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Journal of Immunology, ISSN 0022-1767, 10/2017, Volume 199, Issue 7, pp. 2503 - 2514
Heterodimeric IL-27 (p28/EBV-induced gene 3) is an important member of the IL-6/IL-12 cytokine family. IL-27 is predominantly synthesized by mononuclear... 
ENDOGENOUS CATECHOLAMINES | ALTERNATIVELY ACTIVATED MACROPHAGES | HUMAN DENDRITIC CELLS | CYTOKINE PRODUCTION | CELLULAR IMMUNE FUNCTIONS | FAMILY-MEMBERS | REGULATORY T-CELLS | GENE-EXPRESSION | KAPPA-B | IMMUNOLOGY | BLOOD-PRESSURE | Norepinephrine - pharmacology | Albuterol - pharmacology | Sympathetic Nervous System - immunology | Zymosan - pharmacology | Interleukins - metabolism | Interleukins - genetics | Sympathetic Nervous System - physiology | Receptors, Adrenergic - drug effects | Interleukins - immunology | Macrophages - immunology | Thiadiazoles - pharmacology | Interleukins - blood | Formoterol Fumarate - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Inflammation | Sulfonamides - pharmacology | Toll-Like Receptor 3 - metabolism | Anthracenes - pharmacology | Animals | Shock, Septic | Signal Transduction - drug effects | Poly I-C - metabolism | Lipopolysaccharides - pharmacology | Interleukin-10 - biosynthesis | Macrophages - drug effects | Mice | Macrophage Activation - drug effects | Interleukin-10 - immunology | Epinephrine - pharmacology | Shock | Adrenal glands | Glands | Nervous system | Leukocytes (mononuclear) | Activation | Feedback loops | Macrophages | Neuromodulation | Interleukin 27 | Neoplasms | Neuroendocrine system | Interleukin 6 | Cell activation | Autonomic nervous system | Modulation | Formoterol | Autocrine signalling | Noradrenaline | Endotoxemia | Epinephrine | CD11b antigen | Immune response | Immunoregulation | Interleukin 12 | Catecholamines | JNK protein | Pharmacology | Sympathetic nervous system | Catecholamine | Gene silencing | Interleukin 10 | Adrenergic receptors | Receptors (physiology) | Hypothermia
Journal Article
European Journal of Immunology, ISSN 0014-2980, 06/2007, Volume 37, Issue 6, pp. 1600 - 1612
Zymosan is a particulate yeast preparation that elicits high levels of IL‐2 and IL‐10 from dendritic cells (DC) and engages multiple innate receptors,... 
Zymosan | Dendritic cells | Syk | C‐type lectins | Pattern recognition receptors | C-type lectins | C-FOS | PROTEIN-KINASE | TOLL-LIKE RECEPTOR | LIPOPOLYSACCHARIDE ACTIVATION | INNATE IMMUNE-SYSTEM | IMMUNOLOGY | pattern recognition receptors | BETA-GLUCAN RECEPTOR | SIGNAL-TRANSDUCTION | TUMOR-NECROSIS-FACTOR | dendritic cells | zymosan | MESSENGER-RNA DECAY | Cysteine - analogs & derivatives | Interleukin-12 Subunit p40 - genetics | Gene Expression - drug effects | Nitriles - pharmacology | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Zymosan - pharmacology | Protein-Tyrosine Kinases - physiology | Signal Transduction - immunology | Protein-Tyrosine Kinases - genetics | Cysteine - pharmacology | Interleukin-10 - metabolism | Dendritic Cells - drug effects | Flavonoids - pharmacology | Phosphorylation - drug effects | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Dendritic Cells - metabolism | Interleukin-2 - metabolism | Cell Line | Butadienes - pharmacology | Membrane Proteins - genetics | Lectins, C-Type | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Myeloid Differentiation Factor 88 - genetics | Glucans - pharmacology | Nerve Tissue Proteins - genetics | Mice, Knockout | Interleukin-2 - genetics | Animals | Signal Transduction - drug effects | Lipoproteins - pharmacology | Interleukin-10 - genetics | Mice | Enzyme Activation | Intracellular Signaling Peptides and Proteins - physiology | Oligopeptides - pharmacology | Peptidoglycan - pharmacology | Lipopeptides
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2009, Volume 206, Issue 1, pp. 15 - 23
The endogenous cellular and molecular mechanisms that control acute inflammation and its resolution are of wide interest. Using self-resolving inflammatory... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | RESOLVINS | DOCOSATRIENES | DOCOSAHEXAENOIC ACID | INFLAMMATION | OMEGA-3-FATTY-ACIDS | RESOLUTION | ATHEROSCLEROSIS | LIPID MEDIATORS | IMMUNOLOGY | NEUROPROTECTIN-D1 | Leukocytes, Mononuclear - metabolism | Neutrophils - cytology | Stereoisomerism | Eicosapentaenoic Acid - analogs & derivatives | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Macrophages, Peritoneal - cytology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Lipoxygenase - metabolism | Autacoids - metabolism | Eicosapentaenoic Acid - pharmacology | Inflammation Mediators - pharmacology | Inflammation Mediators - metabolism | Autacoids - pharmacology | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Macrophages, Peritoneal - drug effects | Neutrophils - metabolism | Dinoprostone - pharmacology | Phagocytosis - drug effects | Leukocytes, Mononuclear - drug effects | Docosahexaenoic Acids - chemistry | Neutrophils - drug effects | Peritonitis - metabolism | Peritonitis - chemically induced | Macrophages - cytology | Autacoids - chemistry | Mice, Inbred Strains | Cell Movement - drug effects | Docosahexaenoic Acids - pharmacology | Macrophages - metabolism | Animals | Lipid Metabolism - drug effects | Lipoxygenase - genetics | Inflammation Mediators - chemistry | Leukocytes, Mononuclear - cytology | Macrophages - drug effects | Zymosan - toxicity | Mice | Macrophages, Peritoneal - metabolism | Docosahexaenoic Acids - metabolism | Index Medicus | Brief Definitive Reports
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 09/2011, Volume 164, Issue 2b, pp. 828 - 835
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 11/2016, Volume 119, pp. 17 - 26
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/2010, Volume 159, Issue 4, pp. 842 - 855
Background and purpose:  Apremilast is an orally administered phosphodiesterase-4 inhibitor, currently in phase 2 clinical studies of psoriasis and other... 
immunopharmacology | anti-inflammatory drugs | PDE inhibitor | chemokines | inflammation | skin pharmacology | anti‐inflammatory drugs | Skin pharmacology | Inflammation | Anti-inflammatory drugs | Immunopharmacology | Chemokines | TRANSCRIPTION FACTORS | DIFFERENTIAL EXPRESSION | ELEMENT-BINDING PROTEIN | NECROSIS-FACTOR-ALPHA | PERITONEAL-MACROPHAGES | PDE4 INHIBITORS | OBSTRUCTIVE PULMONARY-DISEASE | CYCLIC-AMP PHOSPHODIESTERASE | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | PLAQUE-TYPE PSORIASIS | Humans | Middle Aged | Thalidomide - pharmacology | RNA, Messenger - metabolism | Zymosan - metabolism | Thalidomide - analogs & derivatives | Ultraviolet Rays | Psoriasis - pathology | Time Factors | U937 Cells | Anti-Inflammatory Agents - administration & dosage | Skin Transplantation | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cytokines - genetics | Keratinocytes - enzymology | Disease Models, Animal | Psoriasis - immunology | Leukocytes, Mononuclear - drug effects | Psoriasis - drug therapy | Administration, Oral | Anti-Inflammatory Agents - pharmacology | Thalidomide - administration & dosage | Skin - enzymology | Keratinocytes - immunology | Killer Cells, Natural - enzymology | Keratinocytes - drug effects | Lipopolysaccharides - pharmacology | Killer Cells, Natural - drug effects | Mice | Transplantation, Heterologous | Dose-Response Relationship, Drug | Psoriasis - genetics | Enterotoxins - immunology | Leukocytes, Mononuclear - immunology | Inflammation Mediators - metabolism | Phosphodiesterase 4 Inhibitors | Killer Cells, Natural - immunology | Adult | Skin - pathology | Skin - immunology | Severity of Illness Index | Cytokines - metabolism | Phosphodiesterase Inhibitors - pharmacology | Mice, SCID | Gene Expression Regulation - drug effects | Phosphodiesterase Inhibitors - administration & dosage | Animals | Skin - radiation effects | Leukocytes, Mononuclear - enzymology | Cell Proliferation - drug effects | Psoriasis - enzymology | Skin - drug effects | Psoriasis | Tumor necrosis factor-TNF | Rodents | Research Papers
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2000, Volume 387, Issue 1, pp. 111 - 118
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2001, Volume 133, Issue 6, pp. 920 - 926
Phagocytosis of unopsonized zymosan by RAW 264.7 macrophages upregulated protein expression of haem oxygenase‐1 (HO‐1), inducible nitric oxide synthase (iNOS)... 
nitric oxide | cyclo‐oxygenase‐2 | RAW 264.7 macrophages | 5‐lipoxygenase | Haem oxygenase‐1 | leukotrienes | inducible nitric oxide synthase | Cyclo-oxygenase-2 | Leukotrienes | Inducible nitric oxide synthase | Nitric oxide | 5-Lipoxygenase | Haem oxygenase-1 | KAPPA-B ACTIVATION | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PERITONEAL-MACROPHAGES | INDUCTION | cyclo-oxygenase-2 | FIBROBLASTS | SYNTHASE | GENE | CARBON-MONOXIDE | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | haem oxygenase-1 | HEME OXYGENASE-1 | 5-lipoxygenase | Hydroxyurea - analogs & derivatives | Prostaglandin-Endoperoxide Synthases - biosynthesis | Hydroxyurea - pharmacology | Cyclooxygenase 2 | Leukotrienes - pharmacology | Nitric Oxide Synthase - drug effects | Nitrites - metabolism | NF-kappa B - metabolism | Quinolones - pharmacology | Nitrobenzenes - pharmacology | Nitric Oxide Synthase Type II | Transcription Factor AP-1 - metabolism | Zymosan - pharmacology | Dose-Response Relationship, Drug | Dexamethasone - pharmacology | Heme Oxygenase (Decyclizing) - biosynthesis | Time Factors | Protein Binding - drug effects | Heme Oxygenase (Decyclizing) - drug effects | Heme Oxygenase-1 | Nitric Oxide Synthase - biosynthesis | Leukotriene C4 - pharmacology | Pyrans - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Cell Line | Dinoprostone - pharmacology | Eicosanoids - pharmacology | Enzyme Inhibitors - pharmacology | Prostaglandin-Endoperoxide Synthases - drug effects | Macrophages - cytology | Sulfonamides - pharmacology | Chick Embryo | Indomethacin - pharmacology | Leukotriene B4 - pharmacology | Macrophages - metabolism | Animals | Macrophages - drug effects | Amidines - pharmacology | Isoenzymes - drug effects | Isoenzymes - biosynthesis | Macrophage Activation - drug effects | Nitric Oxide - metabolism | Benzylamines - pharmacology | Papers
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e58963
Background and Purpose: Although the 'cromones' (di-sodium cromoglycate and sodium nedocromil) are used to treat allergy and asthma, their 'mast cell... 
NEDOCROMIL SODIUM | PERIPHERAL-BLOOD LEUKOCYTES | ANTI-ALLERGIC COMPOUNDS | PROTEIN-KINASE-C | DISODIUM-CROMOGLYCATE | MULTIDISCIPLINARY SCIENCES | INDUCED AIRWAY RESPONSES | MOUSE MODEL | ALKALINE-PHOSPHATASE INHIBITION | ZYMOSAN INFLAMMATION | MEDIATOR RELEASE | Anti-Asthmatic Agents - pharmacology | Mast Cells - immunology | Annexin A1 - genetics | Annexin A1 - secretion | Humans | Cells, Cultured | Antibodies, Anti-Idiotypic - immunology | Eicosanoids - secretion | Anti-Allergic Agents - pharmacology | Recombinant Proteins | Mast Cells - drug effects | Mice, Knockout | Nedocromil - pharmacology | Annexin A1 - pharmacology | Animals | Dexamethasone - pharmacology | Immunoglobulin E - immunology | Prostaglandin D2 - secretion | Cromolyn Sodium - pharmacology | Mast Cells - metabolism | Mice | Phosphorylation - drug effects | Histamine Release - drug effects | Histamine | Crosslinked polymers | Corticosteroids | Cromolyn sodium | Immunoglobulin E | Monoclonal antibodies | Hostages | Annexins | Protein kinases | Asthma | Drugs | Flow cytometry | Protein kinase C | Phosphorylation | compound 48/80 | Kinases | Phosphatase | Experiments | Proteins | Protein folding | Penicillin | Bone marrow | Sodium cromoglycate | Inhibition | Pretreatment | Recombinant | Dexamethasone | Cytokines | Incubation | Secretion | Hypersensitivity | Crosslinking | Inflammation | Pharmacology | Allergies | Medicine | Sodium | Mast cells
Journal Article