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Handbook of Experimental Pharmacology, ISSN 0171-2004, 2013, Volume 215, Issue 215, pp. 77 - 88
The enzyme acid sphingomyelinase catalyzes the hydrolysis of sphingomyelin to ceramide. The importance of the enzyme for cell functions was first recognized in... 
Ceramide | Membrane domains | Cell stress | Acid sphingomyelinase | Signal Transduction - physiology | Animals | Sphingomyelin Phosphodiesterase - chemistry | Enzyme Activation | Sphingomyelin Phosphodiesterase - physiology | Humans
Conference Proceeding
Molecular Genetics and Metabolism, ISSN 1096-7192, 02/2015, Volume 114, Issue 2, pp. 217 - 225
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2010, Volume 285, Issue 46, pp. 35706 - 35718
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 2010, Volume 584, Issue 9, pp. 1887 - 1894
The plasma membrane (PM) is a major resource for production of bioactive lipids and contains a large proportion of the cellular sphingomyelin (SM) content.... 
Sphingolipid | Sphingomyelin synthase | Sphingomyelinase | Cell signaling | Plasma membrane | L-SMase | low density lipoprotein | bSMase | PLC | sphingosine kinase | bacterial sphingomyelinase | LDL | phosphatidylcholine | phospholipase C | plasma membrane | SMase | lysosomal acid sphingomyelinase | neutral sphingomyelinase | sphingomyelinase synthase 1 | sphingomyelin synthase 2 | sphingomyelinase | sphingomyelin | S-SMase | secretory sphingomyelinase | N-SMase | SMS1 | SMS2 | BETA-TOXIN | NEUTRAL-SPHINGOMYELINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEVATED SPHINGOMYELINASE | SECRETORY SPHINGOMYELINASE | FACTOR-ALPHA | CELL-DEATH | CELL BIOLOGY | LYSOSOMAL SPHINGOMYELINASE | TUMOR-NECROSIS-FACTOR | BIOPHYSICS | STAPHYLOCOCCUS-AUREUS | ACID SPHINGOMYELINASE | Hemolysis - drug effects | Bacteria - metabolism | Sphingomyelins - metabolism | Sphingolipids - pharmacology | Humans | Sphingolipids - metabolism | Sphingolipids - physiology | Inflammation - metabolism | Animals | Cell Death - physiology | Models, Biological | Sphingomyelin Phosphodiesterase - metabolism | Bacteria - enzymology | Biological Transport - drug effects | Biological Transport - physiology | Cell Membrane - metabolism | Cell Death - drug effects | Sphingomyelin Phosphodiesterase - secretion | Hemolysis - physiology | sphingomyelin synthase | sphingolipids
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 131, Issue 2, pp. 421 - 427.e2
Background The skin of patients with atopic dermatitis (AD) has defects in keratinocyte differentiation, particularly in expression of the epidermal barrier... 
Allergy and Immunology | skin barrier | Atopic dermatitis | filaggrin | acid sphingomyelinase | Staphylococcus aureus | α-toxin | BARRIER | MECHANISMS | IMMUNOLOGY | VIRULENCE | PATHOGENESIS | ATOPIC-DERMATITIS | ALLERGY | DISEASE | alpha-toxin | AUREUS | SKIN | MUTATIONS | EXPRESSION | Hemolysin Proteins - immunology | Skin - cytology | Skin - microbiology | Sphingomyelin Phosphodiesterase - immunology | Skin - metabolism | Staphylococcal Infections - pathology | Humans | Cell Death - immunology | Bacterial Toxins - toxicity | Dermatitis, Atopic - microbiology | Dermatitis, Atopic - immunology | Hemolysin Proteins - toxicity | Staphylococcal Infections - microbiology | Cell Death - drug effects | Keratinocytes - enzymology | Skin - immunology | Staphylococcus aureus - metabolism | Cell Survival - drug effects | Intermediate Filament Proteins - immunology | Staphylococcal Infections - immunology | Bacterial Toxins - immunology | Cells, Cultured | Intermediate Filament Proteins - biosynthesis | Dermatitis, Atopic - pathology | Keratinocytes - cytology | Cell Survival - immunology | Keratinocytes - immunology | Cell Differentiation - immunology | Animals | Intermediate Filament Proteins - deficiency | Keratinocytes - drug effects | Cell Differentiation - drug effects | Mice | Mice, Inbred BALB C | Sphingomyelin Phosphodiesterase - secretion
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 1/2004, Volume 164, Issue 1, pp. 123 - 131
Amyloid-β peptide (Aβ) accumulation in senile plaques, a pathological hallmark of Alzheimer's disease (AD), has been implicated in neuronal degeneration. We... 
Oxidative stress | Cell death | Neurons | Ceramides | Lipids | Cultured cells | Cytotoxicity | Amyloids | Alzheimers disease | Apoptosis | Alzheimer's disease | White matter | cell death | DAUNORUBICIN-INDUCED APOPTOSIS | ALZHEIMERS-DISEASE | apoptosis | PC12 CELL-DEATH | INITIATE APOPTOSIS | CELL BIOLOGY | white matter | TUMOR-NECROSIS-FACTOR | GLUTATHIONE DEPLETION | IONIZING-RADIATION | IONIZATION MASS-SPECTROMETRY | NF-KAPPA-B | oxidative stress | Ethanolamines - pharmacology | Oligodendroglia - metabolism | Glutathione - metabolism | Amyloid beta-Peptides - pharmacology | Oxidative Stress - physiology | Nerve Degeneration - physiopathology | Spheroids, Cellular - cytology | Nerve Degeneration - metabolism | Oligodendroglia - drug effects | Sphingomyelin Phosphodiesterase - metabolism | Up-Regulation - physiology | Amyloid beta-Peptides - metabolism | Cell Death - drug effects | Oligodendroglia - cytology | Endocannabinoids | Alzheimer Disease - physiopathology | Ceramides - metabolism | Cells, Cultured | Oleic Acids | Rats | Ceramides - pharmacology | Up-Regulation - drug effects | Animals | Cell Death - physiology | Alzheimer Disease - metabolism | Signal Transduction - physiology | Sphingomyelins - pharmacology | Oxidative Stress - drug effects | Alzheimer's disease; apoptosis; cell death; oxidative stress; white matter
Journal Article
FEBS Journal, ISSN 1742-464X, 03/2016, Volume 283, Issue 6, pp. 1107 - 1123