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1. Full Text Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet - Induced obesity in mice
by Shaul, Merav E and Bennett, Grace and Strissel, Katherine J and Greenberg, Andrew S and Obin, Martin S
Diabetes, ISSN 0012-1797, 05/2010, Volume 59, Issue 5, pp. 1171 - 1181
OBJECTIVE To identify, localize, and determine M1/M2 polarization of epidydimal adipose tissue (eAT) macrophages (Phi(S)) during high-fat diet (HFD)-induced... 
ADIPOCYTE DEATH | PIOGLITAZONE | METABOLISM | INFLAMMATION | IN-VIVO | ENDOCRINOLOGY & METABOLISM | PPAR-GAMMA | MECHANISMS | ALTERNATIVE ACTIVATION | INDUCED INSULIN-RESISTANCE | ADIPOSE-TISSUE | Immunohistochemistry | Interleukin-12 Subunit p40 - metabolism | Dietary Fats - adverse effects | Obesity - chemically induced | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Male | Obesity - physiopathology | Interleukin-13 - metabolism | Antigens, CD - metabolism | Obesity - metabolism | CD11c Antigen - metabolism | Adipose Tissue - metabolism | B7-2 Antigen - metabolism | Macrophages - metabolism | Animals | Flow Cytometry | Antigens, Differentiation, Myelomonocytic - metabolism | Interleukin 1 Receptor Antagonist Protein - metabolism | Polymerase Chain Reaction | Mice | Adipose tissues | Obesity | Complications and side effects | Dietary fat | Development and progression | Insulin resistance | Genetic aspects | Properties | Macrophages | Health aspects | Original
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2. Full Text Cardiac Remodeling in Obesity
by E. Dale Abel and Sheldon E. Litwin and Gary Sweeney
Physiological Reviews, ISSN 0031-9333, 04/2008, Volume 88, Issue 2, pp. 389 - 419
The dramatic increase in the prevalence of obesity and its strong association with cardiovascular disease have resulted in unprecedented interest in... 
OBSTRUCTIVE SLEEP-APNEA | PHYSIOLOGY | FATTY-ACID OXIDATION | ACTIVATED-RECEPTOR-GAMMA | SELECTIVE LEPTIN RESISTANCE | EPICARDIAL ADIPOSE-TISSUE | LEFT-VENTRICULAR MASS | CORONARY-HEART-DISEASE | TYPE-2 DIABETES-MELLITUS | INDUCED INSULIN-RESISTANCE | GLYCATION END-PRODUCTS | Heart - physiopathology | Animals | Humans | Myocardium - pathology | Obesity - physiopathology | Ventricular Remodeling - physiology | Adipokines - physiology | Disease Models, Animal | Obesity - pathology | Adipose tissues | Heart | Obesity | Analysis | Physiological aspects | Research | Cardiovascular diseases | Risk factors | Apoptosis
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3. Full Text Adipose tissue remodeling and obesity
by Sun, Kai and Kusminski, Christine M and Scherer, Philipp E
Journal of Clinical Investigation, ISSN 0021-9738, 06/2011, Volume 121, Issue 6, pp. 2094 - 2101
To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost... 
MEDICINE, RESEARCH & EXPERIMENTAL | HYPOXIA-INDUCIBLE FACTOR | METABOLIC SYNDROME | FREE FATTY-ACIDS | IN-VIVO | NECROSIS-FACTOR-ALPHA | DIET-INDUCED OBESITY | CHRONIC INFLAMMATION | RECEPTOR TYROSINE KINASE | INDUCED INSULIN-RESISTANCE | ENDOTHELIAL GROWTH-FACTOR | Adaptation, Physiological | Macrophages - physiology | Macrophages - classification | Adipose Tissue - growth & development | Humans | Adipose Tissue - pathology | Adipose Tissue - physiopathology | Cell Size | Mice, Transgenic | Obesity - physiopathology | Adipocytes - physiology | Adipocytes - pathology | Cell Hypoxia | Animals | Adipose Tissue - blood supply | Cell Division | Extracellular Matrix - physiology | Weight Loss - physiology | Mice | Energy Metabolism - physiology | Fatty Acids - metabolism | Endothelial Cells - physiology | Neovascularization, Physiologic | Inflammation - physiopathology | Adipose tissues | Obesity | Review
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4. Full Text Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis
by Sung, Myong-Hee and Loft, Anne and Baek, Songjoon and Mandrup, Susanne and Nielsen, Ronni and Hager, Gordon L and Siersbæk, Rasmus and John, Sam
The EMBO Journal, ISSN 0261-4189, 04/2011, Volume 30, Issue 8, pp. 1459 - 1472
Adipogenesis is tightly controlled by a complex network of transcription factors acting at different stages of differentiation. Peroxisome... 
C/EBPβ | adipocyte differentiation | DNase I hypersensitivity | chromatin remodelling | ChIP‐seq | ChIP-seq | C/EBP beta | C/EBP-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | BINDING PROTEIN-BETA | HUMAN GENOME | GLUCOCORTICOID-RECEPTOR | IN-VIVO | ACTIVATED-RECEPTOR-GAMMA | PPAR-GAMMA | STIMULATES ADIPOGENESIS | ADIPOSE-TISSUE | CCAAT-Enhancer-Binding Protein-alpha - metabolism | Adipocytes - cytology | Adipogenesis - physiology | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Chromatin Immunoprecipitation | Tumor Suppressor Proteins - genetics | Transcription, Genetic | Cell Differentiation | Retinoid X Receptors - genetics | Retinoid X Receptors - metabolism | Tumor Suppressor Proteins - metabolism | CCAAT-Enhancer-Binding Protein-beta - genetics | RNA, Messenger - genetics | Chromatin Assembly and Disassembly | Transcription Factors - genetics | 3T3-L1 Cells | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | CCAAT-Enhancer-Binding Protein-beta - metabolism | Transcription Factors - metabolism | Algorithms | Animals | Adipocytes - metabolism | CCAAT-Enhancer-Binding Protein-alpha - genetics | Mice | Chromatin | Genes | Adipocytes | EBPβ
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5. Full Text PNPLA3 mediates hepatocyte triacylglycerol remodeling
by Ruhanen, Hanna and Perttilä, Julia and Hölttä-Vuori, Maarit and Zhou, You and Yki-Järvinen, Hannele and Ikonen, Elina and Käkelä, Reijo and Olkkonen, Vesa M
Journal of Lipid Research, ISSN 0022-2275, 2014, Volume 55, Issue 4, pp. 739 - 746
The I148M substitution in patatin-like phospholipase domain containing 3 (PNPLA3(I148M)) determines a genetic form of nonalcoholic fatty liver disease. To... 
Patatin-like phospholipase domain containing 3 | Adiponutrin | Lipidomics | Nonalcoholic fatty liver disease | Lipid droplet | Lipase | lipid droplet | patatin-like phospholipase domain containing 3 | FATTY LIVER-DISEASE | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | lipase | INSULIN | adiponutrin | nonalcoholic fatty liver disease | ADIPONUTRIN/PNPLA3 GENE | TRIGLYCERIDE HYDROLYSIS | I148M | DOMAIN-CONTAINING 3 | HEPATIC STEATOSIS | EXPRESSION | lipidomics | ADIPOSE-TISSUE | Lipid Droplets - enzymology | Membrane Proteins - physiology | Humans | Cell Line, Tumor | Lipase - physiology | Lipid Metabolism | Mutation, Missense | Phospholipids - metabolism | Fatty Acids - metabolism | Hepatocytes - enzymology | Protein Transport | Triglycerides - metabolism
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6. Full Text Extracellular matrix remodeling and transforming growth factor-βsignaling abnormalities induced by lamin a/c variants that cause lipodystrophy
by Dour, Caroline Le and Wu, Wei and Béréziat, Véronique and Capeau, Jacqueline and Vigouroux, Corinne and Worman, Howard J
Journal of Lipid Research, ISSN 0022-2275, 01/2017, Volume 58, Issue 1, pp. 151 - 163
Mutations in the lamin A/C gene encoding nuclear lamins A and C (lamin A/C) cause familial partial lipodystrophy type 2 (FPLD2) and related lipodystrophy... 
Adipose tissue | Supplementary adipocytes | Nuclear envelope | Fibrosis | METABOLIC SYNDROME | FAMILIAL PARTIAL LIPODYSTROPHY | BIOCHEMISTRY & MOLECULAR BIOLOGY | adipose tissue | nuclear envelope | MUSCULAR-DYSTROPHY | HUTCHINSON-GILFORD PROGERIA | DILATED CARDIOMYOPATHY | LMNA MUTATIONS | MANDIBULOACRAL DYSPLASIA | NUCLEAR LAMIN | fibrosis | C-TERMINAL DOMAIN | adipocytes | ADIPOSE-TISSUE | Cell Line | Matrix Metalloproteinase 9 - biosynthesis | Humans | Middle Aged | Adipose Tissue - pathology | Gene Expression Regulation | Lipodystrophy, Familial Partial - pathology | Extracellular Matrix - metabolism | Male | Lipodystrophy, Familial Partial - genetics | Transforming Growth Factor beta - biosynthesis | Mice, Knockout | Adipose Tissue - metabolism | Extracellular Matrix - genetics | Animals | Transforming Growth Factor beta - genetics | Matrix Metalloproteinase 9 - genetics | Lamin Type A - genetics | Aged, 80 and over | Aged | Mice | Mutation | Lipodystrophy, Familial Partial - metabolism | Transforming growth factor | Transgenic mice | Matrix metalloproteinase | Lamins | Insulin | C gene | Rodents | Fibroblasts | Lipodystrophy | Extracellular matrix | Metalloproteinase | Growth factors
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7. Full Text Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
by Qiang, Li and Wang, Liheng and Kon, Ning and Zhao, Yingming and Zhao, Wenhui and Lee, Sangkyu and Zhang, Yiying and Rosenbaum, Michael and Gu, Wei and Farmer, Stephen R and Accili, Domenico
Cell, ISSN 0092-8674, 08/2012, Volume 150, Issue 3, pp. 620 - 632
Brown adipose tissue (BAT) can disperse stored energy as heat. Promoting BAT-like features in white adipose (WAT) is an attractive, if elusive, therapeutic... 
THERMOGENESIS | OBESITY | ADIPOCYTES | METABOLISM | INSULIN-RESISTANCE | PGC-1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACTIVATED-RECEPTOR-GAMMA | FAT | MICE | SIRT1 | CELL BIOLOGY | Sirtuin 1 - metabolism | Humans | Adipose Tissue, White - metabolism | Molecular Sequence Data | Mice, 129 Strain | Stilbenes - pharmacology | PPAR gamma - metabolism | Sirtuin 1 - genetics | Adult | Female | Lysine - metabolism | Acetylation | Sirtuin 1 - chemistry | Thiazolidinediones - pharmacology | Lysine - analysis | Amino Acid Sequence | Mutagenesis, Site-Directed | Obesity - complications | Mice, Inbred C57BL | Cells, Cultured | Insulin Resistance | Models, Molecular | Obesity - metabolism | Sequence Alignment | Animals | Thermogenesis | Energy Metabolism | Ligands | Adipose Tissue, Brown - metabolism | Mice | Mutation | 3T3 Cells | PPAR gamma - chemistry
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8. Full Text A PPAR gamma-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
by Jonker, Johan W and Suh, Jae Myoung and Atkins, Annette R and Ahmadian, Maryam and Li, Pingping and Whyte, Jamie and He, Mingxiao and Juguilon, Henry and Yin, Yun-Qiang and Phillips, Colin T and Yu, Ruth T and Olefsky, Jerrold M and Henry, Robert R and Downes, Michael and Evans, Ronald M
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7398, pp. 391 - 395
Although feast and famine cycles illustrate that remodelling of adipose tissue in response to fluctuations in nutrient availability is essential for... 
OBESITY | FIBROBLAST-GROWTH-FACTOR-1 | ADIPOCYTES | CAUSES INSULIN-RESISTANCE | TISSUE | BIOLOGY | MUSCLE | PPAR-GAMMA | FAT NECROSIS | FAMILY | MULTIDISCIPLINARY SCIENCES | Humans | Diabetes Mellitus, Experimental - genetics | Diet, High-Fat - adverse effects | Male | Fibroblast Growth Factor 1 - genetics | Adipocytes - drug effects | PPAR gamma - metabolism | Promoter Regions, Genetic - genetics | Base Sequence | Diabetes Mellitus, Experimental - chemically induced | Intra-Abdominal Fat - drug effects | Response Elements - genetics | Homeostasis - drug effects | Cell Size - drug effects | Mice, Inbred C57BL | Fibroblast Growth Factor 1 - metabolism | Insulin Resistance | Intra-Abdominal Fat - metabolism | Adipocytes - pathology | Fibroblast Growth Factor 1 - deficiency | Mice, Knockout | Insulin - metabolism | Animals | Adipocytes - metabolism | Diabetes Mellitus, Experimental - pathology | Inflammation - genetics | Mice | Intra-Abdominal Fat - pathology | Necrosis - enzymology | adipose remodelling | FGF1 | insulin resistance | PPARγ | Thiazolidinedione
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9. Full Text Global Remodeling of the Vascular Stem Cell Niche in Bone Marrow of Diabetic Patients: Implication of the microRNA-155/FOXO3a Signaling Pathway
by Spinetti, Gaia and Cordella, Daniela and Fortunato, Orazio and Sangalli, Elena and Losa, Sergio and Gotti, Ambra and Carnelli, Franco and Rosa, Francesco and Riboldi, Stefano and Sessa, Fausto and Avolio, Elisa and Beltrami, Antonio Paolo and Emanueli, Constanza and Madeddu, Paolo
Circulation Research, ISSN 0009-7330, 02/2013, Volume 112, Issue 3, pp. 510 - 522
RATIONALE:The impact of diabetes mellitus on bone marrow (BM) structure is incompletely understood. OBJECTIVE:Investigate the effect of type-2 diabetes... 
microangiopathy | stem cells | macroangiopathy | diabetes mellitus type 2 | bone marrow | CARDIAC & CARDIOVASCULAR SYSTEMS | TRANSCRIPTION | MICRORNAS | TRANSPLANTATION | HEART | ENDOTHELIAL PROGENITOR CELLS | DISEASE | PERIPHERAL VASCULAR DISEASE | COMPLICATIONS | NEOVASCULARIZATION | DIFFERENTIATION | HEMATOLOGY | EXPRESSION | Immunohistochemistry | Humans | Middle Aged | Microvessels - metabolism | Hematopoietic Stem Cells - pathology | Microvessels - pathology | Male | MicroRNAs - metabolism | Ischemia - genetics | Adipose Tissue - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Forkhead Transcription Factors - metabolism | Bone Marrow Cells - immunology | Aged, 80 and over | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Ischemia - pathology | Biomarkers - metabolism | Peripheral Arterial Disease - metabolism | Stem Cell Niche | Signal Transduction | Endothelial Cells - metabolism | Adipose Tissue - pathology | Bone Marrow Cells - pathology | Bone Marrow Examination | Cell Lineage | MicroRNAs - genetics | Diabetes Mellitus, Type 2 - pathology | Endothelial Cells - pathology | Forkhead Box Protein O3 | Antigens, CD34 - metabolism | Peripheral Arterial Disease - pathology | Diabetes Mellitus, Type 2 - genetics | Diabetes Mellitus, Type 2 - metabolism | Microvessels - immunology | Case-Control Studies | Hematopoietic Stem Cells - immunology | Diabetic Angiopathies - pathology | Flow Cytometry | Transfection | Peripheral Arterial Disease - genetics | Adult | Female | Diabetic Angiopathies - genetics | Diabetic Angiopathies - metabolism | Cells, Cultured | Gene Expression Regulation | Ischemia - metabolism | Hematopoietic Stem Cells - metabolism | Forkhead Transcription Factors - genetics | Aged | Bone Marrow Cells - metabolism | Apoptosis
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10. Full Text Redox regulation of vascular remodeling
by Karimi Galougahi, Keyvan and Karimi Galougahi, Keyvan and Ashley, Euan A and Ashley, Euan A and Ali, Ziad A and Ali, Ziad A
Cellular and Molecular Life Sciences, ISSN 1420-682X, 1/2016, Volume 73, Issue 2, pp. 349 - 363
Vascular remodeling is a dynamic process of structural and functional changes in response to biochemical and biomechanical signals in a complex in vivo milieu.... 
Life Sciences | Biochemistry, general | Vascular remodeling | Signal transduction | Reactive oxygen species | Life Sciences, general | Redox stress | Biomedicine general | Cell Biology | NADPH OXIDASE | OXIDATIVE STRESS | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXYGEN SPECIES GENERATION | THIOREDOXIN-INTERACTING PROTEIN | ANGIOTENSIN-II | HYDROGEN-SULFIDE | CELL BIOLOGY | SIGNAL-TRANSDUCTION | SMOOTH-MUSCLE-CELLS | PERIVASCULAR ADIPOSE-TISSUE | Vascular Remodeling | Reactive Oxygen Species - metabolism | Oxidative Stress | Signal Transduction | Endothelial Cells - metabolism | Humans | Myocytes, Smooth Muscle - pathology | Homeostasis | Animals | Endothelial Cells - cytology | Nitric Oxide Synthase Type III - metabolism | Endothelial Cells - pathology | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Cardiology | Analysis | Cellular signal transduction | Cellular biology | Stress response
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