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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2018, Volume 26, Issue 12, pp. 3502 - 3513
(+)-Cyclazosin is one of most selective antagonists of the α -adrenoceptor subtype (selectivity ratios, α /α  = 13, α /α  = 38–39). To improve the selectivity,... 
(+)-Cyclazosin analogues | α1-Adrenoceptor subtypes | α1-Adrenoceptor antagonists | α1B-Adrenoceptor selective antagonists | Adrenoceptor selective antagonists | Adrenoceptor antagonists | Adrenoceptor subtypes | (+)-cyclazosin analogues | α1-adrenoceptor subtypes | α1-adrenoceptor antagonists | α1B-adrenoceptor selective antagonists
Journal Article
European Urology, ISSN 0302-2838, 2012, Volume 63, Issue 2, pp. 283 - 295
Abstract Background Mirabegron, a β3 -adrenoceptor agonist, has been developed for the treatment of overactive bladder (OAB). Objective To assess the efficacy... 
Urology | Mirabegron | β3-Adrenoceptor agonist | Overactive bladder (OAB) | Adrenoceptor agonist
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/2006, Volume 147, Issue 2, pp. S88 - S119
Journal Article
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 08/2018, Volume 137, Issue 4, pp. 366 - 371
α -adrenoceptor antagonists can impact upon sexual function and have potential in the treatment of erectile dysfunction. Human erectile tissue contains... 
Prazosin | Tamsulosin | α1-adrenoceptor subtypes | α1L-adrenoceptor | Erectile tissue | adrenoceptor | adrenoceptor subtypes
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 6/2008, Volume 377, Issue 4, pp. 473 - 481
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 11/2018, Volume 839, pp. 82 - 88
Modulation of cardiac contractility by α-adrenoceptor is well known in several mammals. Mice are useful experimental animals, but α-adrenoceptor-mediated... 
α1B-adrenoceptor | Chronotropic action | α1-adrenoceptor | Mouse atrium | Inotropic action | adrenoceptor
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 11/2018, Volume 838, pp. 120 - 128
Cutaneous arteries show enhanced contraction in response to cooling, which is suggested to be mediated via α -adrenoceptors. We have previously shown that α... 
α1A-adrenoceptor | Cooling | Cutaneous artery | Voltage-dependent calcium channel | α1D-adrenoceptor | adrenoceptor
Journal Article
CELL METABOLISM, ISSN 1550-4131, 01/2015, Volume 21, Issue 1, pp. 33 - 38
Increasing energy expenditure through activation of endogenous brown adipose tissue (BAT) is a potential approach to treat obesity and diabetes. The class of... 
SELECTIVE BETA-ADRENOCEPTOR AGONIST | THERMOGENESIS | ADRENOCEPTOR AGONIST | ENERGY-EXPENDITURE | COLD-EXPOSURE | METABOLISM | MIRABEGRON | ENDOCRINOLOGY & METABOLISM | DOUBLE-BLIND | FAT | ADULT HUMANS | CELL BIOLOGY
Journal Article
BEHAVIOURAL PHARMACOLOGY, ISSN 0955-8810, 02/2015, Volume 26, Issue 1-2, pp. 73 - 80
Intra-accumbal infusion of the alpha(1)-adrenergic agonist methoxamine, which has comparable affinity for alpha(1A)-, alpha(1B)- and alpha(1D)-adrenoceptor... 
rat | alpha(1A)-adrenoceptor | PRAZOSIN | ALPHA(1B)-ADRENOCEPTOR ANTAGONIST | ALPHA-ADRENOCEPTOR SUBTYPES | alpha(1B)-adrenoceptor | nucleus accumbens | alpha(1D)-adrenoceptor | AGONISTS | NEUROSCIENCES | RECEPTOR SUBTYPES | PROFILE | microdialysis | ADRENOCEPTORS | LOCUS-COERULEUS | NEURONS | BEHAVIORAL SCIENCES | PHARMACOLOGY & PHARMACY | dopamine
Journal Article
CELLULAR AND MOLECULAR LIFE SCIENCES, ISSN 1420-682X, 02/2010, Volume 67, Issue 3, pp. 405 - 417
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 02/2006, Volume 147, pp. S88 - S119
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 07/2019, Volume 855, pp. 305 - 320
This review examines the functions of α -adrenoceptor subtypes, particularly in terms of contraction of smooth muscle. There are 3 subtypes of α -adrenoceptor,... 
α1A-adrenoceptors | Blood pressure control | α1B-adrenoceptors | Vascular contractions | α1-adrenoceptors | Vas deferens | α1D-adrenoceptors
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 06/2017, Volume 805, pp. 75 - 83
This study has investigated the role of the α -adrenoceptor subtypes involved in the inhibition of the cardiac sympathetic outflow induced by intravenous (i.v)... 
I1-imidazoline receptor | α2A-adrenoceptor | Agmatine | Sympatho-inhibition | α2C-adrenoceptor | adrenoceptor | imidazoline receptor | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 06/2019, Volume 27, Issue 12, pp. 2306 - 2314
A series of novel β -adrenoceptor agonists with a 5-(2-amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1 )-one moiety was designed, synthesized and evaluated for... 
Indacaterol | β2-Adrenoceptor agonist | Trantinterol | Salmeterol | Asthma | COPD | Adrenoceptor agonist
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 11/2013, Volume 170, Issue 6, pp. 1242 - 1252
Background and PurposeTwo distinct (1)-adrenoceptor phenotypes ((1A) and (1L)) have recently been demonstrated to originate from a single (1A)-adrenoceptor... 
HUMAN PROSTATE | (1A)-adrenoceptor | ALPHA(1A/1L)-ADRENOCEPTOR PARTIAL AGONIST | SELECTIVE ALPHA(1A)-ADRENOCEPTOR ANTAGONIST | agonist profile | IDENTIFICATION | ARRIVE GUIDELINES | (1L)-adrenoceptor | VASCULAR SMOOTH-MUSCLE | ALPHA-1L ADRENOCEPTOR | RECEPTOR SUBTYPES | TISSUE SELECTIVITY | PHARMACOLOGY & PHARMACY | RABBIT | lower urinary tract
Journal Article
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 12/2014, Volume 744, pp. 183 - 189
This study investigates the interaction between cocaine, desipramine and prazosin at alpha(1)-adrenoceptor subtypes mediating contractions to noradrenaline in... 
SELECTIVE ANTAGONISTS | HUMAN PROSTATE | Rat vas deferens | alpha 1A-adrenoceptor | ALPHA-ADRENOCEPTOR SUBTYPES | AORTA | ALPHA-1-ADRENOCEPTOR SUBTYPES | IDENTIFICATION | alpha 1D-adrenoceptor | Prazosin | SPLEEN | alpha 1L-adrenoceptor | PHARMACOLOGY | PHARMACOLOGY & PHARMACY | Noradrenaline transporter | MEDIATING CONTRACTIONS | ALPHA(1A)-ADRENOCEPTOR
Journal Article