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European Journal of Human Genetics, ISSN 1018-4813, 2014, Volume 22, Issue 1, pp. 32 - 39
Journal Article
Journal Article
Human Pathology, ISSN 0046-8177, 04/2017, Volume 62, pp. 206 - 214
Journal Article
International Journal of Cancer, ISSN 0020-7136, 12/2009, Volume 125, Issue 12, pp. 2991 - 2994
Journal Article
Histopathology, ISSN 0309-0167, 07/2009, Volume 55, Issue 1, pp. 53 - 62
Aims:  Gastrointestinal stromal tumours (GISTs) are commonly driven by oncogenic mutations in KIT and PDGFRA. However, 10–40% of these patients are wild‐type... 
wild‐type | MAP kinase | GISTs | mutations | activation | Mutations | Activation | Wild-type | FACTOR-RECEPTOR | C-KIT/SCF | MECHANISMS | PATHOLOGY | CANCER | CELL BIOLOGY | BRAF MUTATIONS | IN-VIVO | B-RAF | wild-type | AZD6244 ARRY-142886 | GASTROINTESTINAL STROMAL TUMORS | Mitogen-Activated Protein Kinase Kinases - genetics | Gastrointestinal Neoplasms - genetics | Prognosis | Humans | Middle Aged | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Gastrointestinal Stromal Tumors - diagnosis | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Proto-Oncogene Proteins c-kit - genetics | Retrospective Studies | Gastrointestinal Stromal Tumors - genetics | Proto-Oncogene Proteins B-raf - metabolism | Gastrointestinal Neoplasms - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Signal Transduction - genetics | Gastrointestinal Neoplasms - diagnosis | Mutation - genetics | Receptor, Platelet-Derived Growth Factor alpha - genetics | Gastrointestinal Stromal Tumors - metabolism | Signal Transduction - physiology | Aged | Biomarkers, Tumor - genetics | Polymerase chain reaction | Immunohistochemistry | Platelet-derived growth factor | Gene mutations | Stem cells | Universities and colleges | Protein kinases | Tumors
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e64102
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2008, Volume 105, Issue 24, pp. 8387 - 8392
A subset of gastrointestinal stromal tumors (GISTs) lack gain-of-function mutations in c-KIT and PDGFRα. These so-called wild-type (WT) GISTs tend to be less... 
Pediatrics | Receptors | Gastrointestinal stromal tumors | Somatomedins | Exons | Cell lines | Genetic mutation | Summarization | Tumors | Cancer | Imatinib mesylase | Adult wild-type GIST | Pediatric GIST | NYP-AEW541 | Tyrosine kinase inhibitors | CARCINOMA CELLS | MULTIDISCIPLINARY SCIENCES | adult wild-type GIST | C-KIT | FACTOR-I | ANTITUMOR-ACTIVITY | pediatric GIST | tyrosine kinase inhibitors | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | imatinib mesylase | COPY NUMBER CHANGES | TYROSINE KINASE INHIBITOR | EXPRESSION | IMATINIB MESYLATE | Gastrointestinal Stromal Tumors - enzymology | RNA, Small Interfering - genetics | Receptor, IGF Type 1 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Mitogen-Activated Protein Kinase Kinases - metabolism | DNA Mutational Analysis | Proto-Oncogene Proteins c-kit - genetics | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Pyrroles - therapeutic use | Gastrointestinal Stromal Tumors - genetics | Signal Transduction | Gene Silencing | Piperazines - therapeutic use | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Receptor, IGF Type 1 - genetics | Pyrroles - pharmacology | Gene Amplification | Gastrointestinal Stromal Tumors - drug therapy | Pyrimidines - therapeutic use | Receptor, Platelet-Derived Growth Factor alpha - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Benzamides | Mutation | Apoptosis | Immunohistochemistry | Prevention | Usage | Care and treatment | Gastrointestinal tumors | Genetic aspects | Research | Insulin-like growth factor 1 | Health aspects | Methods | Risk factors | Biological Sciences
Journal Article
Japanese Journal of Gastroenterological Surgery, ISSN 0386-9768, 2015, Volume 48, Issue 9, pp. 747 - 753
Journal Article
Clinical Epigenetics, ISSN 1868-7075, 01/2019, Volume 11, Issue 1, pp. 2 - 11
BackgroundSuccinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GISTs) constitute a small KIT/PDGFRA-WT GIST subgroup featuring DNA... 
DNA methylation | Gastrointestinal stromal tumors | Succinate dehydrogenase | Molecular diagnosis | Wild-type GIST | methylguanine DNA methyltransferase | SURVIVAL | HYPERMETHYLATION | MANAGEMENT | PDGFRA-MUTANT | TEMOZOLOMIDE | PHASE-II TRIAL | O-6-methylguanine DNA methyltransferase | ONCOLOGY | KIT | MUTATIONS | EXPRESSION | Promoter Regions, Genetic | Gastrointestinal Neoplasms - genetics | Epigenesis, Genetic | Humans | Middle Aged | DNA Repair Enzymes - genetics | Male | Succinate Dehydrogenase - deficiency | Young Adult | DNA Methylation | DNA Modification Methylases - genetics | Receptor, Platelet-Derived Growth Factor alpha - genetics | Tumor Suppressor Proteins - genetics | Aged, 80 and over | Adult | Female | Proto-Oncogene Proteins c-kit - genetics | Aged | Gastrointestinal Stromal Tumors - genetics | Immunohistochemistry | Ethylenediaminetetraacetic acid | Sarcoma | Gliomas | Analysis | Transferases | Colorectal cancer | Non-Hodgkin's lymphomas | Methylation | Dehydrogenases | Methylguanine | Colorectal carcinoma | Alkylating agents | Kinases | Cancer therapies | Investigations | O6-methylguanine-DNA methyltransferase | Genotype & phenotype | Lymphocytes B | Morphology | DNA methyltransferase | Lymphomas | Mutation | Genotypes | Deoxyribonucleic acid--DNA | Tumors | B-cell lymphoma | O 6 -methylguanine DNA methyltransferase
Journal Article