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2013, Cambridge medicine, ISBN 0521149398, xiv, 240
Despite increasing interest in intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) as causes of significant morbidity and mortality... 
Compartment syndrome | Abdomen | Diseases | Hypertension
Book
Atherosclerosis, ISSN 0021-9150, 2011, Volume 217, Issue 2, pp. 350 - 357
Abstract Objective We sought to examine the effect of resveratrol (3,4′,5-trihydroxy-trans-stilbene), a plant-derived polyphenolic compound, on the development... 
Cardiovascular | Neoangiogenesis | Oxidative stress | Extracellular matrix | Inflammation | Abdominal aortic aneurysm | CELLS | ACTIVATION | ANGIOGENESIS | TRANSCRIPTION | COMPOUND | FACTOR-KAPPA-B | ANGIOTENSIN-II | INHIBITION | TRANS-RESVERATROL | PERIPHERAL VASCULAR DISEASE | E-DEFICIENT MICE | Inflammation - chemically induced | Neovascularization, Physiologic - drug effects | Aortic Aneurysm, Abdominal - chemically induced | Phosphorylation | Aortic Aneurysm, Abdominal - prevention & control | Reactive Oxygen Species - metabolism | Aortic Aneurysm, Abdominal - immunology | Extracellular Matrix - metabolism | Stilbenes - pharmacology | Aorta, Abdominal - drug effects | Aortic Aneurysm, Abdominal - metabolism | Inflammation - metabolism | Matrix Metalloproteinase 9 - metabolism | Inflammation Mediators - metabolism | Aorta, Abdominal - pathology | Aorta, Abdominal - metabolism | Aortic Aneurysm, Abdominal - pathology | Macrophages - immunology | Disease Models, Animal | Calcium Chloride | Anti-Inflammatory Agents - pharmacology | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | Angiogenesis Inhibitors - pharmacology | Inflammation - immunology | Antioxidants - pharmacology | Aorta, Abdominal - immunology | Animals | Transcription Factor RelA - metabolism | Aortic Aneurysm, Abdominal - physiopathology | Macrophages - drug effects | Inflammation - prevention & control | Mice | Oxidative Stress - drug effects | Inflammation - physiopathology | Prevention | Medical colleges | Atherosclerosis | Resveratrol | Neovascularization | Abdominal aneurysm
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 08/2014, Volume 34, Issue 8, pp. 1747 - 1755
OBJECTIVE—Inflammation plays a critical role in the development of abdominal aortic aneurysms (AAAs). Because stromal cell–derived factor 1 (SDF-1) is known... 
Chemokine CXCL12 | Inflammation | Pharmacology | Abdominal | Aortic aneurysm | MATRIX | STEM-CELLS | aortic aneurysm, abdominal | CXCR4 ANTAGONIST | LOCAL OVEREXPRESSION | FACTOR-I | chemokine CXCL12 | HEMATOPOIETIC PROGENITOR | RAT MODEL | PATHOGENESIS | THERAPY | inflammation | pharmacology | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Aortic Aneurysm, Abdominal - chemically induced | Aortic Aneurysm, Abdominal - prevention & control | Aortic Aneurysm, Abdominal - immunology | Humans | Rats, Inbred F344 | Heterocyclic Compounds - pharmacology | Male | Green Fluorescent Proteins - genetics | Aorta, Abdominal - drug effects | Aortic Aneurysm, Abdominal - metabolism | Chemokine CXCL12 - genetics | Heterografts | Time Factors | U937 Cells | Bone Marrow Transplantation | Inflammation Mediators - metabolism | Receptors, CXCR4 - genetics | Aorta, Abdominal - pathology | Myocytes, Smooth Muscle - drug effects | Aorta, Abdominal - metabolism | Myocytes, Smooth Muscle - metabolism | Aortic Aneurysm, Abdominal - pathology | Macrophages - immunology | Disease Models, Animal | Calcium Chloride | Guinea Pigs | Anti-Inflammatory Agents - pharmacology | Receptors, CXCR4 - antagonists & inhibitors | Mice, Inbred C57BL | Rats | Mice, Transgenic | Aortic Aneurysm, Abdominal - genetics | Chemotaxis - drug effects | Receptors, CXCR4 - metabolism | Aorta, Abdominal - immunology | Macrophages - metabolism | Animals | Chemokine CXCL12 - metabolism | Green Fluorescent Proteins - biosynthesis | Myocytes, Smooth Muscle - immunology | Macrophages - drug effects | Mice
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2013, Volume 33, Issue 4, pp. 718 - 726
OBJECTIVE—Macrophages are critical contributors to abdominal aortic aneurysm (AAA) disease. We examined the ability of MKEY, a peptide inhibitor of CXCL4–CCL5... 
chemokines | mice | CCL5 | abdominal aortic aneurysm | CXCL4 | ATHEROSCLEROTIC LESIONS | PROGENITOR CELLS | RECRUITMENT | WALL | RECEPTOR CCR2 | RANTES | BONE-MARROW | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | INFUSION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | E-DEFICIENT MICE | Aortic Aneurysm, Abdominal - chemically induced | Aortic Aneurysm, Abdominal - prevention & control | Injections, Intravenous | Aortic Aneurysm, Abdominal - immunology | Apolipoproteins E - deficiency | Male | Aorta, Abdominal - drug effects | Chemokine CCL5 - antagonists & inhibitors | Aortic Aneurysm, Abdominal - metabolism | Leukocytes - immunology | Matrix Metalloproteinase 9 - metabolism | Receptors, CCR5 - metabolism | Chemotaxis, Leukocyte - drug effects | Time Factors | Chemokine CCL5 - metabolism | Aorta, Abdominal - pathology | Angiotensin II | Myocytes, Smooth Muscle - drug effects | Aorta, Abdominal - metabolism | Aortic Aneurysm, Abdominal - pathology | Macrophages - immunology | Disease Models, Animal | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Platelet Factor 4 - antagonists & inhibitors | Disease Progression | Mice, Knockout | Aorta, Abdominal - immunology | Animals | Apolipoproteins E - genetics | Myocytes, Smooth Muscle - immunology | Pancreatic Elastase | Leukocytes - drug effects | Macrophages - drug effects | Mice | Oligopeptides - administration & dosage | Platelet Factor 4 - metabolism | Oligopeptides - pharmacology
Journal Article
Circulation Research, ISSN 0009-7330, 11/2015, Volume 117, Issue 11, pp. e80 - e89
RATIONALE:Matrix metalloproteinases (MMPs)–mediated extracellular matrix destruction is the major cause of development and progression of abdominal aortic... 
drug delivery systems | batimastat | matrix metalloproteinase inhibitors | nanoparticles | cardiovascular diseases | vascular remodeling | abdominal aortic aneurysm | CELLS | PROPRANOLOL | CARDIAC & CARDIOVASCULAR SYSTEMS | BB-94 | CANCER | TRIAL | THERAPY | DISEASE | DOXYCYCLINE | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | Aortic Aneurysm, Abdominal - chemically induced | Aortic Aneurysm, Abdominal - immunology | Phenylalanine - analogs & derivatives | Matrix Metalloproteinase Inhibitors - administration & dosage | Male | Thiophenes - metabolism | Thiophenes - administration & dosage | Immunoconjugates - administration & dosage | Aorta, Abdominal - drug effects | Drug Carriers | Nanoparticles | Time Factors | Phenylalanine - chemistry | Proteolysis | Vascular Calcification - enzymology | Aorta, Abdominal - pathology | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Elastin - metabolism | Calcium Chloride | Aortic Aneurysm, Abdominal - drug therapy | Phenylalanine - metabolism | Immunoconjugates - metabolism | Vascular Calcification - prevention & control | Matrix Metalloproteinase Inhibitors - chemistry | Vascular Calcification - pathology | Aorta, Abdominal - enzymology | Immunoconjugates - chemistry | Matrix Metalloproteinase Inhibitors - metabolism | Rats, Sprague-Dawley | Chemistry, Pharmaceutical | Disease Progression | Macrophages - enzymology | Aorta, Abdominal - immunology | Polyesters - chemistry | Animals | Aortic Aneurysm, Abdominal - enzymology | Macrophages - drug effects | RAW 264.7 Cells | Mice | Matrix Metalloproteinases - metabolism | Phenylalanine - administration & dosage | Thiophenes - chemistry | Elastin - immunology | targeted therapy | cardiovascular disease | Animal models of human disease | Treatment | MMP inhibitors | nanoparticle | Pharmacology | drug delivery system | Aneurysm Abdominal aortic aneurysm
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2016, Volume 36, Issue 2, pp. 236 - 244
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 06/2012, Volume 32, Issue 6, pp. 1400 - 1409
OBJECTIVE—Recently, we reported that angiopoietin-like protein 2 (Angptl2) functions in various chronic inflammatory diseases. In the present study, we asked... 
Angiopoietin-like protein 2 | Matrix metalloproteinase | Chronic inflammation | Abdominal aortic aneurysm | Macrophage | CELLS | RISK-FACTORS | macrophage | RANDOMIZED CONTROLLED-TRIAL | abdominal aortic aneurysm | angiopoietin-like protein 2 | PATHOGENESIS | INHIBITION | INFLAMMATION | GROWTH | METALLOPROTEINASE-9 | SURVEILLANCE | matrix metalloproteinase | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | NF-KAPPA-B | chronic inflammation | Immunohistochemistry | Aortic Aneurysm, Abdominal - chemically induced | Aortic Aneurysm, Abdominal - prevention & control | Aortic Aneurysm, Abdominal - immunology | Humans | Extracellular Matrix - metabolism | Male | Aortic Aneurysm, Abdominal - metabolism | Matrix Metalloproteinase 9 - metabolism | Angiopoietin-like Proteins | Matrix Metalloproteinase 9 - genetics | Bone Marrow Transplantation | Inflammation Mediators - metabolism | Aorta, Abdominal - pathology | Aorta, Abdominal - metabolism | Cytokines - genetics | Aortic Aneurysm, Abdominal - pathology | Macrophages - immunology | Disease Models, Animal | Angiopoietins - metabolism | Calcium Chloride | Cytokines - metabolism | Macrophages - pathology | Mice, Inbred C57BL | Gene Expression Regulation | Angiopoietins - deficiency | Genotype | Aortic Aneurysm, Abdominal - genetics | Mice, Knockout | Aorta, Abdominal - immunology | Macrophages - metabolism | Phenotype | Animals | Mice | Angiopoietins - genetics
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2016, Volume 36, Issue 1, pp. 69 - 77
OBJECTIVE—Asthma and abdominal aortic aneurysms (AAA) both involve inflammation. Patients with asthma have an increased risk of developing AAA or experiencing... 
aortic aneurysm | risk factors | abdominal | asthma | interleukin | angiotensin II | APOPTOSIS | PREDOMINANCE | INCREASED INTERLEUKIN-4 | DEFICIENCY | PATHOGENESIS | INTERFERON-GAMMA | PERIPHERAL VASCULAR DISEASE | MEDIATORS | HEMATOLOGY | EXPRESSION | T-CELLS | Aortic Aneurysm, Abdominal - chemically induced | Vascular Remodeling | Aortic Aneurysm, Abdominal - prevention & control | Aortic Aneurysm, Abdominal - immunology | Apolipoproteins E - deficiency | Pneumonia - prevention & control | Male | Anti-Allergic Agents - pharmacology | Aorta, Abdominal - drug effects | Immunoglobulin E - blood | Aortic Aneurysm, Abdominal - metabolism | Immunoglobulin E - immunology | Pneumonia - chemically induced | Inflammation Mediators - metabolism | Mast Cells - metabolism | Respiratory Hypersensitivity - prevention & control | Pneumonia - immunology | Lung - metabolism | Aorta, Abdominal - pathology | Angiotensin II | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Aortic Aneurysm, Abdominal - pathology | Macrophages - immunology | Disease Models, Animal | Inflammation Mediators - immunology | Mast Cells - immunology | Ovalbumin | Calcium Chloride | Signal Transduction | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Respiratory Hypersensitivity - chemically induced | Risk Factors | Respiratory Hypersensitivity - complications | Respiratory Hypersensitivity - metabolism | Respiratory Hypersensitivity - immunology | Disease Progression | Mice, Knockout | Aorta, Abdominal - immunology | Macrophages - metabolism | Animals | Apolipoproteins E - genetics | Pneumonia - complications | Pneumonia - metabolism | Lung - immunology | risk factor | allergic lung inflammation | abdominal aortic aneurysm
Journal Article