSN 0950-1991, 06/2010, Volume 137, Issue 12, pp. 2001 - 2009
Gli2 and Gli3 are primary transcriptional regulators that mediate hedgehog (Hh) signaling. Mechanisms that stabilize and destabilize Gli2 and Gli3 are... 
Spop | Hedgehog | Sufu | Gli3 | Gli2 | PROTEIN-KINASE-A | UBIQUITIN LIGASE | BETA-TRCP | MOUSE | NEURAL-TUBE | DEVELOPMENTAL BIOLOGY | TARGETS CUBITUS-INTERRUPTUS | FLOOR PLATE | SIGNALING PATHWAY | VERTEBRATE LIMB | Nerve Tissue Proteins - metabolism | Animals | Kruppel-Like Transcription Factors - metabolism | Mice, Mutant Strains | Oncogene Proteins - metabolism | Zinc Finger Protein Gli3 | Neural Tube - physiology | Signal Transduction - physiology | Trans-Activators - metabolism | Mice | Zinc Finger Protein GLI1
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9. Full Text Inhibitory Gli3 Activity Negatively Regulates Wnt/β-Catenin Signaling
by Ulloa, Fausto and Itasaki, Nobue and Briscoe, James
Current Biology, ISSN 0960-9822, 03/2007, Volume 17, Issue 6, pp. 545 - 550
The Hedgehog (Hh) and Wingless (Wnt) families of secreted signaling molecules have key roles in embryonic development and adult tissue homeostasis . In the... 
DEVBIO | ACTIVATION | COMPLEX | XENOPUS-EMBRYOS | SONIC HEDGEHOG | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEURAL-TUBE | BETA-CATENIN | PROTEINS | EXPRESSION | GRADIENT | CELL BIOLOGY | Xenopus | Signal Transduction | Humans | Embryo, Nonmammalian - metabolism | Gene Expression Regulation | Zinc Finger Protein Gli3 | Hedgehog Proteins - metabolism | Embryonic Development | Wnt Proteins - metabolism | Chick Embryo | Nerve Tissue Proteins - genetics | beta Catenin - metabolism | Embryo, Mammalian - metabolism | Protein Interaction Mapping | Nerve Tissue Proteins - metabolism | Animals | Wnt Proteins - genetics | Hedgehog Proteins - genetics | Kruppel-Like Transcription Factors - metabolism | beta Catenin - antagonists & inhibitors | Wnt3 Protein | Mice | Wnt Proteins - antagonists & inhibitors | Kruppel-Like Transcription Factors - genetics
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10. Full Text Mutational screening of GLI3, SHH, preZRS, and ZRS in 102 Chinese children with nonsyndromic polydactyly
by Xiang, Ying and Jiang, Limin and Wang, Bo and Xu, Yunlan and Cai, Haiqing and Fu, Qihua
Developmental Dynamics, ISSN 1058-8388, 05/2017, Volume 246, Issue 5, pp. 392 - 402
Background : Polydactyly is a group of congenital limb malformations that show high degree of phenotypic variability and genetic heterogeneity. Results : In... 
SHH | ZRS | preZRS | GLI3 | polydactyly | NUMBER | PROTEIN | ANATOMY & MORPHOLOGY | DEVELOPMENTAL BIOLOGY | HEDGEHOG | PREDICTION | REGULATOR | GENE | SEQUENCE | SPECTRUM | DEVELOPING LIMB | EXPRESSION | Genetic Testing | Polydactyly - genetics | Membrane Proteins - genetics | Gene Frequency | Humans | Zinc Finger Protein Gli3 | Child, Preschool | Hedgehog Proteins - metabolism | Male | Signal Transduction - genetics | Nerve Tissue Proteins - genetics | Sequence Analysis, DNA | Hand Deformities, Congenital - genetics | Hedgehog Proteins - genetics | Polydactyly - epidemiology | Adolescent | Female | Mutation | Child | Kruppel-Like Transcription Factors - genetics
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11. Full Text GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML
by Chaudhry, Parvesh and Singh, Mohan and Triche, Timothy J and Guzman, Monica and Merchant, Akil A
Blood, ISSN 0006-4971, 06/2017, Volume 129, Issue 26, pp. 3465 - 3475
The Hedgehog (Hh) signaling pathway is activated in many cancers and is a promising target for therapeutic development. Deletions in the receptor Patched... 
PHASE-II TRIAL | SHH | INHIBITION | PROTEIN | BASAL-CELL CARCINOMA | CYCLOPAMINE | ACUTE MYELOID-LEUKEMIA | HEMATOLOGY | CANCER | SONIC-HEDGEHOG | VERTEBRATE LIMB | Nerve Tissue Proteins - physiology | Humans | Leukemia, Myeloid, Acute - metabolism | Zinc Finger Protein Gli3 | Hedgehog Proteins - metabolism | Kruppel-Like Transcription Factors - physiology | Repressor Proteins - physiology | Animals | Heterografts | Cell Line, Tumor | Mice | Oncogene Protein v-akt - metabolism | Smoothened Receptor - antagonists & inhibitors | Myeloid Neoplasia
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12. Full Text Gata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb Development
by Hayashi, Shinichi and Akiyama, Ryutaro and Wong, Julia and Tahara, Naoyuki and Kawakami, Hiroko and Kawakami, Yasuhiko
PLoS Genetics, ISSN 1553-7390, 06/2016, Volume 12, Issue 6, p. e1006138
Gli3 is a major regulator of Hedgehog signaling during limb development. In the anterior mesenchyme, GLI3 is proteolytically processed into GLI3R, a truncated... 
DIGIT NUMBER | SHH | MOUSE EMBRYOS | GENETICS & HEREDITY | GATA6 | POLARIZING ACTIVITY | GENETIC INTERACTION | EXPRESSION | GREIG CEPHALOPOLYSYNDACTYLY SYNDROME | SONIC-HEDGEHOG | VERTEBRATE LIMB | Cell Line | NIH 3T3 Cells | Polydactyly - genetics | Humans | Zinc Finger Protein Gli3 | Gene Expression Regulation, Developmental - genetics | Signal Transduction - genetics | Transcription Factors - genetics | Stem Cells - metabolism | Nerve Tissue Proteins - genetics | Animals | Limb Buds - metabolism | Hedgehog Proteins - genetics | Organogenesis - genetics | HEK293 Cells | Mice | GATA6 Transcription Factor - genetics | Limb Buds - growth & development | Transcription, Genetic - genetics | Extremities - growth & development | Body Patterning - genetics | Kruppel-Like Transcription Factors - genetics | Physiological aspects | Cellular signal transduction | Genetic aspects | Hedgehog proteins | Proteins | Studies | Signal transduction | Immunoglobulins | Transcription factors | Rodents | Morphology | Localization
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13. Full Text Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity
by Dahn, Randall D and Li, Yina and Fallon, John F and Litingtung, Ying and Chiang, Chin
Nature, ISSN 0028-0836, 08/2002, Volume 418, Issue 6901, pp. 979 - 983
Most current models propose Sonic hedgehog (Shh) as the primary determinant of anteroposterior development of amniote limbs. Shh protein is said to be required... 
ACTIVATION | GENE | SONIC HEDGEHOG | MULTIDISCIPLINARY SCIENCES | POLARIZING ACTIVITY | MICE | ZPA | MUTATIONS | REPRESSOR | CUBITUS-INTERRUPTUS PROTEIN | Leg Bones - metabolism | Zinc Finger Protein Gli3 | RNA, Messenger - metabolism | Extremities - embryology | DNA-Binding Proteins - metabolism | Hedgehog Proteins | Morphogenesis | In Situ Hybridization | Leg Bones - embryology | Gene Expression Regulation, Developmental | Gene Deletion | Body Patterning | Trans-Activators - genetics | Extremities - physiology | Signal Transduction | RNA, Messenger - genetics | Nerve Tissue Proteins | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Limb Buds - embryology | Blotting, Western | Mice, Knockout | Kruppel-Like Transcription Factors | Transcription Factors - metabolism | Animals | Limb Buds - metabolism | Trans-Activators - metabolism | Mice | Proteins | Skeletal system | Cellular biology | Genes
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