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Journal Article
Journal Article
Nature, ISSN 0028-0836, 2001, Volume 411, Issue 6835, pp. 261 - 268
There is accumulating evidence that glial cells actively modulate neuronal synaptic transmission. We identified a glia-derived soluble acetylcholine-binding... 
IDENTIFIED LYMNAEA NEURONS | ASTROCYTES IN-SITU | NICOTINIC RECEPTORS | PERISYNAPTIC SCHWANN-CELLS | INTRACELLULAR CALCIUM | SYNAPTOGENESIS | MULTIDISCIPLINARY SCIENCES | FROG NEUROMUSCULAR-JUNCTION | CULTURED HIPPOCAMPAL-NEURONS | COMMUNICATION | SUBUNIT | Central Nervous System - metabolism | Coculture Techniques | Molecular Sequence Data | RNA, Messenger - analysis | Neurons - cytology | Acetylcholine - metabolism | Serotonin - pharmacology | Neuroglia - drug effects | Neuroglia - cytology | Receptors, Nicotinic - chemistry | Lymnaea - physiology | Carrier Proteins - pharmacology | Protein Structure, Quaternary | Inhibitory Concentration 50 | Carrier Proteins - chemistry | Synaptic Transmission - drug effects | Neurons - metabolism | Neurons - drug effects | Bungarotoxins - metabolism | Neuroglia - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Receptors, Nicotinic - metabolism | Lymnaea - genetics | Acetylcholine - pharmacology | RNA, Messenger - genetics | Cells, Cultured | Lymnaea - chemistry | Protein Sorting Signals | Protein Transport | Carrier Proteins - genetics | Sequence Alignment | Animals | Carrier Proteins - metabolism | Central Nervous System - cytology | Serotonin - metabolism | Protein Binding | Ligands | Neuroglia - metabolism | Models, Neurological | Bungarotoxins - pharmacology | Proteins | Ions | Membranes | Neurons | Cells
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, p. e0157363
Journal Article
Journal Article
EMBO JOURNAL, ISSN 0261-4189, 10/2009, Volume 28, Issue 19, pp. 3040 - 3051
The pentameric acetylcholine-binding protein ( AChBP) is a soluble surrogate of the ligand binding domain of nicotinic acetylcholine receptors. Agonists bind... 
anabaseine | acetylcholine binding protein | GATED ION-CHANNEL | RECOGNITION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | X-RAY-STRUCTURE | ACHBP | CELL BIOLOGY | ANTAGONIST PROPERTIES | partial agonist | CONFORMATIONAL-CHANGES | crystal structure | BENZYLIDENE ANALOGS | nicotinic acetylcholine receptor | REVEALS
Journal Article
The EMBO Journal, ISSN 0261-4189, 10/2009, Volume 28, Issue 19, pp. 3040 - 3051
The pentameric acetylcholine‐binding protein (AChBP) is a soluble surrogate of the ligand binding domain of nicotinic acetylcholine receptors. Agonists bind... 
crystal structure | anabaseine | acetylcholine binding protein | partial agonist | nicotinic acetylcholine receptor | Partial agonist | Acetylcholine binding protein | Anabaseine | Nicotinic acetylcholine receptor | Crystal structure | Life Sciences | Biochemistry, Molecular Biology
Journal Article
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, p. 1875
Acetylcholine-binding protein is a water-soluble homologue of the extracellular ligand-binding domain of cys-loop receptors. It is used as a structurally... 
Acridine Orange - metabolism | Animals | Carrier Proteins - metabolism | Fluorescence | Models, Molecular | Protein Binding | Carrier Proteins - chemistry | Crystallography, X-Ray | Ligands | Acetylcholine - metabolism | Binding Sites | Electrons
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 03/2012, Volume 83, Issue 6, pp. 705 - 714
CREB-mediated transcription can be initiated by membrane receptor stimulation and subsequent activation of intracellular pathways to the cell nucleus, and has... 
CREB phosphorylation | H3 antagonist | HSD1 inhibitor | Alzheimer's disease | α7 nAChR agonist | ACTIVATION | LONG-TERM-MEMORY | AMYLOID PRECURSOR PROTEIN | ERK MAP KINASE | alpha 7 nAChR agonist | DORSAL HIPPOCAMPUS | NICOTINIC ACETYLCHOLINE-RECEPTOR | IMPAIRED PHOSPHORYLATION | PHARMACOLOGY & PHARMACY | APLYSIA SENSORY NEURONS | HISTAMINE H-3 RECEPTOR | SIGNAL-REGULATED KINASE | Memory - drug effects | Brain-Derived Neurotrophic Factor - genetics | Humans | Rats, Inbred F344 | Hippocampus - drug effects | Cerebral Cortex - metabolism | Cerebral Cortex - physiopathology | Cognition - physiology | Brain-Derived Neurotrophic Factor - metabolism | Neurons - metabolism | Cerebral Cortex - drug effects | Histamine H3 Antagonists - therapeutic use | Phosphorylation - drug effects | Receptors, Histamine H3 - metabolism | Nicotinic Agonists - pharmacology | Biomarkers - metabolism | Receptors, Nicotinic - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Rats | Mice, Transgenic | Cognition - drug effects | Nicotinic Agonists - therapeutic use | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Histamine H3 Antagonists - pharmacology | Hippocampus - metabolism | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism | Animals | Signal Transduction - drug effects | Models, Biological | Alzheimer Disease - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Signal Transduction - physiology | Mice | Hippocampus - physiopathology | Memory - physiology | alpha7 Nicotinic Acetylcholine Receptor | Phosphorylation | Neurodegenerative diseases | Transcription | Memory | Cognitive ability | Cortex | Antagonists | Regulatory sequences | Cyclic AMP response element-binding protein | Learning | Brain-derived neurotrophic factor | Plasticity (synaptic) | DNA | Transcription activation | Hippocampus
Journal Article