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1. Full Text New pediatric percentiles of liver enzyme serum levels (alanine aminotransferase, aspartate aminotransferase, γ‐glutamyltransferase): Effects of age, sex, body mass index, and pubertal stage
by Bussler, Sarah and Vogel, Mandy and Pietzner, Diana and Harms, Kristian and Buzek, Theresa and Penke, Melanie and Händel, Norman and Körner, Antje and Baumann, Ulrich and Kiess, Wieland and Flemming, Gunter
Hepatology, ISSN 0270-9139, 10/2018, Volume 68, Issue 4, pp. 1319 - 1330
The present study aims to clarify the effects of sex, age, body mass index (BMI), and puberty on transaminase serum levels in children and adolescents and to... 
REFERENCE INTERVALS | GERMANY | PATTERN | ADOLESCENTS | DISEASE | FATTY LIVER | COHORT | ETHNICITY | GASTROENTEROLOGY & HEPATOLOGY | DIRECTIONS | CHILDREN | Body Mass Index | Multivariate Analysis | Liver - enzymology | Prospective Studies | Puberty - blood | Age Factors | gamma-Glutamyltransferase - blood | Anthropometry | Humans | Child, Preschool | Infant | Logistic Models | Male | Reference Values | Alanine Transaminase - blood | Puberty - physiology | Aspartate Aminotransferases - blood | Adolescent | Sex Factors | Female | Child | Longitudinal Studies | Germany | Index Medicus
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2. Full Text Aminotransferase Elevations in Healthy Adults Receiving 4 Grams of Acetaminophen Daily: A Randomized Controlled Trial
by Watkins, Paul B and Kaplowitz, Neil and Slattery, John T and Colonese, Connie R and Colucci, Salvatore V and Stewart, Paul W and Harris, Stephen C
JAMA, ISSN 0098-7484, 07/2006, Volume 296, Issue 1, pp. 87 - 93
CONTEXT During a clinical trial of a novel hydrocodone/acetaminophen combination, a high incidence of serum alanine aminotransferase (ALT) elevations was... 
UNITED-STATES | KNEE | IBUPROFEN | MEDICINE, GENERAL & INTERNAL | RISK-FACTORS | PHARMACOKINETICS | PARACETAMOL | INJURY | NAPROXEN | OSTEOARTHRITIS | PREVALENCE | Single-Blind Method | Analgesics, Non-Narcotic - pharmacokinetics | Humans | Acetaminophen - administration & dosage | Analgesics, Opioid - therapeutic use | Male | Alanine Transaminase - blood | Analgesics, Non-Narcotic - administration & dosage | Analgesics, Non-Narcotic - therapeutic use | Adult | Female | Acetaminophen - pharmacokinetics | Acetaminophen - therapeutic use | Longitudinal Studies | Care and treatment | Alanine aminotransferase | Substance abuse | Research | Acetaminophen | Health aspects | Liver diseases | Analgesics | Narcotics | Drug therapy | Placebo effect | Blood tests
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3. Full Text AGXT2: a promiscuous aminotransferase
by Rodionov, Roman N and Jarzebska, Natalia and Weiss, Norbert and Lentz, Steven R
Trends in Pharmacological Sciences, ISSN 0165-6147, 2014, Volume 35, Issue 11, pp. 575 - 582
Highlights • AGXT2 is a mitochondrial aminotransferase that has diverse functions in cellular physiology. • Several substrates and products of AGXT2 are... 
Advanced Basic Science | methylarginine | alanine | aminotransferase | glyoxylate | amino acid metabolism | Alanine | Glyoxylate | Amino acid metabolism | Aminotransferase | Methylarginine | RAT-LIVER | D-3-AMINOISOBUTYRATE-PYRUVATE AMINOTRANSFERASE | NITRIC-OXIDE SYNTHASE | PRIMARY HYPEROXALURIA TYPE-1 | CARDIOVASCULAR RISK-FACTOR | FLUORO-BETA-ALANINE | PHARMACOLOGY & PHARMACY | PORPHYRIN PRECURSORS | ALANINE-GLYOXYLATE AMINOTRANSFERASE | PYRUVATE AMINOTRANSFERASE | GENOME-WIDE ASSOCIATION | Animals | Transaminases - genetics | Humans | Transaminases - metabolism
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4. Full Text Alanine Aminotransferase Homologs Catalyze the Glutamate:Glyoxylate Aminotransferase Reaction in Peroxisomes of Arabidopsis
by Aaron H. Liepman and Laura J. Olsen
Plant Physiology, ISSN 0032-0889, 1/2003, Volume 131, Issue 1, pp. 215 - 227
Plant peroxisomal glyoxylate aminotransferases play central roles within the photorespiratory pathway. Genes encoding glyoxylate aminotransferases have been... 
Enzymes | Peroxisomes | Biochemical Processes and Macromolecular Structures | Complementary DNA | Reverse transcriptase polymerase chain reaction | Photorespiration | Amino acids | Glyoxylates | Plants | Kinetics | Seedlings | RAT-KIDNEY | ASPARTATE-AMINOTRANSFERASE | METABOLITE CONCENTRATIONS | MOLECULAR-CLONING | PYRUVATE AMINOTRANSFERASE | CDNA | L-ALANINE-2-OXOGLUTARATE AMINOTRANSFERASE | PANICUM-MILIACEUM | SPINACH LEAVES | SUBCELLULAR VOLUMES | PLANT SCIENCES | Amino Acid Sequence | Arabidopsis - enzymology | Isoenzymes - genetics | Transaminases - genetics | gamma-Glutamyltransferase | Molecular Sequence Data | Substrate Specificity | Phylogeny | Arabidopsis - genetics | Gene Expression Regulation, Enzymologic | Sequence Homology, Amino Acid | Alanine Transaminase - genetics | Escherichia coli - genetics | Isoenzymes - metabolism | Light | Escherichia coli - metabolism | Gene Expression Regulation, Plant | Transaminases - metabolism | Alanine Transaminase - metabolism | Peroxisomes - enzymology | Arabidopsis | Physiological aspects | Alanine aminotransferase | Chemical properties | Research | Glutamate
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5. Full Text A systematic review of data on biological variation for alanine aminotransferase, aspartate aminotransferase and γ-glutamyl transferase
by Carobene, Anna and Braga, Federica and Roraas, Thomas and Sandberg, Sverre and Bartlett, William A
Clinical Chemistry and Laboratory Medicine, ISSN 1434-6621, 10/2013, Volume 51, Issue 10, pp. 1997 - 2007
Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamyl transferase (GGT) are enzymes measured in serum or plasma to investigate liver... 
quality specification | enzymes | biological variation | reference change value | Enzymes | Biological variation | Reference change value | Quality specification | LONG-TERM | COLLATED DATA | CATALYTIC ACTIVITY CONCENTRATIONS | ANALYTIC COMPONENTS | VARIABILITY | DAY-TO-DAY | 37-DEGREES-C | SERUM CONSTITUENTS | INTRAINDIVIDUAL VARIATION | VALUES | MEDICAL LABORATORY TECHNOLOGY | Liver Diseases - blood | Data Interpretation, Statistical | gamma-Glutamyltransferase - blood | Humans | Middle Aged | Male | Reference Values | Alanine Transaminase - blood | Aspartate Aminotransferases - blood | Adolescent | Adult | Female | Liver Diseases - diagnosis | Aged | Databases, Bibliographic | Chronic Disease | Quality Control
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6. Full Text NMR Studies of Protonation and Hydrogen Bond States of Internal Aldimines of Pyridoxal 5′-Phosphate Acid–Base in Alanine Racemase, Aspartate Aminotransferase, and Poly‑l‑lysine
by Chan-Huot, Monique and Dos, Alexandra and Zander, Reinhard and Sharif, Shasad and Tolstoy, Peter M and Compton, Shara and Fogle, Emily and Toney, Michael D and Shenderovich, Ilya and Denisov, Gleb S and Limbach, Hans-Heinrich
Journal of the American Chemical Society, ISSN 0002-7863, 12/2013, Volume 135, Issue 48, pp. 18160 - 18175
Using 15N solid-state NMR, we have studied protonation and H-bonded states of the cofactor pyridoxal 5′-phosphate (PLP) linked as an internal aldimine in... 
COLI TRYPTOPHAN SYNTHASE | ULTRAVIOLET-VISIBLE SPECTROSCOPY | ACTIVE-SITE | TYROSINE PHENOL-LYASE | SCHIFF-BASES | NUCLEAR-MAGNETIC-RESONANCE | ESCHERICHIA-COLI | INITIO MODEL-CALCULATIONS | GEMINAL DIAMINE FORMATION | CHEMISTRY, MULTIDISCIPLINARY | SOLID-STATE | Protons | Pyridoxal Phosphate - chemistry | Geobacillus stearothermophilus - chemistry | Geobacillus stearothermophilus - enzymology | Escherichia coli - enzymology | Hydrogen Bonding | Magnetic Resonance Spectroscopy | Alanine Racemase - chemistry | Aspartate Aminotransferases - chemistry | Polylysine - chemistry | Escherichia coli - chemistry
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7. Full Text Does turmeric/curcumin supplementation improve serum alanine aminotransferase and aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease? A systematic review and meta‐analysis of randomized controlled trials
by Goodarzi, Reza and Sabzian, Kamran and Shishehbor, Farideh and Mansoori, Anahita
Phytotherapy Research, ISSN 0951-418X, 03/2019, Volume 33, Issue 3, pp. 561 - 570
We performed a meta‐analysis to evaluate the efficacy of turmeric/curcumin supplementation on serum alanine aminotransferase (ALT) and aspartate... 
nonalcoholic fatty liver disease | turmeric | meta‐analysis | curcumin | meta-analysis | NAFLD | CHEMISTRY, MEDICINAL | EFFICACY | SAFETY | NATURAL-HISTORY | GINGER | PHARMACOLOGY & PHARMACY | STEATOHEPATITIS | EXPRESSION | EPIDEMIOLOGY | Medicine, Experimental | Medical research | Aspartate | Care and treatment | Fatty liver | Analysis | Alanine | Liver diseases | Liver | Clinical trials | Disease control | Patients | Scientific papers | Randomization | Alanine transaminase | Search engines | Aspartate aminotransferase | Curcumin | Supplementation
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8. Full Text A noninvasive model to predict liver histology in HBeAg-positive chronic hepatitis B with alanine aminotransferase ≤ 2upper limit of normal
by Gao, Shuai and Li, Xin-You and Fan, Yu-Chen and Sun, Feng-Kai and Han, Li-Yan and Li, Feng and Ji, Xiang-Fen and Wang, Kai
Journal of Gastroenterology and Hepatology (Australia), ISSN 0815-9319, 01/2017, Volume 32, Issue 1, pp. 215 - 220
Background and AimLiver biopsy remains the gold standard to evaluate liver histology. However, it has several limitations. This study aims to construct a... 
chronic hepatitis B | noninvasive model | liver biopsy | liver histology | SUBSTITUTE | BIOPSY | NATURAL-HISTORY | NEED | VIRUS GENOTYPE-C | SIGNIFICANT FIBROSIS | CIRRHOSIS | DISEASE | INFECTION | GASTROENTEROLOGY & HEPATOLOGY | CHRONIC VIRAL-HEPATITIS | Predictive Value of Tests | Liver - pathology | Humans | Middle Aged | Logistic Models | Male | Alanine Transaminase - blood | Biomarkers - blood | Hepatitis B, Chronic - diagnosis | Antiviral Agents - administration & dosage | Hepatitis B, Chronic - virology | Hepatitis B, Chronic - drug therapy | Adult | Female | Hepatitis B e Antigens - blood | Hepatitis B, Chronic - pathology | Antiviral agents | Models | Liver | Hepatitis B | Alanine | Hepatitis B surface antigen | Albumin | Histology | Hepatitis B e antigen | Hepatitis | Biopsy | Fibrosis | Alanine transaminase | Aspartate aminotransferase | Interferon | Deoxyribonucleic acid--DNA
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9. Full Text An association study of functional polymorphic genes IRF -1, IFNGR -1, and IFN -γ with disease progression, aspartate aminotransferase, alanine aminotransferase, and viral load in chronic hepatitis B and C
by Korachi, May and Ceran, Nurgül and Adaleti, Riza and Nigdelioglu, Adil and Sökmen, Mehmet
International Journal of Infectious Diseases, ISSN 1201-9712, 2012, Volume 17, Issue 1, pp. e44 - e49
Summary Background Investigational approaches based on genome-wide association studies have proven useful in identifying genetic predictors for many diseases,... 
Infectious Disease | Pulmonary/Respiratory | Hepatitis | IFN-γ | IRF-1 | Viral load | IFNGR-1 | Genetic polymorphisms | HIV-1 | INFECTIOUS DISEASES | TRANSCRIPTION | RECEPTOR | RISK | IFN-gamma | INTERFERON-GAMMA | INFECTION | Humans | Middle Aged | Hepatitis C, Chronic - virology | Male | Alanine Transaminase - blood | Case-Control Studies | Viral Load | Hepatitis B, Chronic - genetics | Adult | Female | Hepacivirus - physiology | Hepatitis B, Chronic - blood | Interferon-gamma - genetics | Receptors, Interferon - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Genotype | Hepatitis B virus - physiology | Hepatitis C, Chronic - blood | Disease Progression | Interferon Regulatory Factor-1 - genetics | Hepatitis B, Chronic - virology | Turkey | Aspartate Aminotransferases - blood | Aged | Polymorphism, Single Nucleotide | Hepatitis C, Chronic - genetics
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10. Full Text Prevalence of Elevated Alanine Aminotransferase Among US Adolescents and Associated Factors: NHANES 1999–2004
by Fraser, Abigail and Longnecker, Matthew P and Lawlor, Debbie A
Gastroenterology, ISSN 0016-5085, 2007, Volume 133, Issue 6, pp. 1814 - 1820
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is a common cause of liver disease in children and adolescents. The majority of studies of NAFLD in... 
Gastroenterology and Hepatology | UNITED-STATES | OBESE CHILDREN | METABOLIC SYNDROME | FATTY LIVER-DISEASE | INSULIN-RESISTANCE | GAMMA-GLUTAMYL-TRANSFERASE | RISK | STEATOHEPATITIS | CORONARY HEART-DISEASE | GASTROENTEROLOGY & HEPATOLOGY | CHILDHOOD OBESITY | Prevalence | Nutrition Surveys | Humans | Risk Factors | Male | Alanine Transaminase - blood | Disease Progression | Fatty Liver, Alcoholic - blood | Fatty Liver, Alcoholic - diagnosis | Adolescent | Adult | Female | Child | Alanine | Analysis | Alanine aminotransferase
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11. Full Text Structural analysis of phosphoserine aminotransferase (isoform 1) from arabidopsis Thaliana– the enzyme involved in the phosphorylated pathway of serine biosynthesis
by Sekula, Bartosz and Ruszkowski, Milosz and Dauter, Zbigniew and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Frontiers in Plant Science, ISSN 1664-462X, 07/2018, Volume 9, Issue 7, 2018, p. 876
Phosphoserine aminotransferase (PSAT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the conversion of 3-phosphohydroxypyruvate (3-PHP) to... 
Serine metabolism | Geminal diamine | Pyridoxal 5′-phosphate | PSAT | PLP | Transaminase | CRYSTAL-STRUCTURE | ALANINE AMINOTRANSFERASE | transaminase | MULTIPLE SEQUENCE ALIGNMENT | HYDROXYMETHYLTRANSFERASE | ACCURACY | PLANT SCIENCES | REFINEMENT | CONSERVATION | STRUCTURE VALIDATION | pyridoxal 5 '-phosphate | MEDICAGO-TRUNCATULA | ELECTROSTATICS | serine metabolism | geminal diamine | Arabidopsis thaliana | Physiological aspects | Biosynthesis | Aminotransferases | Observations | pyridoxal 5′-phosphate
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12. Full Text The Effect of General Anesthesia on Aminotransferase Levels in Patients with Elevated Aminotransferase Levels: A Single-Center 5-Year Retrospective Study
by Cho, Youn Joung and Park, Young Jae and Min, Se Hee and Ryu, Ho-Geol
Anesthesia & Analgesia, ISSN 0003-2999, 12/2015, Volume 121, Issue 6, pp. 1529 - 1533
BACKGROUND:The effect of commonly used anesthetics on postoperative aminotransferase levels in patients with preoperatively elevated values is unclear.... 
SEVOFLURANE ANESTHESIA | ENZYMES | SERUM ALANINE AMINOTRANSFERASE | ANESTHESIOLOGY | RIGHT HEPATECTOMY | DONORS | PREVALENCE | LIVER-DISEASE | DESFLURANE | HALOTHANE | RENAL-FUNCTIONS | Time Factors | Humans | Middle Aged | Adult | Female | Male | Aged | Alanine Transaminase - blood | Retrospective Studies | Anesthesia, General - adverse effects | Biomarkers - blood | Preoperative Care - methods
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13. Full Text Prognostic value of pretreatment serum alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and gamma glutamyltransferase (GGT) in patients with esophageal squamous cell carcinoma
by Huang, Hao and Wang, Xue-Ping and Li, Xiao-Hui and Chen, Hao and Zheng, Xin and Lin, Jian-Hua and Kang, Ting and Zhang, Lin and Chen, Pei-Song
BMC Cancer, ISSN 1471-2407, 08/2017, Volume 17, Issue 1, pp. 544 - 11
Background: The levels of liver function tests (LFTs) are often used to assess liver injury and non-liver disease- related mortality. In our study, the... 
Gamma glutamyltransferase | Esophageal squamous cell carcinoma | Prognosis | Alanine aminotransferase/aspartate aminotransferase ratio | Overall survival | MORTALITY | GLUTAMYL-TRANSFERASE | METAANALYSIS | MARKERS | RISK | ALCOHOL-CONSUMPTION | BREAST-CANCER | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | INFLAMMATION | ASSOCIATION | Carcinoma, Squamous Cell - blood | Carcinoma, Squamous Cell - enzymology | gamma-Glutamyltransferase - blood | Esophageal Neoplasms - blood | Humans | Middle Aged | Proportional Hazards Models | Male | Alanine Transaminase - blood | Carcinoma, Squamous Cell - diagnosis | Esophageal Neoplasms - enzymology | Carcinoma, Squamous Cell - mortality | Aspartate Aminotransferases - blood | Esophageal Neoplasms - mortality | Esophageal Neoplasms - diagnosis | Female | Retrospective Studies | Esophageal Squamous Cell Carcinoma | Usage | Squamous cell carcinoma | Diagnosis | Liver function tests
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14. Full Text Alanine aminotransferase‐based algorithms of liver stiffness measurement by transient elastography (Fibroscan) for liver fibrosis in chronic hepatitis B
by Chan, H. L.‐Y and Wong, G. L.‐H and Choi, P. C.‐L and Chan, A. W.‐H and Chim, A. M.‐L and Yiu, K. K.‐L and Chan, F. K.‐L and Sung, J. J.‐Y and Wong, V. W.‐S
Journal of Viral Hepatitis, ISSN 1352-0504, 01/2009, Volume 16, Issue 1, pp. 36 - 44
The aim of this study is to know the liver stiffness measurement (LSM) cutoffs for different stages of liver fibrosis in chronic hepatitis B (CHB) and to... 
histology | liver biopsy | hepatitis B virus | liver cirrhosis | Liver biopsy | Histology | Hepatitis B virus | Liver cirrhosis | DIAGNOSIS | INFECTIOUS DISEASES | BIOPSY | MARKERS | RISK | LAMIVUDINE | HEPATOCELLULAR-CARCINOMA | VIROLOGY | CIRRHOSIS | DISEASE | INFECTION | GASTROENTEROLOGY & HEPATOLOGY | Severity of Illness Index | Liver - pathology | Liver Cirrhosis - diagnosis | Humans | Middle Aged | Male | Alanine Transaminase - blood | Adult | Female | ROC Curve | Retrospective Studies | Hepatitis B, Chronic - pathology | Elasticity Imaging Techniques | Measurement | Alanine | Algorithms | Liver | Fibrosis | Hepatitis B
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15. Full Text Association of total testosterone, free testosterone, bioavailable testosterone and sex hormone–binding globulin with hepatic steatosis and the ratio of aspartate aminotransferase to alanine aminotransferase
by Yang, Qingtao and Wu, Kusheng and Zhuang, Yiyi and Wu, Haoqiang and Lu, Liang and Li, Wencai and Li, Zhenjie and Sui, Xuxia
Endocrine Journal, ISSN 0918-8959, 2018, Volume 65, Issue 9, pp. 915 - 921
Several articles have shown the inverse association between total testosterone (TT) or sex hormone–binding globulin (SHBG) and hepatic steatosis. No articles... 
Sex hormone–binding globulin | Alanine aminotransferase | Hepatic steatosis | Total testosterone | Sex hormone-binding globulin | REDUCTION | FATTY LIVER-DISEASE | ENZYMES | ENDOCRINOLOGY & METABOLISM | NONALCOHOLIC STEATOHEPATITIS | SHBG | Cross-Sectional Studies | Fatty Liver - blood | Humans | Middle Aged | Sex Hormone-Binding Globulin - metabolism | Male | Alanine Transaminase - blood | Case-Control Studies | Testosterone - metabolism | Fatty Liver - diagnosis | Aspartate Aminotransferases - blood | Aged, 80 and over | Adult | Sex Hormone-Binding Globulin - analysis | Aged | Testosterone - blood | Alanine | Physical activity | Liver | Alcohol | Bioavailability | Steatosis | Testosterone | Fatty liver | Globulins | Alanine transaminase | Aspartate aminotransferase | Ultrasound | Smoking
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