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Medicine Today, ISSN 1443-430X, 01/2011, Volume 12, Issue 1, pp. 28 - 39
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2002, Volume 277, Issue 25, pp. 22201 - 22208
Osteoarthritis is a degenerative joint disorder characterized by breakdown of articular cartilage. Degradation of aggrecan, which together with type II... 
aggrecan
Journal Article
Endocrinology, ISSN 0013-7227, 04/2002, Volume 143, Issue 4, pp. 1467 - 1474
Previous studies in chondrogenic RCJ3.1C5.18 (C5.18) cells showed that growth of these cells at high extracellular Ca super(2+) concentrations ([Ca super(2+)]... 
aggrecan
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2002, Volume 361, Issue 3, pp. 689 - 696
Although the effects of mechanical loading on chondrocyte metabolic activities have been extensively characterized, the sequence of events through which... 
aggrecan
Journal Article
Journal of Cell Science, ISSN 0021-9533, 11/2001, Volume 114, Issue 21, pp. 3813 - 3822
Cells of the monocyte/macrophage lineage are involved in the development of inflammatory joint diseases such as rheumatoid arthritis. This disease is... 
aggrecan
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2001, Volume 358, Issue 3, pp. 615 - 626
Studies of aggrecan proteolysis in human joints have implicated both the aggrecanase [ADAMTS, a disintegrin-like and metalloprotease (reprolysin-type) with... 
aggrecan
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 11/2002, Volume 30, Issue 6, pp. 869 - 874
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2013, Volume 210, Issue 12, pp. 2569 - 2582
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 12225 - 6
Short stature is a common pediatric disorder affecting 3% of the population. However, the clinical variability and genetic heterogeneity prevents the... 
VARIANTS | FORM | MULTIDISCIPLINARY SCIENCES | GROWTH | GUIDELINES | SPONDYLOEPIPHYSEAL DYSPLASIA | AGGRECAN GENE | IDENTIFICATION | CHILDREN | Cartilage | Aggrecan | Mutation | Genetic screening
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 05/2017, Volume 18, Issue 5, p. 975
Slow growth and rapid loss of chondrogenic phenotypes are the major problems affecting chronic cartilage lesions. The role of microRNA-195 (miR-195) and its... 
Signal pathway | Col2a1/aggrecan | MiR-195 | Cartilage lesion | Chondrocyte proliferation | FGF18 | cartilage lesion | MICROFRACTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | chondrocyte proliferation | CHEMISTRY, MULTIDISCIPLINARY | MESENCHYMAL STEM-CELLS | COLLAGEN-II | ARTICULAR-CARTILAGE REPAIR | IN-VIVO | miR-195 | GENE-THERAPY | GROWTH-PLATE | signal pathway | OSTEOCHONDRITIS-DISSECANS | OSTEOARTHRITIS | EXPRESSION | Chondrocytes - cytology | Cell Proliferation | Osteochondritis - genetics | Humans | Osteochondritis - pathology | Fibroblast Growth Factors - genetics | MicroRNAs - metabolism | Case-Control Studies | Collagen Type II - metabolism | Fibroblast Growth Factors - metabolism | Chondrocytes - physiology | Osteochondritis - metabolism | HEK293 Cells | Female | 3' Untranslated Regions | Chondrogenesis | Chondrocytes - metabolism | Cells, Cultured | Rats | Aggrecans - metabolism | Aggrecans - genetics | Rats, Sprague-Dawley | Collagen Type II - genetics | Phenotype | Animals | MicroRNAs - genetics | Knee | Fibroblast growth factor | Collagen (type II) | Homeostasis | Chains | Antisense | Assaying | Cartilage | Genotype & phenotype | Transfection | Mathematical models | Fibroblast growth factor 18 | Lesions | Informatics | MiRNA | Maintenance | Ribonucleic acid--RNA | Patients | Anterior cruciate ligament | Inhibitors | 3' Untranslated regions | Chondrocytes | In vivo methods and tests | Aggrecan | Internet
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 01/2001, Volume 19, Issue 3, pp. 478 - 481
Human adult cartilage is an inherently difficult tissue from which to isolate RNA. The RNA isolation techniques described so far have generally only been... 
aggrecan
Journal Article
蛋白质与细胞:英文版, ISSN 1674-800X, 2017, Volume 8, Issue 8, pp. 560 - 572
Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type Ⅱ... 
基质蛋白 | 胶原蛋白 | 结缔组织 | 细胞外基质 | 关节软骨 | 临床试验 | 生物学功能 | 蛋白聚糖 | Life Sciences | Biochemistry, general | Protein Science | Stem Cells | Human Genetics | arthritis | collagen | Developmental Biology | biomarker | Cell Biology | VI COLLAGEN | PERICELLULAR MATRIX | X COLLAGEN | INFLAMMATORY ARTHRITIS | XVI COLLAGEN | CELL BIOLOGY | MULTIPLE EPIPHYSEAL DYSPLASIA | IX COLLAGEN | CHONDROCYTE HYPERTROPHY | HIP-OSTEOARTHRITIS | II COLLAGEN | Aggrecans - chemistry | Humans | Collagen - chemistry | Protein Isoforms - metabolism | Protein Isoforms - classification | Cartilage, Articular - metabolism | Protein Isoforms - chemistry | Collagen - genetics | Osteoarthritis - pathology | Extracellular Matrix Proteins - metabolism | Cartilage, Articular - chemistry | Biomarkers - metabolism | Extracellular Matrix Proteins - chemistry | Gene Expression | Extracellular Matrix Proteins - genetics | Collagen - classification | Osteoarthritis - metabolism | Aggrecans - metabolism | Aggrecans - genetics | Osteoarthritis - diagnosis | Osteoarthritis - genetics | Cartilage, Articular - pathology | Collagen - metabolism | Animals | Protein Isoforms - genetics | Medicine, Experimental | Medical research | Development and progression | Arthritis | Research institutes | Collagen | Knee | Collagen (type II) | Connective tissue diseases | Clinical trials | Mechanical properties | Extracellular matrix | Cartilage (articular) | Aggrecan | Drug development | Biochemical markers | Mini-Review | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Reumatologi och inflammation | Cell and Molecular Biology | Klinisk medicin | Rheumatology and Autoimmunity | Clinical Medicine | Medicinska och farmaceutiska grundvetenskaper | Cell- och molekylärbiologi
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2000, Volume 275, Issue 9, pp. 6321 - 6327
The effect of age on the incorporation of newly synthesized aggrecan into the extracellular matrix of human articular cartilage was investigated. This property... 
aggrecan
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2017, Volume 488, Issue 3, pp. 554 - 561
Journal Article